FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors

Identification of FMR1-regulated molecular networks in human neurodevelopment

(2020) Meng Li et al.   GENOME RESEARCH

Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis

(2020) Youli Yao et al.   Frontiers in Pharmacology

Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity

(2020) Lifeng Zheng et al.   Nature Communications

RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis

(2020) Yu Gao et al.   Cell Reports

Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice

(2019) Minjie Shen et al.   NATURE NEUROSCIENCE

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

(2019) Kristie M. Garza et al.   JOURNAL OF NEUROSCIENCE

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

Mini-review: Update on the genetics of schizophrenia

(2018) Leda Coelewij et al.   ANNALS OF HUMAN GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

(2018) John Lisman et al.   NATURE NEUROSCIENCE

In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice

(2018) Haibo Zhou et al.   NATURE NEUROSCIENCE

A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence

(2018) Sira A. Franchi et al.   Frontiers in Cellular Neuroscience

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

(2018) Yue Li et al.   Nature Communications

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes

(2018) Qiping Dong et al.   eLife

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

(2018) Jivan Khlghatyan et al.   Frontiers in Molecular Neuroscience

Novel candidate genes and variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability

(2018) Regie Lyn P. Santos-Cortez et al.   HUMAN GENETICS

Widespread RNA editing dysregulation in brains from autistic individuals

(2018) Stephen S. Tran et al.   NATURE NEUROSCIENCE

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

(2018) Prashanth Rajarajan et al.   SCIENCE

Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells

(2017) Natalie E. Patzlaff et al.   HUMAN MOLECULAR GENETICS

The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders

(2017) Alexandre Bureau et al.   JOURNAL OF AFFECTIVE DISORDERS

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci

(2017) Atsushi Takata et al.   Nature Communications

T-type calcium channels in synaptic plasticity

(2016) Nathalie Leresche et al.   Channels

Continuous spike-waves during slow-wave sleep in a mouse model of focal cortical dysplasia

(2016) Qian-Quan Sun et al.   EPILEPSIA

A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region

(2016) Xiaohua Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Methyl-CpG-Binding Protein MBD1 Regulates Neuronal Lineage Commitment through Maintaining Adult Neural Stem Cell Identity

(2016) Emily M. Jobe et al.   JOURNAL OF NEUROSCIENCE

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1

(2016) M Niwa et al.   MOLECULAR PSYCHIATRY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Reduced Prepulse Inhibition as a Biomarker of Schizophrenia

(2016) Auxiliadora Mena et al.   Frontiers in Behavioral Neuroscience

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy

(2015) Guangfu Wang et al.   GENES & DEVELOPMENT

Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex

(2015) F. Luo et al.   NEUROSCIENCE

FXR1P is a GSK3β substrate regulating mood and emotion processing

(2015) Thomas Del’Guidice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility

(2015) Andrew J. Murray et al.   Scientific Reports

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Interneuron subtypes and orientation tuning

(2014) Seung-Hee Lee et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Concise Review: Fragile X Proteins in Stem Cell Maintenance and Differentiation

(2014) Yue Li et al.   STEM CELLS

FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation

(2014) Denise Cook et al.   Cell Reports

T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants

(2014) Giuseppe Gangarossa et al.   Frontiers in Behavioral Neuroscience

Volatile Solvents as Drugs of Abuse: Focus on the Cortico-Mesolimbic Circuitry

(2013) Jacob T Beckley et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

Fragile hearts: New insights into translational control in cardiac muscle

(2013) Daniela C. Zarnescu et al.   TRENDS IN CARDIOVASCULAR MEDICINE

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability

(2013) Laetitia Davidovic et al.   PLoS Genetics

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain

(2012) Miao He et al.   NEURON

Parvalbumin-Expressing Interneurons Linearly Transform Cortical Responses to Visual Stimuli

(2012) Bassam V. Atallah et al.   NEURON

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

FXR1P But Not FMRP Regulates the Levels of Mammalian Brain-Specific microRNA-9 and microRNA-124

(2011) X.-L. Xu et al.   JOURNAL OF NEUROSCIENCE

How Inhibition Shapes Cortical Activity

(2011) Jeffry S. Isaacson et al.   NEURON

Discrete Forebrain Neuronal Networks Supporting Noradrenergic Regulation of Sensorimotor Gating

(2011) Karen M Alsene et al.   NEUROPSYCHOPHARMACOLOGY

Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus

(2011) Denise Cook et al.   PLoS One

Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

(2011) Y. Sakai et al.   Science Translational Medicine

Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway

(2010) Anne Cheever et al.   RNA Biology

Fragile X protein family member FXR1P is regulated by microRNAs

(2010) A. Cheever et al.   RNA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs

(2009) J. C. Darnell et al.   HUMAN MOLECULAR GENETICS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior

(2009) Shlomit Flaisher-Grinberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits

(2008) A. M. Allan et al.   HUMAN MOLECULAR GENETICS

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE