Article
Medicine, General & Internal
Misaki Shinzato, Chika Miyagi-Shiohira, Kazuho Kuwae, Kai Nishime, Yoshihito Tamaki, Tasuku Yonaha, Mayuko Sakai-Yonaha, Ikuo Yamasaki, Ryusei Otsuka, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Summary: This study found that adding AP39 to the culture medium can reduce the deterioration of isolated islets and improve islet function. Additionally, islet transplantation outcomes were improved in diabetic mice when cultured with AP39, further advancing beta-cell replacement therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Weirun Li, Peier Chen, Yuxuan Pan, Ling Lu, Xiaodong Ning, Jiamin Liu, Jintao Wei, Minsheng Chen, Peng Zhao, Caiwen Ou
Summary: By using a complex scaffold and nanocomposite scaffold, a band-aid like patch can slowly release H2S and attach to the myocardium, relieving inflammation and promoting angiogenesis after myocardial infarction and recovering heart function.
Article
Biochemistry & Molecular Biology
Lifei Yang, Huimin Yang, Zhiwei Bian, Haiyan Lu, Li Zhang, Jian Chen
Summary: In plants exposed to combined stress of mercury and selenium, endogenous hydrogen sulfide was found to play a defensive role by decreasing reactive oxygen species levels, alleviating cell death, and promoting root growth. This study expands our understanding of the regulatory role of H2S in response to multiple stress conditions in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Lina Zhou, Xiaoyu Gao, Daan A. Weits, Peng Zeng, Xinyu Wang, Jing Cai
Summary: Our study reveals that endogenous H2S production is induced by anoxia, and appropriate application of exogenous H2S can alleviate damage caused by submergence stress. Mutants related to H2S metabolism exhibit different sensitivities to low oxygen levels compared to the wild type. Furthermore, ER stress response genes are up-regulated in wild type upon anoxia, and mutants related to ER stress response show increased sensitivity to submergence or anoxia.
Article
Biochemistry & Molecular Biology
Francisco Luis Espinosa-Vellarino, Inmaculada Garrido, Alfonso Ortega, Ilda Casimiro, Francisco Espinosa
Summary: The study demonstrates that Dittrichia viscosa plants preferentially accumulate Sb in roots, leading to differing behavior in the enzymatic antioxidant systems of roots and leaves. Sb appears to act by binding to thiol groups, altering free GSH content and SOD and GST activities, increasing the effects of NO and H2S to limit the Sb-induced redox imbalance. The interaction between NO, H2S, and H2O2 appears to be key in the response to stress induced by Sb.
Review
Biochemistry & Molecular Biology
Constantin Munteanu, Mariana Rotariu, Marius Turnea, Gabriela Dogaru, Cristina Popescu, Aura Spinu, Ioana Andone, Ruxandra Postoiu, Elena Valentina Ionescu, Carmen Oprea, Irina Albadi, Gelu Onose
Summary: This paper aims to systematically review the recent literature on the therapeutic role of hydrogen sulfide (H2S) in diabetes mellitus (DM) and summarize the research methods used. The results of the study indicate that although several compounds that release or stimulate H2S have been developed, the development of H2S as a therapeutic agent is still in its early stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eui Kyun Jeong, Baskar Selvaraj, Shyaka Clovis, Yun Jeong Son, Tae Hoo Park, Ashokkumar Veeramanoharan, Hoe-In Kim, Ki-Yeon Yoo, Jae Wook Lee, Chung-Min Park
Summary: Hydrogen sulfide (H2S) functions as an endogenous signaling molecule in various physiological and pathological processes in human cells. A study has developed hybrid molecules combining a slow-releasing H2S donor with powerful antioxidant natural products, exhibiting complementary neuroprotective effects against oxidative stress-induced neuronal damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Joshua J. Woods, Justin J. Wilson
Summary: A metal-based H2S donor has been developed for selective delivery of H2S to hypoxic cells, showing potential protective effects against ischemic reperfusion injury in rat cardiomyoblasts. These findings demonstrate the utility of redox-activated metal complexes as hypoxia-selective H2S-releasing agents for studying the role of this gas in complex biological systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biology
Varun Kamat, Brian M. Robbings, Seung-Ryoung Jung, John Kelly, James B. Hurley, Kenneth P. Bube, Ian R. Sweet
Summary: The study developed a fluidics system to control and measure the effects of dissolved gases on cell metabolism and function, evaluating the impacts of oxygen and H2S on pancreatic islets, retina, and liver. Findings revealed distinct effects of oxygen and H2S, showcasing the system's ability to quantify metabolic state and cell function in response to changes in dissolved gases.
Review
Biochemistry & Molecular Biology
Linda de Bont, Xiujie Mu, Bo Wei, Yi Han
Summary: Hydrogen sulfide (H2S) plays an important role in plant growth and adaptation to abiotic stress. It functions in defense by activating plant hormones and is involved in oxidative stress responses. Additionally, H2S interacts with nitric oxide and reactive oxygen species, regulating oxidative stress responses.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoling Yan, Meijun He, Hui Huang, Qi Wang, Yu Hu, Xiaoying Wang, Meng Jin, Yi Wang, Yiqing Xia, Yi Li, Gang Chen, Jian Cheng, Jia Jia
Summary: This study found that hydrogen sulfide (H2S), a gasotransmitter, is an endogenous modulator of continual phagocytosis following intracerebral hemorrhage (ICH). H2S promotes continual phagocytosis of dead cells by brain-resident phagocytic microglia through the CBS-H2S-complex I axis. This discovery has important implications for the treatment of ICH.
Article
Plant Sciences
Ting-Ying Zhong, Gai-Fang Yao, Sha-Sha Wang, Ting-Ting Li, Ke-Ke Sun, Jun Tang, Zhong-Qin Huang, Feng Yang, Yan-Hong Li, Xiao-Yan Chen, Lan-Ying Hu, Hua Zhang, Kang-Di Hu
Summary: Hydrogen sulfide (H2S) plays a crucial role in delaying ripening process, maintaining color and nutritional quality, and activating antioxidative system in postharvest tomato fruits.
JOURNAL OF PLANT GROWTH REGULATION
(2021)
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Article
Pharmacology & Pharmacy
Chuchu Lin, Chenyi Huang, Zhaoqing Shi, Meitong Ou, Shengjie Sun, Mian Yu, Ting Chen, Yunfei Yi, Xiaoyuan Ji, Feng Lv, Meiying Wu, Lin Mei
Summary: Hydrogen sulfide (H2S) acts as a gasotransmitter molecule, activating intracellular signaling pathways and exerting concentration-dependent antitumor effects. By encapsulating calcium sulfide (CaS) and indocyanine green (ICG) into a biodegradable nanomodulator, researchers have achieved pH-responsive H2S release, enabling the suppression of catalase activity, abnormal Ca2?? retention, mitochondrial destruction, and oxidative stress amplification. This leads to blocked ATP synthesis and downregulated heat shock protein expression, effectively inhibiting tumor growth.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Agriculture, Multidisciplinary
Wenwen Jiang, Dan Zhu, Longgang Zhao, Yu Liu, Chaoping Wang, Muhammad Salman Farid, Yuyi Gu, Jing Li, Tianhao Li, Yanan Sun, Wenxiang Li, Fansheng Cheng
Summary: Treatment with L-Cys can delay the aging process, reduce browning and weight loss, improve soluble protein and total phenolic content, and enhance antioxidant enzyme activity in fresh-cut button mushrooms.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shuai Bai, Muhua Mao, Libing Tian, Yanzhen Yu, Jiujiang Zeng, Kai Ouyang, Lidong Yu, Linling Li, Danbi Wang, Xianqing Deng, Churong Wei, Yougen Luo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Jianying Tian, Yougen Luo, Weiwei Chen, Shengsen Yang, Hao Wang, Jing Cui, Zhiyan Lu, Yuanye Lin, Yongyi Bi
BIOLOGICAL TRACE ELEMENT RESEARCH
(2016)
Article
Cell Biology
Liping Zhu, Yougen Luo, Taoxiang Chen, Fengrong Chen, Tao Wang, Qinghua Hu
JOURNAL OF CELL SCIENCE
(2008)
Article
Biochemistry & Molecular Biology
Yougen Luo, Xifei Yang, Shenting Zhao, Churong Wei, Yedong Yin, Ting Liu, Sainv Jiang, Jiajun Xie, Xiaomei Wan, Muhua Mao, Jiyun Wu
NEUROCHEMISTRY INTERNATIONAL
(2013)
Article
Toxicology
Xifei Yang, Chun'e He, Jie Li, Hongbin Chen, Quan Ma, Xiaojing Sui, Shengli Tian, Ming Ying, Qian Zhang, Yougen Luo, Zhixiong Zhuang, Jianjun Liu
TOXICOLOGY LETTERS
(2014)
Article
Biotechnology & Applied Microbiology
Libing Tian, Rui Pei, Xiaojun Zhang, Kun Li, Yuting Zhong, Yougen Luo, Shu-Feng Zhou, Lichan Chen
Summary: This study proposes a hydrogen sulfide (H2S) gas-involved chemosensitization strategy for improving the effectiveness of chemotherapy in pancreatic cancer treatment. The developed nanomedicine has the ability to penetrate tumors and release drugs and H2S, resulting in enhanced therapeutic effect. The nanomedicine also shows high in vivo biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Ming-Xia Song, Bao-Qi Rao, Bin-Bin Cheng, Yi, Wu, Hong Zeng, You-gen Luo, Xian-Qing Deng
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2017)
Article
Neurosciences
Yougen Luo, Xinwen Zhou, Xifei Yang, Jianzhi Wang
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)