Review
Biochemistry & Molecular Biology
Annamaria Tonazzi, Nicola Giangregorio, Lara Console, Ferdinando Palmieri, Cesare Indiveri
Summary: The SLC25A20 transporter, also known as the carnitine acyl-carnitine carrier (CAC), plays a crucial role in the transport of short, medium, and long carbon chain acyl-carnitines. Despite the lack of a clear 3D structure, CAC is one of the most extensively studied transport proteins in the inner mitochondrial membrane. Post-translational modifications have been found to regulate the transport activity of CAC, which can be influenced by drugs, toxic substances, and dietary compounds.
Article
Biochemistry & Molecular Biology
Nicola Giangregorio, Annamaria Tonazzi, Cosima Damiana Calvano, Ciro Leonardo Pierri, Giovanna Incampo, Tommaso R. I. Cataldi, Cesare Indiveri
Summary: The effect of mycotoxin patulin on the mitochondrial carnitine/acylcarnitine carrier was investigated. Patulin inhibited the transport function of the carrier in a competitive manner, interacting with a protein region including the substrate-binding area. Site-directed mutagenesis confirmed the key role of the C136 residue in the inhibition of patulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Perez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Celine Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martin, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero
Summary: Mitochondrial pyruvate uptake instructs metabolic flexibility for guiding T cell differentiation and antitumor responses.
Article
Multidisciplinary Sciences
Siobhan S. Pattwell, Sonali Arora, Nicholas Nuechterlein, Michael Zager, Keith R. Loeb, Patrick J. Cimino, Nikolas C. Holland, Noemi Reche-Ley, Hamid Bolouri, Damian A. Almiron Bonnin, Frank Szulzewsky, Vaishnavi V. Phadnis, Tatsuya Ozawa, Michael J. Wagner, Michael C. Haffner, Junyue Cao, Jay Shendure, Eric C. Holland
Summary: This article highlights the previously unidentified role of the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, embryogenesis, transformation, and oncogenesis. TrkB.T1 is an important isoform in these processes and is expressed in both embryonic and adult tumors. The study also reveals its interaction with developmental and oncogenic signaling pathways, suggesting its potential to reshape our understanding of developmental systems and oncology.
Article
Multidisciplinary Sciences
Manjul Rana, Jianrong Dong, Matthew J. Robertson, Cristian Coarfa, Nancy L. Weigel
Summary: This study found differences in transcription and splicing regulation between AR-V7 and AR in prostate cancer, leading to the generation of different gene products.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariafrancesca Scalise, Cesare Indiveri
Summary: Summary of the Study:
The interaction between Cys and itaconate was investigated, and it was found that itaconate reacts with CAC causing irreversible inhibition. By lowering the pH, the inhibitory effect of itaconate on CAC was reduced. C136 was identified as the main target of itaconate, and administration of dimethyl itaconate to HeLa cells resulted in inhibition of CAC transport activity.
Article
Medicine, Research & Experimental
Peng Zheng, Hengfang Wu, Yilu Gu, Luo Li, Ran Hu, Wenjing Ma, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Chen
Summary: This study investigates whether the cardiac pleiotropic effects of atorvastatin are associated with the regulation of fatty acid oxidation (FAO) through the carnitine palmitoyltransferase 1 (CPT1). The results show that atorvastatin improves mitochondrial dysfunction and cardiac hypertrophy induced by high-fat diet, and lowers CPT1 and FAO levels. It is the first study to explore the cardiac pleiotropic effects of atorvastatin with respect to FAO.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Philipp Rentzsch, Max Schubach, Jay Shendure, Martin Kircher
Summary: The study compared several machine learning methods that score variant effects on splicing using an experimental dataset, integrating the best methods into general variant effect prediction models and evaluating the impact on the classification of known pathogenic variants. The inclusion of splicing DNN effect scores substantially improved predictions across multiple variant categories in the new CADD-Splice model, without compromising overall performance.
Review
Biochemistry & Molecular Biology
Vincenzo Zara, Graziana Assalve, Alessandra Ferramosca
Summary: This review critically analyzes the multiple roles of mitochondrial CIC in cellular processes and discusses the regulation of its activity and the metabolic significance of citrate flux.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rachid Boutoual, Hyunsun Jo, Indra Heckenbach, Ritesh Tiwari, Herbert Kasler, Chad A. Lerner, Samah Shah, Birgit Schilling, Vincenzo Calvanese, Matthew J. Rardin, Morten Scheibye-Knudsen, Eric Verdin
Summary: In this study, a novel mitochondrial protein mt-ELP3 was identified, which was found to regulate the post-transcriptional modification of mitochondrial-transfer RNAs (mt-tRNAs). Overexpression of mt-ELP3 led to increased mitochondrial translation and expression of OXPHOS complexes.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Eugenia Messina, Camilla Pires de Souza, Claudia Cappella, Simona Nicole Barile, Pasquale Scarcia, Isabella Pisano, Luigi Palmieri, Jean-Marc Nicaud, Gennaro Agrimi
Summary: The study identified the mitochondrial carrier YlCrc1 involved in the Carnitine/Acetyl-Carnitine shuttle in Y. lipolytica. Manipulation of YlCrc1 improved propionate utilization and its conversion into OCFAs. These genetic modifications and the use of a lipogenic medium led to enhanced accumulation of OCFAs in Y. lipolytica.
MICROBIAL CELL FACTORIES
(2023)
Article
Pathology
Donna C. Ferguson, Douglas A. Mata, Timothy Ky Tay, Tiffany A. Traina, Ayca Gucalp, Sarat Chandarlapaty, Timothy M. D'Alfonso, Edi Brogi, Kerry Mullaney, Marc Ladanyi, Maria E. Arcila, Ryma Benayed, Dara S. Ross
Summary: The prevalence of AR-V7 in breast cancer is 9.7%, with a correlation to AR positivity and apocrine morphology. Notably, AR-V7 was detected in both primary and metastatic/recurrent breast cancer patients without prior endocrine therapy, suggesting potential implications for targeted treatment.
Article
Biology
Alicia Tapias, David Lazaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Summary: The study reveals the importance of TRRAP for neuroprotection and the network connecting TRRAP, HAT, and SP1 in regulating microtubule dynamics.
Review
Biochemistry & Molecular Biology
Rami Mosaoa, Anna Kasprzyk-Pawelec, Harvey R. Fernandez, Maria Laura Avantaggiati
Summary: The mitochondrial citrate/isocitrate carrier (CIC) plays a crucial role in human diseases by facilitating the transport of ions and metabolites through the mitochondrial membrane, impacting mitochondrial metabolism and respiration. Additionally, CIC also serves various fundamental activities in the cytosol, such as acting as a metabolic substrate, an allosteric enzymatic regulator, and an epigenetic modifier.
Article
Multidisciplinary Sciences
Shur Galecka, Bogusz Kulawiak, Piotr Bednarczyk, Harpreet Singh, Adam Szewczyk
Summary: The study found that the VEDEC splice variant forms a functional channel in the inner mitochondrial membrane, providing a new insight into cell survival during ischemia/reperfusion injury of cardiac cells. The results demonstrate that HEK293T cells can be a promising experimental model for the expression and electrophysiological studies of mitochondrial potassium channels.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Luisa Jasper, Pasquale Scarcia, Stephan Rust, Janine Reunert, Ferdinando Palmieri, Thorsten Marquardt
Summary: SLC25A36 is a crucial nucleotide carrier for mitochondrial biogenesis. Mutations in SLC25A36 can lead to various diseases, including hypothyroidism. Oral uridine supplementation may be beneficial in improving symptoms and promoting patient development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Nicoletta Guaragnella, Gennaro Agrimi, Pasquale Scarcia, Clelia Suriano, Isabella Pisano, Antonella Bobba, Cristina Mazzoni, Luigi Palmieri, Sergio Giannattasio
Summary: The mitochondrial RTG-dependent retrograde signaling plays a role in various environmental stresses, with regulators identified in Saccharomyces cerevisiae. The activity of the transcriptional complex Rtg1/3 is modulated by Hog1 in response to osmotic stress, and RTG pathway contributes to osmoadaptation in an HOG1-dependent manner. Impairment of RTG signaling causes a decrease in mitochondrial respiratory capacity exclusively under osmostress, suggesting possible sequential interaction between HOG1 and the RTG pathway in stress signaling cascade.
Article
Food Science & Technology
Gabriella Siesto, Rocchina Pietrafesa, Vittoria Infantino, Channmuny Thanh, Ilaria Pappalardo, Patrizia Romano, Angela Capece
Summary: This study aimed to evaluate the probiotic and health-beneficial potential of indigenous Saccharomyces cerevisiae strains, and several strains with potential probiotic ability were identified. These strains could be used as dietary supplements, starters for functional food production, or therapeutically.
Review
Biology
Simona Todisco, Anna Santarsiero, Paolo Convertini, Giulio De Stefano, Michele Gilio, Vito Iacobazzi, Vittoria Infantino
Summary: Non-alcoholic steatohepatitis (NASH) is a serious transformation from simple steatosis to inflammation and hepatic injury. Profound metabolic dysregulations are associated with NASH, and the peroxisomal-proliferator-activated receptor alpha (PPAR alpha) plays a key role in its pathogenesis. However, many aspects of NASH have not yet been fully clarified.
Article
Energy & Fuels
Mattia Colacicco, Cosetta Ciliberti, Gennaro Agrimi, Antonino Biundo, Isabella Pisano
Summary: The yeast Yarrowia lipolytica has been used to convert waste cooking oil into high-value bio-based products. This study focused on the simultaneous production of intracellular lipids and extracellular lipases by optimizing the culture conditions. The results showed a direct correlation between the availability of free fatty acids in the media and the levels of lipase activity and single-cell oil accumulation.
Article
Biochemistry & Molecular Biology
Anna Santarsiero, Ilaria Pappalardo, Gabriella Margherita Rosa, Isabella Pisano, Stefano Superchi, Paolo Convertini, Simona Todisco, Patrizia Scafato, Vittoria Infantino
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and a significant cause of cancer-related deaths. In this study, a newly synthesized chalcone ETTC showed cytotoxic activity and induced apoptosis in HCC cells through the activation of the intrinsic pathway of apoptosis and mitochondrial targeting. These findings suggest the potential antitumor effect of ETTC in HCC.
Article
Biochemistry & Molecular Biology
Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, Michael A. Cahill
Summary: Sigma-2 receptor (S2R) is functionally associated with both transmembrane protein TMEM97 and translocator protein (TSPO). This study provides evidence of the interaction between S2R and TSPO, as well as the physical colocalization of TMEM97 and TSPO in certain cancer cells. Additionally, the role of S2R-interacting partner PGRMC1 was clarified. This is the first suggestion of a functional interaction between TSPO and TMEM97, which can be influenced by S2R ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Antonietta Di Noia, Pasquale Scarcia, Gennaro Agrimi, Ohiemi Benjamin Ocheja, Ehtisham Wahid, Isabella Pisano, Eleonora Paradies, Luigi Palmieri, Cataldo Guaragnella, Nicoletta Guaragnella
Summary: Mitochondrial RTG signaling pathway plays a cytoprotective role in response to intracellular or environmental stresses. In this study, the interplay between RTG2 and HAP4 in osmoadaptation was investigated, revealing their roles in enhancing cellular adaptability and mediating peroxisomes-mitochondria communication through modulation of mitochondrial metabolic function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Simone Pani, Ilaria Pappalardo, Anna Santarsiero, Antonio Vassallo, Rosa Paola Radice, Giuseppe Martelli, Francesco Siano, Simona Todisco, Paolo Convertini, Carla Caddeo, Vittoria Infantino
Summary: Multiple studies have shown that plant extracts can effectively combat various diseases, especially skin disorders, by providing overall protective effects. Pistachio is known for its bioactive compounds that contribute to overall health, but the toxicity and low bioavailability of these compounds limit their benefits. To overcome these limitations, phospholipid vesicles can be used as delivery systems. This study produced essential oil and hydrolate from discarded Pistachio stalks and formulated them in phospholipid vesicles for skin application. The results showed that transfersomes in particular not only reduced the cytotoxicity of the essential oil but also enhanced its ability to inhibit inflammatory mediators.
Review
Biochemistry & Molecular Biology
Giovanni Davide Barone, Anita Emmerstorfer-Augustin, Antonino Biundo, Isabella Pisano, Paola Coccetti, Valeria Mapelli, Andrea Camattari
Summary: Since the mid-1960s, the methylotrophic yeast Komagataella phaffii has gained scientific attention for its industrial production of proteins. This review provides a summary of fundamental and specific information in this field, including the products produced at industrial levels by various companies and the patents and workflow for protein production with this strain.
Review
Biology
Dominga Iacobazzi, Paolo Convertini, Simona Todisco, Anna Santarsiero, Vito Iacobazzi, Vittoria Infantino
Summary: NF-κB transcription factors play a pivotal role in regulating immune cell activation and have a complex interplay with energetic metabolism in innate immunity. New insights into NF-κB function and its crosstalk with immunometabolism contribute to a deeper understanding of molecular mechanisms and potential therapeutic targets for inflammatory/immune chronic diseases.
Article
Medicine, Research & Experimental
Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto, Vittoria Infantino
Summary: This study explores the role of the immunometabolic enzyme ATP citrate lyase (ACLY) in liver function and the pathogenesis of MASH. Inhibition of ACLY can reverse lipid accumulation and oxidative damage while reducing the secretion of inflammatory cytokines. ACLY and ME1 mRNA levels are increased in macrophages from MASH patients, and the use of ACLY inhibitors and red wine powder can significantly lower these levels and reduce the production of inflammatory mediators.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Ilaria Pappalardo, Anna Santarsiero, Rosa Paola Radice, Giuseppe Martelli, Giulia Grassi, Marcos Roberto de Oliveira, Vittoria Infantino, Simona Todisco
Summary: This study investigated the effects of two strains of H. pluvialis (FBR1 and FBR2) on lipid metabolism, lipolysis, and adipogenesis. The results showed that FBR2 extract reduced lipid deposition, decreased the secretion of interleukin-6 and tumor necrosis factor-a, and improved mitochondrial function. These findings suggest that FBR2 extract may be a promising strategy in overweight and obesity prevention and treatment.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)