Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase

The I-TASSER Suite: protein structure and function prediction

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Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

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Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

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Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

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Allosteric Regulation of the Hsp90 Dynamics and Stability by Client Recruiter Cochaperones: Protein Structure Network Modeling

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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

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Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase

(2014) M. G. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric Oxide-Induced Conformational Changes in Soluble Guanylate Cyclase

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Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery

(2014) C. Ratzke et al.   Nature Communications

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90

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Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking

(2013) Bradley G. Fritz et al.   BIOCHEMISTRY

YC-1 Binding to the β Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the α Subunit

(2013) Rahul Purohit et al.   BIOCHEMISTRY

Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase

(2013) E. S. Underbakke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Function and Regulation of the Hsp90 Machinery

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Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

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The Therapeutic Target Hsp90 and Cancer Hallmarks

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The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

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The network interaction of the human cytosolic 90kDa heat shock protein Hsp90: A target for cancer therapeutics

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Uncovering a Region of Heat Shock Protein 90 Important for Client Binding in E. coli and Chaperone Function in Yeast

(2012) Olivier Genest et al.   MOLECULAR CELL

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

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Post-translational modifications of Hsp90 and their contributions to chaperone regulation

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Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

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Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process

(2011) Arnab Ghosh et al.   FASEB JOURNAL

Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination

(2011) Hwei-Ming Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

(2011) Anatoly Soshilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-Monomer Substrate Contacts Reposition the Hsp90 N-Terminal Domain and Prime the Chaperone Activity

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Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex

(2011) Daniel R. Southworth et al.   MOLECULAR CELL

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53

(2011) Franz Hagn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Hexameric Structures of Human Heat Shock Protein 90

(2011) Cheng-Chung Lee et al.   PLoS One

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

(2011) M. B. Winter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of a Heme-Regulated Eukaryotic Initiation Factor 2αkinase Enhances the Interaction with Heat-Shock Protein 90 and Substantially Upregulates kinase Activity

(2011) Kentaro Mukai et al.   PROTEIN AND PEPTIDE LETTERS

Atomic-Level Protein Structure Refinement Using Fragment-Guided Molecular Dynamics Conformation Sampling

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The HADDOCK web server for data-driven biomolecular docking

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Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase

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The function of NO-sensitive guanylyl cyclase: What we can learn from genetic mouse models

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A Unique Mechanism of Chaperone Action: Heme Regulation of Hap1 Activity Involves Separate Control of Repression and Activation

(2009) Hee Lee et al.   PROTEIN AND PEPTIDE LETTERS

How well can the accuracy of comparative protein structure models be predicted?

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