Bordetella pertussisLipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

(2014) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

Tetraacylated Lipid A and Paclitaxel-Selective Activation of TLR4/MD-2 Conferred through Hydrophobic Interactions

(2014) N. Resman et al.   JOURNAL OF IMMUNOLOGY

TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation

(2014) W. Cui et al.   JOURNAL OF IMMUNOLOGY

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

(2013) Alena Fornůsková et al.   BMC EVOLUTIONARY BIOLOGY

Adjuvant Activity of Naturally Occurring Monophosphoryl Lipopolysaccharide Preparations from Mucosa-Associated Bacteria

(2013) Paula M. Chilton et al.   INFECTION AND IMMUNITY

Minor Modifications to the Phosphate Groups and the C3′ Acyl Chain Length of Lipid A in TwoBordetella pertussisStrains, BP338 and 18-323, Independently Affect Toll-like Receptor 4 Protein Activation

(2013) Nita R. Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

(2012) Adeline M. Hajjar et al.   PLoS Pathogens

Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions

(2011) J. Meng et al.   JOURNAL OF IMMUNOLOGY

Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF- B Activation and Release of Proinflammatory Cytokines in Cells Expressing Human but Not Murine Toll-Like Receptor 4-MD-2-CD14

(2010) N. Marr et al.   INFECTION AND IMMUNITY

MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA

(2010) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variability in the Lipooligosaccharide Structure and Endotoxicity amongBordetella pertussisStrains

(2010) Nico Marr et al.   JOURNAL OF INFECTIOUS DISEASES

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Glucosamine Found as a Substituent of Both Phosphate Groups in Bordetella Lipid A Backbones: Role of a BvgAS-Activated ArnT Ortholog

(2008) N. Marr et al.   JOURNAL OF BACTERIOLOGY