Article
Plant Sciences
Dahae Lee, Sungyoul Choi, Ki Sung Kang
Summary: This study evaluated the effect of ginsenosides on palmitic acid-induced pancreatic beta-cell death and impairment of glucose-stimulated insulin secretion (GSIS). Protopanaxadiol (PPD) was identified as a potential therapeutic agent, which protected against apoptosis and lipid accumulation. PPD also prevented palmitic acid-induced impairment of insulin secretion.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Hematology
Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Cade Owens, Kumuda C. Das
Summary: The study identified Nrg1 beta as a RIPC factor that interacts with endothelial ErbB2 to prevent degradation and decrease myocardial apoptosis through other molecular pathways. This finding is crucial for understanding the protective mechanism of RIPC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue Tian, Xu Chen, Qianqian Jiang, Qianbin Sun, Tiantian Liu, Yiqin Hong, Yawen Zhang, Yanyan Jiang, Mingyan Shao, Ran Yang, Chun Li, Qiyan Wang, Yong Wang
Summary: NGR1 can improve heart function and reduce cardiac lipotoxicity in mice with heart failure by activating the AMPK pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexandra Griffiths, Jun Wang, Qing Song, Samuel Man Lee, Jose Cordoba-Chacon, Zhenyuan Song
Summary: This study found that ATF4 is a major transcription factor mediating hepatic CD36 expression, and its activation is associated with CD36 upregulation induced by palmitate and endoplasmic reticulum stress. The study further confirmed that the activation of the ATF4-CD36 pathway is involved in palmitate-induced hepatic lipotoxicity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zih-Syuan Wu, Shih-Ming Huang, Yu-Chi Wang
Summary: Endometrial cancer is the most common gynecological cancer worldwide. This study found that exogenous palmitate can induce cell cycle arrest, DNA damage, autophagy, and apoptosis in endometrial cancer cells, as well as increase chemosensitivity, providing a potential therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jin Wang, Jie Huang, Yuan-Quan Li, Shan Yao, Cui-Hong Wu, Ying Wang, Feng Gao, Min-Dong Xu, Guo-Bin Huang, Chang-Qin Zhao, Jia-Hui Wu, Yun-Long Zhang, Renjie Jiao, Zi-Hao Deng, Wei Jie, Hui-Bin Li, Aiguo Xuan, Xiang-Dong Sun
Summary: The ketogenic diet suppresses seizures by increasing Nrg1 gene expression, enhancing presynaptic GABA release probability in the hippocampus. The critical role of Nrg1 in mediating the effects of KD on GABAergic activity and seizures highlights the potential for developing new therapeutic interventions for seizure control.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E. Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Lee
Summary: This study investigates the molecular mechanisms of empagliflozin (EMPA), an SGLT2 inhibitor, in mitigating palmitate (PA)-induced cardiomyocyte injury and finds that EMPA significantly attenuates PA-induced impairments and enhances fatty acid oxidation. This study reveals a novel mechanism of EMPA's protective effects against PA-induced cardiomyocyte injury and provides new therapeutic insights.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Mengting Ke, Guangzhen He, Huawei Wang, Siyuan Cheng, Yancheng Xu
Summary: Deficiency of Sig-1R in MIN6 cells can affect cell proliferation, apoptosis, and insulin secretion, and exacerbate PA-induced beta cell apoptosis.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Agnese Filippello, Stefania Di Mauro, Alessandra Scamporrino, Sebastiano Alfio Torrisi, Gian Marco Leggio, Antonino Di Pino, Roberto Scicali, Maurizio Di Marco, Roberta Malaguarnera, Francesco Purrello, Salvatore Piro
Summary: The dysfunctions of intestinal cells in obesity and associated diabetes may be related to impaired intestinal cell development. Lipotoxicity affects the differentiation of specific intestinal cell types, including enterocytes, goblet cells, and CCK cells. These findings provide new targets for obesity and diabetes therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Carmen Miano, Donatella Romaniello, Martina Mazzeschi, Alessandra Morselli, Silvia Da Pra, Francesca Sacchi, Chiara Bongiovanni, Michela Sgarzi, Elvira Pantano, Mattia Lauriola, Gabriele D'Uva
Summary: ERBB4 levels are correlated with relapse-free survival in breast cancer patients, and it plays a cancer-protecting role in HER2-enriched and luminal A molecular subtypes. NRG1 may have both pro- and anti-proliferative effects on breast cancer cells, while NRG4 can enhance the anti-proliferative effects of anti-HER2 agents.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Heath L. Robinson, Zhibing Tan, Ivan Santiago-Marrero, Emily P. Arzola, Timothy Vladimir Dong, Wen-Cheng Xiong, Lin Mei
Summary: This study reveals the important roles of neuregulin 1 (NRG1) and its receptor ErbB4 in regulating hippocampal Sharp wave ripples (SW-Rs) and spatial working memory. The findings are further confirmed by experiments using chemical genetic mutant mice.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Qing Song, Jun Wang, Alexandra Griffiths, Samuel Man Lee, Iredia D. Iyamu, Rong Huang, Jose Cordoba-Chacon, Zhenyuan Song
Summary: This study investigated the effects of palmitate, the most abundant saturated fatty acid in human blood, on the transactivation of PPARy in hepatocytes. The results showed that palmitate exposure can activate PPARy through the upregulation of NNMT, which degrades nicotinamide, the precursor for cellular NAD+ biosynthesis. Furthermore, the decline in cellular NAD+ content caused by NNMT upregulation was identified as a potential mechanism behind palmitate-induced PPARy transactivation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eloisa Aparecida Vilas-Boas, Lisa Nalbach, Emmanuel Ampofo, Camila Ferraz Lucena, Lea Naudet, Fernanda Ortis, Angelo Rafael Carpinelli, Bruce Morgan, Leticia Prates Roma
Summary: Modern lifestyles, lack of physical activity, poor nutrition, and high levels of saturated free fatty acids in obese individuals contribute to the increasing prevalence of obesity and type 2 diabetes. The study suggests that transient NOX2-dependent H2O2 production may be a key factor in early palmitate-induced lipotoxic effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei Chen, Yang Lu, Dongwen Hu, Jianling Mo, Jingdan Ni
Summary: BP1 polysaccharide fraction isolated from black mulberry shows a better protective effect against lipotoxicity, and it can reduce lipotoxicity by activating the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Ryota Kawahara, Siro Simizu
Summary: ErbB4 negatively regulates vasculogenic mimicry (VM) formation in human breast cancer cells. NRG1 can promote VM formation by activating ErbB4, but excessive activation of ErbB4 has a negative effect. The E872K mutation of ErbB4 enhances ErbB4-mediated VM formation, suggesting it as a potential effective target for breast cancer.
Article
Biochemistry & Molecular Biology
Dan Zhou, Ryan A. Hlady, Marissa J. Schafer, Thomas A. White, Chen Liu, Jeong-Hyeon Choi, Jordan D. Miller, Lewis R. Roberts, Nathan K. LeBrasseur, Keith D. Robertson
Article
Geriatrics & Gerontology
Michael B. Stout, Frederik J. Steyn, Michael J. Jurczak, Joao-Paulo G. Camporez, Yi Zhu, John R. Hawse, Diana Jurk, Allyson K. Palmer, Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, James L. Kirkland
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Geriatrics & Gerontology
Brian R. Kotajarvi, Marissa J. Schafer, Elizabeth J. Atkinson, Megan M. Traynor, Charles J. Bruce, Kevin L. Greason, Rakesh M. Suri, Jordan D. Miller, Nathan K. LeBrasseur
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Medicine, General & Internal
Zaira Aversa, Elizabeth J. Atkinson, Marissa J. Schafer, Regan N. Theiler, Walter A. Rocca, Martin J. Blaser, Nathan K. LeBrasseur
Summary: This study found significant associations between early life antibiotic exposure and several distinct health conditions with childhood onset, including asthma, allergic rhinitis, and obesity. Additionally, the associations were influenced by the number, type, and timing of antibiotic exposure.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Biochemistry & Molecular Biology
Zhiyong Wang, Andrea Havasi, Aaron A. Beeler, Steven C. Borkan
Summary: Nucleophosmin (NPM), a nucleolar-based protein chaperone, promotes Bax-mediated mitochondrial injury and regulates cell death during acute kidney injury. The localization of NPM-mediated events causing regulated cell death during ischemia was studied by expressing wild type (WT) and Hsp70 mutant proteins with characterized intracellular trafficking defects in primary murine proximal tubule epithelial cells (PTEC). Overexpressing WT Hsp70 protein improved cell survival and reduced apoptosis, highlighting the inhibitory effect of Hsp70 on NPM-mediated toxicity.
Article
Cell Biology
Davis A. Englund, Xu Zhang, Zaira Aversa, Nathan K. LeBrasseur
Summary: Cellular senescence is a cell cycle arrest state induced by metabolic stress, with senescent cells accumulating with age and negatively impacting tissue health. Understanding the vulnerability of different cell types in the skeletal muscle microenvironment to senescence is limited, but could have implications for muscle aging and dysfunction. Advances in this area may lead to new therapeutic approaches for age-related muscle deficits.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Matthew R. Brown, Satish K. Sen, Amelia Mazzone, Tracy K. Her, Yuning Xiong, Jeong-Heon Lee, Naureen Javeed, Christopher S. Colwell, Kuntol Rakshit, Nathan K. LeBrasseur, Alexandre Gaspar-Maia, Tamas Ordog, Aleksey Matveyenko
Summary: Circadian rhythm disruption is associated with impaired glucose homeostasis and type 2 diabetes mellitus. Restoring fasting/feeding cycles can prevent dysfunction caused by disruption of circadian rhythms, potentially providing beneficial effects in the prevention of type 2 diabetes. The study provides insights into the circadian regulation of beta cell function and the positive effects of time-restricted feeding in preventing T2DM.
Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
Article
Multidisciplinary Sciences
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, Joao F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Summary: The authors present and validate a senescence gene set called SenMayo, which can accurately identify senescent cells across different tissues and species. Using this gene set, senescent cells can be characterized at the single cell level and key intercellular signaling pathways can be identified.
NATURE COMMUNICATIONS
(2022)
Letter
Dermatology
Bo Shi, Pei-Suen Tsou, Feiyang Ma, Michael P. Mariani, Megan N. Mattichak, Nathan K. LeBrasseur, Eduardo N. Chini, Robert Lafyatis, Dinesh Khanna, Michael L. Whitfield, Johann E. Gudjonsson, John Varga
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Mohamed Hassan Kamel, Ashish Upadhyay, Steven C. C. Borkan
Summary: The patient presented with symptoms of chronic hyponatremia and acute polydipsia, diagnosed as chronic reset osmostat-related hyponatremia. Hypertonic saline treatment was required in the acute phase, while water restriction was needed in the chronic phase. It is important to recognize the presence of a reset osmostat to avoid overcorrecting hyponatremia, expedite hospital discharge, and minimize potential harm.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K. LeBrasseur, James L. L. Kirkland, Eduardo N. N. Chini, Qing Wei, Kun Ling, Jinghua Hu
Summary: Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cilia as a promising senotherapy target.
NATURE COMMUNICATIONS
(2023)
Article
Physiology
Zhiyong Wang, Mostafa Belghasem, Erdjan Salih, Joel Henderson, Chinaemere Igwebuike, Andrea Havasi, Steven C. Borkan
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Article
Surgery
Elizabeth C. Lorenz, Andrea L. Cheville, Hatem Amer, Brian R. Kotajarvi, Mark D. Stegall, Tanya M. Petterson, Walter K. Kremers, Fernando G. Cosio, Nathan K. LeBrasseur
CLINICAL TRANSPLANTATION
(2017)
Article
Gastroenterology & Hepatology
Anuradha Krishnan, Tasduq Sheikh Abdullah, Taofic Mounajjed, Stella Hartono, Andrea McConico, Thomas White, Nathan LeBrasseur, Ian Lanza, Sreekumaran Nair, Gregory Gores, Michael Charlton
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
