Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography

Single particle tomography in EMAN2

(2015) Jesús G. Galaz-Montoya et al.   JOURNAL OF STRUCTURAL BIOLOGY

Fluorescence Anisotropy Uncovers Changes in Protein Packing with Inclusion Growth in a Cellular Model of Polyglutamine Aggregation

(2014) Vishal Bhardwaj et al.   BIOCHEMISTRY

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

(2014) Brett A. Barbaro et al.   HUMAN MOLECULAR GENETICS

Biochemical Characterization of Mutants in Chaperonin Proteins CCT4 and CCT5 Associated with Hereditary Sensory Neuropathy

(2014) Oksana A. Sergeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy

(2014) Valentina Fodale et al.   PLoS One

Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

(2013) Danny M. Hatters   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors

(2013) Boris A. Margulis et al.   FEBS LETTERS

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions

(2013) Nicholas S. Caron et al.   HUMAN MOLECULAR GENETICS

Human CCT4 and CCT5 Chaperonin Subunits Expressed inEscherichia coliForm Biologically Active Homo-oligomers

(2013) Oksana A. Sergeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases

(2013) Herman van der Putten et al.   Neurotherapeutics

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

(2013) E. M. Sontag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrantly splicedHTT,a new player in Huntington’s disease pathogenesis

(2013) Theresa A Gipson et al.   RNA Biology

TRiC’s tricks inhibit huntingtin aggregation

(2013) Sarah H Shahmoradian et al.   eLife

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT

(2012) F. Russmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Mannerin Vitroandin Vivo

(2010) Justin Legleiter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is human thioredoxin monomeric or dimeric?

(2010) Angela M. Gronenborn et al.   PROTEIN SCIENCE

A visualization and segmentation toolbox for electron microscopy

(2008) Sabine Pruggnaller et al.   JOURNAL OF STRUCTURAL BIOLOGY

Methods for aligning and for averaging 3D volumes with missing data

(2007) Michael F. Schmid et al.   JOURNAL OF STRUCTURAL BIOLOGY