TRiC’s tricks inhibit huntingtin aggregation

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

(2013) E. M. Sontag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Novel Potentially Toxic Oligomers Formedin Vitrofrom Mammalian-derived Expanded huntingtin Exon-1 Protein

(2012) Leslie G. Nucifora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle

(2011) Yao Cong et al.   EMBO JOURNAL

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

(2011) Carien Dekker et al.   EMBO JOURNAL

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Flipping a switch on huntingtin

(2011) Erin R Greiner et al.   Nature Chemical Biology

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

(2010) Adam J. Trexler et al.   BIOPHYSICAL JOURNAL

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

(2010) Inés G Muñoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

(2009) Kirupa Sathasivam et al.   HUMAN MOLECULAR GENETICS

Protein folding: Sticky N17 speeds huntingtin pile-up

(2009) Susan W Liebman et al.   Nature Chemical Biology

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

(2009) Y. Nekooki-Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification and 3D averaging with missing wedge correction in biological electron tomography☆

(2008) A. Bartesaghi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

(2008) Christopher R Booth et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methods for aligning and for averaging 3D volumes with missing data

(2007) Michael F. Schmid et al.   JOURNAL OF STRUCTURAL BIOLOGY

Classification of cryo-electron sub-tomograms using constrained correlation

(2007) Friedrich Förster et al.   JOURNAL OF STRUCTURAL BIOLOGY