Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells

Zip4 Mediated Zinc Influx Stimulates Insulin Secretion in Pancreatic Beta Cells

(2015) Alexandre B. Hardy et al.   PLoS One

The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction

(2014) Kacey J. Prentice et al.   Cell Metabolism

Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)

(2014) Natascha A. Wolff et al.   FASEB JOURNAL

A mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)

(2013) Christer Hogstrand et al.   BIOCHEMICAL JOURNAL

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

(2013) X. Huang et al.   MOLECULAR ENDOCRINOLOGY

The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells

(2013) Stephen A. Myers et al.   PLoS One

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

(2012) A. B. Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Zinc networks: the cell-specific compartmentalization of zinc for specialized functions

(2012) Stephen R. Hennigar et al.   BIOLOGICAL CHEMISTRY

Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth

(2012) Dan Zhu et al.   Cell Metabolism

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

(2012) E. Favaro et al.   DIABETOLOGIA

Rising Intracellular Zinc by Membrane Depolarization and Glucose in Insulin-Secreting Clonal HIT-T15 Beta Cells

(2012) Kira G. Slepchenko et al.   Experimental Diabetes Research

Zinc and the modulation of redox homeostasis

(2012) Patricia I. Oteiza   FREE RADICAL BIOLOGY AND MEDICINE

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia andEx VivoAcute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways

(2012) Miguel Mendivil-Perez et al.   Oxidative Medicine and Cellular Longevity

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease

(2012) Travis J. A. Craddock et al.   PLoS One

High-Throughput Screening and Rapid Inhibitor Triage Using an Infectious Chimeric Hepatitis C Virus

(2012) Michael J. Wichroski et al.   PLoS One

Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7

(2012) K. M. Taylor et al.   Science Signaling

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

(2011) Elisa A. Bellomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc homeostasis and signaling in health and diseases

(2011) Toshiyuki Fukada et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Zinc: new clues to diverse roles in brain ischemia

(2011) C. William Shuttleworth et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Zinc and Redox Signaling: Perturbations Associated with Cardiovascular Disease and Diabetes Mellitus

(2010) Meika Foster et al.   ANTIOXIDANTS & REDOX SIGNALING

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

The Essential Toxin: Impact of Zinc on Human Health

(2010) Laura M. Plum et al.   International Journal of Environmental Research and Public Health

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With  -Cell Dysfunction in a Mouse Model of Type 2 Diabetes

(2009) H. Lu et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Characterization of Erg K+Channels in α- and β-Cells of Mouse and Human Islets

(2009) Alexandre B. Hardy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

(2009) Julie Quoyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin

(2009) Simon C Lee et al.   JOURNAL OF ENDOCRINOLOGY

Zinc and diabetes — clinical links and molecular mechanisms

(2009) Judith Jansen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cytosolic Superoxide Dismutase (SOD1) Is Critical for Tolerating the Oxidative Stress of Zinc Deficiency in Yeast

(2009) Chang-Yi Wu et al.   PLoS One

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation

(2009) C. Hogstrand et al.   TRENDS IN MOLECULAR MEDICINE

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

(2008) Beth Besecker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions

(2008) Winyoo Chowanadisai et al.   BRAIN RESEARCH

Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis

(2008) P Makhov et al.   CELL DEATH AND DIFFERENTIATION

ZIP7-Mediated Intracellular Zinc Transport Contributes to Aberrant Growth Factor Signaling in Antihormone-Resistant Breast Cancer Cells

(2008) Kathryn M. Taylor et al.   ENDOCRINOLOGY

High-content Functional Screen to Identify Proteins that Correct F508del-CFTR Function

(2008) Agata M. Trzcińska-Daneluti et al.   MOLECULAR & CELLULAR PROTEOMICS

UCP2 is highly expressed in pancreatic  -cells and influences secretion and survival

(2008) J. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients

(2008) Bin Bao et al.   Translational Research