Article
Clinical Neurology
Delia Gagliardi, Paolo Ripellino, Megi Meneri, Roberto Del Bo, Sara Antognozzi, Giacomo Pietro Comi, Claudio Gobbi, Antonia Ratti, Nicola Ticozzi, Vincenzo Silani, Dario Ronchi, Stefania Corti
Summary: In this study, the authors provided a clinical and molecular description of a cohort of SOD1-ALS patients, revealing the heterogeneity in clinical and molecular characteristics of SOD1 mutations. The cohort exhibited variable expressivity, atypical presentations, and different modes of inheritance. With the availability of SOD1-directed antisense oligonucleotide for SOD1-ALS patients, prompt screening for SOD1 mutations in ALS patients is recommended.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Wen-Chao Liu, Na Liu, Yan Wang, Chen Huang, Yan-Fang Li, Hao Wang, Xiao-Gang Li, Min Deng
Summary: Research shows that motor neurons (MNs) derived from ALS patient-specific iPSC lines can replicate key aspects of ALS pathogenesis, providing insights into the disease's pathophysiological processes. Incremental mutant expressions of SOD1 in MNs may disrupt cellular function, leading to intracellular calcium disturbances and contributing to the onset of the disease.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Shlomit Ezer, Muhannad Daana, Julien H. Park, Shira Yanovsky-Dagan, Ulrika Nordstrom, Adily Basal, Simon Edvardson, Ann Saada, Markus Otto, Vardiella Meiner, Stefan L. Marklund, Peter Munch Andersen, Tamar Harel
Summary: Pathogenic variants in the SOD1 gene are associated with a severe motor-neurological syndrome in infants, characterized by global developmental delay and movement impairments. This study identified a homozygous loss-of-function variant in the SOD1 gene in an infant with severe neurological symptoms. Further analysis showed that this variant leads to instability and degeneration of the SOD1 protein. The study highlights the importance of specific valine residues in the SOD1 protein and suggests implications for future therapeutic research.
Article
Biochemistry & Molecular Biology
Venkatesan Santhanam, Priya Modi, Umesh K. Mishra, Ishrat Jahan, Namakkal G. Ramesh, Shashank Deep
Summary: In this study, the first iminosugar that inhibits superoxide dismutase fibrillation associated with ALS is reported. Novel triazole and tetrazole embedded iminosugars were successfully synthesized, and one of these designed iminosugars was found to inhibit SOD1 fibrillation and break pre-formed fibrils. Docking and MD simulation studies indicated that this compound interacts with the key residue Arg69 of SOD1 through hydrogen bonding.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Laura Lopez-Pingarron, Henrique Almeida, Marisol Soria-Aznar, Marcos C. C. Reyes-Gonzales, Maria Pilar Terron, Joaquin J. Garcia
Summary: In this review, the etiology and pathophysiological mechanisms involved in ALS were discussed. ALS can be divided into hereditary and sporadic types, and its pathophysiology is characterized by oxidative stress, glutamate excitotoxicity, and neuroinflammation. Further research is needed to improve our understanding of the etiopathogenesis of ALS and enhance patients' prognosis and survival.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biology
Achinta Sannigrahi, Sourav Chowdhury, Bidisha Das, Amrita Banerjee, Animesh Halder, Amaresh Kumar, Mohammed Saleem, Athi N. Naganathan, Sanat Karmakar, Krishnananda Chattopadhyay
Summary: Research shows that the stability and aggregation behavior of SOD1 in membrane environment are affected by Zn, not Cu. Two loop regions play a role in membrane attachment of SOD1 and aggregation driven by lipid-induced conformational changes.
Article
Neurosciences
Hirofumi Yamashita, Okiru Komine, Noriko Fujimori-Tonou, Koji Yamanaka
Summary: Non-cell autonomous mechanisms play a role in the pathogenesis of ALS, with glial cells being involved, but the specific role of glial cells has not been fully elucidated. Using microarrays, this study examined mRNA expression changes in the spinal cords of mutant SOD1 transgenic mice, revealing that the majority of differentially expressed genes were highly expressed in microglia and involved in immunological reactions. Additionally, disease-associated microglial genes were upregulated, while homeostatic microglial genes were not, and abnormal expression patterns were predicted in astrocytes. This analysis provides valuable insights into the molecular pathologies and cellular crosstalk in the CNS under physiological and pathological conditions in neurodegenerative diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Pavlina Hemerkova, Martin Valis
Summary: ALS is a neurodegenerative disease that affects motor neurons and currently has no cure. Free oxygen radicals are known to play a role in the pathogenesis of ALS, while antioxidant enzymes like SOD1 are crucial for antioxidant protection.
Review
Biochemistry & Molecular Biology
Valentina Rubino, Giuliana La Rosa, Flavia Carriero, Luca Pipicelli, Simona Damiano, Mariarosaria Santillo, Giuseppe Terrazzano, Giuseppina Ruggiero, Paolo Mondola
Summary: Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease with unclear pathogenesis involving astrocytes, microglial cells, and ROS.
Article
Multidisciplinary Sciences
Eanna B. Ryan, Jianhua Yan, Nimrod Miller, Sudarshan Dayanidhi, Yongchao C. Ma, Han-Xiang Deng, Teepu Siddique
Summary: Mutations in the CHCHD10 gene have been linked to various degenerative diseases, including ALS. Transgenic mice overexpressing an ALS-linked CHCHD10 mutation showed an abbreviated lifespan and exhibited pathology in the CNS, skeletal muscle, and cardiac tissue. The study provides insights into the pathogenesis of CHCHD10-related disorders, suggesting a contribution of CNS, skeletal muscle, and cardiac pathology to the disease.
Article
Biochemistry & Molecular Biology
Munishikha Kalia, Mattia Miotto, Deborah Ness, Sarah Opie-Martin, Thomas P. Spargo, Lorenzo Di Rienzo, Tommaso Biagini, Francesco Petrizzelli, Ahmad Al Khleifat, Renata Kabiljo, Tommaso Mazza, Giancarlo Ruocco, Edoardo Milanetti, Richard J. B. Dobson, Ammar Al-Chalabi, Alfredo Iacoangeli
Summary: This study investigates the influence of SOD1 gene mutations on the clinical phenotype of ALS. By analyzing structural and dynamic differences as well as clinical data, it was found that patients carrying MBR variants generally have a longer survival time compared to those with WTL variants. The results support the hypothesis of a decoupling between mechanisms of onset and progression of SOD1 ALS.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Clinical Neurology
Georgiana Soares Leandro, Mario Emilio Teixeira Dourado Junior, Glauciane Costa Santana, Luan Samy Xavier Dantas
Summary: The main coping strategy used by ALS patients is seeking social support, while Confrontive coping and Distancing are less commonly mentioned. The coping strategies of ALS patients do not seem to focus on emotions or stress-triggering problems, and age and gender do not modify the chosen strategy.
JOURNAL OF NEUROLOGY
(2022)
Article
Virology
Jacob I. Ayers, Guilian Xu, Qing Lu, Kristy Dillon, Susan Fromholt, David R. Borchelt
Summary: Mutations in SOD1 associated with ALS cause misfolding and aggregation. This study investigated the transmission of different isolates of G93A-SOD1 ALS conformers in transgenic mice. The findings support the notion that SOD1 acts as a prion-like host protein in ALS.
Article
Multidisciplinary Sciences
Hong Yien Tan, Yean Kong Yong, Yuan Chao Xue, Huitao Liu, Tomomi Furihata, Esaki Muthu Shankar, Chen Seng Ng
Summary: Neuroinflammation worsens the development of ALS caused by SOD1 mutation. The mitochondrial damage triggered by ALS leads to the release of mtDNA and RNA:DNA hybrids, activating the IRF3- and IFNAR-dependent IFN-I and interferon-stimulating genes, causing high levels of IFN-I and pro-inflammatory response. Inter-neuronal gap junctions amplify the response through cGAS/DDX41-STING signaling. This highlights the role of a common DNA sensing pathway between SOD1 and TDP-43 in ALS progression.
Article
Biology
Tae-Gyun Woo, Min-Ho Yoon, So-mi Kang, Soyoung Park, Jung-Hyun Cho, Young Jun Hwang, Jinsook Ahn, Hyewon Jang, Yun-Jeong Shin, Eui-Man Jung, Nam-Chul Ha, Bae-Hoon Kim, Yonghoon Kwon, Bum-Joon Park
Summary: Using ELISA-based screening, a new small molecule PRG-A01 is identified by Woo et al., which can block the misfolding/aggregation of SOD1 or TDP-43 in a human neuroblastoma cell line. Its administration in an ALS mouse model results in significant improvement in muscle strength, motor neuron viability, and mobility, suggesting its potential therapeutic value in ALS.
COMMUNICATIONS BIOLOGY
(2021)
Article
Clinical Neurology
Jesse Mez, Michael L. Alosco, Daniel H. Daneshvar, Nicole Saltiel, Zachary Baucom, Bobak Abdolmohammadi, Madeline Uretsky, Raymond Nicks, Brett M. Martin, Joseph N. Palmisano, Christopher J. Nowinski, Philip Montenigro, Todd M. Solomon, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Brigid Dwyer, Lee E. Goldstein, Douglas Katz, Robert C. Cantu, Neil W. Kowall, Yorghos Tripodis, Bertrand R. Huber, Thor D. Stein, Robert A. Stern, Ann C. McKee
Summary: The study found that the 2014 traumatic encephalopathy syndrome (TES) criteria had good evidence for ruling out chronic traumatic encephalopathy (CTE) pathology, but limited evidence for confirming CTE pathology. Adding cognitive symptoms in revised criteria and using Alzheimer's disease biomarkers may improve the prediction accuracy of CTE pathology.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Frank A. Greco, Ann C. McKee, Neil W. Kowall, Eugene B. Hanlon
Summary: The study aimed to determine whether NIR spectroscopy can distinguish Alzheimer's disease patients from controls in clinical applications and show the potential of NIR as a clinical screen and monitor of therapeutic efficacy. The results indicate that two regions around 860 and 895 nm can completely separate AD patients from controls and differentiate MCI subjects according to the degree of impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Seung Jae Hyeon, Jinyoung Park, Junsang Yoo, Su-Hyun Kim, Yu Jin Hwang, Seung-Chan Kim, Tian Liu, Hyun Soo Shim, Yunha Kim, Yakdol Cho, Jiwan Woo, Key-Sun Kim, Richard H. Myers, Hannah L. Ryu, Neil W. Kowall, Eun Joo Song, Eun Mi Hwang, Hyemyung Seo, Junghee Lee, Hoon Ryu
Summary: Mitochondrial dysfunction in Huntington's disease is associated with a decrease in XIAP-p53 colocalization and a reduction in XIAP levels due to mutant Huntingtin overexpression, leading to mitochondrial localization of p53. XIAP interacts with p53 C-terminal domain and decreases its stability via autophagy, preventing mitochondrial oxidative stress and cell death. Dysregulation of XIAP triggers mitochondrial dysfunction and neuropathological processes, while XIAP overexpression improves neuropathology in mouse models of HD.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Michael L. Alosco, Megan L. Mariani, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Sylvain Bouix, Robert C. Cantu, Michael J. Coleman, David W. Dodick, Lindsay A. Farrer, Yonas E. Geda, Douglas I. Katz, Inga K. Koerte, Neil W. Kowall, Alexander P. Lin, Daniel S. Marcus, Kenneth L. Marek, Michael D. McClean, Ann C. McKee, Jesse Mez, Joseph N. Palmisano, Elaine R. Peskind, Yorghos Tripodis, Robert W. Turner, Jennifer V. Wethe, Jeffrey L. Cummings, Eric M. Reiman, Martha E. Shenton, Robert A. Stern
Summary: The DIAGNOSE CTE Research Project aims to develop biomarkers for CTE, characterize its clinical presentation, validate diagnostic criteria, study risk factors, and share resources. With 240 male participants enrolled and baseline evaluations completed, the study is expected to contribute significantly to CTE research.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A. Sugarman, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkina, Katherine W. Turk, Andrew E. Budson, Maureen K. O'Connor, Rhoda Au, Lee E. Goldstein, Gyungah R. Jun, Neil W. Kowall, Thor D. Stein, Ann C. McKee, Ronald Killiany, Wei Qiao Qiu, Robert A. Stern, Jesse Mez, Michael L. Alosco
Summary: The study found that plasma p-tau(181) is effective in detecting AD dementia and supports the use of blood-based biomarkers for optimal disease detection. Plasma NfL also showed potential in discriminating diagnostic groups, while p-tau(181) had a direct association with cognitive diagnosis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Madeline Uretsky, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Z. Mian, Karen Buch, Chad Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee Goldstein, Douglas Katz, Christopher Nowinski, Robert Cantu, Neil Kowall, Bertrand Russell Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann McKee, Jesse Mez, Michael L. Alosco
Summary: This study investigated the neuropathologic correlates of white matter hyperintensities (WMH) in brain donors exposed to repetitive head impacts. The results suggest that WMH may capture long-term white matter pathologies from repetitive head impacts, including white matter rarefaction and p-tau accumulation, in addition to microvascular disease. Prospective imaging-pathologic correlation studies are needed to further understand these associations.
Article
Clinical Neurology
Michael L. Alosco, Asim Z. Mian, Karen Buch, Chad W. Farris, Madeline Uretsky, Yorghos Tripodis, Zachary Baucom, Brett Martin, Joseph Palmisano, Christian Puzo, Ting Fang Alvin Ang, Prajakta Joshi, Lee E. Goldstein, Rhoda Au, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand Russell Huber, Victor E. Alvarez, Robert A. Stern, Thor D. Stein, Ronald J. Killiany, Ann C. McKee, Jesse Mez
Summary: The study characterized the macrostructural MRI features of brain donors with autopsy-confirmed CTE, finding frontal-temporal atrophy as a prominent MRI feature of CTE and showing the association between p-tau accumulation and atrophy in CTE.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Katherine W. Turk, Alexandra Geada, Victor E. Alvarez, Weiming Xia, Jonathan D. Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R. Huber, Andrew E. Budson, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein
Summary: CSF levels of p-tau(231) were higher in CTE patients, indicating it may be a potential biomarker for CTE diagnosis. Additionally, A beta(1-42) levels were lower in CTE patients, suggesting further investigation is needed for its role in CTE. The study highlights the differences in CSF analytes between CTE and AD patients.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Madeline S. Morrison, Hugo J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Michael A. Sugarman, Brandon Frank, Eric G. Steinberg, Katherine W. Turk, Andrew E. Budson, Rhoda Au, Lee E. Goldstein, Gyungah R. Jun, Neil W. Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A. Stern, Jesse Mez, Ann C. McKee, Thor D. Stein, Michael L. Alosco
Summary: In one of the largest studies of its kind, researchers found that ante-mortem plasma phosphorylated-tau(181) concentrations can accurately differentiate brain donors with and without Alzheimer's disease. This blood test could serve as a minimally invasive and cost-effective tool for the detection and monitoring of Alzheimer's disease.
Article
Clinical Neurology
Leigh E. Colvin, Zachariah W. Foster, Thor D. Stein, Manisha Thakore-James, Mohammad Kian Salajegheh, Kendall Carr, Keith R. Spencer, Nazifa Abdul Rauf, Latease Adams, James G. Averill, Sean E. Walker, Ian Robey, Victor E. Alvarez, Bertrand R. Huber, Ann C. McKee, Neil W. Kowall, Christopher B. Brady
Summary: This study examined the association between ALSFRS-R scores and postmortem neuropathology in military veterans with autopsy-confirmed ALS. The results revealed that discrete patterns of motor dysfunction based on ALSFRS-R subdomain scores were related to neuropathology. These findings support the use of ALSFRS-R subdomain scores to capture the heterogeneity of ALS and may help identify endophenotypes for separate assessment in clinical trials.
Article
Clinical Neurology
Brandon Frank, Madeline Ally, Yorghos Tripodis, Christian Puzo, Caroline Labriolo, Landon Hurley, Brett Martin, Joseph Palmisano, Lawrence Chan, Eric Steinberg, Katherine Turk, Andrew Budson, Maureen O'Connor, Rhoda Au, Wei Qiao Qiu, Lee Goldstein, Walter Kukull, Neil Kowall, Ronald Killiany, Robert Stern, Thor Stein, Ann McKee, Jesse Mez, Michael Alosco
Summary: In this study, the cognitive and functional trajectories of brain donors with Alzheimer's disease and comorbid cerebrovascular disease were compared. The results showed that the group with cerebrovascular disease had accelerated decline in processing speed, working memory, and language compared to the group without comorbidity. They also had poorer performance in naming and the Clinical Dementia Rating Scale.
Article
Neurosciences
Marcela Alvia, Nurgul Aytan, Keith R. Spencer, Zachariah W. Foster, Nazifa Abdul Rauf, Latease Guilderson, Ian Robey, James G. Averill, Sean E. Walker, Victor E. Alvarez, Bertrand R. Huber, Rebecca Mathais, Kerry A. Cormier, Raymond Nicks, Morgan Pothast, Adam Labadorf, Filisia Agus, Michael L. Alosco, Jesse Mez, Neil W. Kowall, Ann C. McKee, Christopher B. Brady, Thor D. Stein
Summary: Repetitive head impacts and traumatic brain injuries are risk factors for chronic traumatic encephalopathy and amyotrophic lateral sclerosis. This study identified associations between miRNA levels and disease state within the prefrontal cortex, providing insights into the shared and distinct mechanisms of pathogenesis in CTE and ALS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kathryn Atherton, Xudong Han, Jaeyoon Chung, Jonathan D. Cherry, Zachary Baucom, Nicole Saltiel, Evan Nair, Bobak Abdolmohammadi, Madeline Uretsky, Mohammed Muzamil Khan, Conor Shea, Shruti Durape, Brett M. Martin, Joseph N. Palmisano, Kurt Farrell, Christopher J. Nowinski, Victor E. Alvarez, Brigid Dwyer, Daniel H. Daneshvar, Douglas Katz, Lee E. Goldstein, Robert C. Cantu, Neil W. Kowall, Michael L. Alosco, Bertrand R. Huber, Yorghos Tripodis, John F. Crary, Lindsay Farrer, Robert A. Stern, Thor D. Stein, Ann C. McKee, Jesse Mez
Summary: This study analyzed brain donors from February 2008 to August 2019 and found that APOEε4 may increase the risk of CTE-related neuropathological and clinical outcomes among older individuals with a history of repetitive head impacts. Further validation in an independent sample is needed.
Article
Clinical Neurology
Michael L. Alosco, Monica Ly, Sydney Mosaheb, Nicole Saltiel, Madeline Uretsky, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Lisa Delano-Wood, Mark W. Bondi, Gaoyuan Meng, Weiming Xia, Sarah Daley, Lee E. Goldstein, Douglas Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Jesse Mez, Bertrand Russell Huber, Ann C. McKee, Thor D. Stein
Summary: American football players and others exposed to repetitive head impacts may experience cognitive and neuropsychiatric symptoms later in life. This study found a link between myelin integrity and risk factors, as well as clinical outcomes in brain donors exposed to repetitive head impacts from American football.
BRAIN COMMUNICATIONS
(2023)
Article
Cell Biology
Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu, Junghee Lee
Summary: In this study, researchers found that modulating the activity of LSD1 can improve the neuropathology of ALS mice, delay disease onset, and extend lifespan, potentially serving as an effective therapeutic strategy for treating ALS.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)