The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

Conformational Switch Driven Membrane Pore Formation by Mycobacterium Secretory Protein MPT63 Induces Macrophage Cell Death

(2019) Achinta Sannigrahi et al.   ACS Chemical Biology

Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra

(2019) Sourav Chowdhury et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

(2019) Luke McAlary et al.   Frontiers in Molecular Neuroscience

Amyloid-β Peptide Triggers Membrane Remodeling in Supported Lipid Bilayers Depending on Their Hydrophobic Thickness

(2018) Sigalit Meker et al.   LANGMUIR

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

(2018) Carlos HM Rodrigues et al.   NUCLEIC ACIDS RESEARCH

The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1

(2018) Fan Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The presence of non-native helical structure in the unfolding of a beta-sheet protein MPT63

(2017) Amrita Kundu et al.   PROTEIN SCIENCE

Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories

(2017) Supratik Sen Mojumdar et al.   Nature Communications

A novel nanohybrid for cancer theranostics: folate sensitized Fe2O3 nanoparticles for colorectal cancer diagnosis and photodynamic therapy

(2017) Ramesh Nandi et al.   Journal of Materials Chemistry B

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1 ‐ and SOD1 ‐linked ALS

(2016) Seiji Watanabe et al.   EMBO Molecular Medicine

Quantifying Protein Disorder through Measures of Excess Conformational Entropy

(2016) Nandakumar Rajasekaran et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis

(2016) Giovanni Manfredi et al.   NEUROBIOLOGY OF DISEASE

Protein aggregates stimulate macropinocytosis facilitating their propagation

(2016) Justin J. Yerbury   Prion

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme

(2016) Paolo Mondola et al.   Frontiers in Physiology

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

(2015) Liangzhong Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Obtaining information about protein secondary structures in aqueous solution using Fourier transform IR spectroscopy

(2015) Huayan Yang et al.   Nature Protocols

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

(2015) Ashok Sekhar et al.   eLife

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense

(2014) J. E. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-associated aggregate formation of superoxide dismutase-1 is initiated by membrane-targeting loops

(2014) Choon-Peng Chng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

Comparative structural and conformational studies on H43R and W32F mutants of copper–zinc superoxide dismutase by molecular dynamics simulation

(2013) Gurusamy Muneeswaran et al.   BIOPHYSICAL CHEMISTRY

Global structural motions from the strain of a single hydrogen bond

(2013) J. Danielsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes

(2013) C. R. Pope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand binding and aggregation of pathogenic SOD1

(2013) Gareth S.A. Wright et al.   Nature Communications

Membrane lipid phase transitions and phase organization studied by Fourier transform infrared spectroscopy

(2012) Ruthven N.A.H. Lewis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Predictions from an Ising-like Statistical Mechanical Model on the Dynamic and Thermodynamic Effects of Protein Surface Electrostatics

(2012) Athi N. Naganathan   Journal of Chemical Theory and Computation

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

(2012) S. Guareschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid molecules induce the cytotoxic aggregation of Cu/Zn superoxide dismutase with structurally disordered regions

(2010) Inhee Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Folding Catalysis by Transient Coordination of Zn2+to the Cu Ligands of the ALS-Associated Enzyme Cu/Zn Superoxide Dismutase 1

(2010) Lina Leinartaitė et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study

(2010) Danilo Milardi et al.   Molecular BioSystems

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord

(2009) Jianjun Zhai et al.   FEBS Journal

Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand: Figure 1.

(2009) Vishal M. Gohil et al.   JOURNAL OF CELL BIOLOGY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

(2009) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Giant unilamellar vesicle formation under physiologically relevant conditions

(2008) Tanja Pott et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

(2008) Qi Wang et al.   PLOS BIOLOGY