Article
Virology
Hao Liao, He Zhang, Jinman Shao, Xiaoyong Li, Wei V. Zheng, Le Li, Guangxin Yu, Lanlan Si, Tao Zhou, Zengtao Yao, Jiuzeng Dai, Dongping Xu, Guanxun Cheng, Jiuxin Qu, Yan Liu, Junhui Chen, Fengmin Lu
Summary: This study aimed to investigate the dynamic changes of serum hepatitis B virus (HBV) RNA levels and the quasispecies of HBV RNA virus-like particles in nucleos(t)ide analogues (NAs)-experienced chronic hepatitis B patients with NAs-resistant mutations and their effects on NAs resistance. The results showed that serum HBV RNA can reflect virological breakthrough and rebound earlier than HBV DNA in some patients. However, there are limitations in the detection of serum HBV RNA levels and drug-resistant mutations compared to serum HBV DNA.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Haruna Hatooka, Yumi Shimomura, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Grace Naswa Makokha, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe-Chayama, C. Nelson Hayes, Hiroshi Aikata, Shinji Tanaka, Kazuaki Chayama
Summary: The study developed an antibody against preS1 and an ELISA system for measuring serum preS1 levels. PreS1 may serve as a novel tool to predict the need for antiviral therapy in HBeAg-negative HBV-infected patients.
JOURNAL OF INFECTION
(2022)
Article
Medicine, General & Internal
Yu Xiang, Yang Yang, Pu Chen, Xiaofei Lai, Shan Shi, Shuang Li, Wenxian You
Summary: This study examined levels of hepatitis B virus pgRNA in HBsAg and HBsAb copositive patients and found a positive correlation with HBV DNA, HBsAg, ALT, and AST levels. The study also demonstrated significant differences in HBV RNA, HBV DNA, HBsAg, ALT, and AST levels in different natural phases of HBV infection, and suggested that HBV RNA could be used as a virological indicator for antiviral therapy in HBsAg and HBsAb copositive hepatitis B patients.
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Zhanqing Zhang, Wei Lu, Dong Zeng, Dan Huang, Weijia Lin, Li Yan, Yanling Feng
Summary: Quantitative HBsAg is more valuable than HBV DNA in predicting significant hepatitis activity of HBeAg-positive chronic HBV infection, with higher sensitivity and specificity levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Percy A. Knolle, Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, Ulrike Protzer
Summary: Chronic hepatitis B affects over 250 million individuals worldwide, with prophylactic vaccination only establishing protective immunity but not eliminating HBV infections in patients. Current research focuses on therapeutic vaccination strategies and additional immune stimulation measures to improve efficacy in treating chronic hepatitis B.
Article
Biochemistry & Molecular Biology
Keiji Ueda, Yadarat Suwanmanee
Summary: The precise mechanism of HBV entry into cells is still largely unknown. However, researchers have identified ATP5B as an essential factor for HBV entry, which is believed to bind with myristoylated preS1 2-47. Knockdown of ATP5B in NTCP-expressing HepG2 cells reduced HBV infectivity, indicating that ATP5B is involved in the HBV entry process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura
Summary: Hepatitis B is a viral hepatitis caused by HBV infection, leading to chronic hepatitis, cirrhosis, and liver cancer. The HBc protein, which is related to the transcriptional regulation of HBV, serves as an attractive target for the complete cure of hepatitis B. By screening a compound library, Cpd4 was identified as a small molecule that binds to HBc and shows potential anti-HBV activity.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Virology
Meng-Lan Wang, Juan Liao, Feng Ye, Ya-Chao Tao, Dong-Bo Wu, Min He, Hong Tang, En-Qiang Chen
Summary: This study found strong correlation between serum HBV pgRNA and HBcrAg levels in Chinese chronic hepatitis B patients, with moderate correlation with HBV DNA and HBsAg. Differences in serum HBV pgRNA levels and correlations were observed between HBeAg-positive and HBeAg-negative patients, with HBcrAg showing the most stable correlation with HBV pgRNA.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Yael Gozlan, Daniella Aaron, Yana Davidov, Maria Likhter, Gil Ben Yakov, Oranit Cohen-Ezra, Orit Picard, Oran Erster, Ella Mendelson, Ziv Ben-Ari, Fadi Abu Baker, Orna Mor
Summary: In this study, a comprehensive characterization of CHB patients was conducted to assess the cumulative impact of classical and novel biomarkers on clinical categorization. The results showed that the combined assessment of classical and novel serum biomarkers, especially in HBeAgNeg patients, may assist in clinical decisions.
Article
Virology
Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata
Summary: This study investigated the effects of chronic HBV infection on cellular senescence in human hepatocytes and humanized-liver chimeric mice. The results showed that HBV infection perturbed multiple senescence-associated markers in both human hepatocytes and humanized-mice liver, while treatment with the anti-HBV drug E-CFCP restored this phenomenon.
Article
Gastroenterology & Hepatology
Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramirez, Floriane Fusil, Fouzia Amirache, Axel Rossi, Anne-Flore Legrand, Emilie Charles, Serena Vegna, Rayan Farhat, Michel Rivoire, Guillaume Passot, Nicolas Gadot, Barbara Testoni, Charlotte Bach, Thomas F. Baumert, Anastasia Hyrina, Rudolf K. Beran, Fabien Zoulim, Andre Boonstra, Hildegard Buening, Eloi R. Verrier, Francois-Loic Cosset, Simon P. Fletcher, Anna Salvetti, David Durantel
Summary: This study elucidates the molecular mechanisms underlying how HDV interferes with HBV in patients with chronic coinfection. The researchers found that HDV induces the expression of interferon-stimulated genes (ISGs), and these genes are upregulated in HDV/HBV-coinfected patients. Inhibiting the hepatocyte's response to interferon partially restores the levels of HBV.
JOURNAL OF HEPATOLOGY
(2023)
Article
Virology
Daniela Cavallone, Eric David B. Ornos, Gabriele Ricco, Filippo Oliveri, Barbara Coco, Piero Colombatto, Laura De Rosa, Leslie Michelle M. Dalmacio, Ferruccio Bonino, Maurizia Rossana Brunetto
Summary: This study investigated the expression of miRNAs in the serum of patients with chronic hepatitis B and chronic hepatitis D, and found that the profiles of these miRNAs were highly similar between the two groups and significantly different from individuals with HBeAg-negative infection and without liver disease.
Article
Gastroenterology & Hepatology
Marc G. Ghany, Wendy C. King, Mauricio Lisker-Melman, Anna S. F. Lok, Norah Terrault, Harry L. A. Janssen, Mandana Khalili, Raymond T. Chung, William M. Lee, Daryl T. Y. Lau, Gavin A. Cloherty, Richard K. Sterling
Summary: The study found that HBV RNA and HBcrAg are moderately strongly correlated with HBV DNA levels, and the levels of these two markers also have certain correlations with clinical disease indicators for both HBeAg+ and HBeAg- phases of chronic hepatitis B patients.
Review
Biotechnology & Applied Microbiology
Yuan Zhang, Xiaorong Chen, Yajuan Cao, Zongguo Yang
Summary: APOBEC3 (A3) cytidine deaminases play important roles in inhibiting HBV infection, but their deaminated deoxycytidine activity can also cause cellular genetic mutations, affecting genomic stability and cancer development.
Article
Multidisciplinary Sciences
Philipp Raffeiner, Jonathan R. Hart, Daniel Garcia-Caballero, Liron Bar-Peled, Marc S. Weinberg, Peter K. Vogt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Virology
Fiona van den Berg, Shonisani Wendy Limani, Njabulo Mnyandu, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot
Review
Biochemistry & Molecular Biology
Kristie Bloom, Fiona van den Berg, Patrick Arbuthnot
Summary: Vaccinology is moving towards synthetic RNA platforms, which offer rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, potentially improving immunity and becoming important vaccine candidates.
Article
Medicine, Research & Experimental
Tristan A. Scott, Denis O'Meally, Nicole Anne Grepo, Citradewi Soemardy, Daniel C. Lazar, Yue Zheng, Marc S. Weinberg, Vicente Planelles, Kevin Morris
Summary: The study introduces a novel recombinant zinc finger protein transactivator, ZFP-362-VPR, that specifically and potently enhances proviral HIV-1 transcription in established latency models and across different viral clades. The research provides clear proof of concept for the application of this novel protein transactivator to purge cellular reservoirs of HIV-1.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Laura Mosti, Lukas M. Langner, Kay O. Chmielewski, Patrick Arbuthnot, Jamal Alzubi, Toni Cathomen
Summary: CAR T cell technology has been successful in treating lymphoid malignancies, but currently faces limitations in manufacturing procedures and immunological side effects. Integrating multi-epitope molecules into CAR T cells may help improve production processes and clinical safety.
Article
Virology
Tiffany Smith, Prashika Singh, Kay Ole Chmielewski, Kristie Bloom, Toni Cathomen, Patrick Arbuthnot, Abdullah Ely
Summary: Chronic hepatitis B virus (HBV) infection remains a serious global medical issue, with limited therapeutic options available. Vaccination, immunomodulators, and nucleotide and nucleoside analogs have limited impact on chronic sufferers. Transcription activator-like effector nucleases (TALENs) offer a novel therapeutic approach by targeting viral DNA, potentially disabling the virus permanently. However, potential off-target effects and toxicity remain a concern for this technology, despite promising results in mouse models.
Article
Virology
Shonisani Wendy Limani, Njabulo Mnyandu, Abdullah Ely, Reubina Wadee, Anna Kramvis, Patrick Arbuthnot, Mohube Betty Maepa
Summary: The study demonstrated the use of recombinant adeno-associated viruses (AAVs) to model the replication of different hepatitis B virus (HBV) subgenotypes, showcasing the efficacy of the AAV8-A1 murine model for anti-HBV drug development.
Review
Biochemistry & Molecular Biology
Ridhwaanah Jacobs, Prashika Singh, Tiffany Smith, Patrick Arbuthnot, Mohube Betty Maepa
Summary: Current treatment for chronic hepatitis B virus (HBV) infection has limited efficacy, so researchers have focused on developing therapies that disable the viral replicative intermediate called cccDNA. Gene editing tools, particularly using viral vectors, have shown promise in permanently inactivating cccDNA.
Article
Multidisciplinary Sciences
Pia Laitinen, Mari-Anna Vaananen, Ida-Liisa Kolari, Petri Makinen, Minna U. Kaikkonen, Marc S. Weinberg, Kevin Morris, Paula Korhonen, Tarja Malm, Seppo Yla-Herttuala, Thomas C. Roberts, Mikko P. Turunen, Tiia A. Turunen
Summary: This study reveals the involvement of nuclear miR-466c in the regulation of Vegfa gene expression in mouse endothelial cells under hypoxic conditions. The research demonstrates that miR-466c directly targets the promoter region to modulate Vegfa transcription in the nucleus, expanding our understanding of miRNA functionality.
Review
Virology
Mohube B. Maepa, Abdullah Ely, Anna Kramvis, Kristie Bloom, Kubendran Naidoo, Omphile E. Simani, Tongai G. Maponga, Patrick Arbuthnot
Summary: Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains a significant burden on public health in South Africa. Over 1.9 million people in South Africa are chronically infected with HBV, with 70% of Black chronic carriers infected with HBV subgenotype A1. HIV infection amplifies HBV replication and complicates management of the infection. Research on HBV in South Africa has made progress in understanding its epidemiology and management challenges, leading to recent revision of national guidelines and development of new vaccines and gene therapies.
Review
Genetics & Heredity
Tasneem Farhad, Keila Neves, Patrick Arbuthnot, Mohube Betty Maepa
Summary: Adenoviral vaccines have been widely used in the fight against viral infections such as Ebola and COVID-19. They are also promising for the treatment and prevention of hepatitis B virus. Current hepatitis B therapies are not curative, but adenoviral vaccines have the potential to induce a strong immune response and efficiently target the liver.
Article
Medicine, Research & Experimental
Britt Hanson, Sofia Stenler, Nina Ahlskog, Katarzyna Chwalenia, Nenad Svrzikapa, Anna M. L. Coenen-Stass, Marc S. Weinberg, Matthew J. A. Wood, Thomas C. Roberts
Summary: This study investigates the use of the CRISPR-Cas9 system for dystrophin restoration in a mouse model of Duchenne muscular dystrophy (DMD). The study shows that dystrophin restoration was most effective in the diaphragm, but did not extend the lifespan of the mice. Additionally, the study revealed non-productive DNA repair events and AAV genome integration at the CRISPR cut sites.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Infectious Diseases
Bavesh D. Kana, Patrick Arbuthnot, Benjamin K. Botwe, Yahya E. Choonara, Fatima Hassan, Hechmi Louzir, Precious Matsoso, Penny L. Moore, Apollo Muhairwe, Kubendran Naidoo, Margareth Ndomondo-Sigonda, Shabir A. Madhi
Summary: The COVID-19 pandemic has led to global collaboration in vaccine development, but vaccine distribution in Africa has been unequal. Initiatives are being taken to develop and manufacture COVID-19 vaccines in Africa, but challenges such as diminishing demand, cost competitiveness, intellectual property rights, and complex regulations may hinder these efforts. It is important to diversify vaccine manufacturing in Africa, enhance partnerships, and intensify research to ensure sustainability and preparedness.
LANCET INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Dylan Kairuz, Nazia Samudh, Abdullah Ely, Patrick Arbuthnot, Kristie Bloom
Summary: Africa, burdened with infectious diseases, relies heavily on First World countries for life-saving vaccines, which was evident during the COVID-19 pandemic. There is now a growing interest in establishing mRNA vaccine manufacturing capabilities in Africa. This study explores the use of alphavirus-based self-amplifying RNAs delivered by lipid nanoparticles as an alternative to conventional mRNA vaccines, aiming to produce dose-sparing vaccines for resource-constrained countries. The optimization of saRNA production and identification of potential LNP candidates will facilitate saRNA vaccine and therapeutic development, with the saRNA platform offering simplicity, versatility, and a rapid response to future pandemics.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)