Article
Environmental Sciences
Qing Shan, Minghui Liu, Rui Li, Qinghua Shi, Yan Li, Biao Gong
Summary: In this study, we investigated the role of GABA in crops and found that exogenous application or endogenous regulation of GABA by gene-editing technology can promote pesticide detoxification and enhance crop tolerance. This is achieved by regulating the GABA shunt pathway and polyamine pathway in plants. Additionally, we unexpectedly discovered that GABA promotes stomatal closure, reducing pesticide absorption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Plant Sciences
Qian Liu, Guang-Rui Dong, Yu-Qing Ma, Xiu-Xiu Huang, Tian-Jiao Mu, Xu-Xu Huang, Yan-Jie Li, Xugang Li, Bing-Kai Hou
Summary: Plants have developed metabolic mechanisms to cope with ATP deficiency caused by hypoxia, including the glycosylation of GABA catalyzed by glycosyltransferase UGT79B7. This process controls the accumulation of GABA in response to hypoxia, revealing a new mechanism of regulation for the hypoxia response.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Food Science & Technology
Yingjie Yu, Min Li, Chunxiao Li, Meng Niu, Huilong Dong, Siming Zhao, Caihua Jia, Yan Xu
Summary: Germination combined with cold stress results in enhanced accumulation of GABA in black rice grains. Cold stress at 0 degrees C for 1 h and germination for 72 h induces the highest GABA content, with a 51.54% higher level compared to the control. The GABA shunt plays a major role in enhancing GABA accumulation, while the degradation of polyamines is partly promoted but the direct synthesis of GABA is suppressed.
Article
Environmental Sciences
Yunshi Liang, Yi Wu, Jianping Li, Ruibing Peng, Maowang Jiang, Xiamin Jiang, Siqing Chen, Jianyuan Lin
Summary: This study examined the effect of gamma-aminobutyric acid (GABA) as a supplement on the ammonia stress resistance of S. pharaonis. The results showed that the application of GABA significantly alleviated the adverse effects of ammonia poisoning, with the best effect observed at a dosage of 80-100 mg/kg.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nutrition & Dietetics
Francine Ngaffo Mekontso, Wenhui Duan, El Hadji Malick Cisse, Tianye Chen, Xiangbin Xu
Summary: The study found that exogenous GABA treatment helps reduce chilling injury in carambola fruit, maintain pericarp lightness, decrease electrolyte leakage and malondialdehyde content, while increasing antioxidant enzyme activities. Additionally, the treatment promoted the accumulation of proline and ascorbic acid.
FRONTIERS IN NUTRITION
(2021)
Article
Agronomy
Pengyu Zhao, Weidan Li, Chaoying Zhen, Ke Wang, Zhen Qin, Haiyan Gao
Summary: In this study, RNA-seq sequencing was used to investigate the mechanism by which GABA slows browning and induces resistance against bacterial growth in fresh-cut apples. GABA altered gene expression related to enzyme synthesis and disease resistance, while also maintaining cell wall integrity to reduce browning. These findings reveal the protective role of GABA against browning and bacterial growth in fresh-cut apples.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Xinying Ma, Huiping Lv, Meifeng Chen, Hua Liu, Shouqing Xue, Qi Zhu, Xueliang Wang
Summary: A highly sensitive sensor for determination of propyl gallate (PG) in foodstuffs was developed and demonstrated excellent specificity and good recoveries. The sensor has potential applications in food safety control.
MICROCHEMICAL JOURNAL
(2022)
Article
Plant Sciences
Zainab Waris, Zahra Noreen, Anis Ali Shah, Sheeraz Usman, Adnan Noor Shah, Muhammad Rizwan, Ryan Casini, Hosam O. O. Elansary
Summary: The research shows that cadmium can enter plants easily from the soil solution and cause harmful effects, even at low concentrations. The experiment conducted on lettuce (Lactuca sativa) demonstrates that the addition of γ-aminobutyric acid (GABA) can mitigate the toxicity of cadmium by promoting plant growth and enhancing antioxidant enzyme activity.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Applied
Zhendong He, Jing Zhao, Changqi Liu, Weiwei Li, Yaosong Wang
Summary: The study showed that adding different concentrations of GABA had significant effects on the physical properties of whey protein isolate films. Low concentrations of GABA improved hydration and thermal properties, while high concentrations of GABA caused impairment in these properties.
FOOD HYDROCOLLOIDS
(2022)
Article
Behavioral Sciences
Sum Yi Ma, Kin Ming Kwan
Summary: The study found that early prenatal exposure to VPA in mice led to tail deformation and decreased cerebellar weight and size, with reduced expression of GAD 65 and GAD 67 in the cerebellum of adult mice showing autistic behavior. Additionally, protein expressions of GAT-1 and GABAT were reduced in VPA mice, suggesting alterations in GABA production, recycling, and metabolism that could disrupt the excitatory-inhibitory balance in the autistic cerebellum.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Xinwei Yang, Xiaojing Huo, Yaqian Tang, Mingyue Zhao, Yong Tao, Jianzhong Huang, Chongrong Ke
Summary: Based on enzyme evolution and high-throughput screening methods, this study obtained mutants with enhanced GABA productivity. Introduction of the central regulator GadE and enzymes from a biosynthesis pathway resulted in further improvement. In a 5L bioreactor, using crude L-glutamic acid as the substrate, GABA reached a concentration of 307.5 +/- 5.94 g/L with a productivity of 61.49 g/L/h. Therefore, the constructed biocatalyst combined with the whole-cell bioconversion method is an effective approach for industrial GABA production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Zhen Wu, Pengyu Wang, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zhao
Summary: The study demonstrated that GABA-enriched adzuki bean sprout fermented milk may alleviate and even prevent mild depression symptoms in mice by enhancing social interaction and pleasure derived from movement. The research also highlighted the involvement of the GABA(B)-cAMP-PKA-CREB signaling pathway and increased neurotransmitter levels in the hippocampus after treatment. This suggests a potential dietary therapy for chronic social stress.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Liang Wei, Jinhua Zhao, Yiran Wang, Jinshan Gao, Muhua Du, Yue Zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu, Jun Liu
Summary: Synthetic biology aims to reprogram microbial cells for efficient production of value-added compounds from low-cost renewable substrates. One major challenge in chemical biosynthesis is the competition between cell metabolism and target product synthesis for limited cellular resources. In this study, a tunable growth phase-dependent autonomous bifunctional genetic switch (GABS) was created to dynamically redirect carbon flux for metabolic state switching from cell growth mode to production mode, resulting in high-level GABA production from low-value glycerol in Corynebacterium glutamicum.
METABOLIC ENGINEERING
(2022)
Article
Veterinary Sciences
Yanjing Su, Zhiqiang Cheng, Wengboyang Liu, Tianyou Wu, Wendan Wang, Miao Lin
Summary: In the context of global warming, heat stress is a major factor limiting dairy cattle production. This study investigated the effect of RP-GABA supplementation on milk yield, composition, and serum biochemical parameters in heat-stressed cows. Results showed that supplementing high-yielding cows with 10 g/d of RP-GABA improved milk protein production but had no effect on other production performance or heat stress alleviation.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Oliviero Bruni, Luigi Ferini-Strambi, Elena Giacomoni, Paolo Pellegrino
Summary: Sleep is crucial for physical and emotional wellbeing, but insomnia is a prevalent issue. The interest in using herbal medicines for treating or preventing insomnia has grown. Herbal extracts have been shown to improve sleep quality, potentially through interactions with GABA receptors in the brain.
Article
Cardiac & Cardiovascular Systems
Emanuela Ricciotti, Cecilia Castro, Soon Yew Tang, William T. E. Briggs, James A. West, Dania Malik, Seth D. Rhoades, Hu Meng, Xuanwen Li, Nicholas F. Lahens, Jeffrey A. Sparks, Elizabeth W. Karlson, Aalim M. Weljie, Julian L. Griffin, Garret A. FitzGerald
Article
Biology
Seth D. Rhoades, Katrina Nayak, Shirley L. Zhang, Amita Sehgal, Aalim M. Weljie
JOURNAL OF BIOLOGICAL RHYTHMS
(2018)
Article
Chemistry, Physical
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, Haripalsingh M. Sonawat
CONCEPTS IN MAGNETIC RESONANCE PART A
(2019)
Editorial Material
Oncology
Ai Wen Tan, Aalim M. Weljie
Article
Oncology
Desiree Hao, Arjun Sengupta, Keyue Ding, E. R. Ubeydullah, Saikumari Krishnaiah, Natasha B. Leighl, Frances A. Shepherd, Lesley Seymour, Aalim Weljie
Article
Biochemistry & Molecular Biology
Arjun Sengupta, Soumita Ghosh, Shobhona Sharma, Haripalsingh M. Sonawat
Article
Cell Biology
Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Summary: The factors derived from tumors affect the activity and viability of tumor-specific cytotoxic T lymphocytes (CTLs), but the underlying mechanism is not well understood. These tumor-derived factors alter the lipid composition of cells and regulate the effector trogocytosis between cells. This process is controlled by the ATF3-CH25H axis, which affects tumor immunity, tumor growth, and the efficacy of CAR cell therapy.
Article
Cell Biology
Sean T. Anderson, Hu Meng, Thomas G. Brooks, Soon Yew Tang, Ronan Lordan, Arjun Sengupta, Soumyashant Nayak, Antonijo Mrela, Dimitra Sarantopoulou, Nicholas F. Lahens, Aalim Weljie, Gregory R. Grant, Frederic D. Bushman, Garret A. FitzGerald
Summary: Longitudinal studies suggest a relationship between shiftwork and cardiometabolic disorders, but the causes and mechanisms are not clear. We developed a mouse model to study circadian misalignment in both sexes and found that female mice showed preserved rhythmicity and were protected from the cardiometabolic effects of misalignment on a high-fat diet. Differences were observed in the liver transcriptome and proteome, as well as gut microbiome dysbiosis, which only occurred in male mice. Antibiotic treatment reduced the impact of misalignment. In the UK Biobank, female shiftworkers demonstrated stronger circadian rhythmicity and a lower incidence of metabolic syndrome compared to males. Our findings suggest that females are more resilient to chronic circadian misalignment, and this difference is conserved in humans.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Arjun Sengupta, Jennifer C. Tudor, Danielle Cusmano, Joseph A. Baur, Ted Abel, Aalim M. Weljie
Summary: This study examines the common molecular underpinnings of sleep deprivation and aging by analyzing metabolic features in young and aged mice after acute sleep deprivation. The results show that sleep deprivation primarily impacts peripheral plasma and liver metabolism, while the hippocampus is more affected by aging. Additionally, aged animals exhibit similar metabolic features to sleep deprivation even at baseline.
Article
Genetics & Heredity
Juliana Cazarin, Rachel E. Derollo, Siti Noor Ain Binti Ahmad Shahidan, Jamison B. Burchett, Daniel Mwangi, Saikumari Krishnaiah, Annie L. Hsieh, Zandra E. Walton, Rebekah Brooks, Stephano S. Mello, Aalim M. Weljie, Chi V. Dang, Brian J. Altman
Summary: MYC disrupts the molecular circadian clock, releasing metabolic and biosynthetic processes from circadian control, which may provide an advantage to cancer cells.
Article
Oncology
Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrcela, Divij Mathew, Liudmila L. Mazaleuskaya, Soumita Ghosh, Thomas G. Brooks, Alexandra P. Turner, Alessa Soares Schanoski, Nicholas F. Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G. Letizia, Stuart C. Sealfon, E. John Wherry, Krzysztof Laudanski, Aalim M. Weljie, Nuala J. Meyer, Garret A. FitzGerald
Summary: The study found that certain lipid indicators in the plasma of COVID-19 patients were positively correlated with disease severity, while in non-COVID-19 patients, they reflected viral rather than bacterial infections.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Toxicology
Lisa N. Bottalico, Julia Korlyakova, Aalim M. Weljie, Hamid R. Habibi
Summary: The study found that exposure of goldfish to endocrine disrupting chemicals and natural hormones leads to changes in metabolic levels in different seasons and reproductive stages, with goldfish being most vulnerable to metabolic perturbations in February (mid-recrudescence). Responses induced by contaminants differed from those induced by natural hormones in a season-specific manner, and exposure to the tertiary mixture resulted in a functional gain at the level of biochemical pathways modeling in select tissues and seasons.
FRONTIERS IN TOXICOLOGY
(2021)
Meeting Abstract
Critical Care Medicine
B. W. Winston, M. Banoei, H. J. Vogel, A. M. Weljie, S. Yende, D. C. Angus
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
B. W. Winston, M. Banoei, H. J. Vogel, A. M. Weljie, S. Tende, D. C. Angus
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)