Article
Endocrinology & Metabolism
Vijay K. Sirohi, Theresa Medrano, Ana M. Mesa, Athilakshmi Kannan, Indrani C. Bagchi, Paul S. Cooke
Summary: This study reveals the importance of AKT activation in promoting uterine epithelial proliferation even when it is independent of E2/ESR1 signaling. Additionally, the role of membrane ESR1 in AKT activation is emphasized.
Article
Multidisciplinary Sciences
Tripti Shrestha Bhattarai, Tambudzai Shamu, Alexander N. Gorelick, Matthew T. Chang, Debyani Chakravarty, Elena Gavrila, Mark T. A. Donoghue, JianJong Gao, Swati Patel, Sizhi Paul Gao, Margaret H. Reynolds, Sarah M. Phillips, Tara Soumerai, Wassim Abida, David M. Hyman, Alison M. Schram, David B. Solit, Lillian M. Smyth, Barry S. Taylor
Summary: AKT mutations can affect downstream effector pathways and sensitivity to AKT inhibitors in different solid cancer types.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J. L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Summary: WT1 is a key transcription factor in AML, frequently mutated or upregulated in multiple AML subtypes and predictive for relapse. Different isoforms of WT1 exhibit contrasting biological activities, including enhanced proliferation in two main AML subtypes. WT1 is responsive to oncogenic signaling and part of a transcription factor hub controlling AML growth.
Article
Chemistry, Multidisciplinary
Mingyuan Chen, Tengqian Sun, Yanghao Zhong, Xin Zhou, Jin Zhang
Summary: This study investigates Akt activity and regulation on lysosomes, showing that 3-phosphoinositides accumulate on lysosomal surface and play a crucial role in Akt and mTORC1 activation.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Summary: The study demonstrates the functional expression of TRPM7 in neutrophils and its impact on neutrophil recruitment during inflammation. Blocking TRPM7 channel or kinase activity affects neutrophil function, indicating a potential target to treat excessive neutrophil invasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Integrative & Complementary Medicine
Hong-xiao Li, Ling Shi, Shang-jie Liang, Chen-chen Fang, Qian-qian Xu, Ge Lu, Qian Wang, Jie Cheng, Jie Shen, Mei-hong Shen
Summary: Moxibustion improved ovarian function and suppressed apoptosis of ovarian granulosa cells in a rat model of DOR induced by TGS, and the mechanism may involve the PI3K/AKT signaling pathway.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Oncology
Seamus E. Degan, Irwin H. Gelman
Summary: The PI3K-AKT pathway is frequently mutated in human cancers, with PTEN loss and gain-of-function mutations in PIK3CA and AKT1 being common factors. Drug targeting PI3K or AKT as monotherapies have shown limited efficacy against solid tumors in clinical trials, but may be more effective when combined with inhibitors of other oncogenic drivers. Different AKT isoforms have distinct roles in oncogenic progression, and the success of PI3K/AKT inhibitors may depend on targeting specific AKT isoforms and their preferred pathways.
MOLECULAR CANCER RESEARCH
(2021)
Article
Chemistry, Medicinal
Cheng-Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Yubo Zhou, Jia Li, Xiaowu Dong
Summary: This study successfully synthesized an AKT degrader B4, which efficiently degrades AKT protein and exhibits significant efficacy in anti-proliferation and inhibiting signaling pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Xiao-Fei Ding, Jie Chen, Huai-Lu Ma, Yong Liang, Yun-Fei Wang, Hai-Tao Zhang, Xin Li, Guang Chen
Summary: In this study, it was found that KIR2DL4 is overexpressed in renal cell carcinoma (RCC) cells and promotes RCC progression through the activation of the PI3K/AKT signaling pathway.
Review
Cell Biology
Jiayuan Li, Kuangqi Chen, Xiang Li, Xuhong Zhang, Liyue Zhang, Qianjie Yang, Yutong Xia, Chen Xie, Xiawei Wang, Jianping Tong, Ye Shen
Summary: This review summarizes the changes in the AKT signaling pathway in diabetic retinopathy (DR) and the targeted drugs based on these potential sites.
CELL DEATH DISCOVERY
(2023)
Article
Nutrition & Dietetics
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul
Summary: The study found that Chrysanthemum indicum ethanol extract (CIE) has a protective effect against oxidative damage induced by H2O2, improving neuronal cell viability and reducing intracellular ROS and apoptosis. CIE activates the TrkB/Akt signaling pathway to enhance the expression of neuroprotective factors and antioxidant enzymes, suggesting its potential for treating oxidative stress-related neurodegenerative diseases.
Article
Multidisciplinary Sciences
Simon Miller, Ashutosh Srivastava, Yoshiko Nagai, Yoshiki Aikawa, Florence Tama, Tsuyoshi Hirota
Summary: Intrinsic structural differences between CRY1 and CRY2, particularly in the FAD pocket and lid loop, can be targeted for isoform-selective regulation using compounds like KL101 and TH301.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Summary: The ethanol extract of Selaginella tamariscina (STE) has been found to exhibit neuroprotective effects by reducing oxidative stress and inhibiting autophagic cell death induced by glutamate in HT22 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Radha Mukherjee, Kiran G. Vanaja, Jacob A. Boyer, Sunyana Gadal, Hilla Solomon, Sarat Chandarlapaty, Andre Levchenko, Neal Rosen
Summary: The PI3K pathway regulates cell metabolism, proliferation, and migration, and dysregulation of this pathway is common in cancer. Physiologic and oncogenic activation of PI3K signaling both lead to increased expression of the negative regulator PTEN, limiting signal duration and pathway output. However, inhibition of the pathway reduces PTEN levels, contributing to pathway rebound in tumors treated with PI3K inhibitors.
Article
Anatomy & Morphology
G. El-Akabawy, K. Aabed, L. A. Rashed, S. N. Amin, I. AlSaati, M. Al-Fayez
Summary: This study evaluated the efficacy of intravenous injection of bone marrow-derived mesenchymal stem cells (BMMSCs) in an aging rat model and found that BMMSC transplantation improved locomotor activity and cognitive functions, restored cholinergic system function, protected atrophic cholinergic neurons, induced antioxidative effects, and restored neurotrophic factors, and modulated hippocampal synaptic plasticity. These findings suggest that BMMSCs may be developed into an effective cell therapy for the aging brain.
FOLIA MORPHOLOGICA
(2022)
Article
Genetics & Heredity
Pierre K. Boerkoel, Katherine Dixon, Carrie Fitzsimons, Yaoqing Shen, Stephanie Huynh, Kamilla Schlade-Bartusiak, Luka Culibrk, Simon Chan, Cornelius F. Boerkoel, Steven J. M. Jones, Hui-Lin Chin
Summary: This study reports a newborn with syndromic degenerative anophthalmia and a complex de novo rearrangement of chromosome 13q. Long-read genome sequencing improved the resolution and clinical interpretation of the rearrangement, providing new insights into the molecular etiology of MAC.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Genetics & Heredity
Hui-Lin Chin, Stephanie Huynh, Jahanshah Ashkani, Michael Castaldo, Katherine Dixon, Kathryn Selby, Yaoqing Shen, Marie Wright, Cornelius F. Boerkoel, Glenda Hendson, Steven J. M. Jones
Summary: Monoallelic pathogenic variants in BICD2 cause autosomal dominant Spinal Muscular Atrophy Lower Extremity Predominant 2A and 2B. Dysfunction of BICD2 leads to motor neuron loss. A novel de novo BICD2 variant was identified in a patient with diaphragmatic paralysis without typical muscle weakness and contractures, expanding the phenotypic spectrum of BICD2-related disease.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Biochemistry & Molecular Biology
Hamood AlSudais, Nadine Wiper-Bergeron
Summary: C/EBP beta acts as a regulator of skeletal muscle stem cell function by inhibiting myogenic differentiation in healthy muscle and being stimulated in pathological conditions like cancer cachexia, affecting processes such as muscle regeneration.
Article
Biochemistry & Molecular Biology
Sameera Abuaish, Norah M. Al-Otaibi, Kawther Aabed, Turki S. Abujamel, Saleha Ahmad Alzahrani, Sohailah Masoud Alotaibi, Ramesa Shafi Bhat, Shaista Arzoo, Norah Algahtani, Nadine M. S. Moubayed, Afaf El-Ansary
Summary: Gut microbiota plays a significant role in neurological disorders, including autism, and modulation of the gut microbiota through fecal microbiota transplantation or probiotic administration could alleviate autistic symptoms and have positive effects on the brain.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Turki S. Abujamel, Norah M. Al-Otaibi, Sameera Abuaish, Rahaf H. AlHarbi, Mushref B. Assas, Saleha Ahmad Alzahrani, Sohailah Masoud Alotaibi, Afaf El-Ansary, Kawther Aabed
Summary: This study evaluated the effect of Bifidobacterium (BF) treatment and fecal microbiota transplantation (FT) on gut microbiota in a propionic acid (PPA) rat model of autism using 16S rRNA sequencing. The results demonstrated that BF and FT treatments have the ability to regulate gut microbiota and restore dysbiosis caused by autism.
Article
Geriatrics & Gerontology
Hamood AlSudais, Rashida Rajgara, Aisha Saleh, Nadine Wiper-Bergeron
Summary: C/EBPβ is a transcription factor associated with aggressiveness and poor outcomes in human cancers. It plays a key role in regulating tumor-derived cachexia-inducing factors, highlighting its potential as a therapeutic target for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, Research & Experimental
Afrah E. Mohammed, Fuad Ameen, Kawther Aabed, Rasha Saad Suliman, Sahar Saleh Alghamdi, Fatmah Ahmed Safhi, Dalal Sulaiman Alshaya, Hayat Ali Alafari, Areej S. Jalal, Areej A. Alosaimi, Salha Mesfer Alshamrani, Ishrat Rahman
Summary: In this study, a combination of in vitro experiments and in silico modeling was used to evaluate the pharmacological properties and antibacterial activities of silver nanoparticles synthesized with the shrub Lycium shawii. The results showed that emodin, one of the metabolites identified in the L. shawii extract, exhibited significant anticancer and antibacterial activities, suggesting its potential as a therapeutic agent for drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Correction
Endocrinology & Metabolism
Sameera Abuaish, Norah M. Al-Otaibi, Kawther Aabed, Turki S. Abujamel, Saleha Ahmad Alzahrani, Sohailah Masoud Alotaibi, Ramesa Shafi Bhat, Shaista Arzoo, Afaf El-Ansary
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Munerah Hamed, Jihong Chen, Qiao Li
Summary: Dystroglycan, a key component for muscle membrane integrity, is regulated by retinoid X receptor signaling and plays a crucial role in myoblast differentiation. It is a target gene of the muscle master regulator MyoD and its expression is influenced by residue-specific histone acetylation. Our study provides new insights into the regulation and function of dystroglycan in myoblasts and suggests potential therapeutic approaches for muscle pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Correction
Oncology
Kawther Aabed, Nadine Moubayed, Munerah S. BinShabaib, Shatha Subhi Al Harthi
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yasir Almuhanna, Mohammed Hussein Alqasmi, Hamood AlSudais, Mohammed Alrouji, Fahd A. Kuriri, Mohammed Alissa, Meshari A. Alsuwat, Mohammed Asad, Babu Joseph
Summary: The desert plant Achillea fragrantissima, also known as yarrow, has been traditionally used as an antimicrobial agent in Saudi Arabian folklore medicine. This study investigated its antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and multi-drug-resistant Pseudomonas aeruginosa (MDR-P. aeruginosa) through in vitro and in vivo experiments. The methanolic extract of Achillea fragrantissima inhibited the growth of both pathogens in vitro and promoted the healing of biofilm-formed excision wounds in diabetic mice, demonstrating its antibiofilm, antimicrobial, and wound-healing properties. The extract was found to have concentration-dependent activity, with a stronger effect against MRSA than MDR-P. aeruginosa. It also showed no skin irritation effect in vivo and no cytotoxic effect on HaCaT cell lines in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Mohammed Alrouji, Fahd A. Kuriri, Mohammed Hussein Alqasmi, Hamood AlSudais, Mohammed Alissa, Meshari A. Alsuwat, Mohammed Asad, Babu Joseph, Yasir Almuhanna
Summary: The study developed a simple and inexpensive method to induce biofilm formation in-vivo using Swiss albino mice for the evaluation of the antibiofilm activity of pharmacological agents. Preformed biofilm and MRSA culture were introduced into excision wounds of diabetic mice. The method successfully developed biofilm after 24 hours of incubation, which was confirmed by microscopic examination and a crystal violet assay. It was also effective in inducing profound infection and biofilm formation in the excision wounds within 72 hours.
Article
Pediatrics
Abdulrahman Alshalani, Badi A. Alotaibi, Jehad A. Aldali, Hamood AlSudais, Abdulaziz M. Almuqrin, Nasser A. Alshehri, Nasser B. Alamar, Mogtba A. Alhejji
Summary: This study examines the relationships between key haematology parameters, duration of hospital stay, and mortality rates in pediatric COVID-19 cases. Age is found to be a crucial predictor of mortality, with older patients having lower mortality rates. The study also highlights the influence of COVID-19 on platelet counts and the complexity of relationships between haematological parameters and disease outcomes.