Article
Physiology
Hao Su, Tianhao Wen, Dongsen Liu, Jia Shao, Lei Zhao, Qi Gao
Summary: Sarcopenia caused by aging is a key factor leading to a decline in the quality of life of older individuals. This study aimed to investigate the effects of high-intensity interval training (HIIT) and resistance training (RT) on skeletal muscle-related indices and provide a theoretical basis for delaying sarcopenia. The results showed that both HIIT and RT can reverse the age-related loss of muscle mass, with RT having a better effect. Additionally, HIIT showed better long-term intervention regarding pro-apoptotic factors. Further research is warranted to understand the underlying mechanisms of different exercise methods on aging skeletal muscle.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
M. L. Sanchez-Tocino, S. Mas-Fontao, C. Gracia-Iguacel, M. Pereira, I. Gonzalez-Ibarguren, A. Ortiz, M. D. Arenas, E. Gonzalez Parra
Summary: This study aimed to develop a sarcopenia index based on malnutrition parameters for screening muscle wasting in elderly hemodialysis patients. The results showed that the combination of loss of strength, loss of muscle mass, and low physical performance correlated with malnutrition. Regression equations were developed to predict the severity of sarcopenia, and easily accessible anthropometric and nutritional parameters were used for screening.
Article
Multidisciplinary Sciences
Li Zhang, Jun Jin, You-Yi Tu, Zhe Zhao, Jun Tao, Xiao-yan Zhang
Summary: This study aimed to investigate the performance of the serum creatinine/cystatin C ratio (Cr/CysC) in predicting all-cause mortality in elders over 80 years. The study found that non-survivors with lower baseline Cr/CysC levels had a significantly higher mortality rate, and Cr/CysC levels were positively correlated with calf circumference and handgrip strength. Age, coronary heart disease, and the lowest Cr/CysC level were independent factors of all-cause mortality in older adults over 80 years.
Article
Geriatrics & Gerontology
Nimesh Nagururu, Isaac A. Bernstein, Kristin Voegtline, Sarah Olson, Yuri Agrawal, Nicholas R. Rowan
Summary: This study found that olfactory impairment can serve as a biomarker of frailty. Olfactory identification and olfactory sensitivity are associated with the degree of frailty, suggesting that olfaction may be a potential biomarker and risk factor for frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Li Zhang, You-Yi Tu, Zhe Zhao, Jun Jin, Jun Tao, Xiao-Yan Zhang
Summary: This study investigated the relationship between thyroid hormone levels and all-cause mortality in sarcopenic older adults over 80 years of age. The study found that lower serum FT3 levels were associated with higher mortality in this population.
Article
Geriatrics & Gerontology
Huang-Chun Liu, Der-Sheng Han, Chih-Chin Hsu, Jong-Shyan Wang
Summary: This study suggests that circulating myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) may serve as superior biomarkers for age-related sarcopenia compared to inflammatory peroxide and cytokines in plasma.
Article
Nutrition & Dietetics
Hui-Hui Wang, Yan Zhang, Tai-Qi Qu, Xue-Qin Sang, Yi-Xuan Li, Fa-Zheng Ren, Peng-Cheng Wen, Ya-Nan Sun
Summary: Sarcopenia, a decrease in skeletal muscle mass and function caused by aging, can lead to mobility impairments, increased risk of fractures, diabetes, and other illnesses, and significantly affects the quality of life for seniors. Nobiletin (Nob), a polymethoxyl flavonoid, has potential effects in regulating protein homeostasis to prevent and treat sarcopenia.
Review
Nutrition & Dietetics
Kuan-Cheng Chen, Ying Jeng, Wei-Ting Wu, Tyng-Guey Wang, Der-Sheng Han, Levent oezcakar, Ke-Vin Chang
Summary: Sarcopenia in elderly can lead to dysphagia, making early detection and intervention crucial. Various tools are available to assess swallowing-related muscle function, strength, and mass. Integrated intervention including muscle strengthening, nutrition support, and physical therapy is recommended for patients with sarcopenic dysphagia.
Article
Cell Biology
Ying Wang, Steven S. Welc, Michelle Wehling-Henricks, Ying Kong, Connor Thomas, Enca Montecino-Rodriguez, Kenneth Dorshkind, James G. Tidball
Summary: Intramuscular macrophages play key roles in regulating skeletal muscle response to injury and disease. Changes in the numbers and phenotype of these macrophages during aging can influence the aging process. A study using a mouse model with a myeloid cell-specific mutation of Spi1 showed that this mutation reduced the numbers of M2 phenotype macrophages in aging muscles, and also reduced age-related muscle fibrosis and sarcopenia. These findings highlight the significance of intramuscular M2-biased macrophages in promoting detrimental, age-related changes in muscle.
Article
Cell Biology
Lauren Wimer, Elena Goncharova, Sofiya Galkina, Edna Nyangau, Mahalakshmi Shankaran, Asia Davis, Leandro Prado, Maria Castro Munoz, Sharon Epstein, Cavan Patterson, Nicholas Shaum, Mark Hellerstein, William Evans, Simon Melov
Summary: Developing accurate methods to quantify age-related muscle loss is crucial for developing therapies, and the D3Cr method offers a faster, cheaper, and more accurate alternative to DXA for measuring muscle mass in mice.
Review
Cell Biology
Giulia Coletta, Stuart M. Phillips
Summary: Consensus on what constitutes sarcopenia is critical to propel research in the field and provide prognostic value and treatment options for patients.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Eduardo Antuna, Cristina Cachan-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez
Summary: In a world where life expectancy is increasing, understanding and promoting healthy aging has become a contemporary demand. Inflammaging, a chronic and low-grade systemic inflammation in the elderly, is linked with many age-associated diseases. There are correlations between sarcopenia, the loss of strength and mass in skeletal muscle related to aging, and inflammaging. Inflammatory signals from chronic diseases negatively affect skeletal muscle, and autophagic mechanisms play a role in inflammation. Strategies such as using melatonin or senotherapeutic compounds could counteract inflammation in the muscle. This review aims to present the factors regulating skeletal muscle inflammaging and their implications in sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
David H. Lynch, Curtis L. Petersen, Matthew J. Van Dongen, Hillary B. Spangler, Seth A. Berkowitz, John A. Batsis
Summary: This study aimed to investigate the relationship between food insecurity and probable sarcopenia in older adults. The results showed a significant association between food insecurity and probable sarcopenia, especially when using the definition based on grip strength alone. Interventions targeting food insecurity may help reduce probable sarcopenia and its adverse outcomes.
CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Sian Robinson, Antoneta Granic, Alfonso J. Cruz-Jentoft, Avan A. Sayer
Summary: Sarcopenia is a common skeletal muscle disorder characterized by a loss of muscle mass and impaired muscle function. The relationship between diet and sarcopenia risk in older age is limited and fragmented, with different outcomes reported across studies. However, there is evidence to suggest that diets of higher quality in earlier adulthood are beneficial for later physical performance.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Laura M. de Smalen, Anastasiya Borsch, Aurel B. Leuchtmann, Jonathan F. Gill, Danilo Ritz, Mihaela Zavolan, Christoph Handschin
Summary: Sarcopenia, the age-related loss of skeletal muscle mass and function, can significantly impact quality of life and mortality. This study found that mitochondrial proteostasis plays an important role in muscle aging and highlights the positive effects of exercise on mitochondrial protein synthesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Joao Ricardhis S. Oliveira, Junaith S. Mohamed, Matthew J. Myers, Matthew J. Brooks, Stephen E. Alway
EXPERIMENTAL GERONTOLOGY
(2019)
Editorial Material
Physiology
Stephen E. Alway
EXERCISE AND SPORT SCIENCES REVIEWS
(2019)
Article
Geriatrics & Gerontology
Matthew J. Myers, Danielle L. Shepherd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Physiology
Peter J. Ferrandi, Stephen E. Alway, Junaith S. Mohamed
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Cell Biology
Brian T. Bennett, Junaith S. Mohamed, Stephen E. Alway
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Genetics & Heredity
Peter J. Ferrandi, Mohammad Moshahid Khan, Hector G. Paez, Christopher R. Pitzer, Stephen E. Alway, Junaith S. Mohamed
Editorial Material
Physiology
Peter J. Ferrandi, Stephen E. Alway, Junaith S. Mohamed
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Neurosciences
Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E. Alway, Mohammad Moshahid Khan
Summary: The study demonstrated that the brain-selective estrogen prodrug DHED can alleviate the PD-like symptoms induced by MPTP in mice, including behavioral impairments and dopaminergic neurodegeneration. Additionally, DHED was found to reduce levels of inflammation and oxidative stress in the striatum.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Matthew J. Myers, Fathima Shaik, Fahema Shaik, Stephen E. Alway, Junaith S. Mohamed
Summary: The study found that aging affects the role of CR in muscle, with CR restoring global gene expression inhibition caused by aging by upregulating transcriptional and translational process-related pathways. However, CR inhibits pathways related to extracellular matrix and cytoskeletal proteins regardless of aging.
Article
Geriatrics & Gerontology
Stephen E. Alway, Hector G. Paez, Christopher R. Pitzer, Peter J. Ferrandi, Mohammad Moshahid Khan, Junaith S. Mohamed, James A. Carson, Michael R. Deschenes
Summary: This study investigated the effect of mitochondrial transplant therapy (MTT) on the restoration of muscle function after neuromuscular injury. The results showed that MTT can enhance muscle regeneration and restoration of muscle function without increasing systemic inflammation in mice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Cell Biology
Hector G. G. Paez, Christopher R. R. Pitzer, Stephen E. E. Alway
Summary: Sarcopenia is a skeletal muscle disease characterized by deficits in muscle strength, mass, quality, and metabolic health, which worsens with age. The causes of sarcopenia are complex and involve a combination of environmental factors and intrinsic age-related changes. Loss of muscle quality, rather than just muscle mass, is the primary defect with advanced age. Dysregulation of proteostasis, an important cellular quality control mechanism, is a significant contributor to age-associated declines in muscle quality, function, and mass. Inhibition of the mTORC1 pathway and caloric restriction show promise in improving muscle quality in aged animals, but further research is needed to fully understand the mechanisms involved.
Review
Cell Biology
Christopher R. Pitzer, Hector G. Paez, Stephen E. Alway
Summary: Cancer cachexia is unintentional weight loss associated with poor prognosis. Exosomes, originating from multivesicular bodies, carry biomolecular cargo that can alter cell signaling. They affect muscle and adipose tissue metabolism, macrophage polarization, and apoptosis, contributing to cachexia phenotype. Tumor-derived exosomes have potential as biomarkers and play a role in cancer cachexia progression by affecting skeletal muscle and adipose tissue.
Article
Endocrinology & Metabolism
Jessica L. L. Halle, Brittany R. R. Counts, Hector G. G. Paez, Dryden R. R. Baumfalk, Quan Zhang, Junaith S. S. Mohamed, Evan S. S. Glazer, Melissa J. J. Puppa, Ashley J. J. Smuder, Stephen E. E. Alway, James A. A. Carson
Summary: FOLFOX chemotherapy has acute and lasting effects on systemic and skeletal muscle metabolism, disrupting body weight and metabolic signaling. Recovery is observed in skeletal muscle metabolic signaling, but not in systemic metabolism. Further studies are needed to prevent and treat FOLFOX-induced metabolic toxicities.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Hector G. Paez, Peter J. Ferrandi, Christopher R. Pitzer, Junaith S. Mohamed, Stephen E. Alway
Summary: The study investigates the impact of NOR-1 deficiency on C2C12 metabolic signaling. The results reveal that NOR-1 acts as a modulator of mTORC1 signaling and its deficiency may contribute to insulin resistance and metabolic disease. Therefore, strategies that improve NOR-1 levels could be important in mitigating muscle metabolic abnormalities.
Article
Biochemistry & Molecular Biology
Kiril Tuntevski, Ameena Hajira, Austin Nichols, Stephen E. Alway, Junaith S. Mohamed
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
