Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes

Toward an integrated pipeline for protein biomarker development

(2015) Andrei P. Drabovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mass spectrometry-based proteomic quest for diabetes biomarkers

(2015) Shiying Shao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Successful generation of structural information for fragment-based drug discovery

(2015) Linda Öster et al.   DRUG DISCOVERY TODAY

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding

(2015) Mun Peak Nyon et al.   PROTEIN SCIENCE

Absolute and multiplex quantification of antibodies in serum using PSAQ™ standards and LC-MS/MS

(2015) Dorothee Lebert et al.   Bioanalysis

Dynamic protein ligand interactions - insights from MS

(2014) Carla Schmidt et al.   FEBS Journal

Application of the Exactive Plus EMR for automated protein-ligand screening by non-covalent mass spectrometry

(2014) Hannah J. Maple et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation

(2013) François Debaene et al.   ANALYTICAL CHEMISTRY

Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry

(2013) Jessica N. Rabuck et al.   ANALYTICAL CHEMISTRY

p-Sulfonato-calix[n]arenes inhibit staphylococcal bicomponent leukotoxins by supramolecular interactions

(2013) Benoît-Joseph Laventie et al.   BIOCHEMICAL JOURNAL

Single molecule insights on conformational selection and induced fit mechanism

(2013) Nikos S. Hatzakis   BIOPHYSICAL CHEMISTRY

Ion mobility-mass spectrometry of intact protein–ligand complexes for pharmaceutical drug discovery and development

(2013) Shuai Niu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Combating multidrug-resistant Gram-negative bacterial infections

(2013) Ze-Qi Xu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009 – 2012)

(2013) Claudiu T Supuran et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Exploring Key Parameters to Detect Subtle Ligand-Induced Protein Conformational Changes Using Traveling Wave Ion Mobility Mass Spectrometry

(2012) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Characterization of Therapeutic Antibodies and Related Products

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Mass spectrometry based tools to investigate protein–ligand interactions for drug discovery

(2012) Kamila J. Pacholarz et al.   CHEMICAL SOCIETY REVIEWS

Ion mobility–mass spectrometry for structural proteomics

(2012) Yueyang Zhong et al.   Expert Review of Proteomics

Reliable Determinations of Protein–Ligand Interactions by Direct ESI-MS Measurements. Are We There Yet?

(2012) Elena N. Kitova et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Integrating mass spectrometry of intact protein complexes into structural proteomics

(2012) Suk-Joon Hyung et al.   PROTEOMICS

Characterizing the resolution and accuracy of a second-generation traveling-wave ion mobility separator for biomolecular ions

(2011) Yueyang Zhong et al.   ANALYST

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mass Spectrometric Strategies and Their Applications for Molecular Mass Determination of Recombinant Therapeutic Proteins

(2011) Marina Carini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Enhancements in travelling wave ion mobility resolution

(2011) Kevin Giles et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis

(2011) Sonia Fieulaine et al.   PLOS BIOLOGY

Combination of Noncovalent Mass Spectrometry and Traveling Wave Ion Mobility Spectrometry Reveals Sugar-Induced Conformational Changes of Central Glycolytic Genes Repressor/DNA Complex

(2010) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Interrogating viral capsid assembly with ion mobility–mass spectrometry

(2010) Charlotte Uetrecht et al.   Nature Chemistry

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

(2010) S. E. Kolstoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion mobility mass spectrometry of proteins and proteinassemblies

(2009) Charlotte Uetrecht et al.   CHEMICAL SOCIETY REVIEWS

Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes

(2009) Suk-Joon Hyung et al.   CHEMISTRY & BIOLOGY

Native MS: an ’ESI‚ way to support structure- and fragment-based drug discovery

(2009) Valerie Vivat Hannah et al.   Future Medicinal Chemistry

Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: The effect of ligand binding on conformational stability

(2009) Jonathan T. S. Hopper et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Cotranslational processing mechanisms: towards a dynamic 3D model

(2009) Carmela Giglione et al.   TRENDS IN BIOCHEMICAL SCIENCES

Probing hemoglobin structure by means of traveling-wave ion mobility mass spectrometry

(2008) Charlotte A. Scarff et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols