An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding

Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody

(2015) Lu Tan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

(2014) James A. Irving et al.   BIOCHEMICAL JOURNAL

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

(2014) Mun Peak Nyon et al.   Future Medicinal Chemistry

Evidence for Two New Solution States of Ubiquitin by IMS–MS Analysis

(2014) Huilin Shi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly

(2014) Theodoros K. Karamanos et al.   MOLECULAR CELL

The Z Mutation Alters the Global Structural Dynamics of α1-Antitrypsin

(2014) Victoria A. Hughes et al.   PLoS One

α-1-Antitrypsin deficiency: clinical variability, assessment, and treatment

(2014) Robert A. Stockley et al.   TRENDS IN MOLECULAR MEDICINE

Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry

(2013) Jessica N. Rabuck et al.   ANALYTICAL CHEMISTRY

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

(2013) Imran Haq et al.   BIOSCIENCE REPORTS

Autophosphorylation Activity of a Soluble Hexameric Histidine Kinase Correlates with the Shift in Protein Conformational Equilibrium

(2013) Marta Wojnowska et al.   CHEMISTRY & BIOLOGY

Conformational States of Macromolecular Assemblies Explored by Integrative Structure Calculation

(2013) Konstantinos Thalassinos et al.   STRUCTURE

The molecular and cellular pathology of α1-antitrypsin deficiency

(2013) Bibek Gooptu et al.   TRENDS IN MOLECULAR MEDICINE

Ion mobility–mass spectrometry for structural proteomics

(2012) Yueyang Zhong et al.   Expert Review of Proteomics

Amphitrite: A program for processing travelling wave ion mobility mass spectrometry data

(2012) Ganesh N. Sivalingam et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

(2012) Mun Peak Nyon et al.   STRUCTURE

Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

(2011) Anathe O. M. Patschull et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

(2011) Mun Peak Nyon et al.   Biomolecular NMR Assignments

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Understanding the complex mechanisms of β2-microglobulin amyloid assembly

(2011) Timo Eichner et al.   FEBS Journal

Conformational Conversion during Amyloid Formation at Atomic Resolution

(2011) Timo Eichner et al.   MOLECULAR CELL

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

(2011) Mary D Holdom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Fityk: a general-purpose peak fitting program

(2010) Marcin Wojdyr   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry

(2010) Gillian R. Hilton et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Defining the mechanism of polymerization in the serpinopathies

(2010) U. I. Ekeowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

(2009) Bibek Gooptu et al.   Annual Review of Biochemistry

Mechanisms of emphysema in  1-antitrypsin deficiency: molecular and cellular insights

(2009) B. Gooptu et al.   EUROPEAN RESPIRATORY JOURNAL

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

(2009) Bibek Gooptu et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinetic Instability of the Serpin Z α1-Antitrypsin Promotes Aggregation

(2009) Anja S. Knaupp et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of Phosphorylated Peptides Using Traveling Wave-Based and Drift Cell Ion Mobility Mass Spectrometry

(2008) Konstantinos Thalassinos et al.   ANALYTICAL CHEMISTRY

Biomolecule Analysis by Ion Mobility Spectrometry

(2008) Brian C. Bohrer et al.   Annual Review of Analytical Chemistry

Small-molecule peptides inhibit Z α1-antitrypsin polymerization

(2008) Yi-Pin Chang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements

(2008) Charlotte A. Scarff et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY