Topoisomerase II from Human Malaria Parasites

Expression of Functional Plasmodium falciparum Enzymes Using a Wheat Germ Cell-Free System

(2013) Devaraja G. Mudeppa et al.   EUKARYOTIC CELL

Total and Putative Surface Proteomics of Malaria Parasite Salivary Gland Sporozoites

(2013) Scott E. Lindner et al.   MOLECULAR & CELLULAR PROTEOMICS

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

(2013) Jennifer L. Guler et al.   PLoS Pathogens

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity

(2012) Bryan H Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum

(2012) Sophie C Oehring et al.   GENOME BIOLOGY

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Advances in structure-based drug design of novel bacterial topoisomerase inhibitors

(2010) Katherine Widdowson et al.   Future Medicinal Chemistry

Protein Export Marks the Early Phase of Gametocytogenesis of the Human Malaria ParasitePlasmodium falciparum

(2010) Francesco Silvestrini et al.   MOLECULAR & CELLULAR PROTEOMICS

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay

(2010) Praveen K. Singh et al.   PROTEIN EXPRESSION AND PURIFICATION

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

(2009) Cullen K.T. Pang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Impact of the Human DNA Topoisomerase II C-Terminal Domain on Activity

(2008) Emma L. Meczes et al.   PLoS One

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

(2008) Karthikeyan Ganesan et al.   PLoS Pathogens

Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity

(2008) Edwin Lasonder et al.   PLoS Pathogens