Article
Oncology
Min Wang, Ding Ding, Tingting Qin, Hebin Wang, Yahui Liu, Jianhua Liu, Jun Liu, Hang Zhang, Junfang Zhao, Chien-Hui Wu, Ammar Javed, Christopher Wolfgang, Shiwei Guo, Qingmin Chen, Weihong Zhao, Wei Shi, Feng Zhu, Xingjun Guo, Xu Li, Ruizhi He, Simiao Xu, Barish Edil, Yu-Wen Tien, Gang Jin, Lei Zheng, Jin He, Renyi Qin
Summary: A study proposed integrating TNM stage and G grade into a TNMG staging system, which was found to be more accurate in predicting the prognosis of panNEN patients compared to using TNM stage or G grade independently.
Article
Endocrinology & Metabolism
Johannes Hofland, Massimo Falconi, Emanuel Christ, Justo P. Castano, Antongiulio Faggiano, Angela Lamarca, Aurel Perren, Simona Petrucci, Vikas Prasad, Philippe Ruszniewski, Christina Thirlwell, Marie-Pierre Vullierme, Staffan Welin, Detlef K. Bartsch
Summary: This guidance paper provides practical advice for clinicians on the diagnosis, treatment, and follow-up of functioning syndromes in pancreatic neuroendocrine tumors (NET). It defines a functioning syndrome as a clinical syndrome combined with biochemical evidence of elevated hormone levels. The paper focuses on the biochemical, genetic, and imaging work-up, as well as therapeutic management of different hormonal syndromes in well-differentiated, grade 1-3, functioning NET with primary tumor originating in the pancreas, and some specific subtypes in the duodenum.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jonathan Ragheb, Shruti Mony, Jason Klapman, Tolga Erim, Angela Reagan, Robert Butler, Yanbin Dong, Michael Cruise, Barbara A. Centeno, Pablo Bejarano, Tyler Stevens, Umar Hayat, Amit Bhatt
Summary: The study suggests that the main predictor of recurrence in low-grade DNETs <1.0 cm is the presence of positive tumor margins at the initial endoscopic resection. Ninety-two percent of recurrences were detected within 3 years of resection, indicating the need for more frequent, earlier surveillance. No recurrences occurred in the cohort after 4 years of surveillance.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Oncology
Tiziana Feola, Roberta Centello, Franz Sesti, Giulia Puliani, Monica Verrico, Valentina Di Vito, Cira Di Gioia, Oreste Bagni, Andrea Lenzi, Andrea M. Isidori, Elisa Giannetta, Antongiulio Faggiano
Summary: NECs are heterogeneous tumors that can be further divided into two prognostically distinct categories based on the Ki67 LI < 55%. Those with lower Ki67 LI have a better prognosis and should be treated and monitored differently from those with higher Ki67 LI.
Article
Endocrinology & Metabolism
Sara Krogh, Henning Gronbaek, Anders Riegels Knudsen, Peter Kissmeyer-Nielsen, Nynne Emilie Hummelshoj, Gitte Dam
Summary: This study aimed to investigate the prognosis and optimal treatment of pancreatic neuroendocrine tumors (PNET). The results showed that larger tumor size, Ki67 index, tumor grade, and stage were predictive of shorter survival, and chromogranin A was a predictor of overall survival. Furthermore, the study supported the active surveillance for small, localized, low-grade PNETs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Kiyoun Yi, Gwang Ha Kim, Su Jin Kim, Cheol Woong Choi, Moon Won Lee, Bong Eun Lee, Geun Am Song
Summary: Endoscopic resection provides favorable long-term outcomes for d-NETs <= 10 mm in size, limited to the submucosal layer, and without lymph node or distant metastasis, when endoscopically complete resection is achieved.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
C. Ricci, S. Partelli, L. Landoni, M. Rinzivillo, C. Ingaldi, V Andreasi, C. Nessi, F. Muffatti, M. Fontana, D. Tamburrino, G. Deiro, L. Alberici, D. Campana, F. Panzuto, C. Bassi, M. Falconi, R. Casadei
Summary: This study evaluated outcomes after surgery for sporadic pancreatic neuroendocrine neoplasms (Pan-NENs), identifying 2019 WHO grade and ENETS TNM stage as important factors. Surgical approach may be without benefit for Pan-NECs, unnecessary for small G1 sporadic Pan-NENs, and insufficient for stage III-IV and G3 Pan-NENs.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Dalvinder Mandair, Lukasz Kamieniarz, Michail Pizanias, Martin O. Weickert, Akshay Narayan, Luke Furtado O'Mahony, Martyn Caplin, John Ramage, Andreas Prachalias, Rajaventhan Srirajaskanthan, Christos Toumpanakis
Summary: Duodenal neuroendocrine neoplasms (dNENs) are rare neoplasms but their incidence is increasing. Age and Ki67 levels are associated with worse prognosis in dNENs. Ki67 > 3% is a predictor of lymph nodes and liver metastases in non-functioning dNENs. Lesions 11-20 mm in size have a higher prediction of lymph node metastases. Non-functioning dNENs smaller than 15 mm have a high sensitivity in predicting lymph node metastases.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Tanaz Vaghaiwalla, Brian Ruhle, Kelvin Memeh, Peter Angelos, Edwin Kaplan, Chih-Yi Liao, Blase Polite, Xavier Keutgen
Summary: This retrospective study evaluated response rates among neuroendocrine tumor patients who received peptide receptor radionuclide therapy, showing that pancreatic neuroendocrine tumors were more likely to have a partial response compared to other primary sites. Patients with stable pancreatic neuroendocrine tumors after 2 cycles were more likely to respond to additional treatment cycles.
Article
Oncology
Stefano Partelli, Valentina Andreasi, Marisa Peralta Ferreira, Diego Palumbo, Francesca Muffatti, Anna Battistella, Francesca Fermi, Paola Mapelli, Domenico Tamburrino, Nicolo Pecorelli, Stefano Crippa, Massimo Falconi
Summary: This study compared the clinicopathologic features and survival between patients with nodal relapse and those with distant relapse after surgery for NF-PanNETs. It also identified predictors of nodal relapse after surgery for NF-PanNETs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Rihong Zhang, Yu Guo, Youliang Wang, Li Hu, Cheng Fang, Yujie Yang, Xianqi Yang, Luohai Chen, Jie Chen, Wei Wang, Xiaowei Sun
Summary: The proposed TNMG staging system can more accurately predict the 3- and 5-year OS rate of gNENs patients than the 8th AJCC TNM staging system.
Article
Medicine, General & Internal
Carolina Sassorossi, Pietro Bertoglio, Filippo Lococo, Gloria Santoro, Elisa Meacci, Dania Nachira, Maria Teresa Congedo, Jury Brandolini, Matteo Petroncini, Adriana Nocera, Diepriye Charles-Davies, Piergiorgio Solli, Stefano Margaritora, Marco Chiappetta
Summary: This study analyzed the correlation between tumor size and overall survival in patients with thymic tumors who underwent surgical treatment. The results showed that tumor size was correlated with some patient characteristics and clinical indicators, but it was not effective in predicting disease-free survival.
Article
Gastroenterology & Hepatology
Sarah Mirzaie, Joon Y. Park, Michael A. Mederos, Mark D. Girgis
Summary: This study compared the survival outcomes between surgical and endoscopic resection in different sizes of duodenal neuroendocrine tumors (dNETs), and found that endoscopic resection demonstrated similar survival outcomes to surgical resection across various dNET sizes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Jordan M. Cloyd, George A. Poultsides
Summary: PNETs are a rare type of tumor originating from pancreatic islet cells, with surgical resection being the standard treatment for most patients and pancreas-preserving approaches being acceptable for smaller tumors. Observation is recommended for small, low-grade PNETs.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Lorenz, Sebastian Lenkiewicz, Mateusz Kozlowski, Sebastian Kwiatkowski, Aneta Cymbaluk-Ploska
Summary: Neuroendocrine tumours of the gastrointestinal and reproductive tracts are rare and have a poor prognosis. Surgical resection is the main treatment, but non-surgical treatments are also used. This article focuses on identifying risk factors, including genetic mutations, and comparing the effectiveness of different non-surgical treatments, such as chemotherapy, radiotherapy, peptide receptor radionuclide therapy, somatostatin analogues, and immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Gianluca Russo, Francesco Pepe, Pasquale Pisapia, Lucia Palumbo, Mariantonia Nacchio, Elena Vigliar, Pierlorenzo Pallante, Paola Parente, Matteo Fassan, Paolo Graziano, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle, Antonino Iaccarino
Summary: This article reviews the results of microsatellite instability (MSI) evaluation using a customized workflow and microfluidic system in a diagnostic routine practice over a period of 4 years. The results showed that the majority of patients with metastatic colorectal cancer (mCRC) had microsatellite stability (MSS) profile, while a minority had microsatellite high (MSI-H) profile. Similarly, in patients without colorectal cancer, both MSS and MSI-H profiles were observed.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Surgery
Corrado Pedrazzani, Cristian Conti, Angelo Di Vittori, Giulia Turri, Laura Bernardoni, Andrea Mafficini, Claudio Luchini, Armando Gabbrielli, Aldo Scarpa, Alfredo Guglielmi
ASIAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Valentina Mari, Valentina Angerilli, Giada Munari, Marco Scarpa, Quoc Riccardo Bao, Salvatore Pucciarelli, Matteo Fassan, Gaya Spolverato
Summary: This review outlines the molecular pathways involved in peritoneal metastatic dissemination in gastric cancer, highlighting the lack of comprehensive understanding of the complex molecular landscape of this disease. The integration of molecular profiling and histological evaluation is recommended for risk prediction assessment of peritoneal dissemination.
DIGESTIVE DISEASES
(2023)
Article
Pathology
Federica Grillo, Luca Carlin, Andrea Remo, Matteo Fassan, Claudia Mescoli, Michela Campora, Luigi Caserta, Fabrizio Mazza, Luca Mastracci
Summary: Dasatinib-induced colitis may present histological features similar to Crohn's disease, including microgranulomas and active inflammation, and complete remission can be achieved after treatment interruption.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Surgery
Gianluca Businello, Valentina Angerilli, Sara Lonardi, Francesca Bergamo, Michele Valmasoni, Fabio Farinati, Edoardo Savarino, Gaya Spolverato, Matteo Fassan
Summary: The comprehensive molecular characterization of gastric and gastroesophageal junction adenocarcinomas has improved targeted and effective treatments, introducing biomarkers into clinical practice. The evaluation mainly relies on limited biopsy material, making pathologists essential in patient selection for precision medicine approaches.
UPDATES IN SURGERY
(2023)
Article
Oncology
Alessandra A. Prete, Paolo Manca, Marco Messina, Vincenzo Formica, Giovanni L. Frassineti, Maria G. Zampino, Domenico C. Corsi, Corrado Orciuolo, Michele Prisciandaro, Francesca Bergamo, Valentina Angerilli, Mario Scartozzi, Mariaelena Casagrande, Gianluca Masi, Monica Ronzoni, Federica Morano, Valentina Vettore, Roberta Salmaso, Cosimo Rasola, Giulia Maddalena, Paola del Bianco, Massimo Milione, Chiara Cremolini, Matteo Fassan, Filippo Pietrantonio, Sara Lonardi
Summary: This study found that patients with high PD-L1 and high TMB had better survival outcomes when treated with immune checkpoint inhibitors for advanced squamous cell anal carcinoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Margherita Rimini, Carles Fabregat-Franco, Mara Persano, Valentina Burgio, Francesca Bergamo, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study investigated the prognostic impact of IDH1 mutations in patients with advanced iCCA after progression on first-line therapies. The presence of IDH1 mutations was associated with worse overall survival and worse objective response rate in second-line therapy. IDH1 mutations were confirmed as an independent negative prognostic factor.
Review
Health Care Sciences & Services
Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi
Summary: Homologous recombination deficiency (HRD) refers to the inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway. It serves as a predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and various methods of analysis have been developed for HRD testing in the clinical setting.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Grazia Vernaci, Edoardo Vincenzo Savarino, Ilaria Patuzzi, Sonia Facchin, Fabiana Zingone, Davide Massa, Giovanni Faggioni, Tommaso Giarratano, Federica Miglietta, Gaia Griguolo, Matteo Fassan, Marcello Lo Mele, Elisa Gasparini, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci
Summary: This article evaluates the feasibility of analyzing the gut microbiome in patients with early stage triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy, and explores its impact on treatment response and clinicopathologic factors. The study suggests that analyzing the gut microbiome may have potential significance in early TNBC, but further investigation is needed to understand its complex correlation with immunity and cancer.
Article
Pathology
Federica Zannier, Valentina Angerilli, Gaya Spolverato, Stefano Brignola, Daniele Sandona, Mariangela Balistreri, Marianna Sabbadin, Sara Lonardi, Francesca Bergamo, Claudia Mescoli, Marco Scarpa, Quoc Riccardo Bao, Angelo Paolo Dei Tos, Salvatore Pucciarelli, Emanuele L. D. Urso, Matteo Fassan
Summary: This study aimed to compare the pathological and clinical characteristics of MMR-deficient (MMRd) tumors and MMR proficient (MMRp) cases, with a particular focus on the relationship between these molecular subgroups and lymph node ratio (LNR). The study found significant differences between MMRd and MMRp tumors in terms of sex, age, size, growth pattern, inflammatory infiltrate, perineural invasion, stage, grade, and LNR. In conclusion, MMRd tumors are a distinct molecular subtype of colorectal cancer characterized by a significantly lower LNR, further supporting the prognostic impact of MMRd status in early-stage CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Nicolo Caldonazzi, Paola Chiara Rizzo, Albino Eccher, Ilaria Girolami, Giuseppe Nicolo Fanelli, Antonio Giuseppe Naccarato, Giuseppina Bonizzi, Nicola Fusco, Giulia d'Amati, Aldo Scarpa, Liron Pantanowitz, Stefano Marletta
Summary: The assessment of lymph node metastases is important in cancer staging and prognosis. By applying artificial intelligence to whole slide images, the automatic detection of metastatic cells can be achieved, leading to increased diagnostic quality. This study reviews the literature on using AI for the assessment of metastases in lymph nodes in whole slide images.
Review
Oncology
Anastasios Gkountakos, Filippo M. M. Martelli, Nicola Silvestris, Michele Bevere, Mario De Bellis, Laura Alaimo, Elena Sapuppo, Francesca Masetto, Aldo Mombello, Michele Simbolo, Elena Bariani, Michele Milella, Matteo Fassan, Aldo Scarpa, Claudio Luchini
Summary: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are aggressive tumors with limited treatment options. They share histomolecular features, making differential diagnosis challenging, but also have significant differences with clinical implications. PDAC and dCCA have different prognosis and oncogenic targets, highlighting the importance of accurate diagnosis and targeted treatments.
Article
Oncology
Laura Bonanno, Martina Lorenzi, Davide Massa, Mattia De Nuzzo, Valentina Angerilli, Fabiana Zingone, Brigida Barberio, Alberto Russi, Fabio Girardi, Alessandra Ferro, Alessandro Dal Maso, Stefano Frega, Giulia Pasello, Angelo Paolo Dei Tos, Marina Coppola, Matteo Fassan, Edoardo Vincenzo Savarino, Valentina Guarneri
Summary: This study collected real-world data on the occurrence of immune-mediated diarrhea and colitis in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors, and assessed the clinical impact of a multidisciplinary approach on the management of this adverse event.
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Review
Biochemistry & Molecular Biology
Federica Danzi, Raffaella Pacchiana, Andrea Mafficini, Maria T. Scupoli, Aldo Scarpa, Massimo Donadelli, Alessandra Fiore
Summary: Tumour cells possess the ability to reprogram their metabolism in order to support tumor growth, progression, and resistance. This reprogramming involves significant changes in bioenergetic, biosynthetic, and redox status to meet the increased energetic demands of the cells. Recent advancements in biochemical technologies, such as metabolomics and fluxomics, have provided researchers with powerful tools to study cancer metabolism and gain a better understanding of its complex activities on both qualitative and mechanistic levels. Additionally, the development of single-cell analysis technologies and functional genomic screening have further enhanced our ability to investigate cancer biology, identify biomarkers, and discover new therapeutic targets and treatment strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
