Article
Pathology
Monika Vyas, Laura H. Tang, Natasha Rekhtman, David S. Klimstra
Summary: This study observed a decrease in Ki67 index and increased heterogeneity in treated high-grade neuroendocrine neoplasms, which may lead to misdiagnosis as low-grade tumors.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Klara Wyffels, Charlotte De Wilde, Jacques Van Huysse, Vincent De Wilde
Summary: Neuroendocrine neoplasms (NENs) are a diverse group of tumors originating from enterochromaffin cells, each with distinct biological and clinical characteristics. This case report discusses the rare finding of peritoneal carcinomatosis in a well-differentiated Grade 1 (G1) small intestinal NEN and the lack of understanding of its progression and management. The study presents the case of a 68-year-old woman with advanced NEN and rapidly progressive peritoneal metastatic disease, highlighting the need for a predictive tool for early identification of such patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Pathology
Claudio Luchini, Liron Pantanowitz, Volkan Adsay, Sylvia L. Asa, Pietro Antonini, Ilaria Girolami, Nicola Veronese, Alessia Nottegar, Sara Cingarlini, Luca Landoni, Lodewijk A. Brosens, Anna V. Verschuur, Paola Mattiolo, Antonio Pea, Andrea Mafficini, Michele Milella, Muhammad K. Niazi, Metin N. Gurcan, Albino Eccher, Ian A. Cree, Aldo Scarpa
Summary: Ki-67 assessment plays a key role in the diagnosis of neuroendocrine neoplasms (NENs) from all anatomic locations. Digital pathology combined with machine learning has shown to be highly accurate and reproducible for evaluating Ki-67 in NENs. In this systematic review, the advantages of digital image analysis (DIA) in assessing Ki-67 in pancreatic NENs (PanNENs) were highlighted, including improved standardization and reliability, as well as increased speed and practicality compared to manual counting. However, limitations such as higher costs and operator qualification issues need to be addressed. A comparative meta-analysis showed a high concordance between DIA and manual counting. These findings support the widespread adoption of validated DIA methods for Ki-67 assessment in PanNENs.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alexander Weich, Sebastian E. Serfling, Steven P. Rowe, Lilja B. Solnes, Andreas K. Buck, Takahiro Higuchi, Rudolf A. Werner
Summary: We present a case of an aggressive pancreatic neuroendocrine tumor (NET G3; Ki67 = 60%) which was treated with pancreatic resection and partial liver lesion removal. The patient refused chemotherapy. Dual-tracer imaging with F-18-FDG and somatostatin receptor (SSTR)-targeted PET/CT revealed radiotracer accumulation in bilobar hepatic lesions. Treatment with cold somatostatin analogues and peptide receptor radionuclide therapy (PRRT) resulted in partial response. Even in highly proliferative G3 NET (Ki67>55%), evaluating SSTR expression in disease sites can guide the use of PRRT as first-line systemic treatment.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Liudmyla Zurnadzhy, Tetiana Bogdanova, Tatiana I. Rogounovitch, Masahiro Ito, Mykola Tronko, Shunichi Yamashita, Norisato Mitsutake, Serhii Chernyshov, Sergii Masiuk, Vladimir A. Saenko
Summary: The frequency of BRAF(V600E) in young Ukrainian patients with radiogenic and sporadic papillary thyroid carcinomas increases with age, but does not confer a more aggressive course regardless of tumor etiology. Major clinicopathological differences between radiogenic and sporadic PTCs are observed among the BRAF(V600E)-negative tumors.
Article
Cell Biology
Ann E. Walts, James M. Mirocha, Alberto M. Marchevsky
Summary: The study aimed to investigate the role of Ki-67% values in large-cell neuroendocrine carcinoma (LCNEC) prognosis. The findings caution against using blanket cutoff values such as 20% or 40% for LCNEC diagnosis or prognostication. The study analyzed overall and disease-free survivals in LCNEC patients using the Kaplan-Meier method, and found no significant correlation between OS or DFS with Ki-67% levels.
Article
Cell Biology
Saad Nadeem, Matthew G. Hanna, Kartik Viswanathan, Joseph Marino, Mahsa Ahadi, Bayan Alzumaili, Mohamed-Amine Bani, Federico Chiarucci, Angela Chou, Antonio De Leo, Talia L. Fuchs, Daniel J. Lubin, Catherine Luxford, Kelly Magliocca, German Martinez, Qiuying Shi, Stan Sidhu, Abir Al Ghuzlan, Anthony J. Gill, Giovanni Tallini, Ronald Ghossein, Bin Xu
Summary: This study evaluated the performance of three counting techniques for the Ki67 index in medullary thyroid carcinoma and found that all three methods correlated near-perfectly with manual counting. Medullary thyroid carcinomas with a high Ki67 index were associated with decreased survival rates. The study validated the effectiveness of machine learning and image analysis software in generating accurate automatic Ki67 proliferation indices in medullary thyroid carcinoma.
Review
Oncology
Agata Mormul, Emilia Wloszek, Julia Nowoszewska, Marta Fudalej, Michal Budzik, Anna Badowska-Kozakiewicz, Andrzej Deptala
Summary: Pancreatic ductal adenocarcinoma is the most common pancreatic tumor, accounting for 85% of cases. The remaining 15% consists of various rare neoplasms. This study gathered the latest data on the epidemiology, diagnosis, biomarkers, and management of six rare pancreatic tumors to provide important insights for their proper classification and treatment.
Article
Pathology
Meng Zhang, Cong Tan, Xin Wang, Xie Ding, Boqiang Zhang, Zuopeng Yang, Yu Wang, Weiqi Sheng, Dan Huang
Summary: Ki67 is a reliable grading and prognostic biomarker of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). The intratumor heterogeneity of Ki67, correlated with tumor progression, is a valuable factor that requires image analysis. Digital image analysis (DIA) allows for the assessment of Ki67 heterogeneity distribution and provides insights into the classification and grading of GEP-NENs. The computation of heterogeneity parameters related to DIA-determined Ki67 can effectively predict the prognosis and disease-free survival of patients with GEP-NEN.
Review
Oncology
Akira Nakano, Kenichi Hirabayashi, Hiroshi Yamamuro, Taro Mashiko, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa, Toshio Nakagohri
Summary: The study presented a rare case of combined-type HCC-NEC tumor that was successfully treated surgically. Multidisciplinary collaboration is crucial for the accurate diagnosis of this disease, and further accumulation of cases is needed to understand its exact pathology, diagnosis, and treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Andrew H. Nguyen, Michael P. O'Leary, James P. De Andrade, Philip H. G. Ituarte, Jonathan Kessler, Daneng Li, Gagandeep Singh, Sue Chang
Summary: Renal neuroendocrine neoplasms are rare and their natural history is poorly understood. The study found that patients with earlier stage and favorable histologies had increased survival rates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Tiina Vesterinen, Jenni Saila, Sami Blom, Mirkka Pennanen, Helena Leijon, Johanna Arola
Summary: A deep learning-based Ki-67 PI algorithm (KAI) was developed to objectively calculate the Ki-67 proliferation index in neuroendocrine tumors (NETs). The algorithm yields results similar to human observers and can assist in the assessment of Ki-67 PI in NETs.
Review
Biochemistry & Molecular Biology
Xiaoyang Lan, Nicola Fazio, Omar Abdel-Rahman
Summary: Obesity is both a risk factor for developing neuroendocrine neoplasms (NENs) and a good prognostic factor. There is evidence suggesting that obesity paradoxically improves outcomes for some cancer patients.
Article
Veterinary Sciences
Fulvio Riondato, Valeria Martini, Maverick Melega, Alessia Poggi, Barbara Miniscalco
Summary: The study described proliferative and apoptotic rates in different canine lymphoma subtypes at diagnosis, revealing variations in proliferation and apoptosis levels among different types of lymphoma, providing groundwork for future clinical and pharmacological studies.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Vikas Ostwal, Sandip Basu, Prabhat Bhargava, Minit Shah, Rahul Vithalrao Parghane, Sujay Srinivas, Vikram Chaudhari, Manish S. Bhandare, Shailesh Shrikhande, Anant Ramaswamy
Summary: This study retrospectively analyzed the activity of CAPTEM chemotherapy in patients with grade 2 and grade 3 NENs, showing that CAPTEM alone or in combination with PRRT has significant activity. A Ki-67 index >5% may predict poorer outcomes.
NEUROENDOCRINOLOGY
(2021)
Correction
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I. Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano, I Aini, I Aini, M. Albertelli, Y. Alessi, B. Altieri, S. Antonini, L. Barrea, F. Birtolo, F. Campolo, G. Cannavale, C. Cantone, S. Carra, R. Centello, A. Cozzolino, S. Molfetta, V. Vito, G. Fanciulli, T. Feola, F. Ferrau, S. Gay, E. Giannetta, F. Grillo, E. Grossrubatscher, V Guarnotta, A. Salvia, A. Laffi, A. Lania, A. Liccardi, P. Malandrino, R. Mazzilli, E. Messina, N. Mikovic, R. Minotta, R. Modica, G. Muscogiuri, C. Pandozzi, G. Pugliese, G. Puliani, A. Ragni, M. Rubino, F. Russo, F. Sesti, L. Verde, A. Veresani, C. Vetrani, G. Vitale, V Zamponi, I Zanata
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Alessandro Calabrese, Domiziana Santucci, Michela Gravina, Eliodoro Faiella, Ermanno Cordelli, Paolo Soda, Giulio Iannello, Carlo Sansone, Bruno Beomonte Zobel, Carlo Catalano, Carlo de Felice
Summary: Breast cancer is the most common cancer in women and a leading cause of cancer death. An artificial intelligence approach using a deep learning model based on neural networks is being studied to predict the risk of distant metastasis in breast cancer patients using MRI images. The performance of the model was evaluated and showed moderate accuracy in predicting distant metastasis.
Article
Cardiac & Cardiovascular Systems
Renzo Laborante, Emiliano Bianchini, Attilio Restivo, Giuseppe Ciliberti, Mattia Galli, Rocco Vergallo, Daniele Rodolico, Andrea Zito, Giuseppe Princi, Antonio Maria Leone, Cristina Aurigemma, Enrico Romagnoli, Rocco Antonio Montone, Francesco Burzotta, Carlo Trani, Filippo Crea, Domenico D'Amario
Summary: The aim of this study was to analyze the effects of adenosine administration in patients with ACS undergoing myocardial revascularization. The results showed that adenosine did not provide any clinical benefit in terms of major adverse cardiac events, death, myocardial infarction, and heart failure. However, it was associated with an increased risk of advanced atrioventricular blocks and adenosine-triggered ventricular arrhythmias in patients with long ischemic time.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Domenico Benvenuto, Massimo Ciccozzi, Alfonso Maria Di Tommaso, Antongiulio Faggiano, Dario Tuccinardi, Mikiko Watanabe, Silvia Manfrini, Yeganeh Manon Khazrai
Summary: The study aimed to evaluate glucose control and insulin regimen modifications during pregnancy in women with T1D, comparing them to non-diabetic, normal-weight pregnant women. The findings showed that women with T1D need to modify their insulin regimen and dietary habits to control weight gain and promote optimal birth outcomes. However, due to the increase in insulin regimen, women with T1D gave birth to babies with higher birth weights than non-diabetic pregnant women.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Oncology
Violante Di Donato, Evangelos Kontopantelis, Ilaria Cuccu, Ludovica Sgamba, Tullio Golia D'Auge, Angelina Pernazza, Carlo Della Rocca, Lucia Manganaro, Carlo Catalano, Giorgia Perniola, Innocenza Palaia, Federica Tomao, Andrea Giannini, Ludovico Muzii, Giorgio Bogani
Summary: This study aimed to assess the role of radiomics analysis in pre-operatively predicting molecular or clinicopathological prognostic factors in patients with endometrial carcinoma. The results showed that MRI has high sensitivity and specificity in predicting high-grade endometrial carcinoma, deep myometrial invasion, lymphovascular space invasion, and nodal metastasis.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Vitale, Silvia Carra, Ylenia Alessi, Federica Campolo, Carla Pandozzi, Isabella Zanata, Annamaria Colao, Antongiulio Faggiano
Summary: Carcinoid syndrome is a debilitating paraneoplastic disease occurring in 10-40% of patients with neuroendocrine tumors. Its main symptoms include flushing, diarrhea, hypotension, tachycardia, bronchoconstriction, venous telangiectasia, dyspnea, and fibrotic complications. Although there are drugs available, lack of therapeutic response and resistance remain challenges. Preclinical models serve as crucial tools for studying tumor progression and developing new therapies. This paper provides an overview of in vitro and in vivo models in NETs with carcinoid syndrome and discusses future developments and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Roberta Centello, Franz Sesti, Tiziana Feola, Valentina Sada, Carla Pandozzi, Marco Di Serafino, Patrizia Pacini, Vito Cantisani, Elisa Giannetta, Maria Grazia Tarsitano
Summary: This article provides a comprehensive review of the applications of ultrasound (US) in clinical practice, discussing the histopathological and US characteristics of the parathyroid glands in normal and pathological conditions, the advantages of preoperative imaging, and novel updates on the most useful and currently available multiparameter US techniques.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alice Laffi, Andrea Gerardo Antonio Lania, Alberto Ragni, Valentina Di Vito, Alessia Liccardi, Manila Rubino, Franz Sesti, Annamaria Colao, Antongiulio Faggiano
Summary: Gastric well-differentiated neuroendocrine tumors (g-NETs) account for 5-15% of neuroendocrine neoplasms in the gastrointestinal tract. Type 3 g-NETs are the most aggressive subcategory, with high rates of lymph-vascular infiltration and metastases. This systematic review found that size, grading, and gastric wall infiltration are important factors in the management of type 3 g-NETs.
Review
Cardiac & Cardiovascular Systems
Mattia Galli, Giovanni M. Vescovo, Felicita Andreotti, Domenico D'amario, Antonio M. Leone, Stefano Benenati, Rocco Vergallo, Giampaolo Niccoli, Carlo Trani, Italo Porto
Summary: In patients with chronic coronary syndromes, the addition of percutaneous coronary intervention (PCI) to optimal medical therapy (OMT) only reduces hard composite outcomes after excluding periprocedural myocardial infarctions (MIs), according to a meta-analysis of randomized controlled trials.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Natalia Pavone, Laura Manfredonia, Francesco Burzotta, Federico Cammertoni, Luisa Vicchio, Claudio Spalletta, Francesca Graziani, Gabriella Locorotondo, Cristina Aurigemma, Enrico Romagnoli, Piergiorgio Bruno, Niccolo Del Zanna, Emanuele Marzetti, Maria Calabrese, Maria Grandinetti, Marialisa Nesta, Antonella Lombardo, Carlo Trani, Massimo Massetti
Summary: This study provides a comprehensive assessment of an original heart valve clinic model. By standardizing access criteria, the team made progress in patient complexity and severity of valve disease, resulting in an increased rate of intervention and no compromise in operative mortality.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Review
Endocrinology & Metabolism
Giulia Puliani, Emilia Sbardella, Alessia Cozzolino, Valentina Sada, Rossella Tozzi, Chiara Andreoli, Marco Fiorelli, Claudio Di Biasi, Diletta Corallino, Andrea Balla, Alessandro M. M. Paganini, Mary Anna Venneri, Andrea Lenzi, Carla Lubrano, Andrea M. M. Isidori
Summary: The study found a quantitative reduction in pituitary intensity in T1-weighted sequences in patients with obesity, which may be explained by changes in the pituitary stromal tissue and low-grade inflammation.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Filippo Luca Gurgoglione, Dario Pitocco, Rocco A. Montone, Riccardo Rinaldi, Riccardo C. Bonadonna, Giulia Magnani, Camilla Calvieri, Emilia Solinas, Alessandro Rizzi, Linda Tartaglione, Andrea Flex, Luca Viti, Carlo Trani, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: The study aimed to investigate the influence of diabetic microvascular complications (DMC) on coronary collateral (CC) vessel development in patients with coronary chronic total occlusion (CTO). Results showed that patients with DMC had a higher prevalence of CC and high-grade CC compared with those without DMC. Furthermore, there was a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Simona Parisse, Alessandra Gianoncelli, Gloria Isani, Francesco Luigi Gambaro, Giulia Andreani, Emil Malucelli, Giuliana Aquilanti, Ilaria Carlomagno, Raffaella Carletti, Monica Mischitelli, Flaminia Ferri, Veronica Paterna, Quirino Lai, Gianluca Mennini, Fabio Melandro, Cira Di Gioia, Massimo Rossi, Stefano Iotti, Michela Fratini, Stefano Ginanni Corradini
Summary: This study aimed to evaluate the magnesium content in human cirrhotic liver and its correlation with serum AST levels, expression of hepatocellular injury, and MELDNa prognostic score. The results showed that patients with cirrhosis had lower hepatic magnesium content and higher percentage of TRPM7-positive hepatocytes. The increase in hepatic magnesium content and TRPM7 expression were associated with worsening of MELDNa score. These findings suggest that severity of hepatocyte injury and prognosis in cirrhosis are closely related to magnesium depletion and overexpression of TRPM7.
Article
Medicine, General & Internal
Gerardo Salerno, Marina Borro, Vincenzo Visco, Soraya Olana, Francesca Gargano, Salvatore Raffa, Virginia Zamponi, Camilla Mancini, Antongiulio Faggiano, Maurizio Simmaco, Rossella Mazzilli
Summary: This study aimed to evaluate the impact of medications on oxidative stress, inflammatory biomarkers, and semen characteristics in males with idiopathic infertility. The findings suggest a correlation between drug use and activation of the inflammatory response, which could help clarify the pathogenic mechanism of action for several pharmacological classes on male infertility.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Luigi Camera, Francesca Boccadifuoco, Roberta Modica, Luca Messerini, Antongiulio Faggiano, Valeria Romeo, Valeria Gaudieri, Annamaria Colao, Simone Maurea, Arturo Brunetti