Article
Gastroenterology & Hepatology
Daniel H. Leung, Sridevi Devaraj, Nathan P. Goodrich, Xinpu Chen, Deepthi Rajapakshe, Wen Ye, Victor Andreev, Charles G. Minard, Danielle Guffey, Jean P. Molleston, Lee M. Bass, Saul J. Karpen, Binita M. Kamath, Kasper S. Wang, Shikha S. Sundaram, Philip Rosenthal, Patrick McKiernan, Kathleen M. Loomes, M. Kyle Jensen, Simon P. Horslen, Jorge A. Bezerra, John C. Magee, Robert M. Merion, Ronald J. Sokol, Benjamin L. Shneider
Summary: This study investigated biomarkers for hepatic fibrosis in pediatric cholestasis patients. The researchers found that endoglin, IL-8, and MMP-7 were positively correlated with liver stiffness in children with biliary atresia, while CTGF was negatively correlated in alpha-1 antitrypsin deficiency patients. These biomarkers may enhance the prediction of liver stiffness and facilitate early interventions.
Article
Gastroenterology & Hepatology
Teresa Broquetas, Paula Herruzo-Pino, Zoe Marino, Dolores Naranjo, Mercedes Vergara, Rosa M. Morillas, Xavier Forns, Jose A. Carrion
Summary: Cirrhosis is present in more than half of HCV-cACLD patients 3 years after SVR, despite the normalization of liver function parameters, serological non-invasive tests, and TE values. The low diagnostic accuracy of non-invasive methods after SVR highlights the necessity of long-term surveillance.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Rolf Reiter, Mehrgan Shahryari, Heiko Tzschatzsch, Dieter Klatt, Britta Siegmund, Bernd Hamm, Jurgen Braun, Ingolf Sack, Patrick Asbach
Summary: The study assessed spatial heterogeneity of hepatic fibrosis in PSC and viral hepatitis using MR elastography, finding significantly increased fibrosis heterogeneity in PSC compared to viral hepatitis. There was no significant difference in shear-wave speed between PSC and viral hepatitis, indicating potential for enhanced diagnosis based on spatial heterogeneity patterns revealed by MRI.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Nilay Danis, Sharon R. Weeks, Ahyoung Kim, Azarakhsh Baghdadi, Maryam Ghadimi, Ihab R. Kamel, Behnam Saberi, Tinsay Woreta, Jacqueline Garonzik-Wang, Benjamin Philosophe, Ahmet Gurakar, Rohit Loomba
Summary: Living donor liver transplantation (LDLT) has increased in the United States over the past decade in an effort to reduce waitlist mortality, but organ shortage remains an issue. The rise in nonalcoholic fatty liver disease (NAFLD) in the general population poses challenges for expanding the living liver donor pool. A clinical assessment algorithm that thoroughly evaluates for NAFLD and fibrosis is crucial for the safe expansion of LDLT.
LIVER TRANSPLANTATION
(2022)
Review
Gastroenterology & Hepatology
Quentin M. Anstee, Laurent Castera, Rohit Loomba
Summary: Over the past two decades, there have been significant advancements in the non-invasive diagnosis and risk stratification of chronic liver diseases (CLDs). Non-invasive approaches, such as quantifying biomarkers in serum samples or measuring liver stiffness using elastography techniques, have played a crucial role in clinical practice, including early cirrhosis identification, portal hypertension diagnosis, prognosis establishment in compensated cirrhosis, antiviral treatment guidance, and fibrosis and cirrhosis screening in primary care.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Wang, Pengpeng Zhang, Juan Liao, Yan Zhu, Xiaoli Liu, Hong Tang
Summary: The study investigated the association between AFP levels and liver stiffness in CHB patients, finding that AFP and PLT levels were independently associated with LS and their combination could improve the predictive performance of liver fibrosis. Additionally, high AFP levels were found to be significantly correlated with higher LS values, even independently of ALT or AST values.
BIOSCIENCE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Jhon Edison Prieto Ortiz, Santiago Sanchez Pardo, Robin German Prieto Ortiz, Nathaly Garzon Orjuela, James S. Ford, Javier Eslava Schmalbach
Summary: Shear-wave elastography is a reliable method for non-invasive evaluation of liver fibrosis in a Hispanic population. By establishing cutoff points for different fibrosis stages, this study demonstrated the usefulness of two-dimensional shear-wave elastography in diagnosing liver fibrosis.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2021)
Article
Pediatrics
Takehisa Ueno, Koki Takase, Chiyoshi Toyama, Koichi Deguchi, Kazunori Masahata, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Kazuhiko Bessho, Hiroomi Okuyama
Summary: This study examined the relationship between serum autotaxin levels and histological findings in pediatric patients who underwent living donor liver transplant (LDLT) for biliary atresia (BA). The results showed that serum autotaxin levels were associated with the degree of fibrosis after transplantation, and were higher in patients with portal vein complications.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Transplantation
Ahad Eshraghian, Mohammad Reza Fattahi, Mohsenreza Mansourian, Saman Nikeghbalian, Seyed Mohsen Dehghani, Alireza Taghavi, Kourosh Kazemi, Alireza Shamsaeefar, Bita Geramizadeh, Seyed Ali Malek-Hosseini
Summary: This study investigates the usefulness of the controlled attenuation parameter in estimating hepatic steatosis in living liver donors before transplant. The results suggest that the controlled attenuation parameter can be a noninvasive method for detecting hepatic steatosis in living donor candidates.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Transplantation
Kemal Murat Haberal, Hale Turnaoglu, Adnan Ozdemir, Nihal Uslu, Asuman Nihan Haberal Reyhan, Gokhan Moray, Mehmet Haberal
Summary: The study assessed the diagnostic efficiency of acoustic radiation force impulse elastography in evaluating fibrosis in orthotopic liver transplant patients and compared the results with pathology specimens. Acoustic radiation force impulse imaging shows promise as a screening test for detecting significant liver fibrosis.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Preeti Malik, Shreejith Pillai, Kriti Agarwal, Salwa Abdelwahed, Renu Bhandari, Abhishek Singh, Anusha Chidharla, Kajal Patel, Priyanka Singh, Pritika Manaktala, Rizwan Rabbani, Thoyaja Koritala, Sachin Gupta
Summary: Ultrasound-based transient elastography has excellent diagnostic accuracy in detecting liver cirrhosis and severe fibrosis stages in patients with chronic liver diseases. Future studies should focus on estimating the diagnostic accuracy of other fibrosis stages.
GASTROENTEROLOGY RESEARCH
(2022)
Review
Medicine, General & Internal
Mark D. Fagala, Yakov Shpak
Summary: The increasing number of hepatitis C cases among younger individuals may be attributed to opioid epidemic and drug use. This study investigates alternative early diagnostic markers, such as hepatic venous portal gradient (HVPG) and liver stiffness tests, to identify cirrhosis-related complications in hepatitis C patients, which may be more effective than percutaneous liver biopsy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)