Impact of non-invasive biomarkers on hepatology practice: Past, present and future

Two-step strategy, FIB-4 followed by magnetic resonance elastography, for detecting advanced fibrosis in NAFLD

(2022) Nobuharu Tamaki et al.   Clinical Gastroenterology and Hepatology

Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD

(2022) Elizabeth M. Brunt et al.   JOURNAL OF HEPATOLOGY

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

(2021) Ferenc Emil Mózes et al.   GUT

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

(2021) Emmanuel Anandraj Selvaraj et al.   JOURNAL OF HEPATOLOGY

Population screening for liver fibrosis: towards early diagnosis and intervention for chronic liver diseases

(2021) Pere Ginès et al.   HEPATOLOGY

MRE plus FIB‐4 (MEFIB) versus FAST in detection of candidates for pharmacological treatment of NASH‐related fibrosis

(2021) Nobuharu Tamaki et al.   HEPATOLOGY

Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis

(2021) Kazuhiro Kozumi et al.   HEPATOLOGY

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

(2021) Annalisa Berzigotti et al.   JOURNAL OF HEPATOLOGY

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

(2021) Mojgan Masoodi et al.   Nature Reviews Gastroenterology & Hepatology

High liver stiffness values by transient elastography related to metabolic syndrome and harmful alcohol use in a large Spanish cohort

(2021) Elba Llop et al.   United European Gastroenterology Journal

Longitudinal association of magnetic resonance elastography‐associated liver stiffness with complications and mortality

(2021) Mayu Higuchi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

(2021) Kathleen E. Corey et al.   JOURNAL OF HEPATOLOGY

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers

(2021) John B. Whitfield et al.   JOURNAL OF HEPATOLOGY

Incidence of liver- and non-liver-related outcomes in patients with HCV-cirrhosis after SVR

(2021) Roberta D’Ambrosio et al.   JOURNAL OF HEPATOLOGY

MRI-based (MAST) score accurately identifies patients with NASH and significant fibrosis

(2021) Mazen Noureddin et al.   JOURNAL OF HEPATOLOGY

Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD

(2021) Nobuharu Tamaki et al.   Nature Reviews Endocrinology

Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

(2021) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors

(2021) Sophie C. Cazanave et al.   Science Translational Medicine

Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

(2021) Anne Linde Mak et al.   Biomedicines

Expert Panel Review to Compare FDA and EMA Guidance on Drug Development and Endpoints in Nonalcoholic Steatohepatitis

(2021) Rohit Loomba et al.   GASTROENTEROLOGY

Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study

(2021) Mary E. Rinella et al.   JOURNAL OF HEPATOLOGY

Non‐invasive tests for liver fibrosis in NAFLD: Creating pathways between primary healthcare and liver clinics

(2020) Laurent Castera   LIVER INTERNATIONAL

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

(2020) Philip N Newsome et al.   Lancet Gastroenterology & Hepatology

Cost Effectiveness of Different Strategies for Detecting Cirrhosis in Patients With Non-alcoholic Fatty Liver Disease Based on United States Health Care System

(2020) Eduardo Vilar-Gomez et al.   Clinical Gastroenterology and Hepatology

Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis

(2020) Yasaman Vali et al.   JOURNAL OF HEPATOLOGY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis

(2020) Tae Gyu Oh et al.   Cell Metabolism

Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials

(2020) Beth A. Davison et al.   JOURNAL OF HEPATOLOGY

Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension

(2020) Sabela Lens et al.   JOURNAL OF HEPATOLOGY

Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease

(2020) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

(2020) Stephen A Harrison et al.   Lancet Gastroenterology & Hepatology

Change in MRI-PDFF and Histologic Response in Patients with Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis

(2020) Jonathan G. Stine et al.   Clinical Gastroenterology and Hepatology

Liver Stiffness by Magnetic Resonance Elastography Predicts Future Cirrhosis, Decompensation and Death in NAFLD

(2020) Tolga Gidener et al.   Clinical Gastroenterology and Hepatology

Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study

(2020) I Mikolasevic et al.   European Journal of Internal Medicine

Genome‐wide association study and meta‐analysis on alcohol‐related liver cirrhosis identifies novel genetic risk factors

(2020) Tae‐Hwi Schwantes‐An et al.   HEPATOLOGY

A model based on non‐invasive markers predicts very low hepatocellular carcinoma risk after viral response in HCV‐advanced fibrosis

(2020) Sonia Alonso et al.   HEPATOLOGY

Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease

(2020) S.R. Sharpton et al.   Cell Metabolism

Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening

(2020) Romina Lomonaco et al.   DIABETES CARE

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2021

(2020)   DIABETES CARE

MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis

(2020) Jinho Jung et al.   GUT

Refining the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease

(2020) Margarita Papatheodoridi et al.   JOURNAL OF HEPATOLOGY

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

(2020) Olivier Govaere et al.   Science Translational Medicine

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

(2020) Cristiana Bianco et al.   JOURNAL OF HEPATOLOGY

Non-Invasive Assessment of Liver Disease in Patients with NAFLD

(2019) Laurent Castera et al.   GASTROENTEROLOGY

β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial

(2019) Càndid Villanueva et al.   LANCET

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study

(2019) Fabrice Carrat et al.   LANCET

NGM 282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients with Nonalcoholic Steatohepatitis

(2019) Stephen A. Harrison et al.   HEPATOLOGY

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2019) Peter J. Eddowes et al.   GASTROENTEROLOGY

Performance of Baveno VI and Expanded Baveno VI Criteria for Excluding High-risk Varices in Patients with Chronic Liver Diseases: A Systematic Review and Meta-analysis

(2019) Maria Stafylidou et al.   Clinical Gastroenterology and Hepatology

The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials

(2019) Arun J. Sanyal et al.   HEPATOLOGY

Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease

(2019) Ankur Srivastava et al.   JOURNAL OF HEPATOLOGY

New sequential combinations of noninvasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD

(2019) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

Cost-comparison analysis of FIB-4, ELF and fibroscan in community pathways for non-alcoholic fatty liver disease

(2019) Ankur Srivastava et al.   BMC GASTROENTEROLOGY

Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores

(2019) George N. Ioannou et al.   GASTROENTEROLOGY

Noninvasive tests accurately identify advanced fibrosis due to NASH : Baseline data from the STELLAR trials

(2019) Quentin M. Anstee et al.   HEPATOLOGY

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Obesity Is the Most Common Risk Factor for Chronic Liver Disease

(2019) Rebecca Harris et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Ability of Noninvasive Scoring Systems to Identify Individuals in the Population at Risk for Severe Liver Disease

(2019) Hannes Hagström et al.   GASTROENTEROLOGY

Editorial: The 20% Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis due to NASH

(2019) Rohit Loomba et al.   HEPATOLOGY

Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia

(2019) Miquel Serra-Burriel et al.   JOURNAL OF HEPATOLOGY

Referral pathways for patients with NAFLD based on non‐invasive fibrosis tests: Diagnostic accuracy and cost analysis

(2019) Catriona Crossan et al.   LIVER INTERNATIONAL

Baveno Criteria Safely Identify Patients With Compensated Advanced Chronic Liver Disease Who Can Avoid Variceal Screening Endoscopy: A Diagnostic Test Accuracy Meta-Analysis

(2019) Zsolt Szakács et al.   Frontiers in Physiology

Non-invasive prediction of liver-related events in patients with HCV-associated compensated advanced chronic liver disease after oral antivirals

(2019) Mònica Pons et al.   JOURNAL OF HEPATOLOGY

Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease

(2019) Stephen A. Hoang et al.   Scientific Reports

Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

(2019) Marc G. Ghany et al.   HEPATOLOGY

Clinical utility of hepatocellular carcinoma risk scores in chronic hepatitis B

(2019) Thodoris Voulgaris et al.   LIVER INTERNATIONAL

Vibration-controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease

(2018) Mohammad S. Siddiqui et al.   Clinical Gastroenterology and Hepatology

High Prevalence of Liver Fibrosis Among European Adults With Unknown Liver Disease: A Population-Based Study

(2018) Llorenç Caballería et al.   Clinical Gastroenterology and Hepatology

Magnitude and Kinetics of Decrease in Liver Stiffness After Antiviral Therapy in Patients With Chronic Hepatitis C: A Systematic Review and Meta-analysis

(2018) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

ADAPT: An algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis

(2018) Samuel J. Daniels et al.   HEPATOLOGY

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

(2018) Norah A. Terrault et al.   HEPATOLOGY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population

(2018) Salvatore Petta et al.   LIVER INTERNATIONAL

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

(2018) S.R. Sharpton et al.   Clinical Gastroenterology and Hepatology

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Gut microbiome, microbial metabolites and the development of NAFLD

(2018) Cyrielle Caussy et al.   Nature Reviews Gastroenterology & Hepatology

Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2017) Charlie C. Park et al.   GASTROENTEROLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis

(2017) Parambir S. Dulai et al.   HEPATOLOGY

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

(2017) Pietro Lampertico et al.   JOURNAL OF HEPATOLOGY

Concomitant screening for liver fibrosis and steatosis in French type 2 diabetic patients using Fibroscan

(2017) Dominique Roulot et al.   LIVER INTERNATIONAL

Use of Liver Imaging and Biopsy in Clinical Practice

(2017) Elliot B. Tapper et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Meta-analysis for the Diagnostic Performance of Transient Elastography for Clinically Significant Portal Hypertension

(2017) Myung-Won You et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

(2017) Benedetta Donati et al.   Scientific Reports

Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference

(2016) M. Munteanu et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

(2016) Stuart McPherson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy

(2016) Morten A. Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

(2016) Kento Imajo et al.   GASTROENTEROLOGY

Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease

(2016) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

The Application of Liver Stiffness Measurement in Residents Without Overt Liver Diseases Through a Community-Based Screening Program

(2016) Pin-Nan Cheng et al.   MEDICINE

Critical comparison of elastography methods to assess chronic liver disease

(2016) Mireen Friedrich-Rust et al.   Nature Reviews Gastroenterology & Hepatology

Tissue Inhibitors of Metalloproteinase-1 and 2 and Obesity Related Non-Alcoholic Fatty Liver Disease: Is There a Relationship?

(2015) Rokaya Abdelaziz et al.   DIGESTION

Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study

(2015) Raymond Kwok et al.   GUT

Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study

(2015) Edith M. Koehler et al.   HEPATOLOGY

Expanding consensus in portal hypertension

(2015) Roberto de Franchis   JOURNAL OF HEPATOLOGY

EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis

(2015)   JOURNAL OF HEPATOLOGY

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

Nonalcoholic Fatty Liver Disease is Underrecognized in the Primary Care Setting

(2014) Pierre Blais et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study

(2014) Rohit Loomba et al.   HEPATOLOGY

Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

(2014) Pierre Bedossa et al.   HEPATOLOGY

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Are simple noninvasive scoring systems for fibrosis reliable in patients with NAFLD and normal ALT levels?

(2013) Stuart McPherson et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis

(2012) Roberta D'Ambrosio et al.   HEPATOLOGY

Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

(2012) Sudeep Tanwar et al.   HEPATOLOGY

Determination of reliability criteria for liver stiffness evaluation by transient elastography

(2012) Jérôme Boursier et al.   HEPATOLOGY

Does This Patient With Liver Disease Have Cirrhosis?

(2012) Jacob A. Udell et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography

(2011) Vincent Wai-Sun Wong et al.   GUT

Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest)

(2010) Thierry Poynard et al.   BMC GASTROENTEROLOGY

Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years

(2010) D. Roulot et al.   GUT

Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease

(2010) S. McPherson et al.   GUT

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Amy G. Shah et al.   Clinical Gastroenterology and Hepatology

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease

(2008) S A Harrison et al.   GUT

Comparison of blood tests for liver fibrosis specific or not to NAFLD

(2008) Paul Calès et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

The Utility of the “NAFLD Fibrosis Score” in Morbidly Obese Subjects with NAFLD

(2008) Kamran Qureshi et al.   OBESITY SURGERY