Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)

mTOR signaling: PLD takes center stage

(2011) Yuting Sun et al.   CELL CYCLE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic β cells

(2010) Wei-na Ma et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Regulation of mTORC1 by the Rab and Arf GTPases

(2010) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of HalogenatedN-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor

(2010) Robert R. Lavieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

(2010) Andrew Y. Choo et al.   MOLECULAR CELL

Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

(2010) T Sato et al.   ONCOGENE

Rag proteins regulate amino-acid-induced mTORC1 signalling

(2009) Yasemin Sancak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

(2009) David A. Foster   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

(2009) Jana A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nutrient control of TORC1, a cell-cycle regulator

(2009) Xuemin Wang et al.   TRENDS IN CELL BIOLOGY

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

(2008) Ying Yan et al.   BIOCHEMICAL JOURNAL

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System

(2008) Tomohiko Maehama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE