Article
Psychiatry
Biswadip Chatterjee, Raka Jain, Nishtha Chawla, Rahul Raghav
Summary: The study found significantly higher levels of serum CRF and perceived stress among opioid-dependent subjects compared to non-using controls, with no significant correlation with craving. The significant difference in serum CRF levels suggests the feasibility of measuring CRF levels in peripheral fluids as a biochemical measure of stress.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Agriculture, Dairy & Animal Science
Yuanli Cai, Zhigang Song
Summary: This study investigated the effects of corticotropin-releasing factor (CRF) on the feed intake of broiler chickens. The results showed that CRF at a dose of 10 μg suppressed feed intake and increased the expression of ghrelin in the hypothalamus and CRFR1 in the small intestine.
Article
Neurosciences
Nana Baidoo, Francesco Leri
Summary: The aim of this study was to test the hypothesis that unconditioned and conditioned opioid withdrawal enhance memory consolidation through overlapping neural systems. The results showed that both pharmacological and psychological withdrawal activate overlapping noradrenaline and corticotrophin-releasing factor systems, which impact memory storage.
Article
Multidisciplinary Sciences
Rafael Conte, Carolline M. S. Zangirolame, Denise R. Gobbo, Lais da S. Pereira, Carlos E. Panfilio, Rejane D. Reginato, Luciana L. S. Maluf, Debora A. Scerni, Isabel C. Cespedes
Summary: This study analyzed the effects of chronic moderate alcohol consumption on behavior and neurochemical changes. The results showed a slight anxiolytic effect and alterations in the dopaminergic and CRFergic systems in rats that consumed moderate doses of alcohol chronically.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Integrative & Complementary Medicine
Yu-Xue Zhao, Chang-Xiang Cui, Jun-Hong Gao, Jun Liu, Qun Liu, Feng-Yan Lu, Juan-Juan Xin, Xiao-Chun Yu, Bing Zhu
Summary: This study demonstrated that electroacupuncture treatment can improve stress-induced jejunal motility disorder, potentially through down-regulation of CRFr2.
ACUPUNCTURE IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Abdullahi Ibrahim Uba, Nicolas Scorese, Emily Dean, Haiguang Liu, Chun Wu
Summary: This study constructed a full-length homology model of CRF1R and conducted molecular dynamics simulations of its complexes with agonist and antagonist, revealing important conformational changes in TMD and key residues. The observed dynamic rearrangements and residue interactions provide insights for ligand design targeting CRF1R activation.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Andy J. Kim, Simon B. Sherry, Logan J. Nealis, Aislin Mushquash, Dayna Lee-Baggley, Sherry H. Stewart
Summary: This study found a positive association between depressive symptoms and heavy episodic drinking, and a negative association between anxiety symptoms and heavy episodic drinking. Furthermore, heavy episodic drinking did not predict future depressive and anxiety symptoms.
ADDICTIVE BEHAVIORS
(2022)
Article
Behavioral Sciences
Trevor J. Buhr, Carter H. Reed, Allyse Shoeman, Ella E. Bauer, Rudy J. Valentine, Peter J. Clark
Summary: This study examined the impact of daily moderate physical activity on monoamine-related neurochemical concentrations in response to high volume ethanol ingestion in mice. The results showed that physical activity did not significantly affect ethanol intake, but could mildly influence norepinephrine and serotonin concentrations in certain brain regions. Additionally, access to alcohol during binge-like drinking procedure eliminated some effects of physical activity on neurochemical concentrations.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Georgios Giannopoulos, Ioannis Anagnostopoulos, Maria Kousta, Stavros Vergopoulos, Spyridon Deftereos, Vassilios Vassilikos
Summary: Moderate alcohol consumption significantly reduces the risk of developing new-onset atrial fibrillation (AF), while heavy drinking increases the risk. The relationship between alcohol consumption and incident AF appears to be J-shaped.
Article
Psychology, Clinical
Vivien Bodnar, Krisztina Nagy, Adam Cziboly, Gyorgy Bardos
Summary: The study examines how expectations associated with alcohol affect individuals' subjective states. The results demonstrate a significant impact of expectations on the psychological and physiological effects of alcohol, with a greater influence observed in social settings. Additionally, the study suggests that expectations formed through socialization and personal experiences play a key role in explaining behavioral changes following alcohol consumption.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
Article
Biochemistry & Molecular Biology
Laura Almeida-Toledano, Vicente Andreu-Fernandez, Rosa Aras-Lopez, Oscar Garcia-Algar, Leopoldo Martinez, Maria Dolores Gomez-Roig
Summary: Prenatal alcohol exposure can lead to fetal growth restriction, affect placental angiogenesis, and disrupt neurodevelopmental processes. Treatment with epigallocatechin-3-gallate can improve fetal growth restriction, mitigate alcohol-induced changes in placental angiogenic factors, and partially rescue neuronal nuclear antigen, doublecortin, and glial fibrillary acidic protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
S. Alex Marshall, Stacey L. Robinson, Suzahn E. Ebert, Michel A. Companion, Todd E. Thiele
Summary: Silencing CRF neurons in the central amygdala (CeA) can decrease binge-like ethanol consumption, with no effect on sucrose consumption.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Brenda Abdelmesih, Robyn Anderson, Dhananjay Bambah-Mukku, Ilaria Carta, Anita E. Autry
Summary: Activation of PeFA(Ucn3) neurons promotes infant avoidance and aggression. Chronic restraint stress reduces pup-retrieval behavior in virgin females and increases activity of PeFA(Ucn3) neurons. Inhibition of PeFA(Ucn3) neurons mitigates the impact of stress on pup-directed behavior in virgin females.
MOLECULAR PSYCHIATRY
(2023)
Article
Substance Abuse
Matthew R. Pearson, Adam D. Wilson, Dylan K. Richards, Katie Witkiewitz
Summary: Long-term follow-up studies on individuals with AUD revealed that those who displayed high functionality but did not meet low-risk drinking standards after one year of treatment maintained a high level of psychosocial functioning up to three years post-treatment.
Article
Neurosciences
Francisco J. Flores-Ramirez, Alessandra Matzeu, Laura Sanchez-Marin, Remi Martin-Fardon
Summary: Alcohol use disrupts the response to stress through the corticotropin-releasing factor (CRF). The repeated use of alcohol leads to a decreased response in the hypothalamic-pituitary-adrenal axis, making individuals more vulnerable to alcohol-seeking behavior during stressful situations. Orexin, which regulates stress, interacts with CRF. In the infralimbic cortex (IL), a region rich in CRF, CRF and orexin interact. This study tested the effects of blocking CRF1 and dual orexin receptors in the IL on stress-induced alcohol-seeking behavior. The results show that blocking CRF1 receptors prevents reinstatement of alcohol-seeking behavior, while blocking orexin receptors alone does not have the same effect. However, when orexin and CRF receptors are blocked together, the effect of blocking CRF1 receptors is reversed. These findings suggest that blocking CRF1 receptors may help reduce stress-induced alcohol-seeking behavior.
Article
Neurosciences
Nora M. McCall, Lydia Kotecki, Sergio Dominguez-Lopez, Ezequiel Marron Fernandez de Velasco, Nicholas Carlblom, Amanda L. Sharpe, Michael J. Beckstead, Kevin Wickman
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Clinical Neurology
Sergio Dominguez-Lopez, Elisabeth Piccart, William B. Lynch, Mackenna B. Wollet, Amanda L. Sharpe, Michael J. Beckstead
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Geriatrics & Gerontology
Sreemathi Logan, Daniel Owen, Sixia Chen, Wei-Jen Chen, Zoltan Ungvari, Julie Farley, Anna Csiszar, Amanda Sharpe, Maarten Loos, Bastijn Koopmans, Arlan Richardson, William E. Sonntag
Article
Endocrinology & Metabolism
Megan E. Bardgett, Amanda L. Sharpe, Glenn M. Toney
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Cardiac & Cardiovascular Systems
Amanda L. Sharpe, Alfredo S. Calderon, Mary Ann Andrade, J. Thomas Cunningham, Steven W. Mifflin, Glenn M. Toney
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Amanda L. Sharpe, Mary Ann Andrade, Myrna Herrera-Rosales, Steven L. Britton, Lauren G. Koch, Glenn M. Toney
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2013)
Article
Clinical Neurology
Amanda L. Sharpe, Erika Varela, Lynne Bettinger, Michael J. Beckstead
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Sarah Y. Branch, R. Brandon Goertz, Amanda L. Sharpe, Janie Pierce, Sudip Roy, Daijin Ko, Carlos A. Paladini, Michael J. Beckstead
JOURNAL OF NEUROSCIENCE
(2013)
Article
Multidisciplinary Sciences
Amanda L. Sharpe, Erika Varela, Michael J. Beckstead
Article
Clinical Neurology
William B. Lynch, Christopher W. Tschumi, Amanda L. Sharpe, Sarah Y. Branch, Cang Chen, Guo Ge, Senlin Li, Michael J. Beckstead
MOVEMENT DISORDERS
(2018)
Article
Biochemistry & Molecular Biology
Christopher W. Tschumi, Anna W. Daszkowski, Amanda L. Sharpe, Marta Trzeciak, Michael J. Beckstead
Article
Biology
Ana J. Chucair-Elliott, Sarah R. Ocanas, David R. Stanford, Victor A. Ansere, Kyla B. Buettner, Hunter Porter, Nicole L. Eliason, Justin J. Reid, Amanda L. Sharpe, Michael B. Stout, Michael J. Beckstead, Benjamin F. Miller, Arlan Richardson, Willard M. Freeman
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Amanda L. Sharpe, Marta Trzeciak, Nicole L. Eliason, Harris E. Blankenship, Bre' Ana M. Byrd, Phillip D. Douglas, Willard M. Freeman, Michael J. Beckstead
Summary: The study reveals that the expression of GLAST and CRF2 in astrocytes in the SN/VTA is significantly affected by psychostimulant drugs, which may influence neurotransmission and related behaviors.
Article
Endocrinology & Metabolism
Nicole L. Eliason, Lynne Martin, Malcolm J. Low, Amanda L. Sharpe
Summary: The study investigated the role of melanocortins in the NAcc on food consumption and motivation. Results showed that injecting MT-II into the NAcc decreased both consumption and motivation without affecting metabolism or inducing an aversive state.
Article
Psychology, Biological
Nicole L. Eliason, Amanda L. Sharpe
Summary: Obesity is a crisis in the United States and understanding the underlying appetitive neurocircuitry is essential for therapeutic intervention. POMC peptides play a complex role in the reward-based learning and food intake regulation. Stimulating POMC projections in the NAcc increases acquisition and accuracy of operant self-administration of a palatable food while decreasing consumption after experiencing it.
PHYSIOLOGY & BEHAVIOR
(2023)