Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Maria Varghese, Kaitlynn A. Sockett, Sara El-Arid, Jenny Korunes-Miller, Jean-Michel Guigner, Mark W. Grinsta
Summary: We synthesized diblock poly-amido-saccharides (PASs) using living anionic ring-opening polymerization. The resulting amphiphilic polymers self-assembled into nanoparticles in water, forming spherical structures and exhibiting no cytotoxicity.
Article
Chemistry, Multidisciplinary
Lei Shi, Shuting Lu, Tiedong Sun, Gaolei Xi, Zhifei Chen, Kejing Xu, Xu Zhao, Meihua Shen, Tao Jia, Xiuhua Zhao
Summary: Stimuli-responsive polymeric micelle is a research hotspot as a drug carrier material, which can reduce damage of anticancer drugs to healthy tissues and enrich drug concentration at tumor sites. SRPM with fluorescence imaging capability can be used for drug delivery and therapy monitoring, providing a promising approach for developing new pharmaceutical preparations.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Chie Kojima, Tomoka Hirose, Risa Katayama, Akikazu Matsumoto
Summary: 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as coating agents and drug delivery carriers in medical devices. In this study, amphiphilic MPC polymers were used, and their self-assembling properties and PTX solubilization were examined. The results suggest that the hydrophobicity and self-assembling properties of amphiphilic MPC polymers play a crucial role in PTX solubilization and drug action, which need to be controlled by the polymer sequence and composition of the hydrophobic monomer.
Review
Pharmacology & Pharmacy
Irina Negut, Bogdan Bita
Summary: Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The advancement in the field of material science and nanomedicine has led to improved drug delivery systems with proven efficacy and fewer side effects. Various intelligent nanomedicines are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Thorough knowledge of these nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are simple to make and have high solubilization characteristics, making them a promising alternative in nanosystems for cancer treatment.
Review
Chemistry, Physical
Didier Gigmes, Thomas Trimaille
Summary: Amphiphilic copolymer micelles are key candidates in drug delivery, with PLA-based micelles and controlled radical polymerizations offering new opportunities for advanced drug delivery systems. Key properties such as stealth character, cell targeting and stimuli-responsiveness have been advanced in the past decade for PLA/vinyl polymer based nano-carriers.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Balaram Ghosh, Swati Biswas
Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Zhongjie Fei, Mehdi Yoosefian
Summary: This study investigates the assembly mechanism of Ribociclib encapsulated by DPC micelle using all-atom molecular dynamics simulations. The main forces involved in the drug encapsulation process are hydrophobic and van der Waals interactions, with hydrogen bonding and electrostatic interactions also contributing. Solvent accessible surface area and radial distribution function analyses show that DPC micelles can improve the aqueous solubility of hydrophobic drugs, providing a new pathway for designing drug delivery systems with necessary properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
W. Chen, P. Liu
Summary: Researchers have successfully developed a novel dendritic polyurethane-based prodrug using ultrasound technology, which enables precise localized drug delivery. The prodrug exhibits excellent pH/ultrasound dual-triggered drug release performance and demonstrates enhanced inhibition of tumor growth under ultrasound stimulation.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Article
Chemistry, Multidisciplinary
Lu Zhang, Quanling Guo, Ruixue Zheng, Qingyu Yu, Ying Liang, Guanglong Ma, Qiurong Li, Xiaoyu Zhang, Haiyan Xiao, Longgang Wang
Summary: Chemotherapy is the main method of treating malignant tumors, but commonly used drugs have high toxicity, poor solubility, low targeting ability, and high side effects. In this study, zwitterionic micelles assembled by modified amphiphilic dendrimers showed great stability and controlled drug release. Moreover, these micelles had higher cellular uptake rates and cytotoxicity, resulting in better tumor inhibition compared to free drugs. Therefore, the prepared targeting nanodrug has great potential for antitumor therapy.
Article
Biochemistry & Molecular Biology
Tatsuya Sakuma, Kimiko Makino, Hiroshi Terada, Issei Takeuchi, Violeta Mitova, Kolio Troev
Summary: Amphiphilic diblock polyphosphoesters containing lactic acid units were synthesized through multistep one-pot polycondensation reactions. The effects of polymer composition on micelle formation, stability, and size were studied, and the hydrophilic/hydrophobic balance could be controlled by changing the chain lengths of hydrophobic alcohols. The encapsulation efficiency and loading capacity of hydrophobic substances inside the polymer micelles were dependent on the length of alkyl side chains.
Article
Polymer Science
Wei Chen, Peng Liu
Summary: Unimolecular micelles, as drug delivery systems, have attracted attention due to their stability. By designing GSH-triggered disintegrable dendritic polyurethane, drug leakage during circulation can be minimized and tumor-specific chemotherapy can be achieved.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Instruments & Instrumentation
Rosario Pignatello, Roberta Corsaro, Angela Bonaccorso, Elide Zingale, Claudia Carbone, Teresa Musumeci
Summary: This study characterized Soluplus(R) nanomicelles to enhance the apparent solubility of drugs in BCS class II. The prepared nanomicelles showed small and stable particle size and could be easily filtered. The freeze-dried powder materials maintained the micelle size upon reconstitution. Additionally, the nanomicelles demonstrated potential applications in topical ocular administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Yue Cao, Kathryn E. Uhrich
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2019)
Article
Biotechnology & Applied Microbiology
Sabrina S. Snyder, Yue Cao, Kathryn E. Uhrich
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2019)
Article
Chemistry, Multidisciplinary
Alysha Moretti, Richard M. Weeks, Michael Chikindas, Kathryn E. Uhrich
Article
Chemistry, Multidisciplinary
Marcio M. Almeida, Katia R. Perez, Allison Faig, Kathryn E. Uhrich, Karin A. Riske
Article
Immunology
Richard M. Weeks, Alysha Moretti, Shuang Song, Kathryn E. Uhrich, Andrey V. Karlyshev, Michael L. Chikindas
PATHOGENS AND DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Thomas W. Dugger, Sourangsu Sarkar, Sandra M. Correa-Garhwal, Mikhail Zhernenkov, Yugang Zhang, Gitanjali Kolhatkar, Ramya Mohan, Luz Cruz, Aura D. Lubio, Andreas Ruediger, Cheryl Y. Hayashi, Kathryn E. Uhrich, David J. Kisailus
Article
Biotechnology & Applied Microbiology
Nanxia Zhao, Xue Yang, Hannah R. Calvelli, Yue Cao, Nicola L. Francis, Rebecca A. Chmielowski, Laurie B. Joseph, Zhiping P. Pang, Kathryn E. Uhrich, Jean Baum, Prabhas Moghe
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Engineering, Biomedical
Emma R. Brannon, William J. Kelley, Michael W. Newstead, Alison L. Banka, Kathryn E. Uhrich, Colleen E. O'Connor, Theodore J. Standiford, Omolola Eniola-Adefeso
Summary: A technology using Poly-Aspirin (Poly-A) polymer microparticles has been developed to intervene in acute respiratory distress syndrome (ARDS), reducing neutrophil-mediated lung injury and inflammation, and enhancing survival rates.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sammy Gulrajani, Sabrina Snyder, Jason D. Hackenberg, Kathryn Uhrich
Summary: This is the first study to systematically evaluate the degradation of salicylic acid-based poly(anhydride-esters) (SAPAEs) under different pH conditions. The results show that degradation is faster under more basic conditions, while slower under acidic conditions.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Alison L. Banka, M. Valentina Guevara, Emma R. Brannon, Nhien Q. Nguyen, Shuang Song, Gillian Cady, David J. Pinsky, Kathryn E. Uhrich, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
Summary: The authors used cargo-free particles to block the adhesion of platelet-neutrophil aggregates to the vascular wall, potentially providing an effective therapy for thromboinflammation. Platelets are recruited to areas of inflammation through the interaction of PSGL-1 on leukocytes and P-selectin on activated platelets, leading to platelet-leukocyte aggregates that bind to the endothelium. In this study, polymeric particles were found to divert platelets away from inflamed blood vessels both in vitro and in vivo, suggesting their potential as anti-platelet therapeutics for thromboinflammatory conditions.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych, Hannah R. Calvelli, Cody L. Hoop, Zhiping P. Pang, Jean Baum, Kathryn E. Uhrich, Prabhas Moghe
Summary: This study introduces a novel polymeric nanotechnology platform for modulating neuroinflammation by inhibiting aSYN-CD36 binding. Experimental results demonstrate that AM NPs with intermediate side chain lengths have the strongest inhibitory activity, reducing aSYN internalization and inhibiting the release of proinflammatory molecules.
ADVANCED NANOBIOMED RESEARCH
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Shuang Song, Kathryn Uhrich
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Chinmay Kulkarni, Dana Graves, Kathryn Uhrich
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Yue Cao, Kathryn Uhrich
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Yue Cao, Shuang Song, Kathryn Uhrich
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)