Article
Environmental Sciences
Chen Zhao, Wenyuan Pu, Mengyuan Niu, Junaid Wazir, Shiyu Song, Lulu Wei, Li Li, Zhonglan Su, Hongwei Wang
Summary: Exposure to PM2.5 soluble extract activates NF-κB and MAPK signaling pathways, induces the production of pro-inflammatory cytokines, alters transcription profiles of genes, and leads to phagocytic dysfunction, potentially exacerbating lung injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Barbara Gierlikowska, Albert Stachura, Wojciech Gierlikowski, Urszula Demkow
Summary: Neutrophils play a crucial role in the innate immune system by carrying out effector functions such as phagocytosis, degranulation, and NET formation. Research suggests that modulation of neutrophil effector functions can impact treatment efficacy, with pharmacological modulation influencing molecular mechanisms involved in these processes. This review highlights the versatility and plasticity of neutrophils in physiology, bacterial and viral infections, as well as the potential impact of plant extracts, plant-derived compounds, and synthetic drugs on neutrophil effector functions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena Mikhalchik, Liliya Yu Basyreva, Sergey A. Gusev, Oleg M. Panasenko, Dmitry Klinov, Nikolay A. Barinov, Olga Morozova, Alexander P. Moscalets, Liliya N. Maltseva, Lyubov Yu Filatova, Evgeniy A. Pronkin, Julia A. Bespyatykh, Nadezhda G. Balabushevich
Summary: Nano- and microparticles can enter the body through the respiratory airways and the digestive system, or form as biominerals in various organs. The study found that calcium, magnesium, and phosphate ions can precipitate from biological fluids and form hybrid nanoparticles with mucin, as well as assemble into hybrid microparticles with calcium carbonate. These particles can trigger inflammatory reactions and activate neutrophils, resulting in increased oxidant production, cell aggregation, and NET-like structure formation. This research provides important insights into the effects of nano- and microparticles on the human body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Shujing Zou, Hongyu Jie, Xinai Han, Jinghong Wang
Summary: Neutrophil extracellular traps (NETs) play a critical role in the inflammatory response and bacterial clearance, but their excessive activation can cause an inflammatory storm and organ dysfunction. Acute lung injury caused by sepsis is the main cause of organ damage. NET formation can accelerate the development of acute lung injury through the release of cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Lukasz Suprewicz, Karol Sklodowski, Alicja Walewska, Piotr Deptula, Alicja Sadzynska, Andrzej Eljaszewicz, Marcin Moniuszko, Paul A. Janmey, Robert Bucki
Summary: This study found that plasma gelsolin (pGSN), in addition to its role in actin depolymerization, can bind bacterial molecules and stimulate bacterial phagocytosis by macrophages. It was also demonstrated that pGSN enhances Candida auris uptake and killing by human neutrophils, suggesting the possibility of using recombinant pGSN as an immunomodulator during C. auris infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Critical Care Medicine
Jieyan Wang, Yingyi Luan, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Jie Fan
Summary: The study identifies an intra-PMN mechanism that negatively regulates necroptosis mediated through TBK1/IKK epsilon, reducing inflammation by suppressing the formation of the necrosome complex. The LPS-TLR4-TBK1 axis serves as a negative regulator for PMN necroptosis, suggesting it may be a therapeutic target for modulating PMN death and inflammation.
Article
Rheumatology
Angelo A. Manfredi, Giuseppe A. Ramirez, Cosmo Godino, Annalisa Capobianco, Antonella Monno, Stefano Franchini, Enrico Tombetti, Sara Corradetti, Jorg H. W. Distler, Marco E. Bianchi, Patrizia Rovere-Querini, Norma Maugeri
Summary: In patients with systemic sclerosis (SSc), there is an accumulation of activated P-selectin+ platelets and platelet-derived HMGB1+ microparticles (MPs) in the blood, indicating a potential defect in phagocytosis. Compared to patients with stable coronary artery disease (CAD), SSc patients have decreased expression of PSGL-1 in neutrophils, leading to impaired recognition and clearance of activated platelets, and subsequent release of MPs. This imbalance in platelet clearance may contribute to vascular inflammation and fibrosis in SSc.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Trim Lajqi, Natascha Koestlin-Gille, Stefan Hillmer, Maylis Braun, Simon A. Kranig, Stefanie Dietz, Christian Krause, Jessica Ruehle, David Frommhold, Johannes Poeschl, Christian Gille, Hannes Hudalla
Summary: Research has shown that small extracellular vesicles from the gut can mediate adaptive responses in neutrophils in vitro. Low-dose stimulation enhances neutrophils' pro-inflammatory sensitivity and activity, while high-dose stimulation leads to a tolerant phenotype.
Article
Respiratory System
Masahiro Yamashita, Miyuki Niisato, Yasushi Kawasaki, Sinem Karaman, Marius R. Robciuc, Yuji Shibata, Yoji Ishida, Ryosuke Nishio, Tomoyuki Masuda, Tamotsu Sugai, Masao Ono, Rubin M. Tuder, Kari Alitalo, Kohei Yamauchi
Summary: This study investigates the role of vascular endothelial growth factor (VEGF)-C/VEGF receptor 3 (VEGFR-3) signaling in the recovery process of lung injury. The results show that VEGF-C/VEGFR-3 signaling can alleviate lung injury and promote macrophage phagocytosis.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Meriem Sekheri, Salma A. Rizo-Tellez, Amira Othman, Driss El Kebir, Janos G. Filepa
Summary: Studies have shown that interferon-beta (IFN-beta) cooperates with lipid mediators such as 15-epi-LXA(4) to regulate TLR9-induced lung inflammation and facilitate the clearance of neutrophils, contributing to the resolution of inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Shigeyuki Tamiya, Eisuke Yoshikawa, Monami Ogura, Etsushi Kuroda, Koichiro Suzuki, Yasuo Yoshioka
Summary: This study found that neutrophil infiltration is detrimental to the host in Mycoplasma pneumoniae-induced pneumonia in mice. Furthermore, the TLR2-dependent production of IL-1 alpha and IL-12 p40, and CARDS toxin play important roles in neutrophil infiltration into the lung, subsequently leading to lung injury. These findings contribute to the development of novel therapeutics and vaccines against Mycoplasma pneumoniae.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Joanna M. Poczobutt, Andrew M. Mikosz, Christophe Poirier, Erica L. Beatman, Karina A. Serban, Fabienne Gally, Danting Cao, Alexandra L. McCubbrey, Christina F. Cornell, Kelly S. Schweitzer, Evgeny Berdyshev, Irina A. Bronova, Francois Paris, Irina Petrache
Summary: The deficiency of ASM is associated with a complex inflammatory phenotype in the lungs, characterized by accumulation of specific macrophages and abnormal release of proinflammatory cytokines. This new insight may provide a novel link between ASM and the development of crystal-associated lung inflammation with alterations in macrophage biology.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tingting Zhai, Jingjing Zhang, Jie Zhang, Bilian Liu, Zhiguang Zhou, Feng Liu, Yan Wu
Summary: This study aimed to test whether cathelicidin (Camp) protects mice against APAP-induced liver injury and ALF. The results showed that Camp promotes liver recovery by facilitating inflammation resolution, suggesting a therapeutic potential for late-presenting patients with AILI with or without ALF.
Article
Immunology
Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang
Summary: The study showed that mice lacking Properdin exhibited more severe renal injury during the repair phase post IR, with Properdin playing a crucial role in optimizing damaged cells and regulating phagocytic ability to effectively clear apoptotic cells and reduce inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Caleb Nwongbouwoh Muefong, Olumuyiwa Owolabi, Simon Donkor, Salome Charalambous, Abhishek Bakuli, Andrea Rachow, Christof Geldmacher, Jayne S. Sutherland
Summary: The study used flow cytometry to monitor changes in neutrophils in the blood of tuberculosis patients before and after treatment, finding associations between high reactive oxygen species generation, low levels of banded neutrophils, and high levels of IL-10-expressing CD16(dim)CD62L(lo) neutrophils with reduced lung pathology, suggesting potential early indicators of tuberculosis severity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Margaret B. Fish, Alison L. Banka, Margaret Braunreuther, Catherine A. Fromen, William J. Kelley, Jonathan Lee, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
Summary: The localization and adhesion of vascular-targeted drug carriers to the diseased endothelium are crucial for clinical utility. The physical properties, such as particle size and modulus, play a significant role in determining the efficacy of particle margination and transport to the vascular wall. Deformable hydrogel microparticles have been shown to enhance the delivery of nanoparticles to the vessel wall, demonstrating the importance of optimizing microparticles for efficient margination.
Article
Cell Biology
Alison Leigh Banka, Omolola Eniola-Adefeso
Summary: This study introduces a tunable in vitro model for studying platelet behavior in human whole blood flow and demonstrates its effectiveness in screening potential anti-platelet or anti-thrombotic compounds. The model is adaptable across various conditions and shows promising results in reducing platelet adhesion to damaged endothelium, suggesting it can successfully screen compounds that target platelets or endothelium.
Review
Engineering, Biomedical
Violet V. Sheffey, Emily B. Siew, Eden E. L. Tanner, Omoiola Eniola-Adefeso
Summary: Polymeric nanoparticles have the potential to deliver drugs intravenously in a targeted manner. Poly(lactic-co-glycolic) acid (PLGA) is a promising biomaterial for intravenous drug delivery due to its biocompatibility and biodegradability. However, there are limitations to the clinical use of PLGA, particularly when it is PEGylated.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Medicinal
Hanieh Safari, Michael L. Felder, Nicholas Kaczorowski, Omolola Eniola-Adefeso
Summary: This study improved the loading efficiency of anti-CD47 by utilizing cosolvents and the emulsion solvent evaporation technique, enabling targeted delivery of anti-CD47 encapsulated in polymeric nanoparticles.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Genesis Lopez-Cazares, Omolola Eniola-Adefeso
Summary: This study improved the adhesion of poly (lactic-co-glycolic acid) (PLGA) vascular-targeted carriers (VTCs) by coating PLGA microparticles with chitosan (CS), human serum albumin (HSA), or both. The adhesion of these coated particles to activated endothelial cells was evaluated under different shear conditions. HSA-only coated PLGA VTCs showed improved adhesion in the presence of plasma, while VTCs with dual coating (CS and HSA) maintained high adhesion at low and intermediate shears.
Review
Nanoscience & Nanotechnology
Emma R. Brannon, M. Valentina Guevara, Noah J. Pacifici, Jonathan K. Lee, Jamal S. Lewis, Omolola Eniola-Adefeso
Summary: This review outlines the design aspects of polymeric particles for optimizing acute inflammation targeting, highlighting their advantages as an ideal platform for immune modulation.
NATURE REVIEWS MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sammy Gulrajani, Sabrina Snyder, Jason D. Hackenberg, Kathryn Uhrich
Summary: This is the first study to systematically evaluate the degradation of salicylic acid-based poly(anhydride-esters) (SAPAEs) under different pH conditions. The results show that degradation is faster under more basic conditions, while slower under acidic conditions.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Engineering, Biomedical
Martin T. Spang, Ryan Middleton, Miranda Diaz, Jervaughn Hunter, Joshua Mesfin, Alison Banka, Holly Sullivan, Raymond Wang, Tori S. Lazerson, Saumya Bhatia, James Corbitt, Gavin D'Elia, Gerardo Sandoval-Gomez, Rebecca Kandell, Maria A. Vratsanos, Karthikeyan Gnanasekaran, Takayuki Kato, Sachiyo Igata, Colin Luo, Kent G. Osborn, Nathan C. Gianneschi, Omolola Eniola-Adefeso, Pedro Cabrales, Ester J. Kwon, Francisco Contijoch, Ryan R. Reeves, Anthony N. DeMaria, Karen L. Christman
Summary: This study demonstrates the safety and feasibility of using intravascularly infused extracellular matrix as a biomaterial for tissue repair in animal models of acute myocardial infarction, traumatic brain injury, and pulmonary arterial hypertension. The biomaterial, consisting of decellularized myocardial tissue, localizes to injured tissues and is degraded in 3 days. In animal models of myocardial infarction, the intracoronary infusion of the biomaterial led to reduced left ventricular volumes, improved wall-motion scores, and differential gene expression associated with tissue repair and inflammation. This intravascular delivery of pro-healing extracellular matrix may provide translational advantages for healing inflamed tissues 'from the inside out'.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Alison L. Banka, M. Valentina Guevara, Emma R. Brannon, Nhien Q. Nguyen, Shuang Song, Gillian Cady, David J. Pinsky, Kathryn E. Uhrich, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
Summary: The authors used cargo-free particles to block the adhesion of platelet-neutrophil aggregates to the vascular wall, potentially providing an effective therapy for thromboinflammation. Platelets are recruited to areas of inflammation through the interaction of PSGL-1 on leukocytes and P-selectin on activated platelets, leading to platelet-leukocyte aggregates that bind to the endothelium. In this study, polymeric particles were found to divert platelets away from inflamed blood vessels both in vitro and in vivo, suggesting their potential as anti-platelet therapeutics for thromboinflammatory conditions.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych, Hannah R. Calvelli, Cody L. Hoop, Zhiping P. Pang, Jean Baum, Kathryn E. Uhrich, Prabhas Moghe
Summary: This study introduces a novel polymeric nanotechnology platform for modulating neuroinflammation by inhibiting aSYN-CD36 binding. Experimental results demonstrate that AM NPs with intermediate side chain lengths have the strongest inhibitory activity, reducing aSYN internalization and inhibiting the release of proinflammatory molecules.
ADVANCED NANOBIOMED RESEARCH
(2022)
Article
Engineering, Environmental
P. Takunda Chazovachii, Julie M. Rieland, Violet V. Sheffey, Timothy M. E. Jugovic, Paul M. Zimmerman, Omolola Eniola-Adefeso, Brian J. Love, Anne J. McNeil
Summary: Microplastic pollution is widespread and a major concern, but removing microplastics from water using adhesives shows promising results. This method can efficiently remove up to 99% of microplastics within 5 minutes, offering a potential solution for remediating microplastic pollution in aquatic environments.
ACS ES&T ENGINEERING
(2021)
