Article
Multidisciplinary Sciences
Sara Jafakesh, Arshiya Sangchooli, Ardalan Aarabi, Mohammad Sadegh Helfroush, Amirhossein Dakhili, Mohammad Ali Oghabian, Kamran Kazemi, Hamed Ekhtiari
Summary: Cue-induced drug craving and disinhibition are crucial factors in the continued drug use and relapse of substance use disorders. This study found that over time, there is a decline in craving-related activations and an increase in inhibition-associated activations in response to drug cues. Additionally, these dynamic cue-reactivity and response inhibition are correlated with clinical measures such as severity of drug use and craving, impulsivity, and inhibitory task performance.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Nana Feng, Lena Palaniyappan, Trevor W. Robbins, Luolong Cao, Shuanfeng Fang, Xingwei Luo, Xiang Wang, Qiang Luo
Summary: Impaired working memory (WM) is a core dysfunction in schizophrenia, characterized by deficits in both attention and WM processing. Patients show linear modulation of brain activation in frontoparietal and dorsal attention networks, while controls exhibit an inverted U-shaped response pattern in the left anterior cingulate cortex. These modulation effects are associated with gene expressions related to the dopamine neurotransmitter system.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
A. C. Rosen, J. V. Bhat, V. A. Cardenas, T. J. Ehrlich, A. M. Horwege, D. H. Mathalon, B. J. Roach, G. H. Glover, B. W. Badran, S. D. Forman, M. S. George, M. E. Thase, D. Yurgelun-Todd, M. E. Sughrue, S. P. Doyen, P. J. Nicholas, J. C. Scott, L. Tian, J. A. Yesavage
Summary: This study analyzed imaging data from a failed clinical trial of rTMS in Veterans to investigate the association between treatment response and rTMS coil location. Findings revealed that the accuracy in targeting the region within DLPFC negatively correlated with the subgenual cingulate is related to clinical response to rTMS in treatment resistant major depression, providing evidence for a neuro-functionally informed rTMS therapy target in Veterans.
Article
Clinical Neurology
Toshiharu Kamishikiryo, Go Okada, Eri Itai, Yoshikazu Masuda, Satoshi Yokoyama, Masahiro Takamura, Manabu Fuchikami, Atsuo Yoshino, Kazuaki Mawatari, Shusuke Numata, Akira Takahashi, Tetsuro Ohmori, Yasumasa Okamoto
Summary: To establish treatment response biomarkers for depression, this study investigated the relationship between regional brain activity and blood metabolites related to escitalopram treatment response. The results showed that lower resting-state activity of the left dorsolateral prefrontal cortex (DLPFC) and decreased plasma kynurenine levels were associated with a better response to escitalopram treatment.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Behavioral Sciences
Maria Stein, Leonie Steiner, Werner Fey, Frauke Conring, Kathryn Rieger, Andrea Federspiel, Franz Moggi
Summary: The study used a new alcohol-related Go/NoGo task to investigate how exposure to alcohol-related cues affects inhibitory control in AUD patients. The findings suggest that AUD patients recruit enhanced neuronal resources for successful inhibition, with hyperactivation observed in certain regions, especially in an alcohol-related context. The preliminary results imply that exposure to alcohol-related cues intensifies the demand on inhibitory system in recently abstinent patients with AUD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Chun Yin Liu, Ran Tao, Lang Qin, Stephen Matthews, Wai Ting Siok
Summary: This study investigated the neurocognitive mechanism and functional connectivity of brain regions involved in single word reading. The results showed that orthography, phonology, and meaning processes have a shared core network, but also have distinct activation areas and functional connectivity networks.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Pitna Kim, Madeline R. Scott, James H. Meador-Woodruff
Summary: Research has identified abnormalities in protein processing in schizophrenia patients, particularly dysregulation in the IRE1α pathway. This dysfunction may lead to abnormal responses to cellular stress and contribute to the protein processing abnormalities previously observed in schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Joseph P. Happer, Laura C. Wagner, Lauren E. Beaton, Burke Q. Rosen, Ksenija Marinkovic
Summary: Inhibitory control relies on integrated functions across neural networks, which are better captured using aMEG that combines MEG with MRI. Experimental results show that visually salient stimuli can facilitate response withholding on certain trials and hinder responding to others, highlighting the interplay between attention and inhibitory processes. The study emphasizes the role of neural synchrony in theta band in underlying inhibitory control and attentional processes.
Article
Behavioral Sciences
Claire J. Hanley, Natasha Burns, Hannah R. Thomas, Lars Marstaller, Hana Burianova
Summary: This study reveals that age-based in-group bias affects neural information processing during response inhibition, highlighting the significance of age in inhibitory control.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Yi-Bing Guo, Qing Jiao, Xiao-Tong Zhang, Qian Xiao, Zhou Wu, Wei-Fang Cao, Dong Cui, Guang-Hui Yu, Ru-Hai Dou, Lin-Yan Su, Guang-Ming Lu
Summary: This study investigated the fractal characteristics of brain blood oxygen level-dependent signals in pediatric bipolar disorder patients when responding to external emotional stimuli. The findings showed that patients exhibited overactivation, increased self-similarity, and decreased complexity during an emotional task compared to healthy controls. These results provide evidence of altered emotional modulation of cognitive control in pediatric bipolar disorder patients.
Article
Geriatrics & Gerontology
Claire J. Hanley, Natasha Burns, Hannah R. Thomas, Lars Marstaller, Hana Burianova
Summary: Facilitating communication between generations has become increasingly important. However, individuals often demonstrate a preference for their own age group, which can impact social interactions, and such bias in young adults even extends to inhibitory control. To assess whether older adults also experience this phenomenon, a group of younger and older adults completed a Go/NoGo task incorporating young and old faces, while undergoing functional magnetic resonance imaging. Within the networks subserving successful and unsuccessful response inhibition, patterns of activity demonstrated distinct neural age bias effects in each age group. Consequently, the findings of the study confirm that neural responses to successful and unsuccessful inhibition can be contingent on the stimulus-specific attribute of age in both younger and older adults. These findings have important implications in regard to minimizing the emergence of negative consequences, such as ageism, as a result of related implicit biases.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
JeYoung Jung, Matthew A. Lambon Ralph, Rebecca L. Jackson
Summary: The dorsolateral prefrontal cortex (DLPFC), located in the human brain, plays significant roles in various executive functions. This study aimed to investigate whether there are functional subdivisions within the DLPFC. The researchers divided the DLPFC into seven regions and examined their structural and functional connectivity patterns. The findings suggest that the DLPFC may be subdivided along different axes, reflecting its integrative executive function.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Damien Brevers, Chris Baeken, Stefanie De Smet, Beatriz Catoira, Sara De Witte, Qinghua He, Pierre Maurage, Laimi Schulze-Steinen, Guillaume Sescousse, Claudia Vila Verde, Claus Vogele, Joel Billieux
Summary: Brain imaging studies have found that stimulation of the left dorsolateral prefrontal cortex (dlPFC) can modulate brain reactivity to reward-related cues. However, the impact of contextual factors on this modulation effect remains unclear. In this study, researchers tested the effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on brain reactivity to cues signaling reward availability or unavailability. The results showed that HF-rTMS modulated brain activity in response to game cues, with increases in posterior insula and caudate nucleus activation and a decrease in occipital pole activation. HF-rTMS also increased ventral striatal activity for cues available for betting but had no effect on cues unavailable for betting.
Article
Clinical Neurology
Valeria Tretyak, Dylan E. Kirsch, Sepeadeh Radpour, Wade A. Weber, Kim Fromme, Stephen M. Strakowski, Elizabeth T. C. Lippard
Summary: This study found that there are differences in subjective response to alcohol between individuals with bipolar disorder and typically developing individuals, which are associated with variations in gray matter volume in the OFC. Individuals with bipolar disorder and typically developing individuals exhibit differences in subjective response and drinking patterns, which are related to OFC biology.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Tatsunori Watanabe, Nami Kubo, Xiaoxiao Chen, Keisuke Yunoki, Takuya Matsumoto, Takayuki Kuwabara, Toru Sunagawa, Shota Date, Tatsuya Mima, Hikari Kirimoto
Summary: This pilot study investigated the effects of transcranial static magnetic field stimulation (tSMS) on inhibitory control when applied over the dorsolateral prefrontal cortex (DLPFC). The results showed that tSMS did not affect reaction time, suggesting the possibility that it may not be capable of modulating inhibitory control or that the cognitive load in the study was insufficient to detect any effects.
Article
Neuroimaging
Vita Droutman, Feng Xue, Emily Barkley-Levenson, Hei Yeung Lam, Antoine Bechara, Benjamin Smith, Zhong-Lin Lu, Gue Xue, Lynn C. Miller, Stephen J. Read
NEUROIMAGE-CLINICAL
(2019)
Article
Immunology
Eileen M. Martin, Raul Gonzalez, Jasmin Vassileva, Antoine Bechara
Article
Behavioral Sciences
Qinghua He, Dandan Li, Ofir Turel, Antoine Bechara, Yih-Ing Hser
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neuroimaging
Qinghua He, Ofir Turel, Lei Wei, Antoine Bechara
Summary: This study focused on extensive gamers who play about 3 hours per day and found that they have morphological alterations in brain regions associated with control and visuomotor skills. These findings suggest potential indicators for Internet Gaming Disorder development and highlight the impact of gaming on brain morphology.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Psychology, Biological
Tasha Poppa, Sara de Witte, Marie-Anne Vanderhasselt, Antoine Bechara, Chris Baeken
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ofir Turel, Qinghua He, Lei Wei, Antoine Bechara
Summary: This study aimed to investigate the neural etiology of Internet gaming disorder, with findings supporting stronger reward system activation and weaker prefrontal activation in gamers, as well as increased insula activation under deprivation conditions when exposed to video game cues.
Article
Behavioral Sciences
Haichao Zhao, Ofir Turel, Damien Brevers, Antoine Bechara, Qinghua He
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Multidisciplinary Sciences
Kanchna Ramchandran, Jess Fiedorowicz, Zhaoying Chen, Yilin Bu, Antoine Bechara, Nancy C. Andreasen
Article
Biochemistry & Molecular Biology
Damien Brevers, Chris Baeken, Antoine Bechara, Qinghua He, Pierre Maurage, Mathieu Petieau, Guillaume Sescousse, Claus Voegele, Joel Billieux
Summary: The study investigated the impact of sports betting on brain activity, finding that nonavailable sports betting cues elicited higher brain activity in problem bettors, and lower trait-self-control was associated with increased brain reactivity to sports events with high levels of winning confidence that were nonavailable for betting.
Article
Business
Ofir Turel, Antoine Bechara
Summary: This study expands on the neuro-marketing literature on normal consumption by describing a triple neural model of maladaptive consumption, highlighting the roles of reward, self-control/inhibition, and interoceptive awareness circuits in maladaptive consumption. Imbalance between these systems drives maladaptive consumption.
JOURNAL OF THE ASSOCIATION FOR CONSUMER RESEARCH
(2021)
Article
Clinical Neurology
Tasha Poppa, Lars Benschop, Paula Horczak, Marie-Anne Vanderhasselt, Evelien Carrette, Antoine Bechara, Chris Baeken, Kristl Vonck
Summary: This study investigated the impact of transcutaneous auricular vagus nerve stimulation (taVNS) on interoceptive mechanisms, revealing that taVNS can alter the amplitudes of heart-evoked potentials (HEP) and affect activity in brain regions such as the insula and operculum.
Article
Psychiatry
Florent Wyckmans, Nilosmita Banerjee, Melanie Saeremans, Ross Otto, Charles Kornreich, Laetitia Vanderijst, Damien Gruson, Vincenzo Carbone, Antoine Bechara, Tony Buchanan, Xavier Noel
Summary: This study investigated the influence of acute stress on the balance between habitual response and the goal-directed system in individuals with gambling disorder. The results showed that stress-induced cortisol response had a deleterious effect on the orchestration between model-based and model-free learning in healthy controls, but not in individuals with gambling disorder.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Psychology, Developmental
Hey Tou Chiu, Isaac Nam Ip, Fiona Ngai Ying Ching, Bernard Pak-Ho Wong, Wan-Hap Lui, Chi-Shing Tse, Savio Wai Ho Wong
Summary: This study examined the relationship between emotion dysregulation and resting heart rate variability (HRV) in adolescents with autism spectrum disorder (ASD). The results showed that lower resting HRV was more strongly associated with greater emotion dysregulation in ASD adolescents compared to typically developing adolescents. These findings support the idea that disruptions in autonomic functioning may contribute to emotion dysregulation in individuals with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Neurosciences
Fiona N. Y. Ching, Winnie W. M. So, Sing Kai Lo, Savio W. H. Wong
TRENDS IN NEUROSCIENCE AND EDUCATION
(2020)
Article
Psychology, Multidisciplinary
Chi-Shing Tse, Meingold Hiu-Ming Chan, Wai-Shing Tse, Savio Wai-Ho Wong
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)