Review
Nutrition & Dietetics
Ozaifa Kareem, Sobia Nisar, Masood Tanvir, Umar Muzaffer, G. N. Bader
Summary: During pregnancy, there are physiological changes that require an increase in nutritional needs, particularly for thiamine (vitamin B1). Thiamine deficiency in pregnancy can have detrimental effects on both the mother and fetus, leading to various physical and neurological conditions. This review explores the physiological roles of thiamine, its prevalence and impact during pregnancy, and highlights the knowledge gaps in this area.
FRONTIERS IN NUTRITION
(2023)
Review
Multidisciplinary Sciences
Kyly C. Whitfield, Taryn J. Smith, Fabian Rohner, Frank T. Wieringa, Tim J. Green
Summary: Thiamine is essential for energy metabolism and cognitive health, with deficiencies leading to clinical issues and posing a particular risk to infants. LMICs lack mandatory thiamine fortification programs, highlighting the need for increased thiamine intake and addressing knowledge gaps.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tim J. Green, Kyly C. Whitfield, Lisa Daniels, Rachel C. Brown, Lisa A. Houghton
Summary: In 2014, an outbreak of beriberi occurred on the remote atoll of Kuria in Kiribati due to a thiamine-poor diet. Research showed that the prevalence of inadequate thiamine intakes was over 30% in all groups, and food fortification with rice, sugar, or wheat flour was proposed as a solution to reduce this inadequacy. A regional approach to thiamine fortification is needed due to Kiribati's small size and limited resources.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Medicine, General & Internal
Elisabeth Mates, Deepti Alluri, Tailer Artis, Mark S. Riddle
Summary: Thiamine deficiency (TD) in non-alcoholic hospitalized patients is often underestimated, with symptoms including weakness, neuropsychiatric manifestations, gastrointestinal dysfunction, and ataxia. TD likely develops because of inflammatory stress from chronic inflammatory conditions, combined with decreased energy intake or increased nutrient losses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Francois Mifsud, Diane Messager, Anne-Sophie Jannot, Benoit Vedie, Nadia Aissaoui Balanant, Tigran Poghosyan, Edouard Flamarion, Claire Carette, Lea Lucas-Martini, Sebastien Czernichow, Claire Rives-Lange
Summary: This study describes the clinical presentation of thiamine deficiency, assesses the prescription and results of cerebral imaging, reviews treatments prescribed according to available guidelines or not, and studies the short-term outcome of these patients.
CLINICAL NUTRITION
(2022)
Review
Medicine, General & Internal
Nara Aline Costa, Amanda Gomes Pereira, Clara Sandra Araujo Sugizaki, Nayane Maria Vieira, Leonardo Rufino Garcia, Sergio Alberto Rupp de Paiva, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo, Bertha Furlan Polegato, Marcos Ferreira Minicucci
Summary: Septic shock is a serious condition with high mortality rates, especially in developing countries. Recent studies have explored the potential of micronutrients, specifically thiamine, in improving the outcomes of septic shock patients. While thiamine supplementation has shown positive effects on metabolic processes and oxidative stress, it has not been proven to significantly improve survival rates. Other micronutrients such as vitamin C and D, selenium, and zinc have also been tested but have not demonstrated clear benefits. The combination of thiamine, vitamin C, and corticoids has shown some promise in reducing mortality, but further research is needed to replicate these results.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Larissa M. G. Cassiano, Marina S. Oliveira, Jeanne Pioline, Anna C. M. Salim, Roney S. Coimbra
Summary: Thiamine deficiency can lead to neurodegenerative diseases, such as Wernicke-Korsakoff syndrome, which affects the hippocampus. Thiamine supplementation alone may not be sufficient to prevent cognitive deficits associated with this syndrome.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Jankowska-Kulawy, Joanna Klimaszewska-Lata, Sylwia Gul-Hinc, Anna Ronowska, Andrzej Szutowicz
Summary: The human brain is the most diverse in terms of morphology, metabolism, and functional structure. Neurons secrete various neurotransmitters and regulate their own activity through synaptic connections. Other types of cells in the brain, such as glial cells and neurons, also play a role in regulating metabolism and influencing neuronal viability and neurotransmitter functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Aimee N. N. Reed, Freya E. E. Rowland, Jennifer A. A. Krajcik, Donald E. E. Tillitt
Summary: Steelhead fry reared in Oregon hatcheries have a high mortality rate and show signs of vitamin B1 deficiency. This study explores whether thiamine supplementation can improve their health and survival. The results demonstrate that thiamine-treated fry had significantly higher survival and growth rates compared to those without thiamine supplementation.
VETERINARY SCIENCES
(2023)
Article
Clinical Neurology
Ana Rita Silva, Sofia Almeida-Xavier, Margarida Lopes, Joao P. Soares-Fernandes, Filipa Sousa, Sara Varanda
Summary: This study aimed to investigate the influence of timing of imaging study and thiamine replacement on brain MRI findings in patients with Wernicke encephalopathy (WE). The results suggest that MRI hyperintensities are dependent on the timing and dosage of thiamine correction, and timely prescription of thiamine is associated with a better prognosis at discharge.
NEUROLOGICAL SCIENCES
(2023)
Review
Multidisciplinary Sciences
Iva Bozic, Irena Lavrnja
Summary: Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in energy metabolism and overall health. Benfotiamine, a precursor of thiamine, has higher bioavailability and shows potential antioxidant and anti-inflammatory effects.
Article
Medicine, General & Internal
Julian C. Gilmore, Md Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan
Summary: This study investigates the effect of dolutegravir (DTG) exposure on the functional expression of folate transporters in the placenta. The findings demonstrate that DTG exposure leads to a reduction in the expression of RFC and PCFT, as well as decreased folate uptake.
Article
Clinical Neurology
Sobia Nisar, Irfan Yousuf wani, Umair Altaf, Umar Muzaffer, Ozaifa Kareem, Masood Tanvir, Mohd. Ashraf Ganie
Summary: This observational study investigates the potential responsiveness of peripheral neuropathy of unknown etiology to thiamine administration in Kashmir. The study reveals that thiamine deficiency-related neuropathy primarily manifests as weakness in the lower limbs and can be exacerbated by vomiting, poor food intake, psychiatric illness, and pregnancy. Thiamine therapy should be followed by clinical and biochemical observation to assess its effectiveness.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Szu-Kai Hsu, Cheng-Wei Lu, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su Jane Wang
Summary: Mangiferin was found to reduce glutamate release in rat synaptosomes by decreasing the availability of synaptic vesicles through reducing the activity of protein kinase A and Ca2+/calmodulin-dependent kinase II and the phosphorylation of synapsin I. These findings suggest that mangiferin may have potential therapeutic effects on brain disorders involving excess glutamate.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pediatrics
Dan Zhao, Ming Liu, Huafang Jiang, Tianyu Song, Chaolong Xu, Xin Duan, Ruoyu Duan, Han Xu, Zhimei Liu, Fang Fang
Summary: Thiamine pyrophosphokinase (TPK) deficiency is a rare autosomal recessive disorder caused by variants in the TPK1 gene, leading to obstacles in the thiamine metabolic pathway. This study describes two cases of TPK deficiency with different phenotypes and therapeutic effects, and retrospectively reviews 26 previously reported cases to enhance our understanding of the clinical and genetic features of the disease. Patients with TPK deficiency present with various neurological dysfunctions. Different gene variants may result in distinct clinical features and therapeutic effects. Gene analysis is important for the diagnosis of TPK deficiency caused by TPK1 variants, and thiamine supplementation remains the mainstay of treatment for TPK deficiency.
FRONTIERS IN PEDIATRICS
(2023)
Article
Substance Abuse
Lindsey C. Vedder, Joseph M. Hall, Kimberly R. Jabrouin, Lisa M. Savage
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
J. L. Santerre, E. B. Kolitz, R. Pal, J. A. Rogow, D. F. Werner
NEUROCHEMICAL RESEARCH
(2015)
Article
Substance Abuse
Jenna M. Carter, Justine D. Landin, Eduardo D. Gigante, Samuel P. Rieger, Marvin R. Diaz, David F. Werner
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Neurosciences
Joseph M. Hall, Lisa M. Savage
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
David F. Werner, Patrizia Porcu, Kevin N. Boyd, Todd K. O'Buckley, Jenna M. Carter, Sandeep Kumar, A. Leslie Morrow
MOLECULAR AND CELLULAR NEUROSCIENCE
(2016)
Article
Neurosciences
Melissa M. Conti, Samantha M. Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F. Werner, Christopher Bishop
Article
Neurosciences
A. Suryanarayanan, J. M. Carter, J. D. Landin, A. L. Morrow, D. F. Werner, I. Spigelman
Article
Neurosciences
K. R. Przybysz, D. P. Werner, M. R. Diaz
Article
Neurosciences
Carol A. Dannenhoffer, Esther U. Kim, Jessica Saalfield, David F. Werner, Elena I. Varlinskaya, Linda P. Spear
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Justine D. Landin, Magdalena Palac, Jenna M. Carter, Yvette Dzumaga, Jessica L. Santerre-Anderson, Gina M. Fernandez, Lisa M. Savage, Elena I. Varlinskaya, Linda P. Spear, Scott D. Moore, H. Scott Swartzwelder, Rebekah L. Fleming, David F. Werner
Article
Substance Abuse
Justine D. Landin, Jonathan K. Gore-Langton, Elena I. Varlinskaya, Linda P. Spear, David F. Werner
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Behavioral Sciences
Elena Varlinskaya, Dominika Hosova, Trevor Towner, David F. Werner, Linda P. Spear
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Developmental Biology
Carol A. Dannenhoffer, David F. Werner, Elena I. Varlinskaya, Linda P. Spear
Summary: The study found that AIE exposure did not affect the retention of adolescent-like sensitivity to NR2B receptor antagonism, as well as the social and aversive effects of ifenprodil in adult rats. Additionally, AIE did not induce a shift in vGlut2 to vGAT ratios in the brains of adult rats.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Substance Abuse
Trevor T. Towner, Kimberly M. Papastrat, Linda P. Spear, Elena Varlinskaya, David F. Werner
Summary: Adolescent alcohol use can have gender-specific effects on social behavior, and the hypothalamic oxytocin and vasopressin systems are involved in the effects of ethanol ingestion on social behavior in an age- and sex-dependent manner.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Neurosciences
Trevor T. Towner, Matthew A. Goyden, Harper J. Coleman, Mary K. Drumm, Isabella P. Ritchie, Kayla R. Lieb, Elena I. Varlinskaya, David F. Werner
Summary: Binge drinking during adolescence can lead to behavioral and neurobiological consequences, specifically affecting social interaction. The prelimbic cortex (PrL) plays a role in regulating social interaction, and dysfunction in this area may contribute to reduced social investigation following adolescent ethanol exposure. In a rat study, it was found that AIE-exposed males showed decreased social interaction-induced activity in the PrL compared to controls, while no significant changes were observed in females. Inactivation of PrL ensembles previously activated by social interaction reduced social investigation in control males but not in AIE-exposed males or females.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
