Article
Multidisciplinary Sciences
Jasmine Herszage, Haggai Sharon, Nitzan Censor
Summary: The study demonstrates that motor skill learning can be achieved through brief memory reactivations, with the efficacy depending on the number of consecutive correct sequences during reactivations. Higher continuity reactivations result in higher learning gains, similar to extensive practice, while lower continuity reactivations lead to minimal gains.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Ryosuke O. Tachibana, Dahyun Lee, Kazuki Kai, Satoshi Kojima
Summary: This study investigates the neural substrates underlying motor memory consolidation in birdsong, and finds that consolidation of learned vocal changes occurs during the daytime, and is strongly correlated with the amount of learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Soraya Lahlou, Ella Gabitov, Lucy Owen, Daphna Shohamy, Madeleine Sharp
Summary: Motor memory is preserved in Parkinson's patients and may be supported by compensatory non dopamine-sensitive mechanisms. Initial learning dopamine state does not influence motor memory. Parkinson's disease and aging may affect motor memory in similar ways.
Article
Neurosciences
Yori R. Escalante, Yuming Lei
Summary: A study explored memory interference in motor skill tasks and found that the susceptibility to interference varies depending on expertise. The authors suggest that motor memories of expert chefs and competent home cooks are organized differently based on their experiment with a vegetable-chopping task.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
N. Dolfen, B. R. King, L. Schwabe, M. A. Gann, M. P. Veldman, A. von Leupoldt, S. P. Swinnen, G. Albouy
Summary: According to the study, stress induced a larger recruitment of sensorimotor regions and a greater disengagement of hippocampo-cortical networks during training, which was beneficial for initial performance but detrimental for consolidation.
Article
Neurosciences
Yue Li, Edmund Hollis
Summary: Motor control relies on precise encoding and modulation across various motor centers, refined through learning repetition. The baso-cortical cholinergic pathway plays a critical role in the acquisition of coordinated motor skills in mice, with depletion of cholinergic neurons leading to significant impairments in training. Cholinergic neuromodulation during training is essential for task acquisition, specifically influencing corticostriatal neurons in the prefrontal and motor cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Raphael Hamel, Olivier Demers, Jean-Francois Lepage, Pierre-Michel Bernier
Summary: This study tested the effect of alcohol ingestion on motor memory consolidation and found that it did not enhance motor memory consolidation. This suggests that motor memory consolidation may involve different neurochemical mechanisms compared to declarative memory.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Psychology, Mathematical
Anne L. van Zelst, F. Sayako Earle
Summary: This review discusses the role of memory consolidation in speech-motor learning and how findings from the broader learning and memory consolidation literature can be applied to this area. It explores predictions for the division of labor between conscious and unconscious memory systems in speech-motor learning, as well as the effects of time and sleep on memory consolidation. The discussion highlights methodological challenges and practical importance in advancing empirical work in this field.
PSYCHONOMIC BULLETIN & REVIEW
(2021)
Article
Neurosciences
Menno P. Veldman, Nina Dolfen, Mareike A. Gann, Anke Van Roy, Ronald Peeters, Bradley R. King, Genevieve Albouy
Summary: Increasing evidence supports the importance of reactivating memory traces during postlearning wakefulness for memory consolidation. This study utilized somatosensory targeted memory reactivation (TMR) to enhance the reactivation of a motor memory trace during quiet rest immediately after learning. The results showed that the reactivated motor sequence had a faster learning rate compared to the not-reactivated sequence, and brain imaging data revealed specific reactivation of motor, parietal, frontal, and cerebellar brain regions during TMR. Importantly, the TMR-induced behavioral advantage was accompanied by changes in hippocampal activity and hippocampo-motor connectivity during task practice.
Article
Psychiatry
Ranin Ballan, Simon J. J. Durrant, Robert Stickgold, Alexandra Morgan, Dara S. S. Manoach, Yafit Gabay
Summary: Individuals with ADHD show a failure in sleep-dependent consolidation of procedural learning, which may disrupt automatic control routines and increase the load on attentional resources.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Guillermo Borragan, Charles-Etienne Benoit, Noemie Schul, Melanie Strauss, Melanie De Schepper, Valerie Roekens, Philippe Peigneux
Summary: Investigating motor learning in patients with multiple sclerosis (MS) disease revealed that while MS patients exhibit similar learning performance as healthy controls, the long-term consolidation of sequential motor memories is impaired in MS disease. Despite slower overall reaction times, motor performance evolves similarly in all groups, with sequence learning being similar between MS patients and control groups.
Article
Clinical Neurology
Ellen T. Koch, Marja D. Sepers, Judy Cheng, Lynn A. Raymond
Summary: This study investigated the correlation between striatal activity and behavior in a Huntington's disease mouse model. Decreased striatal activity was observed during motor learning, with an inverse correlation between latency to fall and striatal activity. At an early stage, the YAC128 mice did not show a deficit in latency to fall but exhibited significant differences in paw kinematics and a weaker correlation between latency to fall and striatal activity. However, at 6 to 7 months, the YAC128 mice showed reduced latency to fall, impaired paw kinematics, and increased striatal activity. In the open field, elevated neuronal activity was observed at rest in the YAC128 mice.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Youn Kim, Hee-Sun Kim
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by motor dysfunction due to dopaminergic degeneration. Motor skill learning training, such as rotarod walking exercise (RWE), has been shown to improve motor deficits in PD. In this study, RWE was found to have disease-modifying effects by improving motor function, decreasing dopaminergic degeneration, inhibiting inflammation, reducing oxidative stress, and inhibiting alpha-synuclein oligomerization.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Rajat Saxena, Justin L. Shobe, Bruce L. McNaughton
Summary: Understanding how the brain learns throughout a lifetime remains a long-standing challenge. This study explores a method of rapidly learning new information by interleaving new and old knowledge, and demonstrates its feasibility in artificial neural networks. Additionally, a theoretical model of implementing this learning approach in the brain is proposed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Judith Nicolas, Bradley R. King, David Levesque, Latifa Lazzouni, Emily Coffey, Stephan Swinnen, Julien Doyon, Julie Carrier, Genevieve Albouy
Summary: Targeted memory reactivation during sleep can enhance motor memory consolidation, and the coordination between slow and sigma oscillations plays a crucial role in memory reinstatement or protection against irrelevant information.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)