Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Behavioral Sciences
Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoudi
Summary: This study investigated the effect of BHME on 6-OHDA-induced motor anomalies. Results showed that BHME prevented motor dysfunction and DA cell death following 6-OHDA injection, which was accompanied by an enhancement in Akt activity, decrement of P38 phosphorylation, and reduction in Bax/Bcl-2 ratio.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Adedamola Bayo-Olugbami, Abdulrazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C. Lee, Bamidele Victor Owoyele
Summary: The study showed that VD3 can alleviate behavioral deficits induced by 6-OHDA, proteins associated with dopamine metabolism, and biomarkers of oxidative stress.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Emilie Tresse, Lluis Riera-Ponsati, Elham Jaberi, Wei Qi Guinevere Sew, Karsten Ruscher, Shohreh Issazadeh-Navikas
Summary: The study found that neuronal IFN-beta is crucial for maintaining mitochondrial homeostasis and metabolism by controlling mitochondrial fission, ATP levels, and preventing excessive ROS. Lack of neuronal IFN-beta in a Parkinson's disease model disrupts mitochondrial function, leading to the accumulation of damaged mitochondria and excessive oxidative stress.
Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Junmin Xi, Zhijun Zhang, Zuo Wang, Qingfeng Wu, Ying He, Yanyi Xu, Zhenjiang Ding, Huanhuan Zhao, Honghong Da, Fang Zhang, Haiyu Zhao, Jianguo Fang
Summary: The natural small molecule hinokitiol (Hino) serves as a potent ferroptosis inhibitor by chelating irons and activating Nrf2 to upregulate antioxidant genes, potentially rescuing neuronal damage in neurodegenerative disorders and alleviating paclitaxel-induced neurotoxicity without compromising its efficacy against cancer cells. These findings lay a foundation for the further development of Hino as a neuroprotective agent.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Geriatrics & Gerontology
Ebru Umay, Z. A. Yigman, E. A. Ozturk, I. Gundogdu, B. G. Kocer
Summary: The study found that evaluation parameters of sarcopenia were significantly higher in PD patient groups compared to the control group, and muscle measurements evaluated by MRI in patients with dysphagia are lower than both patients with normal swallowing and control group.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Multidisciplinary Sciences
Nicole K. Polinski, Terina N. Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O. Ahmad, Mali Cosden, Monika Kandebo, Robert E. Drolet, Peter D. Buckett, Weisong Shan, Yi Chen, Lee J. Pellegrino, Gregory D. Ellsworth, Leo B. Dungan, Warren D. Hirst, Sean W. Clark, Kuldip D. Dave
Summary: This study introduces a novel GBA1 mouse model with decreased GCase activity, increased glycosphingolipid substrates in the liver and brain, and potential for pharmacodynamic assessments aimed at restoring GCase as a therapeutic approach.
Article
Geriatrics & Gerontology
Ying Jiang, Huizi Ma, Xuemei Wang, Zhan Wang, Yaqin Yang, Longling Li, Tao Feng
Summary: This study demonstrated that activation of alpha 7nAChR could have anti-inflammatory effects and play a role in modulating the immune balance during 6-OHDA-induced injury, possibly through the alpha 7nAChR/p-Erk/Foxp3 signaling pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Hengjing Cui, Joshua D. Elford, Okko Alitalo, Paula Perez-Pardo, Janne Tampio, Kristiina M. Huttunen, Aletta Kraneveld, Markus M. Forsberg, Timo T. Myohanen, Aaro J. Jalkanen
Summary: Increasing evidence suggests that the gut-brain axis plays a crucial role in Parkinson's disease (PD), and 6-OHDA-induced nigrostriatal dopaminergic damage leads to increased α-synuclein (aSyn) levels and glial cell activation, particularly in the colon. This indicates that the gut-brain axis interactions in PD are bidirectional, and the detrimental process may start in the brain.
NEUROBIOLOGY OF AGING
(2023)
Article
Rehabilitation
Min-Yong Lee, Byung-Mo Oh, Han Gil Seo
Summary: COVID-19 may have a significant impact on patients with Parkinson's disease, potentially leading to severe dysphagia and complications such as pneumonia. Healthcare providers should be aware of these risks and monitor patients closely for any signs of swallowing difficulties.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
Ru-Huei Fu, Chia-Wen Tsai, Shih-Ping Liu, Shao-Chih Chiu, Yen-Chuan Chen, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Lin
Summary: We investigated the antioxidant potential of narcissoside in Parkinson's disease models and found that narcissoside can enhance the miR200a/Nrf2/GSH antioxidant pathway, reduce reactive oxygen species generation, and improve dopamine-related behavior. Moreover, narcissoside can activate the ERK and Akt pathways to resist apoptosis. These findings suggest that narcissoside has neuroprotective potential in Parkinson's disease.
Article
Neurosciences
Erika R. Murphy, Rebecca Thompson, Kate L. Osman, Chandler Haxton, Margaret Brothers, Li Lee, Kristen Warncke, Catherine L. Smith, Amy N. Keilholz, Ali Hamad, Mojgan Golzy, Filiz Bunyak, Lixin Ma, Nicole L. Nichols, Teresa E. Lever
Summary: The study investigated the effect of high-repetition/low-resistance tongue exercise on hypoglossal-tongue axis degeneration in rats, showing that exercise can mitigate degenerative changes and have a safe and effective role in preventing or alleviating signs of degeneration.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Han Soo Yoo, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: White matter hyperintensities in Parkinson's disease patients are associated with nigrostriatal dopamine availability and impact motor symptoms. The effect of white matter hyperintensities on UPDRS total score and bradykinesia subscore is mediated indirectly by dopamine transporter availability in the posterior putamen, while the axial subscore is directly affected by white matter hyperintensities.
MOVEMENT DISORDERS
(2021)
Article
Medicine, Research & Experimental
Corinne A. Jones, Michelle R. Ciucci, Suzan M. Abdelhalim, Timothy M. McCulloch
Summary: This study measured swallowing pressure variability in healthy adults and found that it differed by pharyngeal region, bolus volume, and age, but not by sex. Abnormal swallowing pressure variability may indicate motor control deviations in individuals with swallowing impairment.
Article
Audiology & Speech-Language Pathology
Sana Smaoui, Melanie Peladeau-Pigeon, Catriona M. Steele
Summary: This study investigated hyoid movement in healthy adults consuming liquids of various consistencies, finding stable measures across thin to extremely thick liquids without systematic alterations in movement or position.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Review
Neurosciences
Charles Lenell, Courtney K. Broadfoot, Nicole E. Schaen-Heacock, Michelle R. Ciucci
Summary: The rat model is a useful tool for studying communication and related deficits, as rat produce ultrasonic vocalizations (USVs) that are altered by various experimental conditions. Sex differences are apparent in both the rat larynx and USV acoustics, and are differentially affected by experimental conditions. Therefore, studying these sex differences across the lifespan can provide valuable insights into the effects of experimental conditions.
Article
Behavioral Sciences
Jesse D. Hoffmeister, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Vocal communication impairment and anxiety are common symptoms of Parkinson's Disease and both are influenced by the noradrenergic system. The study revealed significant relationships between vocal impairment, anxiety, and brainstem norepinephrine in a genetic rat model of PD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Audiology & Speech-Language Pathology
Jesse D. Hoffmeister, Christopher L. Ulmschneider, Corinne A. Jones, Michelle R. Ciucci, Timothy M. McCulloch
Summary: This study examined the feasibility of measuring phonatory air pressure at multiple locations in the lower vocal tract simultaneously using high-resolution pharyngeal manometry (HRM). The results showed that air pressures from different locations varied during vocal tract semi-occlusion tasks, with pressures increasing as the occlusion level increased. The high spatial and temporal resolution provided by HRM may be valuable for future studies investigating differences in lower vocal tract air pressures between normal and disordered populations.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Review
Neurosciences
Maryann N. Krasko, Jesse D. Hoffmeister, Nicole E. Schaen-Heacock, Jacob M. Welsch, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Parkinson's disease is a progressive disorder affecting 10 million people worldwide, with over 90% developing hypokinetic dysarthria. Limited understanding of pathological mechanisms and treatment options has led to exploration of rat models for insights into vocal deficits.
Article
Behavioral Sciences
Jesse D. Hoffmeister, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Vocal deficits and anxiety are common symptoms of Parkinson's Disease that have a significant impact on quality of life. Current dopamine replacement therapies are not effective in treating these symptoms, leading researchers to explore drug therapies targeting noradrenaline. The study showed that noradrenergic manipulation with certain drugs can decrease anxiety and modulate vocalization in a PD rat model.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Geriatrics & Gerontology
A. Kurosu, F. Osman, S. Daggett, R. Pena-Chavez, A. Thompson, S. M. Myers, P. VanKampen, S. S. Koenig, M. Ciucci, J. Mahoney, Nicole Rogus-Pulia
Summary: The study aimed to determine the prevalence of self-reported dysphagia in community-dwelling older adults receiving meal support and identify associated factors. Results showed approximately one in five community-dwelling older adults had self-reported dysphagia, with factors such as poor nutritional status, difficulty chewing, prior dysphagia and pneumonia diagnosis, and meal service site being associated with dysphagia.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Neurosciences
Denis Michael Rudisch, Maryann N. Krasko, Alex F. Nisbet, Nicole E. Schaen-Heacock, Michelle R. Ciucci
Summary: This paper reviews the important contributions of measuring tongue behaviors in awake rats and mice and discusses how these methods have been modified by other researchers to advance translational science.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemical Research Methods
David Frantz, Tugba Karamahmutoglu, Allison J. Schaser, Deniz Kirik, Edouard Berrocal
Summary: The SILMAS method combines axially swept light-sheet microscopy with structured illumination to achieve high-contrast and uniform optical sectioning imaging of large-scale scattering samples, without the need for heavy post-processing. It is a valuable addition to the LSFM family.
BIOMEDICAL OPTICS EXPRESS
(2022)
Review
Otorhinolaryngology
Rodolfo E. Pena-Chavez, Nicole E. Schaen-Heacock, Mary E. Hitchcock, Atsuko Kurosu, Ryo Suzuki, Richard W. Hartel, Michelle R. Ciucci, Nicole M. Rogus-Pulia
Summary: This study conducted a scoping review to examine the impact of food and liquid properties on swallowing physiology and function in adults. The findings revealed that various properties of food and liquids can modify the oral and pharyngeal phases of swallowing, including taste, odor, carbonation, viscosity, hardness, adhesiveness, and cohesiveness. These modifications also affect various measurements during swallowing, such as penetration/aspiration, oral transit time, lingual pressures, submental muscle contraction, oral and pharyngeal residue, hyoid and laryngeal movement, pharyngeal and upper esophageal sphincter pressures, and total swallow duration.
Article
Behavioral Sciences
Courtney K. Broadfoot, Charles Lenell, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Social isolation significantly affects vocalization and neurotransmitter levels in the VTA of rats.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Rehabilitation
Maryann N. Krasko, Denis Michael Rudisch, Ryan J. Burdick, Nicole E. Schaen-Heacock, Courtney K. Broadfoot, Alex F. Nisbet, Nicole Rogus-Pulia, Michelle R. Ciucci
Summary: This review summarizes current treatments for PD-associated dysphagia, including pharmacological, surgical, and behavioral interventions, as well as the contributions of translational animal research. Current interventions targeting dopamine dysfunction have limited effects, and behavioral interventions are most effective for dysphagia treatment. Animal research has advanced our understanding of PD and dysphagia mechanisms and shows promise for studying treatment options.
CURRENT PHYSICAL MEDICINE AND REHABILITATION REPORTS
(2023)
Article
Rehabilitation
Denis Michael Rudisch, Maryann N. N. Krasko, Ryan Burdick, Courtney K. K. Broadfoot, Nicole Rogus-Pulia, Michelle R. R. Ciucci
Summary: The majority of individuals with Parkinson disease (PD) experience dysphagia, which is often diagnosed late in the disease progression. This review provides an overview of the current understanding of PD pathophysiology and discusses the diagnostic practices, knowledge gaps, and future directions in dysphagia research.
CURRENT PHYSICAL MEDICINE AND REHABILITATION REPORTS
(2023)
Letter
Clinical Neurology
Cynthia A. Kelm-Nelson, Sarah A. Lechner, Samantha E. Lettenberger, Taylor A. R. Kaldenberg, Natalie K. Pahapill, Amy Regenbaum, Michelle R. Ciucci
BRAIN COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)