Review
Health Care Sciences & Services
Onyoo Yoo, Sin-Ae Park
Summary: Lavender aromatherapy has been found to be a safe and feasible intervention for reducing anxiety levels, with multiple studies providing evidence of its effectiveness.
Article
Environmental Sciences
Yassine Ait Bali, Nour-Eddine Kaikai, Saadia Ba-M'hamed, Marco Sassoe-Pognetto, Maurizio Giustetto, Mohamed Bennis
Summary: Evidence demonstrates that serotonin depletion leads to anxiety behavior. Previous studies have also shown that glyphosate-based herbicides increase anxiety levels and reduce serotonin fibers in exposed mice. In this study, the effects of herbicides on immediate early gene activation in the mPFC and amygdala were investigated, revealing anxiogenic behavior in exposed mice.
Article
Plant Sciences
Yue Xu, Li Ma, Fei Liu, Lei Yao, Wencui Wang, Suzhen Yang, Tingting Han
Summary: This study investigates the effects and mechanisms of different components of lavender essential oil on sleep disorders. The results demonstrate that different fractions of lavender essential oil have different effects in alleviating sleep disturbances induced by anxiety and caffeine, which may be attributed to their compositional differences and complex interactions with the central nervous system.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Angeliki Velli, Chrysoula Iordanidou, Theodora Asimi, Maria-Ioanna Vynichaki, Anastasios Cholevas, Adamantia-Iliana Mantouka, Liesje Nassens, Kleanthi Chalkiadaki, Kyriaki Sidiropoulou
Summary: Gender differences play a role in the differential effects of acute restraint stress on the function of the prefrontal cortex in male and female mice. Females exhibit increased anxiety levels, while males show deficits in the temporal order object recognition task. Corticosterone signaling mediates some of the effects of stress on synaptic plasticity, affecting recency memory and anxiety in males and females differently.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Alessandra Franceschini, Giacomo Mazzamuto, Curzio Checcucci, Lorenzo Chicchi, Duccio Fanelli, Irene Costantini, Maria Beatrice Passani, Bianca Ambrogina Silva, Francesco Saverio Pavone, Ludovico Silvestri
Summary: Fear responses are adaptive behaviors strengthened as memories. Understanding the neural circuitry modulating fear memory is crucial for comprehension of this emotion and its pathological states. The brain-wide neuron quantification toolkit (BRANT) allows for mapping whole-brain neuronal activation at micron-scale resolution, providing a comprehensive characterization of the evolution of fear memory.
Article
Behavioral Sciences
Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-xiang Liu, Cheng Long
Summary: CYLD, a lysine 63 deubiquitinase, is highly expressed in the brain and is associated with anxious and depressive behavior, cognitive inflexibility, and autism disorders. Previous research was limited to certain brain regions and this study aimed to understand its role in adaptation to stress and identify the involved brain regions. The study found that CYLD deficiency unexpectedly affected the reaction to acute restraint stress in mice, leading to neuronal activation in specific brain regions such as the medial prefrontal cortex, dorsal striatum, nucleus accumbens, and basal lateral amygdala, while not involving the ventral hippocampus.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Article
Neurosciences
Sakineh Alijanpour, Ameneh Rezayof
Summary: This study aimed to investigate whether activation of the ventral hippocampal CB1 cannabinoid receptors affects the anxiety-like behaviors induced by ketamine. The results showed that ketamine administration caused anxiogenic-like behavior, but activation of the VH CB1 receptors inhibited these behaviors. Additionally, the levels of BDNF and c-Fos proteins in the hippocampus were altered after ketamine and ACPA treatment.
Article
Polymer Science
Rita de Cassia Siqueira Curto Valle, Jose Alexandre Borges Valle, Fabricio Maesta Bezerra, Jeferson Correia, Cristiane da Costa, Meritxell Marti, Luisa Coderch, Arianne Lopez, Manuel J. Lis Arias
Summary: Researchers have shown significant interest in surface treatments for textile substrates, particularly ozone and plasma treatments. In this study, the impregnation of polymeric microcapsules containing lavender oil in polyester fabrics was evaluated after ozone and plasma treatments. The microcapsules, prepared with chitosan and gum arabic, were characterized for size and morphology, while the surface-treated polyester samples were assessed using various methods including FTIR, TGA, SEM, and lavender release. The results indicated that the ozone and plasma treatments influenced both the amount of lavender delivered and the control of its release.
Article
Psychiatry
Dorien Vandael, Keimpe Wierda, Katlijn Vints, Pieter Baatsen, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia Gounko
Summary: CRF plays a central role in regulating physiological responses to stress by rapidly enhancing synaptic communication in the hippocampus. This process involves changes in both functional and structural aspects of synapses, leading to improvements in synaptic strength and plasticity, which may contribute to enhanced memory consolidation under acute stress.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Materials Science, Multidisciplinary
Dimitrina Todorova, Nikolay Yavorov, Veska Lasheva, Stanka Damyanova, Iliana Kostova
Summary: This research examines the antimicrobial activity of lavender essential oil treatment on packaging papers and monitors its effects on the structural and strength indicators of the paper samples. The results indicate that the lavender treatment is successful, with a more pronounced antifungal effect. The lavender essential oil treatment of wrapping paper holds promising potential for preserving products from microbial spoilage and extending their shelf life.
Article
Neurosciences
Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zhao
Summary: By using FG7142 combined with restraint stress, an anxiety animal model was established, which induced anxiety-like behavior in behavior tests and showed increased c-fos expression in the hippocampus and amygdala, as well as decreased expression of GABA receptor and serotonin receptors in the hippocampus.
Article
Chemistry, Multidisciplinary
Yang Gao, Simin Yang, Minwei She, Jianhong Nie, Yanping Huo, Qian Chen, Xianwei Li, Xiao-Qiang Hu
Summary: We report a practical route for the synthesis of valuable 3-aryl anthranils from readily available anthranils and simple arenes using electrophilic aromatic substitution (EAS) strategy. The method shows good compatibility with a wide range of arenes and delivers various structurally diversified 3-aryl anthranils in good yields and high regioselectivity. The synthesized 3-aryl anthranils are proven to be a highly robust platform for accessing biologically active compounds, drug derivatives, and organic optoelectronic materials.
Article
Physiology
A. B. Cherepov, A. A. Tiunova, K. V. Anokhin
Summary: Newly hatched chicks show a preference for naturalistic stimuli, but artificial imprinting stimuli can initially elicit a stronger response. However, over time, the preference for artificial stimuli decreases and is replaced by a preference for natural stimuli.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Mei Wang, Jianping Zhao, Zulfiqar Ali, Cristina Avonto, Ikhlas A. Khan
Summary: A new method named Q-Index was proposed for lavender essential oil (LEO) quality assessment and adulteration detection. By identifying 14 marker compounds and utilizing a synthetic compound indicator, the method successfully distinguished authentic LEOs from adulterated samples. The Q-Index method showed greater sensitivity in detecting LEO adulteration compared to traditional methods such as NMR analysis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Maria Angeles Cintado, Gabriel Gonzalez, Lucia Carcel, Luis Gonzalo de la Casa
Summary: In three experiments, the potential anxiolytic effects of sodium valproate, a drug used to treat seizures, were analyzed in rats. Injecting valproate prior to introducing a new flavor solution reduced neophobia in the presence of a context associated with the drug. However, a control group that received the drug showed reduced consumption. The drug also had negative effects on locomotor activity, which affected drinking behavior. Additionally, directly injecting the drug before a fear conditioning procedure tested its anxiolytic properties.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)