Article
Cell Biology
Fernanda Huf, Jessie Martins Gutierres, Gabrielle N. da Silva, Adriana M. Zago, Luiz Felipe C. Koenig, Marilda C. Fernandes
Summary: This study aimed to investigate the effects of taurine on short-term and long-term memory in a model of sporadic dementia of the Alzheimer's type (SDAT). The findings showed that taurine enhanced memory and protected against neurodegeneration caused by SDAT.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Immunology
Zhichao Hu, Yiming Gu, Minxiu Ye, Yaoying Ma, Yue Wang, Shengying Pan, Chao Huang, Xu Lu
Summary: Pre-stimulation of the innate immune system can prevent depressive and anxiogenic-like behaviors, as well as reduce neuroinflammatory responses, in female mice exposed to chronic unpredictable stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alaa Sirwi, Nesrine S. El Sayed, Hossam M. Abdallah, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Ali M. El-Halawany, Martin K. Safo, Nora O. Abdel Rasheed
Summary: This study investigated the neuroprotective effects of the methoxy flavonoid umuhengerin in an STZ-induced SAD mouse model, showing that umuhengerin attenuated neuroinflammation and oxidative stress, increased Nrf2 expression, and decreased NF-Kβp65 expression. These results suggest that umuhengerin may be a potential therapy for Alzheimer's disease.
Article
Neurosciences
Giovana Benassi-Cezar, Isabela Miranda Carmona, Daniela Baptista-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Summary: The study found that cohabitation with a conspecific suffering from chronic pain affects the anxiety levels of mice, with changes in neuronal activation observed in the anterior cingulate and insular cortices. Injecting a synaptic blocker in these brain areas can reverse the anxiety-inducing effect caused by cohabitation with a conspecific in chronic pain.
Article
Clinical Neurology
Stephanie Perin, Janice Lai, Matthew Pase, Lisa Bransby, Rachel Buckley, Nawaf Yassi, Robert H. Pietrzak, Paul Maruff, Yen Ying Lim
Summary: Depressive and anxiety symptoms in midlife are associated with cognitive decline, particularly anxiety symptoms are significantly correlated with attention and memory deficits. Clinically meaningful anxiety or depressive symptoms are linked to increased subjective cognitive concerns, with a more pronounced effect when both anxiety and depressive symptoms are present.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Minji Jang, Taesub Jung, Miseon Kang, Jeongyeon Kim, Jihyun Noh
Summary: Research indicates that acute peripheral administration of OT increases anxiety-like behaviors while reducing corticosterone in rats. Despite a negative correlation between anxiety-like behavior and low-dose nicotine consumption, there was no significant impact on nicotine preference.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Plant Sciences
Hui-Ling Zhao, Su-Ying Cui, Yu Qin, Yu-Tong Liu, Xiang-Yu Cui, Xiao Hu, Nurhumar Kurban, Ming-Yan Li, Zhen-Hao Li, Jing Xu, Yong-He Zhang
Summary: The study showed that Ganoderma lucidum spores can prevent learning and memory impairments in a rat model of Alzheimer's disease, by reducing Aβ expression, Tau hyperphosphorylation, and modulating the BDNF-TrkB signaling pathway in the hippocampus.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Neurosciences
Sally Day, Stefanie Roberts, Nathalie H. Launder, Anita M. Y. Goh, Brian Draper, Alex Bahar-Fuchs, Samantha M. Loi, Kate Laver, Adrienne Withall, Monica Cations
Summary: Younger people with Alzheimer's disease (AD) have a worse prognosis in terms of faster cognitive decline compared to older individuals. More research is needed to determine the impact of symptom onset age in vascular dementia (VaD) and frontotemporal dementia (FTD), as well as functional decline in all types of dementias.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Fatemeh Nabavi Zadeh, Maryam Nazari, Abdollah Amini, Soheila Adeli, Amir Barzegar Behrooz, Javad Fahanik Babaei
Summary: The study aimed to investigate the neuroprotective action of alpha-tocopherol on memory-impaired rats induced by icv-STZ. The results demonstrated that alpha-tocopherol could alleviate cognitive impairment, reduce oxidative stress and mitochondrial dysfunction, and correct neurodegenerative defects.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yu Zhou, Shihao Huang, Feilong Wu, Qiuyao Zheng, Fushen Zhang, Yixiao Luo, Xiaohong Jian
Summary: Atractylenolide III has shown antidepressant- and anxiolytic-like effects in rats, which appear to be mediated by inhibition of hippocampal neuronal inflammation.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Sonia C. Correia, Marco G. Alves, Pedro F. Oliveira, Gemma Casadesus, Joseph LaManna, George Perry, Paula I. Moreira
Summary: This study demonstrates that hypoxic preconditioning can prevent the sAD-like phenotype, partly by targeting mitochondria as a preventive strategy in the context of AD. Preconditioning with hypoxia enhances complex II-energized mitochondrial respiration in the hippocampus, improving mitochondrial function and mitochondrial DNA content. These findings provide a novel direction for hypoxic preconditioning as a preventive strategy for AD.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Neurosciences
Maria Willadsen, Rainer K. W. Schwarting, Markus Woehr
Summary: Rats communicate through ultrasonic vocalizations and acute treatment with the SSRI escitalopram (ESC) increases anxiety-related behavior and affects ultrasonic communication.
Article
Clinical Neurology
Weiwei Zhong, Anika Wu, Ken Berglund, Xiaohuan Gu, Michael Qize Jiang, Jay Talati, Jingjie Zhao, Ling Wei, Shan Ping Yu
Summary: The study suggests that GluN3A deficiency may lead to Alzheimer's disease by causing neuronal hyperactivity, elevated intracellular Ca2+ levels, neuroinflammation, impaired synaptic integrity/plasticity, and neuronal loss. It also proposes GluN3A as an early biomarker and a therapeutic target independent of amyloid-beta/tau pathology in AD.
ALZHEIMERS & DEMENTIA
(2022)
Review
Medicine, General & Internal
Berne Ting, Daniel Tzu-Li Chen, Wei-Ti Hsu, Chih-Sung Liang, Ikbal Andrian Malau, Wei-Chih Li, Sheau-Ling Lee, Li Jingling, Kuan-Pin Su
Summary: Music interventions have been widely used to relieve anxiety in dementia patients, and a limited meta-analysis with randomized controlled trials was conducted. The results showed that music interventions significantly reduced anxiety symptoms, especially for Alzheimer's disease and mixed-type dementia. Significant improvements in agitation and depression in dementia were also observed. Several psychological mechanisms related to music interventions were comprehensively reviewed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Nol Swaddiwudhipong, David J. Whiteside, Frank H. Hezemans, Duncan Street, James B. Rowe, Timothy Rittman
Summary: UK Biobank data reveals pre-diagnostic cognitive and functional decline in multiple neurodegenerative diseases years before symptoms appear. Identifying pre-diagnostic changes could enhance selection for preventive and early disease-modifying treatment trials.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Mariana G. Fronza, Rodolfo Baldinotti, Jenifer Fetter, Suzan Goncalves Rosa, Manoela Sacramento, Cristina Wayne Nogueira, Diego Alves, Domenico Pratico, Lucielli Savegnago
Summary: Clinical and preclinical investigations have suggested a biological link between major depressive disorder (MDD) and Alzheimer's disease (AD). A pharmacologic approach using QTC-4-MeOBnE has shown benefits in treating depressive-like behavior and cognitive impairments induced by lipopolysaccharide injections in mice. The effects are associated with restoring blood-brain barrier permeability, reducing oxidative/nitrosative biomarkers, and decreasing neuroinflammation mediated NF-KB signaling.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Renata F. Rodrigues, Bruna C. W. Fulco, Cristina W. Nogueira
Summary: The study found that (mCF3-PhSe)(2) attenuated morphine-induced locomotor sensitization by modulating weight gain, locomotor activity, and protein contents of opioid and glutamate receptors in the cerebral cortex. The compound did not affect dopaminergic receptors in the acquisition phase, but was effective against behavioral and molecular alterations caused by morphine at all phases of locomotor sensitization.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carolina C. Martins, Suzan G. Rosa, Vanessa A. Zborowski, Renata F. Rodrigues, Adriano Maroneze, Cristina W. Nogueira, Gilson Zeni
Summary: This study found that m-trifluoromethyl diphenyl diselenide (TFDD) can alleviate the tolerance development to the analgesic and antidepressant effects of morphine in mice, and restore the effects of morphine on opioid receptors and nitrergic system.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
G. Cassol, R. P. Cipolat, W. L. Papalia, D. B. Godinho, C. B. Quines, C. W. Nogueira, M. Da Veiga, M. I. U. M. Da Rocha, A. F. Furian, M. S. Oliveira, M. R. Fighera, L. F. F. Royes
Summary: Recurrent concussions during adolescence can impair memory in adulthood. This is caused by inflammation and oxidative stress, which disrupts the ability of neurons to maintain proper ionic gradients, leading to cognitive impairment.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Sabrina G. Muller, Suelen O. Heck, Luiza S. Marques, Vanessa A. Zborowski, Cristina W. Nogueira
Summary: This study revealed that the antioxidant effects of (p-ClPhSe)2 are associated with the modulation of the Nrf2/Keap-1 signaling pathway in the kidney of mice exposed to dexamethasone.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Psychology, Biological
Hecson Jesser Segat, Franciele Martini, Karine Roversi, Suzan Goncalves Rosa, Sabrina Grendene Muller, Domenika Rubert Rossato, Cristina Wayne Nogueira, Marilise Escobar Burger
Summary: This study compared the effects of non-weight-loaded and weight-loaded physical exercise on hippocampal molecular parameters and behavioral symptoms associated with AMPH addiction. The results showed that non-weight-loaded exercise was more effective in reducing relapse and anxiety-like behavior induced by AMPH, while weight-loaded exercise did not have any effect on these behaviors.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Chemistry, Multidisciplinary
Guilherme Leonel, Isabella Klann, Davi F. Back, Bernardo A. Iglesias, Cristina W. Nogueira, Gilson Zeni
Summary: A method for the synthesis of 4-organoselanyl oxazinoindolone derivatives using iron(III) chloride and diorganyl diselenides as promoters has been developed. The reaction conditions tolerate a variety of diorganyl diselenides with different substituents. The reaction mechanism seems to proceed through an ionic pathway, and the cooperative action of iron(III) chloride and diorganyl diselenides is crucial for successful cyclization. Additionally, changing the electrophilic source resulted in the formation of 4-iodo-oxazinoindolones.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Organic
Roberto do Carmo Pinheiro, Luiz Eduardo Welter, Bernardo A. Iglesias, Davi F. Back, Luiza Souza Marques, Cristina Wayne Nogueira, Gilson Zeni
Summary: Heterocycles fused to seven-membered rings were synthesized in a highly selective manner using potassium tert-butoxide-catalyzed one-pot cyclization. Systematic study revealed that a catalytic amount of potassium tert-butoxide, dimethyl sulfoxide, and the tert-BuOK/tert-BuOH equilibrium played crucial roles in the formation of products.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Marcel Henrique Marcondes Sari, Luana Mota Ferreira, Vinicius Costa Prado, Cristina Wayne Nogueira, Leticia Cruz
Summary: The combination of organoselenium compounds and nanotechnology is a promising approach to improve the solubility, safety, and pharmacological properties of drugs. In recent years, there has been increasing research focusing on different nanocarrier systems and applications. The findings indicate that the production of nano-based formulations can improve the physicochemical properties and reduce the toxicity of organoselenium compounds.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Neurosciences
Juliano Ten Kathen Jung, Luiza Souza Marques, Vanessa Angonesi Zborowski, Guilherme Lutz Silva, Cristina Wayne Nogueira, Gilson Zeni
Summary: This study evaluated the role of resistance exercise in an anxiety-depression-like dyad in a model of stress. The results showed that resistance exercise can alleviate anxiety and depressive symptoms in stressed mice, while reducing neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sabrina G. Muller, Natalia S. Jardim, Guilherme Lutz, Gilson Zeni, Cristina W. Nogueira
Summary: This study investigated the anxiolytic-like effect of (m-CF3-PhSe)2 and its modulation of synaptic plasticity and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model. The results showed that (m-CF3-PhSe)2 abolished anxiety-like behavior, reversed neurotoxicity, and restored synaptic plasticity-related signaling. These findings suggest that (m-CF3-PhSe)2 may be a potential candidate for anxiolytic drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Sabrina G. Mueller, Natalia S. Jardim, Gilson Zeni, Cristina W. Nogueira
Summary: In this study, the efficacy of (m-CF3-PhSe)2 against lifestyle model-related metabolic disturbances and hypothalamic inflammation in young mice was investigated. The results showed that (m-CF3-PhSe)2 reduced relative adipose tissue weight, hyperglycemia, and dyslipidemia in mice exposed to the lifestyle-induced model. It also modulated various metabolic and inflammatory markers in the liver and hypothalamus of the mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Infectious Diseases
Livia Silveira Munhoz, Vanice Rodrigues Poester, Jessica Louise Benelli, Aryse Martins Melo, Mariana Rodrigues Trapaga, Cristina Wayne Nogueira, Gilson Zeni, Mariana Martins Flores, David A. Stevens, Melissa Orzechowski Xavier
Summary: This study demonstrates the potential use of diphenyl diselenide (PhSe)(2) in the treatment of sporotrichosis caused by S. brasiliensis. PhSe(2) showed antifungal activity against Sporothrix brasiliensis and when used in combination with itraconazole, it enhanced the treatment effect.
Article
Psychology, Biological
Luiza S. Marques, Juliano TK. Jung, Vanessa A. Zborowski, Roberto C. Pinheiro, Cristina W. Nogueira, Gilson Zeni
Summary: Excessive stress can lead to depression and anxiety, affecting gastrointestinal functionality and microbiota changes. The study found that Emotional-Single Prolonged Stress (E-SPS) induced depressive/anxiety-like phenotype and gut dysfunction in adult male mice.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Endocrinology & Metabolism
Eduarda Monteiro Fidelis, Anne Suely P. Savall, Jhuly Dornelles Mello, Caroline Brandao Quines, Antonio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de avila, Suzan Goncalves Rosa, Simone Pinton
Summary: This study investigated the antioxidant and neuroprotective effects of purple pitanga extract (PPE) against early oxidative stress induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropypiridine (MPTP) administration. The findings showed that PPE prevented the increase in reactive oxygen species (ROS) levels and protected against lipid peroxidation caused by MPTP. Furthermore, PPE enhanced the activity of Na+/K+ ATPase, indicating its neuroprotective capacity.
METABOLIC BRAIN DISEASE
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)