Article
Environmental Sciences
Yatao Du, Chaojie Chen, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Baolin Liu, Weiye Charles Wang
Summary: This study investigates the toxicity of PFOA to the genes related to thyroid hormone synthesis and their regulatory network using FRTL-5 rat thyroid follicular cells as a model. The results suggest that PFOA disrupts the TSH-activated cAMP signaling pathway, leading to a decrease in thyroid hormone levels, and increases endoplasmic reticulum stress.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stephanie Clerget-Froidevaux, Valerie Enderlin
Summary: This study investigated the protective mechanisms linking hypothyroidism and neuroinflammation. Hypothyroid WSB/EiJ mice showed no neuroinflammatory response and maintained hippocampal thyroid signaling despite low circulating thyroid hormone levels, while C57BL/6J mice exhibited disturbed thyroid signaling, accompanied by neuroinflammation and memory impairment. The results highlight the importance of the hippocampal thyroid regulatory system in glial reactivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ichiro Yamauchi, Yoriko Sakane, Takafumi Yamashita, Takuro Hakata, Taku Sugawa, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Summary: This study aimed to investigate the effects of peripheral iodothyronine deiodinases (DIOs) on thyroid hormone economy. The results showed that D2 could enhance local thyroid hormone action and promote its circulation, while D3 could decrease circulating T3 and T4 levels with elevated reverse T3, leading to consumptive hypothyroidism. Additionally, the D3 mice are expected to be a novel hypothyroidism model.
Article
Medicine, Research & Experimental
Che-Wei Sung, Wei-Tang Chang, Ming-Huan Chan, Tsung-Han Kuo, Hwei-Hsien Chen
Summary: This study found that L-4FPG has antidepressant-like effects and can improve depression-like behaviors caused by chronic social defeat stress. Furthermore, pretreatment with L-4FPG can prevent social avoidance, anxiety-like behaviors, and depression-like behaviors induced by social defeat stress. The results suggest that L-4FPG may not only be useful in alleviating depression but also in protecting against chronic stress-related psychiatric disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Yi Wang, Shengwen Wang, Yu Xin, Jinyue Zhang, Shaofan Wang, Zhuo Yang, Chunhua Liu
Summary: Studies have shown that NaHS can alleviate anxiety-like and depressive-like behaviors induced by T1DM by modulating various biological molecules and cellular processes.
Article
Neurosciences
Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzic
Summary: Adolescent chronic unpredictable stress can increase the risk of anxiety and depression in adult mice, especially affecting the levels of GR alpha isoforms, leading to different responses based on sex and brain structure.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Qun Lu, Haitao Xiang, Haojie Zhu, Yifan Chen, Xu Lu, Chao Huang
Summary: Intranasal administration of LPS prior to stress exposure can prevent chronic social defeat stress-induced depression and anxiety-like behaviors, as well as reduce neuroinflammatory responses in the hippocampus and prefrontal cortex. This suggests that innate immune stimulation via intranasal administration could be a potential approach for the prevention of depression and anxiety.
Article
Biology
Jae Won Song, Keon-Hee Lee, Hobin Seong, Dong-Mi Shin, Woo-Jeong Shon
Summary: Experimental findings indicated that excessive intake of the Western diet (WD) could increase anxiety levels in male wild-type (WT) mice, while Tas1r3-/- mice were not affected by WD-induced anxiety. Further research suggested that TAS1R3 may play a crucial role in WD-induced alterations in hypothalamic functions, and inhibiting the overactivation of TAS1R3 in the hypothalamus could be a potential therapeutic target for anxiety alleviation.
Article
Environmental Sciences
Ran Ji, Mengqiao Cui, Dongyu Zhou, Xiaoyuan Pan, Yuqi Xie, Xiling Wu, Xin Liang, Hongxing Zhang, Weiyi Song
Summary: BPA exposure during adulthood can lead to sex-specific anxiety-like behaviors in mice, particularly in males. The hyperactivity of glutamatergic neurons in the paraventricular thalamus appears to be a key factor contributing to this anxiety. The down-regulation of alpha-1D adrenergic receptor in the PVT may also play a role in BPA-induced anxiety.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Shijie Yang, Xiequn Xu
Summary: This study assessed the mental health of postoperative thyroid patients during the peak of the COVID-19 pandemic in China and found a significant proportion of patients experiencing insomnia, anxiety, depression, and posttraumatic stress symptoms. Age, marital status, education level, income, general health, surgery timeline, follow-up situation, and searching COVID-19-related information on social media were associated with mental health status.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wen-Hsuan Tsai, Fung-Chang Sung, Lu-Ting Chiu, Ying-Hsiu Shih, Ming-Chieh Tsai, Shu- Wu
Summary: Patients with diabetes mellitus receiving GLP1-RA therapy have a greater reduction in the risk of anxiety than that of depression. The treatment effectiveness is significant for women and patients taking GLP1-RA for longer than 180 days. Dulaglutide could significantly decrease risks of both anxiety and depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Emilie Brule, Tanya L. Silander, Ying Wang, Xiang Zhou, Beata Bak, Stefan Groeneweg, Daniel J. Bernard
Summary: Loss of IGSF1/Igsf1 causes central hypothyroidism. IGSF1 interacts with the thyroid hormone transporter MCT8, but the physiological relevance of this association is unclear.
Article
Chemistry, Medicinal
Amaya Austrich-Olivares, Maria Salud Garcia-Gutierrez, Lucia Illescas, Ani Gasparyan, Jorge Manzanares
Summary: The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in several studies, but the molecular mechanisms are still unclear. This study found that CBD can modulate emotional disturbances and shows the highest effectiveness at a dose of 20mg/kg in mice. The cannabinoid receptor CB1 plays a significant role in the anxiolytic actions of CBD. CBD also modifies the gene expression of GABA(A) subunits alpha 2 and gamma 2 and CB1r, CB2r and GPR55, supporting a multimodal mechanism of action for CBD.
Article
Pharmacology & Pharmacy
Xue Zhao, Yedi Cao, Hongfang Jin, Xiuli Wang, Lanbo Zhang, Yang Zhang, Yang Yu, Youyuan Huang, Ying Gao, Junqing Zhang
Summary: H2S, generated mainly in thyrocytes by CBS, promotes the synthesis and secretion of thyroid hormones and the expression of related molecules by upregulating SIRT1. Serum H2S levels are decreased in hypothyroidism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Joehren, Kerstin Krause, Jens Mittag
Summary: Maternal hyperthyroidism during pregnancy can program the offspring's glucose sensitivity and response to cold via activation of maternal thyroid hormone receptor beta in a sex-dependent manner.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
M. Bauer, S. Berman, T. Stamm, M. Plotkin, M. Adli, M. Pilhatsch, E. D. London, G. S. Hellemann, P. C. Whybrow, F. Schlagenhauf
MOLECULAR PSYCHIATRY
(2016)
Article
Clinical Neurology
Maximilian Pilhatsch, Anne Berghoefer, Rene Mayer-Pelinski, Gunnar Berghoefer, Roland Ricken, Martin Moeckel, York Kuehnle, Cathrin Sauer, Peter C. Whybrow, Michael Bauer
JOURNAL OF AFFECTIVE DISORDERS
(2018)
Review
Pharmacology & Pharmacy
Michael Bauer, A. John Rush, Roland Ricken, Maximilian Pilhatsch, Mazda Adli
PHARMACOPSYCHIATRY
(2019)
Article
Psychiatry
Michael Bauer, Tasha Glenn, Martin Alda, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Claudia Becerra-Palars, Frank Bellivier, Robert H. Belmaker, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Jorge Cabrera, Eric Y. Wo Cheung, Maria Del Zompo, Seetal Dodd, Markus Donix, Bruno Etain, Andrea Fagiolini, Kostas N. Fountoulakis, Mark A. Frye, Ana Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Hirohiko Harima, Chantal Henry, Erkki T. Isometsa, Sven Janno, Flavio Kapczinski, Mathias Kardell, Slim Khaldi, Sebastian Kliwicki, Barbara Konig, Timur L. Kot, Rikke Krogh, Mauricio Kunz, Beny Lafer, Mikael Landen, Erik R. Larsen, Ute Lewitzka, Rasmus W. Licht, Carlos Lopez-Jaramillo, Glenda MacQueen, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Ingrid Melle, Fatima Meza-Urzua, Mok Yee Ming, Scott Monteith, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorova, Rodrigo Munoz, Starlin V. Mythri, Fethi Nacef, Ravi K. Nadella, Fabiano G. Nery, Rene E. Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Helle Ostermark Sorensen, Uta Ouali, Yolanda Pica Ruiz, Maximilian Pilhatsch, Marco Pinna, Francisco D. R. da Ponte, Danilo Quiroz, Raj Ramesar, Natalie Rasgon, M. S. Reddy, Andreas Reif, Philipp Ritter, Janusz K. Rybakowski, Kemal Sagduyu, Bharathram Sathur Raghuraman, Angela M. Scippa, Emanuel Severus, Christian Simhandl, Paul W. Stackhouse, Dan J. Stein, Sergio Strejilevich, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Hiromi Tagata, Yoshitaka Tatebayashi, Leonardo Tondo, Carla Torrent, Arne E. Vaaler, Edgar Vares, Julia Veeh, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Mark Zetina, Yosra Zgueb, Peter C. Whybrow
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Article
Psychiatry
Maximilian Pilhatsch, Thomas J. Stamm, Petra Stahl, Ute Lewitzka, Anne Berghoefer, Cathrin Sauer, Michael Gitlin, Mark A. Frye, Peter C. Whybrow, Michael Bauer
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2019)
Article
Psychiatry
Johannes Petzold, Rene Mayer-Pelinski, Maximilian Pilhatsch, Susan Luthe, Thomas Barth, Michael Bauer, Emanuel Severus
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2019)
Article
Biochemistry & Molecular Biology
Andreas Heinz, Falk Kiefer, Michael N. Smolka, Tanja Endrass, Christian Beste, Anne Beck, Shuyan Liu, Alexander Genauck, Lydia Romund, Tobias Banaschewski, Felix Bermpohl, Lorenz Deserno, Raymond J. Dolan, Daniel Durstewitz, Ulrich Ebner-Priemer, Herta Flor, Anita C. Hansson, Christine Heim, Derik Hermann, Stefan Kiebel, Peter Kirsch, Clemens Kirschbaum, Georgia Koppe, Michael Marxen, Andreas Meyer-Lindenberg, Wolfgang E. Nagel, Hamid R. Noori, Maximilian Pilhatsch, Josef Priller, Marcella Rietschel, Nina Romanczuk-Seiferth, Florian Schlagenhauf, Wolfgang H. Sommer, Jan Stallkamp, Andreas Stroehle, Ann-Kathrin Stock, Georg Winterer, Christine Winter, Henrik Walter, Stephanie Witt, Sabine Vollstaedt-Klein, Michael A. Rapp, Heike Tost, Rainer Spanagel
Article
Psychiatry
Johannes Petzold, Benjamin Weber, Tyler Ray Bassett, Michael Bauer, Nadine Bernhardt, Cornelius Gross, Helena Hasler, Matthias Schuetzwohl, Maximilian Pilhatsch
FRONTIERS IN PSYCHIATRY
(2020)
Article
Psychiatry
Nadine Bernhardt, Johannes Petzold, Cornelius Gross, Anna Scheck, Shakoor Pooseh, Rene Mayer-Pelinski, Ulrich S. Zimmermann, Michael N. Smolka, Maximilian Pilhatsch
FRONTIERS IN PSYCHIATRY
(2020)
Editorial Material
Psychiatry
Milky Kohno, Christian Beste, Maximilian Pilhatsch
FRONTIERS IN PSYCHIATRY
(2020)
Article
Psychiatry
Maximilian Pilhatsch, Shakoor Pooseh, Alexandra Junke, Milky Kohno, Johannes Petzold, Cathrin Sauer, Michael N. Smolka
FRONTIERS IN PSYCHIATRY
(2020)
Article
Neurosciences
Matthew. J. J. Belanger, Hao Chen, Angela Hentschel, Maria Garbusow, Claudia Ebrahimi, Felix. G. G. Knorr, Hilmar. G. G. Zech, Maximilian Pilhatsch, Andreas Heinz, Michael. N. N. Smolka
Summary: This study introduces two PIT paradigms designed to assess outcome-specific and general PIT within the context of addiction. The use of a joystick in the single-lever PIT task successfully evaluates avoidance behavior, while the full transfer task elicits both specific and general transfers in humans with gustatory alcohol rewards.
NEUROPSYCHOBIOLOGY
(2022)
Article
Substance Abuse
Cornelius Gross, Susanna Hahn, Maik Spreer, Silke Behrendt, Juergen Dinger, Joerg Reichert, Maximilian Pilhatsch, Ulrich S. Zimmermann
SUCHT-ZEITSCHRIFT FUR WISSENSCHAFT UND PRAXIS
(2018)
Article
Psychiatry
Maximilian Pilhatsch, Tasha Glenn, Natalie Rasgon, Martin Alda, Kemal Sagduyu, Paul Grof, Rodrigo Munoz, Wendy Marsh, Scott Monteith, Emanuel Severus, Rita Bauer, Philipp Ritter, Peter C. Whybrow, Michael Bauer
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2018)
Review
Psychiatry
M. Bauer, T. Glenn, M. Alda, M. A. Aleksandrovich, O. A. Andreassen, E. Angelopoulos, R. Ardau, Y. Ayhan, C. Baethge, S. R. Bharathram, R. Bauer, B. T. Baune, C. Becerra-Palars, F. Bellivier, R. H. Belmaker, M. Berk, Y. Bersudsky, S. Bicakci, H. Birabwa-Oketcho, T. D. Bjella, L. Bossini, J. Cabrera, E. Y. W. Cheung, M. Del Zompo, S. Dodd, M. Donix, B. Etain, A. Fagiolini, K. N. Fountoulakis, M. A. Frye, A. Gonzalez-Pinto, J. F. Gottlieb, P. Grof, H. Harima, C. Henry, E. T. Isometsae, S. Janno, F. Kapczinski, M. Kardell, S. Khaldi, S. Kliwicki, B. Koenig, T. L. Kot, R. Krogh, M. Kunz, B. Lafer, M. Landen, E. R. Larsen, U. Lewitzka, R. W. Licht, C. Lopez-Jaramillo, G. MacQueen, M. Manchia, W. Marsh, M. Martinez-Cengotitabengoa, I. Melle, F. Meza-Urzua, M. Yee Ming, S. Monteith, G. Morken, E. Mosca, R. Munoz, S. V. Mythri, F. Nacef, R. K. Nadella, F. G. Nery, R. E. Nielsen, C. O'Donovan, A. Omrani, Y. Osher, H. Ostermark Sorensen, U. Ouali, Y. Pica Ruiz, M. Pilhatsch, M. Pinna, F. D. R. da Ponte, D. Quiroz, R. Ramesar, N. Rasgon, M. S. Reddy, A. Reif, P. Ritter, J. K. Rybakowski, K. Sagduyu, A. M. Scippa, E. Severus, C. Simhandl, D. J. Stein, S. Strejilevich, M. Subramaniam, A. H. Sulaiman, K. Suominen, H. Tagata, Y. Tatebayashi, L. Tondo, C. Torrent, A. E. Vaaler, J. Veeh, E. Vieta, B. Viswanath, M. Yoldi-Negrete, M. Zetin, Y. Zgueb, P. C. Whybrow
ACTA PSYCHIATRICA SCANDINAVICA
(2017)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)