Article
Physiology
Tom Bullock, Mary H. MacLean, Tyler Santander, Alexander P. Boone, Viktoriya Babenko, Neil M. Dundon, Alexander Stuber, Liann Jimmons, Jamie Raymer, Gold N. Okafor, Michael B. Miller, Barry Giesbrecht, Scott T. Grafton
Summary: Humans exhibit habituation to aversive events, but little is known about the physiological and neural responses that contribute to stress habituation. This study used a variety of physiological measures and advanced analysis techniques to investigate the stress response to repeated exposure to the cold pressor test (CPT). The results revealed diverse adaptive changes in stress responses and demonstrated the process of habituation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Plant Sciences
Ana J. P. Carcedo, Laura Mayor, Paula Demarco, Geoffrey P. Morris, Jane Lingenfelser, Carlos D. Messina, Ignacio A. Ciampitti
Summary: This study characterized the spatial and temporal variation of the target population of environments (TPE) for sorghum in the United States using the APSIM-sorghum model. The results showed that as the intensity of environmental stress increased, there was a clear reduction in grain yield. The study also identified different water and heat stress patterns and their impact on sorghum yield, which can be used in breeding programs to improve genetic gains and facilitate collaboration between breeders, agronomists, and farmers.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Phanthasin Khanthavong, Shin Yabuta, Hidetoshi Asai, Md. Amzad Hossain, Isao Akagi, Jun-Ichi Sakagami
Summary: The study reveals that crop roots response varies under different soil moisture conditions, with some crops growing deeper roots under continuous waterlogging and gradual soil drying. Gradual soil drying tends to promote root and shoot biomass growth regardless of the crop species, showing that crop adaptation to different soil water conditions influences root distribution and biomass allocation.
Article
Biochemistry & Molecular Biology
Wei-Yun Lai, Christian Schloetterer
Summary: The study found that after 100 generations of adaptation to a new laboratory environment, the variance of gene expression in Drosophila simulans males was significantly reduced in 125 and 97 genes, suggesting that the drastic loss in environmental complexity may have triggered selection for reduced variance. This observation could have important implications for studies of adaptation processes in natural and experimental populations.
Article
Behavioral Sciences
Patrick Dwyer, Zachary J. Williams, Svjetlana Vukusic, Clifford D. Saron, Susan M. Rivera
Summary: This study explored the habituation of electrophysiological responses to auditory complex tones in autistic and typically developing children. The results showed a significant reduction in habituation of the auditory N2 response in autistic participants. However, no clear difference was found in habituation of the P1 response. The habituation differences observed may not be the primary driver of real-world sound intolerance in autistic individuals.
Article
Biology
O. E. Oke, O. M. Oso, M. O. Logunleko, V. A. Uyanga, F. Akinyemi, F. A. Okeniyi, O. A. Akosile, J. J. Baloyi, O. M. Onagbesan
Summary: This review summarizes the adaptation and performance of White Fulani cattle in tropical environments. The study found that the breed adapts to harsh tropical conditions through physiological, morphological, behavioral, genetic, and metabolic responses, which contribute to its productivity and reproductive capacity in the tropics. Additionally, the breed exhibits thermotolerance and high resistance to endemic diseases. The review also discusses the productive performance of White Fulani cattle under different systems, providing crucial information for improving their performance and sustainability.
JOURNAL OF THERMAL BIOLOGY
(2022)
Review
Neurosciences
Annabelle Merchie, Marie Gomot
Summary: Habituation, a simple form of learning, is altered in psychiatric and neurodevelopmental disorders such as autism and ADHD. This alteration affects the ability to predict and detect change, which are important processes in these disorders. This review aims to characterize habituation and its neural adaptation, evaluate their implications in symptomatology, and summarize different approaches to investigating adaptation using animal and human studies.
Review
Plant Sciences
Chuanshun Li, Chonghao Duan, Hengyang Zhang, Yaoyao Zhao, Zhe Meng, Yanxiu Zhao, Quan Zhang
Summary: This article systematically summarizes the research on the morphology, physiology, genome, gene expression and regulation, and protein and metabolite profile of salt cress under salt stress. It emphasizes the latest advances in research on the genome adaptive evolution encountering saline environments and epigenetic regulation, and discusses the mechanisms underlying salt tolerance in salt cress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biodiversity Conservation
Rachel M. Santymire, Allison B. Sacerdote-Velat, Andrew Gygli, Douglas A. Keinath, Sinlan Poo, Kristin M. Hinkson, Elizabeth M. McKeag
Summary: The study utilized a novel method to measure glucocorticoid hormones and disease status, showing that pathogen status did not influence cortisol concentrations, and environmental conditions may be a contributing factor to the decline in endangered amphibian populations.
CONSERVATION PHYSIOLOGY
(2021)
Article
Infectious Diseases
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, Chatchai Tayapiwatana, Bordin Butr-Indr
Summary: This study investigated the adaptive responses of Mycobacterium tuberculosis to isoniazid treatment using a multi-stress system. The expression of stressresponse and lipoarabinomannan-related genes were measured, revealing different adaptations between drug-resistant and drug-susceptible strains. The study demonstrates the complexity of mycobacterial adaptation and provides potential applications for tuberculosis treatment and monitoring in the future.
Article
Behavioral Sciences
Camille Heurteloup, Annabelle Merchie, Sylvie Roux, Frederique Bonnet-Brilhault, Carles Escera, Marie Gomot
Summary: This study aimed to explore the effects of the nature (vocal/non-vocal) of the information to be encoded on the establishment of auditory regularities. The results showed that the repetition positivity (RP) was similar between vocal and non-vocal stimuli, suggesting that the repetition suppression phenomena is independent of the nature of the stimulus. However, the P1 amplitude for non-vocal stimuli stabilized faster than for vocal stimuli, indicating different dynamics in the establishment of regularity encoding for non-vocal and vocal stimuli.
Article
Psychology, Multidisciplinary
Mattis Hartwig, Anjali Bhat, Achim Peters
Summary: This paper explores the explanation and modeling of stress habituation based on the free energy principle. The study introduces adaptation priors and goal priors to simulate the habituation behavior. The findings indicate that habituation minimizes free energy by reducing the precision of goal priors, leading to the attenuation of the stress response.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Endocrinology & Metabolism
Danilo A. Moraes, Ricardo B. Machado, Michael Koban, Gloria E. Hoffman, Deborah Suchecki
Summary: This study compared the stress responses of animals exposed to different stressors to those of animals subjected to paradoxical sleep deprivation (PSD). The results showed that the pituitary-adrenal response to PSD was similar to that induced by psychological stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Thomas Beck Lindhardt, Eugenio Gutierrez-Jimenez, Zhifeng Liang, Brian Hansen
Summary: Traditionally, preclinical MRI has been performed under anesthesia, but anesthesia affects brain function. Awake animal MRI is needed to study the brain in its natural state. Most previous studies used male rodents, but this study found sex differences in response to awake MRI habituation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Reproductive Biology
Shuai Gong, Lin Jiang, Hao Cheng, Liu-Zhu Pan, Ming-Tao Xu, Min Zhang, Hong-Jie Yuan, Jing-He Tan
Summary: Research shows that CRH impairs the competence of pig and mouse oocytes and induces apoptosis. While mouse cumulus cells undergo apoptosis, pig cumulus cells do not.
Article
Endocrinology & Metabolism
Roser Nadal, Marina Gabriel-Salazar, Maria Sanchis-Olle, Humberto Gagliano, Xavier Belda, Antonio Armario
Summary: Through experiments on rats, it was found that the neuroendocrine response of individuals to different stressors is more dependent on the similarity in intensity rather than other characteristics, showing correlations between stressors of similar intensity. Therefore, it is difficult to predict the response to another stressor greatly differing in intensity based on the response to a particular stressor.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
A. Florido, E. R. Velasco, C. M. Soto-Faguas, A. Gomez-Gomez, L. Perez-Caballero, P. Molina, R. Nadal, O. J. Pozo, C. A. Saura, R. Andero
Summary: Memory formation is crucial for brain function, and understanding the mechanisms behind it helps in understanding neural processes. The Tac2 pathway in the central amygdala plays a key role in fear memory consolidation, with opposite effects observed in male and female mice.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Antonio Armario
Summary: The forced swim test is a commonly used method for evaluating antidepressant treatments and depression-like states in rodents, but its theoretical and predictive validity have been questioned. The test mainly assesses coping strategies in an inescapable situation, and proper interpretation of the behavior depends on its relationship with other behavioral traits.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Behavioral Sciences
Ximena Goldberg, Carme Espelt, Daniel Porta-Casteras, Diego Palao, Roser Nadal, Antonio Armario
Summary: Chronic stress can lead to alterations in the stress-response system, impacting the development of non-communicable diseases. Survivors of intimate partner violence may be particularly vulnerable to the effects of prolonged threat exposure.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Maria Sanchis-Oll, Laura Sanchez-Benito, Silvia Fuentes, Humberto Gagliano, Xavier Belda, Patricia Molina, Javier Carrasco, Roser Nadal, Antonio Armario
Summary: Differences in behavioral and physiological characteristics between rat and mouse strains can explain discrepancies in research results. LongEvans (LE) rats show higher levels of ACTH and corticosterone, as well as a stronger HPA responsiveness to stressors. They exhibit hyperactive behavior in novel environments and are prone to passive-like behavior.
NEUROBIOLOGY OF STRESS
(2021)
Article
Psychiatry
Marta Llorens, Maria Barba, Jordi Torralbas, Roser Nadal, Antonio Armario, Humberto Gagliano, Maria Betriu, Lara Urraca, Susana Pujol, Itziar Montalvo, Rebeca Gracia, Olga Gimenez-Palop, Diego Palao, Montserrat Pamias, Javier Labad
Summary: The study found that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD, and childhood maltreatment and sex exert distinct moderating effects depending on the symptom type.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Neurosciences
Antonio Armario, Xavier Belda, Humberto Gagliano, Silvia Fuentes, Patricia Molina, Sara Serrano, Roser Nadal
Summary: The hormones of the HPA axis, especially glucocorticoids, play a crucial role in the behavioral and physiological effects of stress. Studies have shown complex and poorly understood relationships between HPA function and behavioral characteristics. This review discusses methodological considerations, explores differences in HPA function between rat strains, and examines the relationship between HPA differences and relevant behaviors.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Adam Alvarez-Monell, Alex Subias-Gusils, Roger Marine-Casado, Xavier Belda, Humberto Gagliano, Oscar J. Pozo, Noemi Boque, Antoni Caimari, Antonio Armario, Montserrat Solanas, Rosa M. Escorihuela
Summary: The study evaluated the effects of a restricted-cafeteria diet and moderate treadmill exercise on obesity and associated risk factors. It found that both the restricted-cafeteria diet and exercise could reduce abdominal adiposity and hypercholesterolemia, improve locomotor activity and exploratory behavior, but had no significant effect on HPA axis-related parameters.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Maria Sanchis-Olle, Xavier Belda, Humberto Gagliano, Joan Visa, Roser Nadal, Antonio Armario
Summary: A single exposure to some stressors can have long-term consequences similar to those seen in post-traumatic stress disorder (PTSD), but the findings are often controversial. The single prolonged stress (SPS) model, which involves exposure to different stressors in a sequence, has been widely accepted as an animal model for PTSD. However, there is inconsistent evidence, particularly regarding the effect on the hypothalamic-pituitary-adrenal (HPA) axis, and it is unclear whether SPS is distinct from models using a single severe stressor. In this study, we compared the behavioral and neuroendocrine (HPA) effects of immobilization on boards (IMO) with a SPS-like model (SPSi) in male rats. Both procedures had similar effects on food intake, body weight, and sensitization of the HPA response to a novel environment. There were also similarities in the reduction of activity/exploration in a hole-board, although SPSi had a greater impact of sudden noise compared to IMO. Neither IMO nor SPSi significantly affected contextual fear conditioning acquisition, but there was a trend towards impaired fear extinction compared to controls. Additional stressors in the SPSi did not interfere with HPA adaptation to IMO. Overall, there were only modest differences between IMO and SPSi in terms of neuroendocrine and behavioral effects, highlighting the need for further studies comparing different PTSD models.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Behavioral Sciences
Patricia Molina, Raul Andero, Antonio Armario
Summary: This article discusses the use of restricted movement as a model for inducing stress in laboratory animals, which is widely used in stress-related disorder research. Despite the various methods available, few studies directly compare the differential impact of these protocols. Additionally, there is a lack of standardized language distinguishing between restraint and immobilization terms in the literature. This review provides evidence of physiological differences in the impact of distinct restraint and immobilization procedures in rats and mice, highlighting the need for standardized language and further systematic studies to determine the best methodology for specific research objectives.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Jose Antonio Monreal, Neus Salvat-Pujol, Alexandre Gonzalez-Rodriguez, Mikel Urretavizcaya, Jose Manuel Crespo, Roser Nadal, Aida de Arriba-Arnau, Clara Massaneda, Diego Palao, Jose Manuel Menchon, Javier Labad, Virginia Soria
Summary: The aim of this study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. The study found that female sex was associated with an increased cortisol awakening response and a more flattened diurnal cortisol slope. However, a negative significant interaction between harm avoidance and female sex was found. Regarding the cortisol suppression ratio, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Meeting Abstract
Clinical Neurology
Patricia Molina, Xavier Belda, Silvia Fuentes, Humberto Gagliano, Roser Nadal, Raul Andero, Antonio Armario
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)