Article
Multidisciplinary Sciences
Yusaku Takamura, Shintaro Fujii, Satoko Ohmatsu, Shu Morioka, Noritaka Kawashima
Summary: Visuospatial neglect (VSN) is a neurological syndrome where patients fail to detect stimuli on the side opposite a hemispheric lesion. A study found VSN can be divided into elements such as low arousal, exogenous neglect, and spatial working memory deficit, each correlating with specific neural damage. This research sheds light on the complex structure of VSN as a deficit in attention network components.
Article
Clinical Neurology
Jose A. Graterol Perez, Stephanie Guder, Chi-Un Choe, Christian Gerloff, Robert Schulz
Summary: This study found that stroke patients exhibited significantly reduced cortical thickness not only in the ipsilesional primary motor cortex but also in numerous secondary motor and non-motor brain regions. However, there was no significant relationship between the extent of cortical thickness reduction and stroke-related excitability changes of the motor network or clinical scores.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Tomasz Andrzej Dziedzic, Aleksandra Bala, Andrzej Marchel
Summary: This study explores the relationship between the anatomical structures of the parietal lobe and surgical treatment of intra-axial lesions, emphasizing the importance of preoperative planning and intraoperative decision-making. Intra-axial lesions within the parietal lobe can be approached through lateral or superior trajectories based on their location, and accurate identification of key neural structures is crucial during surgery.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Emily B. J. Coffey, Isabelle Arseneau-Bruneau, Xiaochen Zhang, Sylvain Baillet, Robert J. Zatorre
Summary: There is ongoing debate about the presence and function of neural oscillatory mechanisms in the auditory system, with research suggesting that oscillatory entrainment may play a role in representing periodic sound throughout the auditory neuraxis. The study found significant oscillatory activity in auditory cortex and subcortical auditory nuclei, supporting the hypothesis of entrainment and highlighting the potential functional role of this mechanism in enhancing stability and reducing susceptibility to noise in real-life environments.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Daniel Wiesen, Leonardo Bonilha, Christopher Rorden, Hans-Otto Karnath
Summary: Spatial attention and exploration are associated with a predominantly right hemispheric network structure. However, the exact areas of the brain involved and their role are still debated. This study used connectome lesion-symptom mapping combined with multivariate support vector regression to uncover the complex and disconnected network structure in spatial neglect. The results identify several key nodes in the network that are extensively disconnected from other intrahemispheric areas and suggest their potential involvement in spatial neglect.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ilaria Sani, Heiko Stemmann, Bradley Caron, Daniel Bullock, Torsten Stemmler, Manfred Fahle, Franco Pestilli, Winrich A. Freiwald
Summary: Endogenous attention is controlled by dorsal fronto-parietal brain areas, but can also be modulated by a control attention area located in the temporal lobe. This area is functionally distinct and connected to parietal and frontal attentional regions, suggesting a different organizing principle for cognitive control.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Claudia C. Schmidt, Elisabeth I. S. Achilles, Katharina Bolte, Nina N. Kleineberg, Monika K. Richter, Natalie Schloss, Gereon R. Fink, Peter H. Weiss
Summary: The study investigated the association between subcortical gray matter lesions and apraxic deficits in LH stroke patients, finding that lesions in the caudate nucleus were significantly related to apraxic deficits, while lesions in the globus pallidus were associated with a lower likelihood of apraxia. Other subcortical structures did not show significant differences in lesion load between apraxic and nonapraxic patients.
Article
Behavioral Sciences
Marine Lunven, Monica N. Toba, Paolo Bartolomeo
Summary: The meta-analysis by Sze & PRIME;kely et al. found no beneficial effect of prism adaptation in neglect patients, suggesting it may not be an effective therapy. However, they acknowledged that individual differences in the connectional anatomy of the lesions may influence patient response. Our commentary further explores this idea to provide a more balanced perspective on the implications of the study’s findings by Sze & PRIME;kely et al.
Article
Clinical Neurology
Seungwoo Cha, ByeongChang Jeong, Myungwon Choi, Sohyun Kwon, Stephanie Hyeyoung Lee, Nam-Jong Paik, Won-Seok Kim, Cheol E. E. Han
Summary: This study identified white matter tracts associated with USN in patients with subcortical stroke without cortical involvement. Our findings support that USN may result from damage to white matter pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Max Levinson, Ella Podvalny, Steven H. Baete, Biyu J. He
Summary: The study investigates the neural mechanisms underlying conscious recognition and finds that recognized images elicit enhanced activation in more brain regions, with specific content activity in both activated and deactivated cortical networks. Additionally, recognition-related category information can be decoded from widespread cortical activity but not subcortical activity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jianxin Ou, Yin Wu, Yang Hu, Xiaoxue Gao, Hong Li, Philippe N. Tobler
Summary: Recent studies have shown that testosterone can reduce generosity by decreasing consideration for others' welfare. At the neural level, testosterone was found to weaken activity in the temporoparietal junction (TPJ), affecting the neural mechanisms underlying generous decision-making and weakening connectivity between TPJ and other brain regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Huijia Tang, Shuhan Fan, Xingyang Niu, Zhuhao Li, Peiyi Xiao, Jinsheng Zeng, Shihui Xing
Summary: This study aimed to investigate the effects of distant cortical structures on aphasia outcomes in patients with chronic left subcortical stroke and examine the correlation between cortical thickness measures and connecting tracts integrity. The findings suggest that cortical thickness in different parts of the left fronto-temporo-parietal regions is positively related to language performance, and cortical thinning in these regions may relate to integrity loss of fiber tracts connected to stroke lesions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Simona Luzzi, Chiara Fiori, Valentina Ranaldi, Sara Baldinelli, Veronica Cherubini, Mauro Morelli, Mauro Silvestrini, Julie S. Snowden
Summary: This case report describes a patient with topographical disorientation presenting with selective representational allochiria, which is reported for the first time. It also highlights the clinical importance of allochiria as an early sign of posterior cortical atrophy. The study provides insights into the cognitive basis of allochiria and the puzzling clinical presentation of neurodegenerative brain disease.
Article
Biochemistry & Molecular Biology
Laura Otero-Ortega, Elisa Alonso-Lopez, Maria Perez-Mato, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Luke Diekhorst, Maria Laura Garcia-Bermejo, Elisa Conde-Moreno, Blanca Fuentes, Maria Alonso de Lecinana, Susana B. Bravo, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: This study found that circulating EV proteins and microRNAs in patients with ischaemic stroke could serve as markers for different processes such as neurite outgrowth, neurogenesis, inflammation, and atherosclerosis, depending on the location and type of involvement.
Article
Neurosciences
Ruihua Sun, Junkui Shang, Xi Yan, Jingran Zhao, Wan Wang, Wenjing Wang, Wei Li, Chenhao Gao, Fengyu Wang, Haohan Zhang, Yanliang Wang, Huixia Cao, Jiewen Zhang
Summary: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). This study aimed to explore the relationship and molecular mechanisms between BBB dysfunction and neuronal loss. Using a rat model, the authors observed the pathological changes of cortical neurons and BBB following CCH. Transcriptome analysis of cortical microvessels revealed that vascular inflammation-related processes mainly occurred in the chronic phase, and the adhesion molecule VCAM1 played an important role.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Behavioral Sciences
Julia Fellrath, Radek Ptak
Article
Behavioral Sciences
Pierre Nicolo, Radek Ptak, Adrian G. Guggisberg
Article
Neurosciences
Tatiana Aboulafia-Brakha, Radek Ptak
Article
Neurosciences
Radek Ptak, Marie Di Pietro, Jean-Michel Pignat
Article
Clinical Neurology
Tatiana Aboulafia-Brakha, Philippe Allain, Radek Ptak
JOURNAL OF HEAD TRAUMA REHABILITATION
(2016)
Letter
Clinical Neurology
Nicola A. Marchi, Radek Ptak, Corinne Wetzel, Maria I. Vargas, Armin Schnider, Nicolas Nicastro
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2016)
Article
Behavioral Sciences
Julia Fellrath, Anais Mottaz, Armin Schnider, Adrian G. Guggisberg, Radek Ptak
Article
Behavioral Sciences
Tatiana Aboulafia-Brakha, Aurelie L. Manuel, Radek Ptak
Article
Neurosciences
Elena Pedrazzini, Julia Fellrath, Raphael Theze, Radek Ptak
Article
Geriatrics & Gerontology
T. Aboulafia-Brakha, D. Suchecki, F. Gouveia-Paulino, R. Nitrini, R. Ptak
AGING & MENTAL HEALTH
(2014)
Article
Clinical Neurology
Adrian G. Guggisberg, Sviatlana Rizk, Radek Ptak, Marie Di Pietro, Arnaud Saj, Francois Lazeyras, Karl-Olof Lovblad, Armin Schnider, Jean-Michel Pignat
Article
Clinical Neurology
Louis Nahum, Jean-Michel Pignat, Aurelie Bouzerda-Wahlen, Damien Gabriel, Maria Chiara Liverani, Francois Lazeyras, Radek Ptak, Jonas Richiardi, Sven Haller, Gabriel Thorens, Daniele F. Zullino, Adrian G. Guggisberg, Armin Schnider
Article
Neurosciences
Julia Fellrath, Aurelie L. Manuel, Radek Ptak
Article
Behavioral Sciences
Radek Ptak, Francois Lazeyras, Marie Di Pietro, Armin Schnider, Stephane R. Simon
Review
Behavioral Sciences
Armin Schnider, Louis Nahum, Radek Ptak