Metformin Induces Cytotoxicity by Down-Regulating Thymidine Phosphorylase and Excision Repair Cross-Complementation 1 Expression in Non-Small Cell Lung Cancer Cells

2-Deoxy-D-Ribose, a Downstream Mediator of Thymidine Phosphorylase, Regulates Tumor Angiogenesis and Progression

(2012) Yuichi Nakajima et al.   Anti-Cancer Agents in Medicinal Chemistry

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Enhancement of Mitomycin C-Induced Cytotoxicity by Curcumin Results from Down-Regulation of MKK1/2-ERK1/2-Mediated Thymidine Phosphorylase Expression

(2011) Shao-Hsing Weng et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

(2011) Meei-Shyuan Lee et al.   BMC CANCER

Understanding the benefit of metformin use in cancer treatment

(2011) Ryan JO Dowling et al.   BMC Medicine

Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer

(2011) Tomohiko Miyatani et al.   CANCER LETTERS

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Up-Regulation of Extracellular Signal-Regulated Kinase 1/2-Dependent Thymidylate Synthase and Thymidine Phosphorylase Contributes to Cisplatin Resistance in Human Non-Small-Cell Lung Cancer Cells

(2011) J.-C. Ko et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells

(2011) Silvia Monteagudo et al.   Nanomedicine

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase

(2010) Kristy A. Brown et al.   BREAST CANCER RESEARCH AND TREATMENT

Thymidine synthase, thymidine phosphorylase and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcinoma

(2010) S Lee et al.   BRITISH JOURNAL OF CANCER

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Cα-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activat

(2010) Yong P Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin

(2010) Piotr J Wysocki et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Arachidin-1, a Peanut Stilbenoid, Induces Programmed Cell Death in Human Leukemia HL-60 Cells

(2010) Cheng-Po Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methylation Markers for Small Cell Lung Cancer in Peripheral Blood Leukocyte DNA

(2010) Liang Wang et al.   Journal of Thoracic Oncology

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Is it Time to Test Metformin in Breast Cancer Clinical Trials?

(2009) M. Cazzaniga et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin in Breast Cancer: Time for Action

(2009) Pamela J. Goodwin et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Roles of MKK1/2-ERK1/2 and Phosphoinositide 3-Kinase-AKT Signaling Pathways in Erlotinib-Induced Rad51 Suppression and Cytotoxicity in Human Non-Small Cell Lung Cancer Cells

(2009) J.-C. Ko et al.   MOLECULAR CANCER RESEARCH

Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

(2008) Ryuji Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin-Lowering Effects of Metformin in Women with Early Breast Cancer

(2008) Pamela J. Goodwin et al.   Clinical Breast Cancer

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

(2008) Walter H. Gotlieb et al.   GYNECOLOGIC ONCOLOGY

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE