Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

(2013) Shuxi Qiao et al.   Autophagy

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Computational model for autophagic vesicle dynamics in single cells

(2012) Katie R. Martin et al.   Autophagy

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

(2012) Natasha Sharma et al.   CANCER LETTERS

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells

(2012) R. Rao et al.   MOLECULAR CANCER THERAPEUTICS

RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

(2012) Fei Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines

(2012) Brenden Chen et al.   PLoS One

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

(2012) Dan-Dan Li et al.   PLoS One

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

(2011) Joon-Ho Sheen et al.   CANCER CELL

Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells

(2011) Ye Xu et al.   CANCER LETTERS

Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition

(2011) J. L. Armstrong et al.   CLINICAL CANCER RESEARCH

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 Cells

(2011) Weidong Han et al.   PLoS One

Autophagic pathways as new targets for cancer drug development

(2010) Bo Liu et al.   ACTA PHARMACOLOGICA SINICA

Autophagy

(2010) Latika Kohli et al.   AMERICAN JOURNAL OF PATHOLOGY

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

(2010) Kazuhito Sasaki et al.   BMC CANCER

A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

(2010) Han Yan et al.   BMC Systems Biology

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Design and synthesis of chloroquine analogs with anti-breast cancer property

(2010) V.R. Solomon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF

(2010) Nityanand Maddodi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

How can we identify parasite genes that underlie antimalarial drug resistance?

(2010) Tim Anderson et al.   PHARMACOGENOMICS

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity

(2009) Takashi Shingu et al.   Autophagy

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells

(2009) Ya Chun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain

(2009) Daniel P. Iwaniuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of autophagy in tumour development and cancer therapy

(2009) Mathias T. Rosenfeldt et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE