How can we identify parasite genes that underlie antimalarial drug resistance?

Whole-genome sequencing of a laboratory-evolved yeast strain

(2010) Carlos L Araya et al.   BMC GENOMICS

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

(2010) Paul Hunt et al.   BMC GENOMICS

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

(2010) Martin Melcher et al.   CELLULAR MICROBIOLOGY

High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

(2010) Tim J. C. Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

Two Nonrecombining Sympatric Forms of the Human Malaria ParasitePlasmodium ovaleOccur Globally

(2010) Colin J. Sutherland et al.   JOURNAL OF INFECTIOUS DISEASES

Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine

(2010) Allen L Malisa et al.   MALARIA JOURNAL

Dissection of genetically complex traits with extremely large pools of yeast segregants

(2010) Ian M. Ehrenreich et al.   NATURE

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines

(2010) Susanna Atwell et al.   NATURE

Population resequencing reveals local adaptation of Arabidopsis lyrata to serpentine soils

(2010) Thomas L Turner et al.   NATURE GENETICS

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Tracking footprints of artificial selection in the dog genome

(2010) J. M. Akey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inferred relatedness and heritability in malaria parasites

(2010) T. J. C. Anderson et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

(2010) S. R. Grossman et al.   SCIENCE

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance

(2010) Kristan A. Schneider et al.   THEORETICAL POPULATION BIOLOGY

The Scale of Population Structure in Arabidopsis thaliana

(2010) Alexander Platt et al.   PLoS Genetics

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome

(2009) Bharath Balu et al.   BMC MICROBIOLOGY

New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance

(2009) Ric N Price et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Optimizing comparative genomic hybridization probes for genotyping and SNP detection in Plasmodium falciparum

(2009) John C. Tan et al.   GENOMICS

Disruption of aPlasmodium falciparumMultidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

(2009) Dipak Kumar Raj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

(2009) Louis J. Nkrumah et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum

(2009) Jing Yuan et al.   Nature Chemical Biology

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development

(2009) I. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?

(2009) Clemens H.M. Kocken et al.   TRENDS IN PARASITOLOGY

Malaria genomics meets drug-resistance phenotyping in the field

(2009) Paul Hunt et al.   GENOME BIOLOGY

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

(2009) Neekesh V Dharia et al.   GENOME BIOLOGY

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray

(2008) Hongying Jiang et al.   BMC GENOMICS

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

(2008) Alexander G. Maier et al.   CELL

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Erythrocyte Binding Protein PfRH5 Polymorphisms Determine Species-Specific Pathways of Plasmodium falciparum Invasion

(2008) Karen Hayton et al.   Cell Host & Microbe

Efficient Control of Population Structure in Model Organism Association Mapping

(2008) H. M. Kang et al.   GENETICS

A regulatable transgene expression system for cultured Plasmodium falciparum parasites

(2008) Christian Epp et al.   MALARIA JOURNAL

Transformation of the rodent malaria parasite Plasmodium chabaudi and generation of a stable fluorescent line PcGFPCON

(2008) Sarah E Reece et al.   MALARIA JOURNAL

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking

(2008) Rachel Daniels et al.   MALARIA JOURNAL

Local Adaptation and Vector-Mediated Population Structure in Plasmodium vivax Malaria

(2008) D. A. Joy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reverse genetics screen identifies six proteins important for malaria development in the mosquito

(2008) Andrea Ecker et al.   MOLECULAR MICROBIOLOGY

The genome of the simian and human malaria parasite Plasmodium knowlesi

(2008) A. Pain et al.   NATURE

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

(2008) Jane M. Carlton et al.   NATURE

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

(2008) Hongying Jiang et al.   PLoS One

kdr: can a single mutation produce an entire insecticide resistance phenotype?

(2008) Basil D. Brooke   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria

(2008) T.S. Awolola et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation

(2008) Joseph M Gonzales et al.   PLOS BIOLOGY

Adaptive Copy Number Evolution in Malaria Parasites

(2008) Shalini Nair et al.   PLoS Genetics

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

(2008) Daniel E Neafsey et al.   GENOME BIOLOGY