Review
Biochemistry & Molecular Biology
Eshaan Patnaik, Matthew Lyons, Kimberly Tran, Debendra Pattanaik
Summary: Systemic sclerosis, also known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. Endothelial damage and activation occur early, possibly triggered by various factors, leading to defective angiogenesis and fibrosis. The aim of this review is to discuss the molecular aspect of endothelial dysfunction that contributes to the development of systemic sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavy Roseren, Martine Pithioux, Stephane Robert, Laure Balasse, Benjamin Guillet, Edouard Lamy, Sandrine Roffino
Summary: The study showed that G-CSF can accelerate bone regeneration and modulate the mobilization of progenitor cells during the process of distraction osteogenesis, promoting bone consolidation. In the early phase of consolidation, the G-CSF group exhibited lower osteoclast activity and a trend of increased osteoblast activity, while significantly lower neovascularization was observed in the late phase of consolidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Antia Custodia, Alberto Ouro, Joao Sargento-Freitas, Marta Aramburu-Nunez, Juan Manuel Pias-Peleteiro, Pablo Hervella, Anna Rosell, Lino Ferreira, Jose Castillo, Daniel Romaus-Sanjurjo, Tomas Sobrino
Summary: Ischemic stroke is a common cause of death and disability in developed countries. Current therapeutic options are limited, so there is a need for novel treatments. Endothelial progenitor cells (EPCs) have been shown to repair damaged vessels and generate new ones. EPCs appear to be a promising target for stroke treatment, promoting re-endothelialization, angiogenesis, and vasculogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Hyunsook Lee, Yang-Hoon Huh, Kyu-Tae Kang
Summary: This study investigated the role of mesenchymal stem cells (MSCs) in enhancing the vasculogenic capacity of endothelial colony-forming cells (ECFCs) under high-glucose conditions. The researchers found that the combination of ECFCs and MSCs restored the decreased tube formation ability of ECFCs in high-glucose conditions. In vivo experiments using diabetic mice showed that the combined delivery of ECFCs and MSCs led to the formation of perfused blood vessels in diabetic ischemic regions.
Article
Cell & Tissue Engineering
Chi Zhang, Yinuo Lin, Ke Zhang, Luyang Meng, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu
Summary: The study found that GDF11 can enhance the therapeutic effects of stem cells for ischemic diseases by increasing stem cell viability, mobility, and angiogenic paracrine functions.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Mehdi Hassanpour, Amankeldi A. Salybekov, Shuzo Kobayashi, Takayuki Asahara
Summary: CD34 is a cell surface antigen expressed in stem/progenitor cells such as HSCs and EPCs, which are potential sources for regenerative therapy. CD34(+) cells have been shown to improve therapeutic angiogenesis through direct incorporation and paracrine activity. Preclinical, pilot, and clinical trials have demonstrated the safety and efficacy of CD34(+) cell therapy in various diseases. However, the clinical application of CD34(+) cell therapy has sparked debates and controversies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Veronica Pulito-Cueto, Sara Remuzgo-Martinez, Fernanda Genre, Belen Atienza-Mateo, Victor M. Mora-Cuesta, David Iturbe-Fernandez, Leticia Lera-Gomez, Raquel Perez-Fernandez, Diana Prieto-Pena, Virginia Portilla, Ricardo Blanco, Alfonso Corrales, Oreste Gualillo, Jose M. Cifrian, Raquel Lopez-Mejias, Miguel A. Gonzalez-Gay
Summary: Research has shown a significant increase in EPC frequency in SSc-ILD+ patients, which may be related to the pathogenic processes of vasculopathy and lung fibrosis. Additionally, EPC frequency was higher in male patients and negatively correlated with disease duration in SSc patients.
Review
Cell & Tissue Engineering
Jiehan Cui, Lu Jin, Meng Ding, Jingjing He, Lin Yang, Shaoxin Cui, Xiaoping Wang, Jun Ma, Aijing Liu
Summary: This systematic review and meta-analysis found that mesenchymal stem cell (MSC) therapy can improve the degree of skin fibrosis, lung function, and mouth opening, and relieve finger ulcers and pain in patients with systemic sclerosis (SSc) without severe adverse events.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Ghazaleh Hashemi, James Dight, Kiarash Khosrotehrani, Laura Sormani
Summary: Melanoma is an aggressive and potentially lethal form of skin cancer. The role of blood vessel formation, particularly endothelial progenitor cells (EPCs), in melanoma is of significance. Understanding the role of EPCs is important for understanding the abnormal vessel structures in melanoma. The effect of anti-angiogenic drugs on melanoma treatment needs further research.
Article
Biochemistry & Molecular Biology
Dayane Mayumi Miyasaki, Alexandra Cristina Senegaglia, Sergio Adriane Bezerra de Moura, Amanda Leitolis, Luiz Guilherme Achcar Capriglione, Leticia Fracaro, Lidiane Maria Boldrini Leite, Paulo Henrique Utumi, Felipe Yukio Ishikawa Fragoso, Fernando Meyer, Alejandro Correa, Paulo Roberto Slud Brofman
Summary: This study evaluated the effects of extracellular vesicles (EVs) from human umbilical cord tissue and human umbilical cord blood on rats with chronic kidney disease. The results demonstrated that EVs have the potential to improve renal function, suggesting their use as a cell-free treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Huang-Ming Chang, Kang-Yung Peng, Chieh-Kai Chan, Chiao-Yin Sun, Ying-Ying Chen, Han-Mei Chang, Chun-Lin Huang, Pei-Chun Liu, Peng-Ying Chen, Kuo-Chuan Wang, Wei-Jie Wang, Chen-Chi Wu, Yu-Feng Lin, Tai-Shuan Lai, Tao-Min Huang, Guang-Huar Young, Shuei-Liong Lin, Marlies Ostermann, Tzong-Shinn Chu, Jeff S. Chueh, Vin-Cent Wu
Summary: This study reveals the protective role of FGF23 in AKI, promoting renal regeneration, vascular repair, and attenuating damage. FGF23 interacts with the SDF-1/CXCR4 signaling, inhibiting EPC senescence and migration, while not affecting angiogenesis.
CELL DEATH & DISEASE
(2021)
Review
Immunology
P. Di Benedetto, P. Ruscitti, O. Berardicurti, M. Vomero, L. Navarini, V. Dolo, P. Cipriani, R. Giacomelli
Summary: Systemic sclerosis is an autoimmune disease characterized by vascular alterations and multi-organ fibrosis. The process of endothelial-to-mesenchymal transition plays a crucial role in the development of progressive fibrosis in SSc, and understanding this mechanism is important for identifying therapeutic targets.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Min Nie, Bin Kong, Guopu Chen, Ying Xie, Yuanjin Zhao, Lingyun Sun
Summary: The novel MSCs-laden injectable self-healing hydrogel developed for SSc treatment shows promising results in promoting MSCs proliferation, increasing cellular half-life, promoting angiopoiesis, and inhibiting fibrosis in disease model mice.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Dominik Steiner, Lea Reinhardt, Laura Fischer, Vanessa Popp, Carolin Koerner, Carol Geppert, Tobias Baeuerle, Raymund E. Horch, Andreas Arkudas
Summary: The microvascular endothelial network is crucial for osteogenesis and bone tissue engineering. Endothelial progenitor cells (EPCs) have a strong angiogenic potential and can enhance the vascularization and tissue formation of scaffolds. This study investigated the effects of EPCs on the vascularization and bone formation of a hydroxyapatite and beta-tricalcium phosphate-fibrin scaffold. The results showed successful scaffold vascularization in all groups, and the EPC/MSC coimplantation group demonstrated bone formation. The arteriovenous loop was found to be an effective method for vascularization independent of scaffold cellularization with EPCs.
Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Letter
Rheumatology
Paola Di Benedetto, Paola Cipriani, Piero Ruscitti, Vasiliki Liakouli, Roberto Giacomelli
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Piero Ruscitti, Paola Cipriani, Vasiliki Liakouli, Daniela Iacono, Ilenia Pantano, Francesco Caso, Federico Perosa, Fabiola Atzeni, Francesco Paolo Cantatore, Raffaele Scarpa, Francesco Ciccia, Roberto Giacomelli
RHEUMATOLOGY INTERNATIONAL
(2020)
Article
Medicine, Research & Experimental
M. Prete, E. Favoino, R. Giacomelli, A. Afeltra, F. P. Cantatore, C. Bruno, A. Corrado, L. Emmi, G. Emmi, R. D. Grembiale, L. Navarini, A. Marcoccia, V Liakouli, A. Riccardi, G. Valentini, F. Perosa
CLINICAL AND EXPERIMENTAL MEDICINE
(2020)
Review
Immunology
Piero Ruscitti, Onorina Berardicurti, Paola Di Benedetto, Paola Cipriani, Annamaria Iagnocco, Yehuda Shoenfeld, Roberto Giacomelli
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Rheumatology
Piero Ruscitti, Federico Bruno, Onorina Berardicurti, Chiara Acanfora, Viktoriya Pavlych, Pierpaolo Palumbo, Alessandro Conforti, Francesco Carubbi, Ilenia Di Cola, Paola Di Benedetto, Paola Cipriani, Davide Grassi, Carlo Masciocchi, Annamaria Lagnocco, Antonio Barile, Roberto Giacomelli
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Review
Immunology
Vasiliki Liakouli, Jacopo Ciaffi, Francesco Ursini, Piero Ruscitti, Riccardo Meliconi, Francesco Ciccia, Paola Cipriani, Roberto Giacomelli
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2020)
Review
Immunology
Roberto Giacomelli, Antonella Afeltra, Elena Bartoloni, Onorina Berardicurti, Michele Bombardieri, Alessandra Bortoluzzi, Francesco Carubbi, Francesco Caso, Ricard Cervera, Francesco Ciccia, Paola Cipriani, Emmanuel Coloma-Bazan, Fabrizio Conti, Luisa Costa, Salvatore D'Angelo, Oliver Distler, Eugen Feist, Nathan Foulquier, Marco Gabini, Vanessa Gerber, Roberto Gerli, Rosa Daniela Grembiale, Giuliana Guggino, Ariela Hoxha, Annamaria Iagnocco, Suzana Jordan, Bashar Kahaleh, Kim Lauper, Vasiliki Liakouli, Ennio Lubrano, Domenico Margiotta, Saverio Naty, Luca Navarini, Federico Perosa, Carlo Perricone, Roberto Perricone, Marcella Prete, Jacques-Olivier Pers, Costantino Pitzalis, Roberta Priori, Felice Rivellese, Amelia Ruffatti, Piero Ruscitti, Raffaele Scarpa, Yehuda Shoenfeld, Giovanni Triolo, Athanasios Tzioufas
Summary: Autoimmune diseases share common clinical features but have different pathogenic mechanisms and targeted organs. Applying precision medicine principles may improve treatment success by tailoring therapy to individual characteristics and reducing adverse events.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Elvira Favoino, Ettore Grapsi, Giovanna Barbuti, Vasiliki Liakouli, Piero Ruscitti, Caterina Foti, Roberto Giacomelli, Federico Perosa
Summary: This study evaluated whether anti-centromeric protein A (CENP-A) antibodies cross-react with mitochondrial antigens. The results showed that antibodies with a specific mitochondrial antigen (PDC-E2) cross-reacted with anti-centromere antibodies (Ap1-17). This finding is important for investigating the pathogenic significance of these antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Rheumatology
E. Favoino, G. Catacchio, A. Mininni, P. Ruscitti, V. Riccieri, V. Liakouli, A. Corrado, L. Navarini, F. Ciccia, P. Cipriani, F. P. Cantatore, G. Valesini, R. Giacomelli, F. Perosa
Summary: Anti-p4.2 antibodies can identify a subset of systemic sclerosis (SSc) patients at a high risk of developing pulmonary vascular disease (PVD), even in the absence of pulmonary fibrosis (PF).
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
P. Ruscitti, P. Cipriani, V Liakouli, D. Iacono, I Pantano, D. P. E. Margiotta, L. Navarini, G. M. D. Castaniti, N. Maruotti, G. Di Scala, F. Caso, S. Bongiovanni, R. D. Grembiale, F. Atzeni, R. Scarpa, F. Perosa, G. Emmi, F. P. Cantatore, G. Guggino, A. Afeltra, F. Ciccia, R. Giacomelli
Summary: The study observed an increased incidence of high blood pressure, type 2 diabetes, and metabolic syndrome in participants with rheumatoid arthritis. Maintaining remission and therapy with hydroxychloroquine were reported to reduce the risk of developing these cardiovascular risk factors.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
P. Cipriani, P. Di Benedetto, P. Ruscitti, O. Berardicurti, V. Liakouli, F. Carubbi, N. Panzera, N. Grazia, M. Di Vito Nolfi, B. Di Francesco, A. Maurizi, N. Rucci, A. Teti, F. Zazzeroni, E. Alesse, R. Giacomelli
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Piero Ruscitti, Onorina Berardicurti, Daniela Iacono, Ilenia Pantano, Vasiliki Liakouli, Francesco Caso, Giacomo Emmi, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Fabiola Atzeni, Federico Perosa, Raffaele Scarpa, Giuliana Guggino, Francesco Ciccia, Antonio Barile, Paola Cipriani, Roberto Giacomelli
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Rheumatology
Paola Di Benedetto, Giuliana Guggino, Giovanna Manzi, Piero Ruscitti, Onorina Berardicurti, Noemi Panzera, Nicolo Grazia, Roberto Badagliacca, Valeria Riccieri, Carmine Dario Vizza, Ganna Radchenko, Vasiliki Liakouli, Francesco Ciccia, Paola Cipriani, Roberto Giacomelli
ARTHRITIS RESEARCH & THERAPY
(2020)