Article
Cell Biology
Jiaming Gao, Hao Wang, Junyan Shen, Xiaojing Liu, Xiaoqi Zhu, Ce Huang, Gongchen Li, Yao Sun, Zhongmin Liu, Yi Eve Sun, Hailiang Liu
Summary: This study reveals the mechanism by which GDF11 reverses aging of mesenchymal stem cells (MSCs) through the activation of the Smad2/3-PI3K-AKT-mTOR signaling pathway and upregulation of the DNA demethylase Tet2. The mutual regulatory relationship between GDF11 and Tet2 plays a crucial role in the anti-aging effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Farina Mohamad Yusoff, Yukihito Higashi
Summary: Mesenchymal stem/stromal cells (MSCs) have medicinal properties for vascular regeneration. Various conditions, like chronic arterial occlusive disease and diabetic ulcers, cause significant morbidity and MSCs offer treatment options through therapeutic angiogenesis. This review discusses the use of MSCs for therapeutic angiogenesis in vascular research and medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases.
Article
Cell & Tissue Engineering
Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei, Vahid Razban
Summary: The study compared the effects of allogeneic bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue mesenchymal stem cells (AT-MSCs) in the treatment of critical limb ischemia (CLI). The results indicated that BM-MSCs had a stronger effect on endothelial cell migration, muscle restructure, functional improvements, and neovascularization in ischemic tissues compared to AT-MSCs. This suggests that BM-MSC transplantation could be a more effective therapy for diseases with insufficient angiogenesis, such as hindlimb ischemia.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Arturo Ibanez-Fonseca, Ana Rico, Silvia Preciado, Fernando Gonzalez-Perez, Sandra Muntion, Jesus Garcia-Brinon, Maria-Carmen Garcia-Macias, Jose Carlos Rodriguez-Cabello, Miguel Pericacho, Matilde Alonso, Fermin Sanchez-Guijo
Summary: Combination of an elastin-like recombinamer (ELR)-based hydrogel with mesenchymal stromal cells (MSCs) shows potential in improving tissue reperfusion and blood vessel density in a murine hindlimb ischemia model, suggesting a promising approach for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Pharmacology & Pharmacy
Tao Chen, Bo Ye, Jing Tan, Haifeng Yang, Faming He, Raouf A. Khalil
Summary: Mesenchymal stem cells, especially those expressing CD146, show potential in improving vascularity and muscle function in a rat model of hind-limb ischemia, reducing apoptosis and increasing vascular endothelial growth factor expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Kenon Chua, Fui Ping Lim, Victor Kwan Min Lee, Toan Thang Phan, Bee Choo Tai, Yih Kai Tan
Summary: In this study, human Cord Lining Mesenchymal Stem Cells (CL-MSCs) were used in a rabbit hindlimb ischemia model to stimulate neovascularization. The results showed that CL-MSCs had a positive effect on angiogenesis, with more CD31 positive cells and capillaries found in the treated muscles. Additionally, there was a non-statistically significant increase in blood perfusion in the treatment group, and CL-MSCs showed no toxicity or significant local immune reaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yang Zhang, Yanqi Zhong, Weifang Liu, Fanghui Zheng, Yin Zhao, Li Zou, Xiaoxia Liu
Summary: The study revealed the importance of PFKFB3-mediated glycolysis in endothelial differentiation and angiogenesis of PMSCs, showing that PMSCs have a strong potential for endothelial differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Hematology
Liming Zhao, Andrew S. Lee, Koki Sasagawa, Jan Sokol, Yuting Wang, Ryan C. Ransom, Xin Zhao, Chao Ma, Holly M. Steininger, Lauren S. Koepke, Mimi R. Borrelli, Rachel E. Brewer, Lorene L. Y. Lee, Xianxi Huang, Thomas H. Ambrosi, Rahul Sinha, Malachia Y. Hoover, Jun Seita, Irving L. Weissman, Joseph C. Wu, Derrick C. Wan, Jun Xiao, Michael T. Longaker, Patricia K. Nguyen, Charles K. F. Chan
Summary: The study identified two populations of vascular stem/progenitor cells (VSPCs) from adipose-derived mesenchymal stromal cells. Cotransplantation of VSPC1 and VSPC2 could form functional vessels and improve perfusion in the mouse hindlimb ischemia model.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Swarna Rautiainen, Timo Laaksonen, Raili Koivuniemi
Summary: Adipose-derived mesenchymal stem/stromal cells (ASCs) are a promising option for therapeutic angiogenesis, as they can promote blood vessel formation. Co-culturing ASCs with ECs can improve the formation of functional vessels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yang Yu, Xuechun Li, Yimei Li, Renyue Wei, Hai Li, Zhonghua Liu, Yu Zhang
Summary: This study establishes a stable iPSC-EC induction system and investigates the regulatory mechanism of endothelial differentiation. The derived piPSC-ECs form microvessel-like structures in vitro and promote blood vessel formation under pathological conditions. The activation of TGF-beta-Smad2/3 signaling promotes mesoderm formation and prevents endothelial differentiation in this model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Young Cheol Song, Gyu Tae Park, Hye Ji Moon, Eun-Bae Choi, Mi-Ju Lim, Jung Won Yoon, Nayeon Lee, Sang Mo Kwon, Byung-Joo Lee, Jae Ho Kim
Summary: Hybrid cell spheroids can enhance the survival and therapeutic effects of cell transplantation for peripheral artery disease.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Aleen Al Halawani, Lea Abdulkhalek, Suzanne M. Mithieux, Anthony S. Weiss
Summary: The study showed that the pro-angiogenic effects of tropoelastin are mediated indirectly through its action on co-cultured cells, reversing its inhibitory effect on endothelial tube formation. In vitro experiments demonstrated that tropoelastin can mimic its known in vivo pro-angiogenic effects, highlighting its value as an indirect mediator of angiogenesis.
Article
Chemistry, Multidisciplinary
Chiara Gardin, Letizia Ferroni, Yasar Kemal Erdogan, Federica Zanotti, Francesco De Francesco, Martina Trentini, Giulia Brunello, Batur Ercan, Barbara Zavan
Summary: Preconditioning of MSCs on nanotubular Ti surfaces induces elevated exosome secretion that stimulates in vitro endothelial and cell activity, potentially improving in vivo angiogenesis and supporting faster scaffold integration.
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: MSCs are multipotent stem cells that can enhance tissue repair and regeneration by regulating immune cell function, promoting new blood vessel formation, and modulating phenotype and function of immune cells. This review article summarizes the current knowledge about the molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)