Hormones and AID: Balancing immunity and autoimmunity

5-Methylcytosine DNA Demethylation: More Than Losing a Methyl Group

(2012) Don-Marc Franchini et al.   Annual Review of Genetics

Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity

(2012) Chuancang Jiang et al.   AUTOIMMUNITY

B cells as effectors and regulators of autoimmunity

(2012) Eliana Mariño et al.   AUTOIMMUNITY

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

(2012) Sebastian Königsberger et al.   EMBO JOURNAL

A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

(2012) Katharina L. Willmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β

(2012) Dongqi Xing et al.   PLoS One

Activation induced deaminase: How much and where?

(2012) Alexandre Orthwein et al.   SEMINARS IN IMMUNOLOGY

Combinatorial mechanisms regulating AID-dependent DNA deamination: Interacting proteins and post-translational modifications

(2012) Bao Q. Vuong et al.   SEMINARS IN IMMUNOLOGY

AIDing the immune system—DIAbolic in cancer

(2012) Kerstin-Maike Schmitz et al.   SEMINARS IN IMMUNOLOGY

Does DNA repair occur during somatic hypermutation?

(2012) Huseyin Saribasak et al.   SEMINARS IN IMMUNOLOGY

The biochemistry of activation-induced deaminase and its physiological functions

(2012) Mani Larijani et al.   SEMINARS IN IMMUNOLOGY

The cytoplasmic AID complex

(2012) Julien Häsler et al.   SEMINARS IN IMMUNOLOGY

miRNAs and estrogen action

(2012) Carolyn M. Klinge   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination

(2012) Andre Stanlie et al.   PLoS Genetics

Epstein-Barr Virus Infection of Naïve B Cells In Vitro Frequently Selects Clones with Mutated Immunoglobulin Genotypes: Implications for Virus Biology

(2012) Emily Heath et al.   PLoS Pathogens

AID dysregulation in lupus-prone MRL/Faslpr/lprmice increases class switch DNA recombination and promotes interchromosomalc-Myc/IgHloci translocations: Modulation by HoxC4

(2011) Clayton A. White et al.   AUTOIMMUNITY

The role of gender and organ specific autoimmunity

(2011) Udi Nussinovitch et al.   AUTOIMMUNITY REVIEWS

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Molecular Mimicry as a Mechanism of Autoimmune Disease

(2011) Matthew F. Cusick et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Role of microRNA-155 in autoimmunity

(2011) Rui-Xue Leng et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity

(2011) Olga L. Quintero et al.   JOURNAL OF AUTOIMMUNITY

Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus

(2011) Faith M. Strickland et al.   JOURNAL OF AUTOIMMUNITY

Overexpression of the CTLA-4 Isoform Lacking Exons 2 and 3 Causes Autoimmunity

(2011) S. M. Liu et al.   JOURNAL OF IMMUNOLOGY

Hypomethylation of functional retrotransposon-derived genes in the human placenta

(2011) Erin C. Macaulay et al.   MAMMALIAN GENOME

Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

(2011) Hongyan Qin et al.   PLoS One

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

(2011) G. Meyers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity

(2010) Alessandra Fierabracci   AUTOIMMUNITY REVIEWS

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice

(2010) H. CARLSTEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MicroRNAs Prevent the Generation of Autoreactive Antibodies

(2010) Laura Belver et al.   IMMUNITY

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

(2010) Christian Popp et al.   NATURE

Regulatory B Cells in Autoimmune Diseases

(2009) Sébastien Lemoine et al.   Annals of the New York Academy of Sciences

Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

(2009) Hong Zan et al.   AUTOIMMUNITY

Definition of human autoimmunity — autoantibodies versus autoimmune disease

(2009) Ana Lleo et al.   AUTOIMMUNITY REVIEWS

Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity inlprmice on a C57BL/6 background

(2009) L. Chen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural killer cells in human autoimmunity

(2009) Malin Flodström-Tullberg et al.   CURRENT OPINION IN IMMUNOLOGY

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progesterone Inhibits Activation-Induced Deaminase by Binding to the Promoter

(2009) S. Pauklin et al.   JOURNAL OF IMMUNOLOGY

The role of autoimmune regulator (Aire) in the development of the immune system

(2009) Mitsuru Matsumoto   MICROBES AND INFECTION

TAF12 Recruits Gadd45a and the Nucleotide Excision Repair Complex to the Promoter of rRNA Genes Leading to Active DNA Demethylation

(2009) Kerstin-Maike Schmitz et al.   MOLECULAR CELL

RETRACTED: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

(2009) Kaoru Yamagata et al.   MOLECULAR CELL

Active nuclear import and cytoplasmic retention of activation-induced deaminase

(2009) Anne-Marie Patenaude et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Androgens in rheumatoid arthritis: when are they effectors?

(2009) Maurizio Cutolo   ARTHRITIS RESEARCH & THERAPY

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Molecular mechanisms of autoimmunity

(2008) M. Zouhair Atassi et al.   AUTOIMMUNITY

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

miR-181b negatively regulates activation-induced cytidine deaminase in B cells

(2008) Virginia G. de Yébenes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways

(2008) Q. Yin et al.   JOURNAL OF VIROLOGY

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

(2008) A Takai et al.   ONCOGENE

CBP Is a Dosage-Dependent Regulator of Nuclear Factor-κB Suppression by the Estrogen Receptor

(2007) Kendall W. Nettles et al.   MOLECULAR ENDOCRINOLOGY