Article
Engineering, Biomedical
Cho-E Choi, Aishik Chakraborty, Ali Coyle, Yasmeen Shamiya, Arghya Paul
Summary: Considerable progress has been made in synthesizing intelligent, biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Arezoo Esrafili, Avery Wagner, Sahil Inamdar, Abhinav P. Acharya
Summary: Covalent organic frameworks (COFs) are porous organic polymeric materials with desirable properties like high stability, low density, and large surface area, making them suitable for applications in the energy sector and drug delivery. This review discusses different types of COFs, synthesis methods, and their potential applications in the biomedical field, highlighting the specific advantages that can be utilized for specialized biomedical applications such as immune engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Ameya Sharma, Ishnoor Kaur, Divya Dheer, Manju Nagpal, Pradeep Kumar, D. Nagasamy Venkatesh, Vivek Puri, Inderbir Singh
Summary: Numerous compounds in the oceans have extensive applications in biomedical and biotechnological fields, which make them a prime renewable source of natural substances and promote the development of novel medical systems and devices. Polysaccharides, abundantly present in the marine ecosystem, have advantages such as low extraction costs, solubility in extraction media, interactions with biological compounds, and the ability to be modified for various shapes and sizes. These properties have led to their use as raw materials for drug delivery carrier systems.
CARBOHYDRATE POLYMERS
(2023)
Review
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez, Bronach Mallon, Juan Dominguez-Robles, Lalitkumar K. Vora, Qonita K. Anjani, Ryan F. Donnelly
Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Lijuan Wang, Yushuang Shang, Jie Zhang, Jiang Yuan, Jian Shen
Summary: The development of keratin-based biomaterials provides a valuable approach for addressing environmental pollutants and transforming waste into wealth. The properties and biomedical applications of keratin biomaterials, such as drug delivery, wound healing, and tissue engineering, are extensively discussed in this review, offering valuable insights for further research and development.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Hossein Omidian, Sumana Dey Chowdhury, Niloofar Babanejad
Summary: Cryogels, versatile biomaterials composed of synthetic and natural materials, have wide applications in tissue engineering, drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties remains challenging, and researchers are exploring advanced manufacturing techniques and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise, but in vivo evaluation and clinical trials are crucial for determining safety and efficacy. Overcoming practical challenges such as scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness is essential for the successful application of cryogels in biomedical fields.
Review
Polymer Science
Jonathan David Hinchliffe, Alakananda Parassini Madappura, Syed Mohammad Daniel Syed Mohamed, Ipsita Roy
Summary: Plastics have been widely used in various fields, especially in biomedical applications. Recent focus has shifted to manufacturing polymers using biological methods to reduce environmental costs and reliance on toxic substances. Bacteria-derived polymers offer unique biological properties that meet the demands of the biomaterials industry for highly customized, biocompatible materials.
Review
Materials Science, Multidisciplinary
Ashutosh Pandey, Mukesh Kumar Singh, Annika Singh
Summary: The growing interest in bacterial cellulose (BC) is due to its exceptional attributes such as purity, biodegradability, non-toxicity, porous fibrillar structure, and high water retention potential, which expand its applications to tissue engineering, controlled drug delivery, and cosmetics. BC has proved highly promising in manufacturing innovative wound care solutions, drug carriers, and delivering complexes. It can be compounded with other materials such as nanopolymers to explore new frontiers for BC applications in biomedical product developments. BC can accommodate various nanoparticles, biomaterials, synthetic materials, carbon materials, and plant extracts, allowing its use in various biomedical and cosmetic products.
JOURNAL OF MATERIALS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Iwona Cicha, Ronny Priefer, Patricia Severino, Eliana B. Souto, Sona Jain
Summary: Biosensor-integrated drug delivery systems are innovative devices that enable continuous monitoring and drug administration, particularly for chronic diseases such as diabetes, cancer, and cardiovascular diseases. The advantages of this technology include high sensitivity and fast drug release.
Review
Pharmacology & Pharmacy
Sairish Malik, Sundarrajan Subramanian, Tanveer Hussain, Ahsan Nazir, Seeram Ramakrishna
Summary: This paper highlights the importance and potential role of electrosprayed nanoparticles in biomedical applications through a literature review. Electrosprayed nanoparticles offer unique advantages and can be used in drug delivery systems to improve drug efficacy and reduce side effects.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Xikuang Yao, Chao Qi, Changrui Sun, Fengwei Huo, Xiqun Jiang
Summary: Poly(ethylene glycol) (PEG) has been widely used in conjugation with diagnostic and therapeutic agents or surface decoration on nanoplatforms, known as PEGylation, to enhance diagnostic and therapeutic effects. However, studies have shown that PEG abuse can lead to severe side effects and compromise therapeutic efficacy. This review presents alternatives to PEG, including poly(N-vi-nylpyrrolidone), polyacrylamides, polybetaines, poly(2-oxazoline)s, polyesters, and polysarcosine, with their synthesis, characterization, and biomedical applications in agent conjugates, nanocarriers, hydrogels, and antifouling surface coating. The potential of these PEG alternatives in constructing efficient nanoplatforms for precise nanomedicine is highlighted.
Review
Biochemistry & Molecular Biology
Sara La Manna, Concetta Di Natale, Valentina Onesto, Daniela Marasco
Summary: Self-assembling peptides are a novel class of agents with versatile applications in the biomedical field. They exhibit biocompatibility and molecular recognition capabilities, making them suitable for drug delivery and tissue engineering purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yang Gao, Qingming Ma, Jie Cao, Yiwen Wang, Xin Yang, Qiulong Xu, Qing Liang, Yong Sun
Summary: The review highlights the recent progress in fabricating chitosan-based biomaterials using microfluidic technology, emphasizing the precise control over morphology and microstructures, as well as the potential applications of chitosan-based materials in the field of biomedicine.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Materials Science, Biomaterials
Xi Wang, Fuqiang Li, Xin Liu, Hui Zhang
Summary: Hydrogels, functional polymer materials with high water content and controllability, have great potential in the field of ophthalmology.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Yu Chen, Samira Pal, Quanyin Hu
Summary: Relay delivery strategy is a two-step targeting approach that artificially creates a target/environment for subsequent effectors, amplifying targeted signals at the disease site. Cell-based therapeutics, with their inherent homing abilities and feasibility of modifications, serve as excellent candidates in relay delivery strategies. In this review, recent advances in relay delivery systems are surveyed, with a specific focus on the roles of various cells.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Ozgur Ceylan, Hatice Karakus, Huseyin Cicek
Summary: A novel pH-sensitive hydrogel beads loaded with propolis ethanolic extracts were synthesized in this study. The beads exhibited stability and high sensitivity to microorganisms, but showed low antibiofilm activity.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Polymer Science
Gokhan Kocak, Alfred Ngenge Tamfu, Vural Butun, Ozgur Ceylan
Summary: In this study, different molecular weights of PGMA and PHMPPMA homopolymers were synthesized and modified into quaternary compounds, showing potential for combating microbial resistance and severity of infections by inhibiting microbial growth.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Engineering, Environmental
Serkan Emik, Selin Isik, Eren Yildirim
Summary: A novel bead form IPN type resin was synthesized with high dye adsorption capacity. Batch adsorption experiments and modeling calculations demonstrated the resin's significant adsorption capabilities for basic and acidic dyes, mainly through physical adsorption processes.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Chemistry, Applied
Serkan Emik, Tulin Banu Iyim, Saadet Ozgumus
Summary: Vinyltrimethoxysilane was used to modify high-ortho novolac resin to obtain a novel resin with high thermal resistance, flexibility, and excellent film properties. The modified resin can be used as a surface coating material for various applications.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2021)
Article
Materials Science, Biomaterials
Elif Yuce-Erarslan, Rumeysa Tutar, Burcin Izbudak, Emine Alarcin, Banu Kocaaga, F. Seniha Guner, Serkan Emik, Ayca Bal-Ozturk
Summary: In this study, chitosan and gelatin were chemically modified to obtain suitable biomaterials for 3D-bioprinting. The addition of layered double hydroxide nanoparticles improved the printability of the bioinks. The optimal bioink was found to have enhanced mechanical properties and cell-adhesion behaviors, making it suitable for tissue engineering applications.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Chemistry, Applied
Yakup Atici, Serkan Emik, Sah Ismail Kirbaslar
Summary: High-performance epoxy acrylate (EA) coating formulations containing various acrylate-modified diepoxy siloxane (DESA) intermediates were synthesized and characterized in this research. The chain lengths and amounts of DESA were found to significantly impact the properties of UV-cured coatings, particularly enhancing scratch resistance, contact angle, and yellowing resistance with increasing chain length.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2022)
Article
Food Science & Technology
Samah Djebili, Meltem Tas, Ali Bouguerra, Selcuk Kucukaydin, Ozgur Ceylan, Mehmet Emin Duru, Malika Barkat
Summary: This study analyzed the volatile compounds and essential oil composition of three wild Algerian plants, evaluating their antioxidant activities and antibiofilm effects. The results suggest that Thymus algeriensis and Origanum glandulosum could be valuable resources in the pharmaceutical industry, as sources of thymol and carvacrol, respectively.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Chemistry, Multidisciplinary
Eren Yildirim, Burcu Arikan, Oguz Yucel, Ozgur Cakir, Neslihan Turgut Kara, Tulin Banu Iyim, Gulten Gurdag, Serkan Emik
Summary: The study successfully synthesized magnetic nanoparticles for DNA separation and purification processes, characterized through various tests and techniques. The results indicated that after specific modifications, these nanoparticles have a high adsorption capacity and desorption efficiency, suitable for biotechnology and DNA separation.
Article
Biochemistry & Molecular Biology
Alfred Ngenge Tamfu, Ozgur Ceylan, Geta Carac, Emmanuel Talla, Rodica Mihaela Dinica
Summary: Propolis is a popular natural product known for its antimicrobial and antioxidant properties. This study analyzed the chemical composition of propolis samples and evaluated their antioxidant activity and ability to inhibit bacterial biofilm formation. The results showed that propolis contains phenolic compounds with significant antioxidant activity and can effectively inhibit biofilm formation by pathogenic bacteria.
Article
Polymer Science
Alfred Ngenge Tamfu, Gokhan Kocak, Ozgur Ceylan, Funda Citak, Vural Butun, Huseyin Cicek
Summary: In this study, antimicrobial polymers with greater applications than traditional antibiotics were developed. The modified polymeric microparticles showed good antibiofilm activity and can be used to reduce the spread of microbial infections and resistance.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Food Science & Technology
Fatih Cayan, Gulsen Tel-Cayan, Meltem Tas-Kucukaydin, Selcuk Kucukaydin, Cansu Korkmaz, Mehmet Emin Duru, Ozgur Ceylan
Summary: This study investigates the phenolic profiles and various biological activities of twelve cotton honeys from two different regions in Turkey. The results show that different cotton honeys have varying levels of antioxidant, antimicrobial, anti-inflammatory, and enzyme inhibitory activities. The findings also suggest that the activity of cotton honeys may be influenced by geographical factors.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alfred Ngenge Tamfu, Yasemin Ispirli Dogac, Ozgur Ceylan, Andreea Botezatu Dediu, Selahattin Bozkurt, Rodica Mihaela Dinica
Summary: Water is essential, but obtaining clean water remains a global challenge. The synthesized hydrated zirconium oxide-alginate materials show efficient removal of pollutants and inhibition of microorganisms. Increasing the alginate content enhances the antimicrobial and antibiofilm effects. This study is important for its environmental friendliness and sustainability, with potential application in water treatment.
JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alfred Ngenge Tamfu, Selcuk Kucukaydin, Mohammed Mansour Quradha, Ozgur Ceylan, Aysel Ugur, Mehmet Emin Duru
Summary: This study extracted phenolic compounds from Syringa vulgaris, Citrus sinensis, and Hypericum perforatum using ultrasound-assisted extraction and evaluated their medicinal properties. The results showed that these phenolic extracts exhibited inhibitory effects on acetylcholinesterase, urease, and tyrosinase, as well as antimicrobial activity against certain bacteria. These findings suggest the potential application of these phenolic extracts in the treatment of Alzheimer's disease and the development of antimicrobial drugs.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2022)
Article
Veterinary Sciences
Ali Sorucu, Ozgur Ceylan
Summary: The study demonstrated that propolis extracts exhibit antibacterial activity against Gram-positive bacteria and yeast, but not against Gram-negative bacteria. Water extract showed more effective antimicrobial activity compared to ethanol extract, while the effects on anti-quorum sensing and anti-swarming activities were less pronounced with the water extract. Additionally, both extracts displayed violacein inhibition, with the phenolic composition influencing the observed activities.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2021)
