Article
Clinical Neurology
Maximilian Hammer, Felix Jung, Jurij Brankack, Yevgenij Yanovsky, Adriano B. L. Tort, Andreas Draguhn
Summary: This study found correlations between different characteristics of REM sleep, where breathing rate was positively correlated with movement and the length of REM sleep periods. Specifically, short REM sleep episodes had slower breathing, while longer episodes had faster breathing and higher gamma activity. Therefore, REM sleep can be further divided based on its duration.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Maximilian Hammer, Chrysovalandis Schwale, Jurij Brankack, Andreas Draguhn, Adriano B. L. Tort
Summary: This study reveals an unexpected relationship between theta-gamma coupling and respiration in mice, showing that the strength of coupling is inversely related to breathing rate. Interestingly, breathing is found to differently influence theta-gamma coupling during phasic and tonic REM states, suggesting a more complex link between respiration and cortical network activity patterns.
Article
Clinical Neurology
Maximilian Hammer, Chrysovalandis Schwale, Jurij Brankack, Andreas Draguhn, Adriano B. L. Tort
Summary: The study reveals an unexpected but robust relation between theta-gamma coupling and respiration in mice, with the strength of coupling exhibiting an inverted V-shaped dependence on breathing rate. The findings also show that breathing differentially relates to theta-gamma coupling in different sleep states, indicating a more complex link between respiration and brain activity.
Editorial Material
Biochemistry & Molecular Biology
Paul-Antoine Libourel, John A. Lesku
Summary: A recent study reveals that bearded dragons possess a unique mechanism to synchronize sleep state changes between brain hemispheres. The dominant hemisphere during REM sleep-like state exerts its influence on the other hemisphere.
Article
Multidisciplinary Sciences
Celia Lacaux, Thomas Andrillon, Celeste Bastoul, Yannis Idir, Alexandrine Fonteix-Galet, Isabelle Arnulf, Delphine Oudiette
Summary: This study demonstrates that brain activity during the transition period from sleep to wakefulness can ignite creativity; there is a creative "sweet spot" in the onset of sleep that requires individuals to balance easily falling asleep against falling asleep too deeply.
Article
Clinical Neurology
Christophe Bernard, Birgit Frauscher, Jennifer Gelinas, Igor Timofeev
Summary: Sleep and wake states are defined using physiological and behavioral criteria, and can be divided into NREM sleep stages N1, N2, and N3, REM sleep, and wake. The properties of these states vary during the night and day cycle. The relationship between sleep-wake cycles and epilepsy is complex, with seizures occurring during different stages of sleep and wakefulness, and varying across patients and models.
Article
Clinical Neurology
Monika Klikova, Marek Piorecky, Eva Miletinova, Karolina Janku, Daniela Dudysova, Jitka Buskova
Summary: Analysis of polysomnographic recordings in RISP patients and controls revealed higher bifrontal beta activity during REM sleep in the RISP group, indicating an underlying persistent trait of higher cortical activity. However, no significant differences were found in macrostructural parameters or REM sleep fragmentation between the two groups.
Article
Clinical Neurology
Monika Klikova, Marek Piorecky, Eva Miletinova, Karolina Janku, Daniela Dudysova, Jitka Buskova
Summary: Higher bifrontal beta activity was found in RISP patients during REM sleep, suggesting a persistent trait of higher cortical activity. Despite no differences in macrostructural parameters or REM sleep fragmentation, these results indicate a potential predisposition for recurrent episodes in patients with sleep paralysis.
Review
Clinical Neurology
Ambra Stefani, Birgit Hoegl
Summary: Nightmare disorder and isolated sleep paralysis are common REM sleep disorders that can cause distress. Nightmare disorder is related to emotion regulation and hyperarousal, with imagery rehearsal therapy being an effective nonmedication treatment; isolated sleep paralysis may result from REM atonia persisting into wakefulness, and therapy mainly involves avoiding predisposing factors.
Article
Critical Care Medicine
Ludovico Messineo, Danny J. Eckert, Luigi Taranto-Montemurro, Daniel Vena, Ali Azarbarzin, Lauren B. Hess, Nicole Calianese, David P. White, Andrew Wellman, Laura Gell, Scott A. Sands
Summary: This study suggests that the pharyngeal compromise in REM sleep OSA is primarily caused by withdrawal of ventilatory drive rather than decreases in muscle activity or responsiveness. Preventing drive withdrawal may be the key target for treating REM sleep OSA.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Food Science & Technology
Panayiota Xylia, George Botsaris, Panagiotis Skandamis, Nikolaos Tzortzakis
Summary: The study found that the microbial load of minimally processed vegetables increases towards their expiration date, including spoilage microorganisms and foodborne pathogens. Different seasons and salad types also have an impact on the microbial load. It is crucial to consider expiration dates and shelf life when applying postharvest management to processed vegetables for ensuring safety and quality.
Article
Computer Science, Information Systems
Sunday O. Oladejo, Stephen O. Ekwe, Lateef A. Akinyemi, Seyedali A. Mirjalili
Summary: Due to the limitations of single optimisation algorithms, new optimisation techniques are required. This paper proposes a novel metaheuristic called the deep sleep optimiser (DSO), which mimics human sleeping patterns to solve optimisation problems. The DSO is modelled on the rise and fall of homeostatic pressure during the deep sleep stage of human sleep. Its performance is demonstrated and compared with other metaheuristics using various functions and problems, showing that the DSO performs well and often outperforms others.
Article
Health Care Sciences & Services
Liisa Kuula, Anu-Katriina Pesonen
Summary: This study aimed to evaluate the validity of the Firstbeat sleep analysis method based on HRV and accelerometer measurements in healthy adults. The results showed that the Firstbeat method had no significant difference in detecting light and slow wave sleep compared to PSG, but underestimated REM sleep and overestimated wake time. This study suggests that Firstbeat is a feasible method with sufficient validity to measure nocturnal sleep stage variation.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Clinical Neurology
Thea Giacomini, Gianvittorio Luria, Vanessa D'Amario, Carolina Croci, Matteo Cataldi, Maria Piai, Giulia Nobile, Oliviero Bruni, Alessandro Consales, Maria Margherita Mancardi, Lino Nobili
Summary: The study shows that phasic REM sleep (PREM) has a greater suppressive effect on epileptic activity compared to tonic REM sleep (TREM). Even in the extreme condition of Electrical Status Epilepticus during Sleep (ESES), PREM still significantly reduces epileptic activity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Adam Haar Horowitz, Kathleen Esfahany, Tomas Vega Galvez, Pattie Maes, Robert Stickgold
Summary: The link between dreams and creativity has been explored, with recent research suggesting that sleep onset (N1) may be an ideal state for creative ideation. However, the specific relationship between N1 dream content and creativity has been unclear. In this study, targeted dream incubation was used to introduce specific themes into dreams during N1 sleep, and these dreams were found to enhance creative performance and promote greater associative divergence compared to wake. Moreover, successful dream incubation was found to have a stronger effect on creative performance than N1 sleep alone, providing novel evidence for the role of incubating dream content in enhancing creativity.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Rozlyn C. T. Boutin, Zaki Alsahafi, Silvia Pagliardini
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Vishaal Rajani, Yong Zhang, Venkatesh Jalubula, Vladimir Rancic, Shahriar SheikhBahaei, Jennifer D. Zwicker, Silvia Pagliardini, Clayton T. Dickson, Klaus Ballanyi, Sergey Kasparov, Alexander V. Gourine, Gregory D. Funk
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Clinical Neurology
Jasmeen K. Saini, Silvia Pagliardini
Article
Physiology
Glauber S. F. da Silva, Joao P. J. Sabino, Vishaal Rajani, Tucaaue S. Alvares, Silvia Pagliardini, Luiz G. S. Branco, Gregory D. Funk
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Clinical Neurology
Jasmeen K. Saini, Silvia Pagliardini
Article
Physiology
Annette Pisanski, Silvia Pagliardini
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Neurosciences
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Clinical Neurology
Annette Pisanski, Xiuqing Ding, Nils A. Koch, Silvia Pagliardini
Article
Neurosciences
Vivian Biancardi, Jashan Saini, Anileen Pageni, Hema Prashaad M., Gregory D. Funk, Silvia Pagliardini
Summary: The lateral parafacial region is a conditional oscillator that can drive active expiration during high respiratory demand and increase ventilation. Neurons in the pF(L) receive extensive excitatory and inhibitory inputs from several brainstem regions, contributing to the complex modulation of active expiration.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Clinical Neurology
Jasmeen K. Saini, Tara A. Janes, Joanna E. MacLean, Silvia Pagliardini
Summary: A study found that expiratory abdominal muscle activity occurs during sleep in infants aged 0-2 years, mostly during non-rapid eye movement and rapid-eye movement states, and is associated with normal breathing or respiratory events such as apneas or O-2 desaturation. The recruitment of expiratory abdominal muscles may contribute to proper ventilation by counteracting airway resistance and O-2 desaturation in infants during different sleep stages.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Neurosciences
Brandon E. Hauer, Silvia Pagliardini, Clayton T. Dickson
Summary: The nucleus reuniens of the thalamus (RE) plays a crucial role in mediating communication between the medial prefrontal cortex (mPFC) and the hippocampus (HPC) depending on the brain state. Its activity pattern changes in different states, which affects the coordination of slow oscillation (SO) between mPFC and HPC. The study shows that the state-dependent activity pattern of RE neurons is responsible for efficient communication between mPFC and HPC. This has implications for understanding how distant brain regions communicate effectively and its relevance to memory consolidation during slow-wave sleep.
Article
Biochemistry & Molecular Biology
Silvia Cardani, Tara A. Janes, Jasmeen K. Saini, Simona Di Lascio, Roberta Benfante, Diego Fornasari, Silvia Pagliardini
Summary: Chronic administration of Etonogestrel (ETO), a potent progestin drug, improved respiratory function and enhanced chemoreflex response in adult female rats. This effect was associated with reduced expression of PHOX2B and its target genes selectively in the dorsal vagal complex, suggesting a potential role of the nucleus tractus solitarius (NTS) in ETO-induced respiratory modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Vincent Joseph, Silvia Pagliardini, Elise Belaidi
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Vivian Biancardi, Xiaqiu Yang, Xiuqing Ding, Dhruv Passi, Gregory D. Funk, Silvia Pagliardini
Summary: Rhythmic inspiratory activity is generated in the preBotzinger complex (preBotC) in the medulla. Cholinergic neurotransmission affects respiratory rhythmogenic neurons and inhibitory glycinergic neurons in the preBotC. Contrary to previous hypotheses, the source of cholinergic inputs to the preBotC appears to originate from neighboring regions of the medulla rather than the main cholinergic systems in the brainstem.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Brandon E. Hauer, Silvia Pagliardini, Clayton T. Dickson