Review
Biochemistry & Molecular Biology
Yi-Chen Shen, Xiao Sun, Lei Li, Hu-Yunlong Zhang, Zhi-Li Huang, Yi-Qun Wang
Summary: Sleep and wakefulness are fundamental behavioral states that involve coordination between brain regions and multiple neurochemical systems, including neuropeptides. Neuropeptides, produced by neurons and neuroendocrine cells, can bind to specific receptors and regulate neuronal activities. Different neuropeptides play distinct roles in sleep-wake regulation, promoting sleep, inducing wakefulness, or having bidirectional effects. This review provides an overview of the distribution of neuropeptides in the brain and summarizes their roles in sleep-wake regulation, aiming to lay the foundation for further studies on the mechanisms underlying sleep-wake states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Annie Y. Yao, Patrick J. Halloran, Yingying Ge, Neeraj Singh, John Zhou, James Galske, Wanxia He, Riqiang Yan, Xiangyou Hu
Summary: Alzheimer's disease (AD) patients have an increased risk of seizures and sleep disorders. Deletion of Bace1 in neurons increases epileptiform activity, while Bace1 inhibition can reduce epileptic activity and improve sleep disorders.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Vidhya Vijayakrishnan Nair, Brianna R. Kish, Pearlynne L. H. Chong, Ho-Ching (Shawn) Yang, Yu-Chien Wu, Yunjie Tong, A. J. Schwichtenberg
Summary: This study examines the movement of cerebrospinal fluid (CSF) during sleep and its relationship with neuronal-driven and non-neuronal systemic physiology driven movement. The findings suggest that interventions targeting NREM sleep and manipulating systemic physiology may increase CSF movement.
Article
Clinical Neurology
Yu Sun, Ryan Tisdale, Sunmee Park, Shun-Chieh Ma, Jasmine Heu, Meghan Haire, Giancarlo Allocca, Akihiro Yamanaka, Stephen R. Morairty, Thomas S. Kilduff
Summary: This study compared the development of narcoleptic symptomatology in male and female mice with narcolepsy type 1. The study found that female mice showed characteristic symptoms of NT1 as early as the first week after the removal of doxycycline (DOX), while male mice did not consistently show these symptoms until the second week. By the second week, both sexes exhibited impaired ability to sustain wakefulness, lower subcutaneous temperature regulation, and the appearance of the Delta State.
Article
Physics, Multidisciplinary
Dmitry E. Postnov, Ksenia O. Merkulova, Svetlana Postnova
Summary: This study investigates the mechanisms of synchronization and loss of synchrony among three key oscillatory processes controlling sleep-wake cycles in the human brain. Synchronization promotes sleep and brain clearance, while desynchrony is associated with impaired performance and disease development.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Biology
Christina Athanasouli, Kelsey Kalmbach, Victoria Booth, Cecilia G. Diniz Behn
Summary: The temporal structure of human sleep changes across development from polyphasic sleep to single nighttime sleep episode in adults. This study investigates the interaction between sleep architecture and changes in sleep dynamics using a mathematical model. The model analyzes the bifurcations of circle maps representing sleep patterns, identifying disruptions in the transition from biphasic to monophasic sleep. The study shows that the dynamics of NREM-REM alternation play a role in the wide interindividual variation in sleep patterns during the transition from napping to non-napping behavior in young children.
MATHEMATICAL BIOSCIENCES
(2023)
Review
Behavioral Sciences
Joel S. Raymond, Simone Rehn, Camilla M. Hoyos, Michael T. Bowen
Summary: This study evaluated the influence of oxytocin on sleep-wake outcomes and found that manipulation of the OXT system can affect these outcomes. Preclinical evidence suggests that OXT can promote wakefulness, while clinical evidence shows little to no sleep-promoting effects of OXT. OXT dose was identified as a likely modulatory factor of OXT-induced effects on sleep-wake behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Giulia Miracca, Berta Anuncibay-Soto, Kyoko Tossell, Raquel Yustos, Alexei L. Vyssotski, Nicholas P. Franks, William Wisden
Summary: The lateral preoptic hypothalamus plays a crucial role in NREM and REM sleep induction and NREM sleep homeostasis. Surprisingly, calcium signals in the lateral preoptic hypothalamus were found to be highest during REM sleep. NMDA receptors in the lateral preoptic hypothalamus were identified as the main drivers of excitation. Deleting these NMDA receptors led to insomnia and fragmented sleep patterns. The sleep fragmentation was specifically attributed to NMDA receptors on GABA neurons in the lateral preoptic hypothalamus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neuroimaging
Zhuo Fang, Dylan M. Smith, Evan Houldin, Laura Ray, Adrian M. Owen, Stuart Fogel
Summary: Research indicates that the relationship between sleep and intellectual abilities extends beyond sleep spindles to include other brain activities during different sleep-wake states. Specifically, during non-rapid eye movement sleep, fluid intelligence correlated positively with activity in the putamen and paracentral lobule/precuneus, while short-term memory abilities correlated positively with activity in the medial frontal cortex and inferior frontal gyrus. Additionally, during wake, activity in the bilateral postcentral gyri and occipital lobe was positively correlated with short-term memory abilities.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Aditi Pophale, Kazumichi Shimizu, Tomoyuki Mano, Teresa L. Iglesias, Kerry Martin, Makoto Hiroi, Keishu Asada, Paulette Garcia Andaluz, Thi Thu Van Dinh, Leenoy Meshulam, Sam Reiter
Summary: Octopuses exhibit two stages of sleep, quiet sleep and active sleep. Active sleep is characterized by body movements and changes in skin patterning similar to wakefulness. Quiet sleep is characterized by brain activity and specific brain regions resembling mammalian sleep, suggesting convergent features of complex cognition.
Article
Clinical Neurology
Soraia Ventura, Sean R. Mathieson, John M. O'Toole, Vicki Livingstone, Mary-Anne Ryan, Geraldine B. Boylan
Summary: The study aimed to characterize sleep features in 4-5 month old infants, providing normative values for sleep macrostructure and sleep spindles. Sex differences were observed in spindle spectral power and brain symmetry index, with males showing lower power and higher symmetry index compared to females. These findings contribute to a better understanding of infant sleep patterns and potential biomarkers for brain maturation.
Article
Neurosciences
Alejandra Mondino, Joaquin Gonzalez, Duan Li, Diego Mateos, Lucia Osorio, Matias Cavelli, Juan Pedro Castro-Nin, Diego Serantes, Alicia Costa, Giancarlo Vanini, George A. Mashour, Pablo Torterolo
Summary: Urethane, a commonly used anaesthetic in animal research, induces unconsciousness with distinct electrographic states that differ from physiological sleep. This study recorded and analysed EEGs and EMGs in rats under urethane anaesthesia and natural sleep states, finding clear signatures of unconsciousness during urethane and differences in EEG profiles compared to natural sleep.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Elizabeth S. Maywood, Johanna E. Chesham, Raphaelle Winsky-Sommerer, Michael H. Hastings
Summary: This study demonstrates the importance of the suprachiasmatic nucleus (SCN) in regulating circadian rhythms and sleep. By restoring molecular circadian functions in the SCN, improvements in sleep quality and enhanced sleep-dependent memory were observed.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Khalid El Allali, Younes Beniaich, Hicham Farsi, Mohammed El Mehdi M'hani, Mohamed Sobhi Jabal, Mohammed Piro, Mohamed Rachid Achaaban, Mohammed Ouassat, Etienne Challet, Mireille Besson, Jamal Mounach, Paul Pevet, Amal Satte
Summary: This study investigates sleep patterns in camels by combining behavioral and polysomnography (PSG) methods. The results show that camels have a polyphasic sleep pattern at night, with REM sleep primarily occurring in the head lying-down posture.
Review
Cell Biology
Chiara Cirelli, Giulio Tononi
Summary: Sleep is necessary for renormalizing synaptic weights after learning, which is a smart process of synaptic down-selection, explaining the beneficial effects of sleep on cognition. While some molecular mechanisms have been identified, others are still being investigated to understand how most synapses are weakened during sleep while some are protected.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Rozlyn C. T. Boutin, Zaki Alsahafi, Silvia Pagliardini
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Vishaal Rajani, Yong Zhang, Venkatesh Jalubula, Vladimir Rancic, Shahriar SheikhBahaei, Jennifer D. Zwicker, Silvia Pagliardini, Clayton T. Dickson, Klaus Ballanyi, Sergey Kasparov, Alexander V. Gourine, Gregory D. Funk
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Clinical Neurology
Jasmeen K. Saini, Silvia Pagliardini
Article
Physiology
Glauber S. F. da Silva, Joao P. J. Sabino, Vishaal Rajani, Tucaaue S. Alvares, Silvia Pagliardini, Luiz G. S. Branco, Gregory D. Funk
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Physiology
Annette Pisanski, Silvia Pagliardini
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Neurosciences
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Clinical Neurology
Annette Pisanski, Xiuqing Ding, Nils A. Koch, Silvia Pagliardini
Article
Neurosciences
Vivian Biancardi, Jashan Saini, Anileen Pageni, Hema Prashaad M., Gregory D. Funk, Silvia Pagliardini
Summary: The lateral parafacial region is a conditional oscillator that can drive active expiration during high respiratory demand and increase ventilation. Neurons in the pF(L) receive extensive excitatory and inhibitory inputs from several brainstem regions, contributing to the complex modulation of active expiration.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Clinical Neurology
Jasmeen K. Saini, Tara A. Janes, Joanna E. MacLean, Silvia Pagliardini
Summary: A study found that expiratory abdominal muscle activity occurs during sleep in infants aged 0-2 years, mostly during non-rapid eye movement and rapid-eye movement states, and is associated with normal breathing or respiratory events such as apneas or O-2 desaturation. The recruitment of expiratory abdominal muscles may contribute to proper ventilation by counteracting airway resistance and O-2 desaturation in infants during different sleep stages.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Neurosciences
Brandon E. Hauer, Silvia Pagliardini, Clayton T. Dickson
Summary: The nucleus reuniens of the thalamus (RE) plays a crucial role in mediating communication between the medial prefrontal cortex (mPFC) and the hippocampus (HPC) depending on the brain state. Its activity pattern changes in different states, which affects the coordination of slow oscillation (SO) between mPFC and HPC. The study shows that the state-dependent activity pattern of RE neurons is responsible for efficient communication between mPFC and HPC. This has implications for understanding how distant brain regions communicate effectively and its relevance to memory consolidation during slow-wave sleep.
Article
Biochemistry & Molecular Biology
Silvia Cardani, Tara A. Janes, Jasmeen K. Saini, Simona Di Lascio, Roberta Benfante, Diego Fornasari, Silvia Pagliardini
Summary: Chronic administration of Etonogestrel (ETO), a potent progestin drug, improved respiratory function and enhanced chemoreflex response in adult female rats. This effect was associated with reduced expression of PHOX2B and its target genes selectively in the dorsal vagal complex, suggesting a potential role of the nucleus tractus solitarius (NTS) in ETO-induced respiratory modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Vincent Joseph, Silvia Pagliardini, Elise Belaidi
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Vivian Biancardi, Xiaqiu Yang, Xiuqing Ding, Dhruv Passi, Gregory D. Funk, Silvia Pagliardini
Summary: Rhythmic inspiratory activity is generated in the preBotzinger complex (preBotC) in the medulla. Cholinergic neurotransmission affects respiratory rhythmogenic neurons and inhibitory glycinergic neurons in the preBotC. Contrary to previous hypotheses, the source of cholinergic inputs to the preBotC appears to originate from neighboring regions of the medulla rather than the main cholinergic systems in the brainstem.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Brandon E. Hauer, Silvia Pagliardini, Clayton T. Dickson