Article
Nutrition & Dietetics
Aisha A. Siddiq, Asha Martin
Summary: This study found that crocetin inhibits the expression of PCSK9, increases the expression of hepatic LDL receptor, and decreases the expression of SREBPs. It also regulates the expression of sortilin involved in PCSK9 transport. These findings suggest that crocetin has potential therapeutic effects in reducing cholesterol levels.
NUTRITION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Kelly A. Mitok, Mark P. Keller, Alan D. Attie
Summary: Sortilin is a post-Golgi trafficking receptor with diverse biological functions and associations with various diseases. The SORT1 gene has the strongest correlation with LDL-C levels, but the mechanism by which sortilin regulates LDL-C is unclear.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Shuang Wang, Qianming Jiang, Juan J. Loor, Changhong Gao, Mingmao Yang, Yan Tian, Wenwen Fan, Bingbing Zhang, Ming Li, Chuang Xu, Wei Yang
Summary: This study investigated the alterations in cholesterol synthesis, transport, and excretion in peripartal dairy cows with ketosis. It also explored the mechanistic links between SORT1 and fatty acid-mediated cholesterol metabolism.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Carlota Oleaga, Michael D. Shapiro, Joshua Hay, Paul A. Mueller, Joshua Miles, Cecilia Huang, Emily Friz, Hagai Tavori, Peter P. Toth, Cezary Wojcik, Bruce A. Warden, Jonathan Q. Purnell, P. Barton Duell, Nathalie Pamir, Sergio Fazio
Summary: This study investigated the mechanisms behind the increase in plasma PCSK9 levels in response to PCSK9i therapy. The findings suggest that PCSK9i enhances PCSK9 secretion, contributing to the elevated plasma PCSK9 levels in treated subjects.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Peter Loof Moller, Palle D. Rohde, Simon Winther, Peter Breining, Louise Nissen, Anders Nykjaer, Morten Bottcher, Mette Nyegaard, Mads Kjolby
Summary: Genetic variants in the SORT1 region are strongly associated with cholesterol levels and CAD risk. However, circulating sortilin does not appear to be a useful biomarker for CAD in low- to intermediate-risk chest-pain patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shun Ishiyama, Takafumi Hasegawa, Naoto Sugeno, Junpei Kobayashi, Shun Yoshida, Yasuo Miki, Koichi Wakabayashi, Mitsunori Fukuda, Yasushi Kawata, Takaaki Nakamura, Kazuki Sato, Michinori Ezura, Akio Kikuchi, Atsushi Takeda, Masashi Aoki
Summary: Sortilin acts as an endocytic receptor for fibrillar aSYN, and inhibiting its binding can hinder the uptake of aSYN fibrils. Sortilin is also present in the brains of synucleinopathy patients and its expression level may be altered with disease progression.
Article
Biochemistry & Molecular Biology
Nurjannatul Naim Kamaruddin, Nor Azwin Hajri, Yosie Andriani, Aina Farahiyah Abdul Manan, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad
Summary: Atherosclerosis, caused by elevated plasma cholesterols, is a major factor in global cardiovascular disease mortality. While statins are commonly used to lower cholesterol levels, they may have adverse effects, prompting the search for new treatments. Research on the marine invertebrate Acanthaster planci suggests its potential in reducing cholesterol levels without causing harm to the liver.
Article
Chemistry, Medicinal
Nurjannatul Naim Kamaruddin, Lukman Hakim Mohd Din, Allicia Jack, Aina Farahiyah Abdul Manan, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad
Summary: This study investigated the effects of a selected fraction of A. planci on PCSK9 gene expression, LDLR protein level, and LDL-C uptake. The results showed that the selected fraction reduced PCSK9 gene expression, increased LDLR protein level, and promoted LDL-C uptake. These findings suggest that the selected fraction has the potential to lower circulating LDL-C levels and may be a promising therapeutic intervention for preventing the progression of atherosclerosis.
Article
Medicine, Research & Experimental
Khadijeh Mahboobnia, Matteo Pirro, Ettore Marini, Francesco Grignani, Evgeny E. Bezsonov, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: PCSK9 plays an important role in the development and progression of various cancers, highlighting its potential significance in cancer treatment. Inhibiting PCSK9 may help suppress the proliferation and invasion of tumor cells. However, the current lack of data on the role of PCSK9 in cancer and the impact of PCSK9 inhibition in cancer therapy limits our understanding of its effectiveness and safety.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Akihiro Nomura, Atsushi Nohara, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Noboru Fujino, Masayuki Takamura, Masa-aki Kawashiri
Summary: This study aimed to investigate the association between attainment of low-density lipoprotein (LDL) cholesterol treatment target and better prognosis in patients with familial hypercholesterolemia (FH). The findings suggest that attainment of the LDL cholesterol treatment target is associated with a reduced occurrence of major adverse cardiac events (MACEs).
Article
Cardiac & Cardiovascular Systems
Julius L. Katzmann, Maximilian Lehmann, Adrienn Tuennemann-Tarr, Ira An Haack, Alexander Dressel, Winfried Marz, Ulrich Laufs
Summary: Cutaneous manifestations are only present in a minority of contemporary patients with FH, including the subgroup with monogenic FH mutations. Although rare, the cutaneous signs have value in terms of specificity. However, the clinical characteristics shared by the majority of FH patients may be better suited for screening purposes.
Article
Parasitology
Constanza Feliziani, Maria R. Rivero, Gonzalo Quassollo, Andrea S. Ropolo, Maria C. Touz
Summary: This study describes the involvement of receptor-mediated endocytosis (RME) in the cell differentiation process of Giardia lamblia. Inhibition of the medium subunit Gl mu 2 of the giardial adaptin protein GlAP2 impaired RME and triggered the process of encystation in growing cells. However, blocking RME only induced cell differentiation without completing the encystation process. Furthermore, the giardial adaptin protein GlAP2 was found to be necessary for the final steps of encystation by sorting the cyst wall protein CWP1 to the plasma membrane for cyst wall formation.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaole Chang, Yongfang Zhao, Shucun Qin, Hao Wang, Bingxiang Wang, Lei Zhai, Boyan Liu, Hong-mei Gu, Da-wei Zhang
Summary: The adrenal gland in Surf4(LKO) mice shows reduced cholesterol levels and increased expression of genes involved in de novo cholesterol biosynthesis, leading to compensation for the loss of circulating lipoprotein-derived cholesterol and maintenance of adrenal steroid hormone production.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Hirofumi Okada, Atsushi Nohara, Masayuki Takamura, Masa-aki Kawashiri
Summary: The study found that in patients with familial hypercholesterolemia, regression of Achilles tendon thickness (ATT) played a role in controlling the development of major adverse cardiovascular events. Factors such as age, hypertension, and diabetes were positively correlated with changes in ATT, while baseline ATT and FH-related gene mutations were negatively correlated with changes in ATT. Through controlling these factors, regression of ATT was significantly associated with reduced MACE.
Article
Peripheral Vascular Disease
Keiko Nagahara, Tsuyoshi Nishibukuro, Yasuko Ogiwara, Kento Ikegawa, Hayato Tada, Masakazu Yamagishi, Masa-aki Kawashiri, Ayako Ochi, Junya Toyoda, Yuya Nakano, Masanori Adachi, Katsumi Mizuno, Yukihiro Hasegawa, Kazushige Dobashi
Summary: This study aimed to analyze the gene and lipid profiles of children diagnosed with familial hypercholesterolemia (FH). The results showed that approximately half of the children had pathogenic variants in FH causative genes, and these variants had different effects on serum LDL-C levels.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)