Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marta Fanlo-Maresma, Beatriz Candas-Estebanez, Virginia Esteve-Luque, Ariadna Padro-Miquel, Francesc Escrihuela-Vidal, Monica Carratini-Moraes, Emili Corbella, Xavier Corbella, Xavier Pinto
Summary: In women with SLE, plasma TG concentrations, GCKR CC homozygosity, and hypertension are independent predictors of carotid atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Marc Scherlinger, Vivien Guillotin, Isabelle Douchet, Pierre Vacher, Andrea Boizard-Moracchini, Jean-Philippe Guegan, Anne Garreau, Nathalie Merillon, Agathe Vermorel, Emmanuel Ribeiro, Irene Machelart, Estibaliz Lazaro, Lionel Couzi, Pierre Duffau, Thomas Barnetche, Jean-Luc Pellegrin, Jean-Francois Viallard, Maya Saleh, Thierry Schaeverbeke, Patrick Legembre, Marie-Elise Truchetet, Helene Dumortier, Cecile Contin-Bordes, Vanja Sisirak, Christophe Richez, Patrick Blanco
Summary: This study identified a P-selectin-dependent pathway in patients with systemic lupus erythematosus (SLE) and validated it as a potential therapeutic avenue. Platelets from SLE patients interacted with Treg cells via the P-selectin/PSGL-1 axis, affecting Treg cell function and suppressing immune responses. Blocking P-selectin in a mouse model of SLE improved disease features, indicating its potential as a therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Haiping Xing, Haiyu Pang, Tian Du, Xufei Yang, Jing Zhang, Mengtao Li, Shuyang Zhang
Summary: In this study, atherosclerotic risk prediction model was built for SLE patients using RNA sequencing and differential expression analysis. The model, incorporating one gene and two clinical factors, demonstrated relatively high discrimination and calibration performance, providing valuable assistance for identifying atherosclerosis in SLE patients, especially asymptomatic ones.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Leda Coelewij, Kirsty E. Waddington, George A. Robinson, Elvira Chocano, Thomas McDonnell, Filipa Farinha, Junjie Peng, Pierre Donnes, Edward Smith, Sara Croca, Jyoti Bakshi, Maura Griffin, Andrew Nicolaides, Anisur Rahman, Elizabeth C. Jury, Ines Pineda-Torra
Summary: This study found that patients with SLE have global changes in their lipoprotein profiles, but standard serum lipid measurements cannot accurately predict their risk of cardiovascular disease. Serum metabolites may be promising biomarkers to uncover the multi-metabolic phenotypes of subclinical atherosclerosis in SLE patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Immunology
Christopher B. Oliveira, Mariana J. Kaplan
Summary: Patients with systemic lupus erythematosus (SLE) have a higher risk of cardiovascular diseases, and traditional risk factors cannot fully explain this increased risk. SLE-specific factors, such as immune dysregulation and inflammation, may contribute to the development of cardiovascular diseases in SLE patients.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Rheumatology
Apinya Lertratanakul, Julia Sun, Peggy W. Wu, Jungwha Lee, Alan Dyer, William Pearce, David McPherson, Kim Sutton-Tyrrell, Trina Thompson, Emma Barinas-Mitchell, Rosalind Ramsey-Goldman
Summary: The study identified potential modifiable risk factors for carotid IMT and plaque progression in women with SLE, suggesting that monitoring of glucose and waist circumference and use of hydroxychloroquine may be beneficial. The differences in the progression of carotid IMT and plaque between SLE patients and non-SLE patients were observed. In SLE cases, higher fasting glucose and lower fibrinogen were associated with IMT progression, while larger waist circumference and non-use of hydroxychloroquine were associated with plaque progression.
LUPUS SCIENCE & MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Arduino A. Mangoni
Summary: Statins can effectively decrease circulating levels of cell adhesion molecules, including P-selectin, L-selectin, and E-selectin, which are involved in the pathogenesis of atherosclerosis. Research indicates that statins have a significant impact on reducing these selectins independently of baseline lipid profiles and other patient characteristics, potentially contributing to cardiovascular risk reduction.
Review
Immunology
Xiaohong Lu, YanHua Wang, Jing Zhang, Dan Pu, Nan Hu, Jing Luo, Qi An, Lan He
Summary: The systematic review and meta-analysis found that patients with systemic lupus erythematosus (SLE) have a higher risk of developing cardiovascular disease (CVD) compared to the general or healthy population, and the risk of CVD in lupus nephritis (LN) patients is significantly higher than in SLE patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yudong Liu, Xue Yu, Wenduo Zhang, Xuan Zhang, Min Wang, Fusui Ji
Summary: Systemic lupus erythematosus (SLE) is strongly associated with cardiovascular disease (CVD), and the interaction between immune dysregulation and traditional CVD risk factors plays a significant role in the development of premature atherosclerosis and CVD in SLE. Abnormal systemic inflammation in SLE can lead to lipid profile and function irregularities, further promoting a pro-atherosclerotic environment. Profound immune dysregulation, including excessive type I interferon burden, aberrant macrophage, platelet and complements activation, etc., contributes to accelerated CVD in SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Rheumatology
Antonietta Gigante, Francesco Iannazzo, Luca Navarini, Maria Chiara Sgariglia, Domenico Paolo Emanuele Margiotta, Valentina Vaiarello, Federica Foti, Antonella Afeltra, Rosario Cianci, Edoardo Rosato
Summary: The study found a higher prevalence of MetS in patients with systemic lupus erythematosus compared to systemic sclerosis patients. In SLE patients, MetS was associated with adiponectin levels and inflammation/activity disease scores, while in SSc patients, it was associated with disease severity.
CLINICAL RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoichi Miura, Hidenori Suzuki
Summary: Both fasting and non-fasting hypertriglyceridemia are risk factors for atherosclerotic disease, but it is uncertain whether they increase the risks of carotid artery stenosis progression. Statins can prevent carotid plaque progression and improve plaque stability. However, there is currently no evidence that combining non-statin lipid-lowering drugs with statins provides additional benefits in preventing cerebrovascular events and stenosis progression in patients with carotid artery stenosis. This article explores the relationship between hypertriglyceridemia and carotid artery stenosis, as well as the potential role of lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yimin Wang, Wenge Su, Yunlun Li, Jie Yuan, Minghao Yao, Xiaoyi Su, Yifei Wang
Summary: This study investigated the mechanisms of the co-occurrence of systemic lupus erythematosus (SLE) and atherosclerosis (AS). Gene expression profiles were analyzed to identify common differentially expressed genes (DEGs), and enrichment analysis revealed the involvement of the IL-17 signaling pathway. Five key genes (CCR1, CD163, IL1RN, MMP9, and SIGLEC1) were identified as potential drivers of monocyte differentiation into macrophages, and immune cell infiltration analysis showed the importance of monocytes in SLE and M0 macrophages in AS.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Akiko Maehara, Raymond Y. Kwong, Tara Sedlak, Jacqueline Saw, Nathaniel R. Smilowitz, Ehtisham Mahmud, Janet Wei, Kevin Marzo, Mitsuaki Matsumura, Ayako Seno, Anais Hausvater, Caitlin Giesler, Nisha Jhalani, Catalin Toma, Bryan Har, Dwithiya Thomas, Laxmi S. Mehta, Jeffrey Trost, Puja K. Mehta, Bina Ahmed, Kevin R. Bainey, Yuhe Xia, Binita Shah, Michael Attubato, Sripal Bangalore, Louai Razzouk, Ziad A. Ali, Noel Bairey Merz, Ki Park, Ellen Hada, Hua Zhong, Judith S. Hochman
Summary: Multimodality imaging with coronary OCT and CMR identified potential mechanisms in 84.5% of women with a diagnosis of MINOCA, 75.5% of which were ischemic and 24.5% of which were nonischemic, providing valuable guidance for medical therapy in secondary prevention.
Article
Rheumatology
Peter M. Izmirly, Mimi Y. Kim, Marie Samanovic, Ruth Fernandez-Ruiz, Sharon Ohana, Kristina K. Deonaraine, Alexis J. Engel, Mala Masson, Xianhong Xie, Amber R. Cornelius, Ramin S. Herati, Rebecca H. Haberman, Jose U. Scher, Allison Guttmann, Rebecca B. Blank, Benjamin Plotz, Mayce Haj-Ali, Brittany Banbury, Sara Stream, Ghadeer Hasan, Gary Ho, Paula Rackoff, Ashira D. Blazer, Chung-E Tseng, H. Michael Belmont, Amit Saxena, Mark J. Mulligan, Robert M. Clancy, Jill P. Buyon
Summary: In a multiethnic/multiracial study of SLE patients, 29% had a low response to the COVID-19 vaccine which was associated with receiving immunosuppressive therapy. Severe disease flares were rare.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, C. Noel Bairey Merz, Colin Berry, Rohit Samuel, Jacqueline Saw, Nathaniel R. Smilowitz, Ana Carolina do A. H. de Souza, Robert Sykes, Viviany R. Taqueti, Janet Wei
Summary: Ischemic heart disease is the leading cause of mortality in women and requires gender-specific risk stratification for prevention, diagnosis, and treatment. Recent research has improved understanding of cardiovascular disease in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite progress, sex differences in ischemic heart disease outcomes persist.
CIRCULATION RESEARCH
(2022)
Article
Rheumatology
Andrea Fava, Deepak A. Rao, Chandra Mohan, Ting Zhang, Avi Rosenberg, Paride Fenaroli, H. Michael Belmont, Peter Izmirly, Robert Clancy, Jose Monroy Trujillo, Derek Fine, Arnon Arazi, Celine C. Berthier, Anne Davidson, Judith A. James, Betty Diamond, Nir Hacohen, David Wofsy, Soumya Raychaudhuri, William Apruzzese, Jill Buyon, Michelle Petri
Summary: By analyzing longitudinal urinary proteomic profiles in patients with Lupus Nephritis (LN), this study identified multiple biologic pathways and 237 urinary biomarkers associated with LN. IL-16 was identified as a key factor in LN pathogenesis and a potential target for treatment and biomarker.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, John A. Spertus, Susanna R. Stevens, Philip G. Jones, G. B. John Mancini, Jonathon Leipsic, Harmony R. Reynolds, Matthew J. Budoff, Cameron J. Hague, James K. Min, William E. Boden, Sean M. O'Brien, Robert A. Harrington, Jeffrey S. Berger, Roxy Senior, Jesus Peteiro, Neeraj Pandit, Leonid Bershtein, Mark A. de Belder, Hanna Szwed, Rolf Doerr, Lorenzo Monti, Khaled Alfakih, Judith S. Hochman, David J. Maron
Summary: The study found that intermediate left main disease (LMD) was associated with cardiovascular events. An invasive strategy can reduce nonprocedural MI and improve angina-related quality of life.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Health Care Sciences & Services
S. Raquel Ramos, Constance Johnson, Gail Melkus, Trace Kershaw, Marya Gwadz, Harmony Reynolds, Allison Vorderstrasse
Summary: This study proposes the first technology-based virtual environment intervention for addressing behavioral risk factors associated with cardiovascular and metabolic comorbidities in sexual-minority men of color with HIV. The study has been approved by institutional review boards and data collection is ongoing, with expectations of positive outcomes for CVD prevention education and peer social support.
JMIR RESEARCH PROTOCOLS
(2022)
Letter
Cardiac & Cardiovascular Systems
Jill Buyon, Amit Saxena, Deborah Friedman, Peter Izmirly
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Rheumatology
Ghadeer Hasan, Elizabeth D. Ferucci, Jill P. Buyon, H. Michael Belmont, Jane E. Salmon, Anca Askanase, Joan M. Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M. Ginzler, Chaim Putterman, Caroline Gordon, Charles G. Helmick, Hilary Parton, Peter M. Izmirly
Summary: Using data from the MLSP, we estimated the prevalence and incidence of MCTD. The variation in estimates using different case definitions highlights the challenges in defining MCTD in epidemiological studies.
Article
Cardiac & Cardiovascular Systems
Nina Talmor, Michael Gurin, Nathaniel Smilowitz, Dana Gossett, Bruria Eisner, Mitchell Pleasure, Harmony R. Reynolds
Summary: This case report describes a 37-year-old woman with recurrent non-ST elevation myocardial infarction (NSTEMI) during her menstrual periods. Intracoronary acetylcholine provocation testing revealed coronary spasm in the left anterior descending artery (LAD) that was relieved with nitroglycerine. Initiating calcium channel blockade and suppressing cyclical variation in sex hormones improved her symptoms and prevented monthly NSTEMI events caused by coronary spasm.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Priya Panday, Anais Hausvater, Mitchell Pleasure, Nathaniel R. Smilowitz, Harmony R. Reynolds
Summary: Women with myocardial infarction (MI) are more likely to have nonobstructive coronary artery disease (MINOCA), spontaneous coronary artery dissection (SCAD), and takotsubo syndrome (TS) than men. This study aims to determine the prevalence of cancer in women with MI and investigate its association with the mechanism of MI presentation.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Rheumatology
Doua Azzouz, Ze Chen, Peter M. Izmirly, Lea Ann Chen, Zhi Li, Chongda Zhang, David Mieles, Kate Trujillo, Adriana Heguy, Alejandro Pironti, Greg G. Putzel, Dominik Schwudke, David Fenyo, Jill P. Buyon, Alexander Alekseyenko, Nicolas Gisch, Gregg J. Silverman
Summary: This study investigated the relationship between gut microbiota and disease activity in systemic lupus erythematosus (SLE) patients. The results showed that SLE patients had unstable microbiota communities and experienced intestinal growth spikes of pathogenic species during disease flares. The expansion of Ruminococcus (blautia) gnavus (RG) was associated with high-disease activity and lupus nephritis (LN) flares, and specific RG strains isolated during flares expressed a novel type of cell membrane-associated lipoglycan.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Scott D. J. Solomon, Charles J. S. Lowenstein, Ankeet S. Bhatt, Alexander Peikert, Orly N. Vardeny, Mikhail N. S. Kosiborod, Jeffrey S. R. Berger, Harmony R. Reynolds, Stephanie Mavromichalis, Anya D. Barytol, Andrew D. F. Althouse, James F. S. Luther, Eric S. L. Leifer, Andrei L. Kindzelski, Mary N. Cushman, Michelle N. Z. Gong, Lucy Z. Kornblith, Pooja S. Khatri, Keri S. Kim, Lisa Baumann Kreuziger, Lana Wahid, Bridget-Anne W. Kirwan, Mark W. D. Geraci, Matthew D. S. Neal, Judith S. Hochman
Summary: This study aimed to evaluate the efficacy of using the P-selectin inhibitor crizanlizumab in reducing mortality and disease progression in COVID-19 patients. However, the results showed that the drug did not improve organ support-free days in patients hospitalized with COVID-19.
Editorial Material
Cardiac & Cardiovascular Systems
Sunil V. Rao, Harmony R. Reynolds, Judith S. Hochman