Stretching Mechanotransduction from the Lung to the Lab: Approaches and Physiological Relevance in Drug Discovery

A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

(2011) Justin D. Mih et al.   PLoS One

Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces

(2010) Ramaswamy Krishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability

(2010) Anna A. Birukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Biaxial distension of precision-cut lung slices

(2010) C. Dassow et al.   JOURNAL OF APPLIED PHYSIOLOGY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: Implications for atherosclerosis

(2010) Xin Q. Brown et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression

(2010) Wilbur A Lam et al.   Molecular Cancer

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch

(2010) Cheng Chen et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays

(2009) Christopher Moraes et al.   BIOMATERIALS

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Cyclic Mechanical Stretch Decreases Cell Migration by Inhibiting Phosphatidylinositol 3-Kinase- and Focal Adhesion Kinase-mediated JNK1 Activation

(2009) Leena P. Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-α

(2009) Yulian Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation

(2009) Christopher Moraes et al.   LAB ON A CHIP

Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness

(2009) Ramaswamy Krishnan et al.   PLoS One

Individually programmable cell stretching microwell arrays actuated by a Braille display

(2008) Yoko Kamotani et al.   BIOMATERIALS

Frequency and peak stretch magnitude affect alveolar epithelial permeability

(2008) T. S. Cohen et al.   EUROPEAN RESPIRATORY JOURNAL

Cyclic stretch-induced nuclear localization of transcription factors results in increased nuclear targeting of plasmids in alveolar epithelial cells

(2008) Anna P. Lam et al.   JOURNAL OF GENE MEDICINE

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical Stress Upregulates Intercellular Adhesion Molecule-1 in Pulmonary Epithelial Cells

(2008) Xiaobo Hu et al.   RESPIRATION

Cyclic Stretch of Human Lung Cells Induces an Acidification and Promotes Bacterial Growth

(2007) Jérôme Pugin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY