Article
Immunology
Xueyan Li, Xiaoqi Luo, Siru Chen, Jiayi Chen, Xue Deng, Jiahui Zhong, Hui Wu, Xuhui Huang, Changjun Wang
Summary: Hepatocellular carcinoma is characterized by high infiltration of myeloid-derived suppressor cells (MDSCs), which are key drivers of maintaining the immunosuppressive tumor microenvironment. All-trans retinoic acid (ATRA) can differentiate MDSCs into mature myeloid cells, but its effect on liver cancer growth inhibition is unknown.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Shyang Jeng, I-Shyan Sheen, Shu-Sheng Lin, Chuen-Miin Leu, Chiung-Fang Chang
Summary: Endoglin (CD105) is a vital protein associated with angiogenesis in hepatocellular carcinoma (HCC), potentially serving as a diagnostic or prognostic factor. Combining TRC105, an antibody against endoglin, with sorafenib can achieve partial response. While antiangiogenic therapy carries risks, combination therapy with endoglin inhibitors or other targeted therapies shows promise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Wei-Chong Dong, Jia-Liang Guo, Meng-Qiang Zhao, Xi-Kun Wu, Yi-Xuan Cui, Jing-Ying Feng, Chen-Xiao Zhang, Ye Jiang, Zhi-Qing Zhang
Summary: The study introduced a simple and accurate method for monitoring the concentrations of four reduced aminothiols in human blood, and found no significant differences in the levels of these thiols based on different genders, ages, or drug combinations.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pei-Wei Shueng, Hui-Wen Chan, Wei-Chan Lin, Deng-Yu Kuo, Hui-Yen Chuang
Summary: Sorafenib is an effective drug for hepatocellular carcinoma, but resistance often occurs. This study found that resistance to sorafenib could be reversed by inhibiting fatty acid synthesis using orlistat, and this combination treatment enhanced cell killing in hepatocellular carcinoma by altering cell metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ying-Ying Ge, Qing-Mei Zhang, Chang Liu, Xia Zeng, Wei-Xia Nong, Fang Chen, Shui-Qing Bi, Wen-Wen Guo, Bin Luo, Xiao-Xun Xie
Summary: The combination of DAC, VPA, and TSA may enhance the anti-tumor efficacy of ACRBP-specific T cells by upregulating ACRBP expression in HCC, as shown in the study on a murine model of hepatocellular carcinoma.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dahae Lee, Jae Sik Yu, Ji Won Ha, Seoung Rak Lee, Bum Soo Lee, Jin-Chul Kim, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim
Summary: This study investigated the cytotoxicity of Withania somnifera against human hepatocellular carcinoma (HCC) cells and identified potential antitumoral withanolide glycosides. The study also elucidated the molecular mechanisms of these bioactive compounds and found that they induced apoptosis and inhibited angiogenesis in HCC cells.
Article
Oncology
Chen Xie, Song-Yang Li, Jian-Hong Fang, Ying Zhu, Jin-E Yang
Summary: Long non-coding RNAs (lncRNAs) have been identified as important regulators in hepatocellular carcinoma (HCC) development, affecting malignant phenotypes and being associated with diseases. Understanding their regulatory network offers new insights into diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Hongmeng Su, Shihui Shu, Wenqing Tang, Chuqian Zheng, Luyu Zhao, Hong Fan
Summary: ETV4 plays a crucial role in promoting angiogenesis and tumor invasion in hepatocellular carcinoma (HCC), and it induces angiogenesis in HCC by regulating the transcription level of MMP14.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Renata Ballok, Agnes Kis Varga, Peter Erdelyi, Janos Fischer
Summary: Paracetamol and valproic acid, two leading drugs in the world drug market, were examined along with their phosphonate analogues. N-(4-hydroxyphenylcarbamoyl)phosphonic acid exhibited four times greater efficacy than paracetamol in preventing acetic acid-induced writhing. The phosphonate derivative of valproic acid, (2-propylpentanoyl)phosphonic acid, demonstrated similar in vivo activity to valproic acid in the pentylenetetrazole-induced kindling mouse model.
Article
Pharmacology & Pharmacy
Xu Yang, Jing Liu, Qing Liang, Guangchun Sun
Summary: Hepatocellular carcinoma (HCC) is a common lethal human malignancy worldwide, with sorafenib being the first-line drug approved for its treatment. This study established a sorafenib-resistant HCC cell line and found that Notch and Akt pathways may play vital roles in sorafenib resistance, with VPA potentially enhancing sensitivity to sorafenib by suppressing these pathways. This research suggests a potential therapeutic regimen to overcome sorafenib resistance in HCC.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Jichong Li, Shuai Shen, Zijian Liu, Hongwei Zhao, Siyang Liu, Qingbo Liu, Guo-Dong Yao, Shao-Jiang Song
Summary: The prenylated flavonoid icaritin (ICT, 1) was modified to enhance its cytotoxicity against hepatocellular carcinoma (HCC) cells. Rhamnosylation at OH-3 and modification at OH-7 were found to increase the cytotoxicity. Based on the structure-activity relationship (SAR) study, 46 N-containing derivatives were synthesized and evaluated as anti-HCC inhibitors, showing potent inhibitory effects on HCC cell lines. Compound 11c exhibited higher potency than ICT and sorafenib, inducing cell cycle arrest and apoptosis.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Yongbin Meng, Hetong Zhao, Zhihao Zhao, Zifei Yin, Zhe Chen, Juan Du
Summary: This study investigated the role of Sec62 in hepatocellular carcinoma (HCC) and found that Sec62 may play a crucial role in HCC development and angiogenesis by regulating key genes and signaling pathways. Knockdown of Sec62 decreased the expression of key genes related to angiogenesis, while overexpression of Sec62 had the opposite effects. Additionally, Sec62 promoted pro-angiogenesis of HCC under hypoxia by regulating specific genes, suggesting it as a potential angiogenic switch in HCC.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Eun-Hye Jang, Jung-Ho Lee, Soon-Ae Kim
Summary: In this study, we found that treatment with valproic acid induced mitochondrial biogenesis and autophagy in the SH-SY5Y cell line by altering FOXO3a expression and posttranslational modification.
Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Polymer Science
Osama R. M. Metawea, Mohamed Teleb, Nesreen S. Haiba, Ahmed O. Elzoghby, Asmaa F. Khafaga, Ahmed E. Noreldin, Sherine N. Khattab, Hosam H. Khalil
Summary: A smart carrier, PNIPAM-MD NGs, decorated with FA, was developed for efficient delivery of RSV in breast cancer treatment. The FA-PNIPAM-MD F3 NGs displayed dual thermo-and pH-responsivities, high drug-loading capacity, and excellent stability. In vitro and in vivo evaluations demonstrated significant anti-breast cancer potency and tumor growth suppression.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Riham M. Abdelgalil, Sherine N. Khattab, Shaker Ebrahim, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Marwa A. Sallam, Ahmed O. Elzoghby
Summary: Researchers have developed a biocompatible silk-sericin-tagged inorganic nano-hybrid for the treatment and imaging of cancer cells. This nanocarrier can prevent premature release of the chemotherapeutic drug, enhance the stability of layered double hydroxides, and maintain the luminescence properties of zinc oxide quantum dots.
Article
Biochemistry & Molecular Biology
Yomna M. Elmorshedy, Mohamed Teleb, Marwa A. Sallam, Kadria A. Elkhodairy, Mohammed Bahey-El-Din, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Shimaa A. H. Abdel Monaim, Adnan A. Bekhit, Ahmed O. Elzoghby, Fernando Albericio, Sherine N. Khattab
Summary: Despite progress in targeted therapies, there is a need for convenient therapeutics for colorectal cancer (CRC). Lactoferrin nanoparticles (Lf NPs) show promise in cancer therapy, but their oral delivery is hindered by obstacles such as instability and premature uptake. Microencapsulation of Lf NPs provides a solution by protecting them and improving drug release in the colon.
Review
Pharmacology & Pharmacy
Karim Abdelazim, Amr Ghit, Dina Assal, Neamat Dorra, Nehad Noby, Sherine N. Khattab, Shaymaa Essam El Feky, Ahmed Hussein
Summary: Astaxanthin (AXT) is a natural red fat-soluble pigment occurring in aquatic animals, plants, and microorganisms, and can also be artificially synthesized. AXT has shown potential in scavenging free radicals and has been studied for its efficacy in various diseases. However, its limited solubility, stability, and bioavailability have hindered its therapeutic application. Incorporating AXT with nanocarriers has shown promise in improving its properties. This review summarizes recent data on AXT production, characterization, biological activity, and therapeutic usage, with a focus on its applications in nanotechnology era.
PHARMACOLOGICAL REPORTS
(2023)
Correction
Pharmacology & Pharmacy
Karim Abdelazim, Amr Ghit, Dina Assal, Neamat Dorra, Nehad Noby, Sherine N. Khattab, Shaymaa Essam El Feky, Ahmed Hussein
PHARMACOLOGICAL REPORTS
(2023)
Article
Environmental Sciences
Jaspreet Kaur, Gaurav Mudgal, Arvind Negi, Jeewan Tamang, Shambhawi Singh, Gajendra Bahadur Singh, K. Jagadeesh Chandra Bose, Sandip Debnath, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Janne Ruokolainen, Kavindra Kumar Kesari
Summary: The commercial processing of biomaterials produces wastewater containing azo dyes and hydrolyzed by-products. Current treatment methods lack selectivity and efficiency. Microbial-assisted methods, such as the use of Agrobacterium strain JAS1, have been identified as a potential solution for degrading azo dyes and their by-products.
Article
Crystallography
Hessa H. H. Al-Rasheed, Sarah A. A. AL-khamis, Assem Barakat, Ayman El-Faham, Matti Haukka, Saied M. M. Soliman
Summary: A series of novel isatin-s-triazine hydrazone derivatives were synthesized and characterized. The synthetic method involved the reaction of s-triazine hydrazine precursors with isatin derivatives, which resulted in the formation of target products 6a-e with high yields and purities. The crystal structure analysis of compound 6c revealed the presence of significant non-covalent interactions.
Article
Crystallography
Amal Yousri, Ayman El-Faham, Matti Haukka, Mohammed Salah Ayoup, Magda M. F. Ismail, Nagwan G. El Menofy, Saied M. Soliman, Lars Ohrstrom, Assem Barakat, Morsy A. M. Abu-Youssef
Summary: The novel [Na(bpmt)(2)][AuCl4] complex was synthesized using the self-assembly method with the pincer ligand 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (bpmt). The complex exhibited a distorted octahedral geometry around the Na(I) ion, with two bpmt ligands meridionally coordinated via short and slightly longer Na-N bonds. The complex showed significant antibacterial and antifungal activities, with enhanced efficacy compared to free bpmt and a positive control Amoxicillin for most tested bacteria, as well as better antifungal efficacy against C. albicans compared to bpmt.
Article
Chemistry, Inorganic & Nuclear
Eman M. Fathalla, Morsy A. M. Abu-Youssef, Mona M. Sharaf, Ayman El-Faham, Assem Barakat, Matti Haukka, Saied M. Soliman
Summary: Two complexes, [Ni(DPPT)(2)](NO3)(2)*1.5H(2)O (1) and [Ni(DPPT)(NO3)Cl].EtOH (2), were synthesized using the self-assembly of (E)-2,4-di(piperidin-1-yl)-6-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1,3,5-triazine (DPPT) with Ni(NO3)(2)*6H(2)O in the absence and presence of NiCl2*6H(2)O, respectively. Both complexes have neutral tridentate DPPT ligands coordinated to Ni(II) ions. Rating: 7/10
Article
Chemistry, Inorganic & Nuclear
Kholood A. A. Dahlous, Saied M. M. Soliman, Matti Haukka, Ayman El-Faham, Raghdaa A. A. Massoud
Summary: A new 1D Ni(II) coordination polymer was synthesized using NiSO4 center dot 6H(2)O, 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT), and SCN- as a linker. The polymer showed potential as an antibacterial and antifungal agent, with cytotoxic activities against HepG-2 and A-549 cell lines.
Article
Chemistry, Inorganic & Nuclear
Eman M. Fathalla, Morsy A. M. Abu-Youssef, Mona M. Sharaf, Ayman El-Faham, Assem Barakat, Matti Haukka, Saied M. Soliman
Summary: Two new Ni(II) complexes, [Ni(DMPT)(H2O)3](NO3)2.3H2O (1) and [Ni(DMPT)(H2O)3](NO3)2.H2O (2), were successfully synthesized using the hydrazine s-triazine ligand (E)-4,4'-(6-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1,3,5-triazine-2,4-diyl)dimorpholine (DMPT) and a one-pot synthesis strategy. The structures of the complexes were characterized by elemental analysis, FTIR, and single-crystal X-ray diffraction analysis. The DMPT ligand acts as a tridentate NNN-chelate via three Ni-N coordination interactions, and the coordination sphere of the Ni(II) ion is completed by three water molecules. Both complexes exhibit distorted octahedral geometry. The crystal packing of the complexes is driven by strong O... H interactions, attributed to the presence of nitrate anions and water molecules. Complex 1 showed antimicrobial activity against both Gram-negative and Gram-positive bacterial strains, while the free ligand was inactive against all microbial species.
Article
Green & Sustainable Science & Technology
Muhammad Tansar Abbas, Mohammad Ahmad Wadaan, Hidayat Ullah, Muhammad Farooq, Fozia Fozia, Ijaz Ahmad, Muhammad Farooq Khan, Almohannad Baabbad, Zia Ullah
Summary: This study reveals the worldwide environmental concern of heavy metal accumulation in soil and vegetables, as well as the associated health risks. The concentration of heavy metals in wastewater, soil, and vegetables irrigated with wastewater was slightly higher than the WHO-suggested limit. Risk assessment of different vegetables and population groups showed higher health risks associated with certain vegetables and heavy metals for both adults and children.
Article
Green & Sustainable Science & Technology
Eman A. El Desouky, Emad A. Soliman, Hessa H. Al-Rasheed, Ayman El-Faham, M. A. Abu-Saied
Summary: Novel proton exchange membranes (PEMs) based on a composite of sulfonated polyacrylonitrile (SPAN), sulfonated polyglycidyl methacrylate (SPGMA), or sulfonated poly(acrylonitrile-co-glycidyl methacrylate) (SP(AN-co-GMA))/polyvinyl chloride (PVC) were developed for direct methanol fuel cells (DMFCs). The study found that the composite membranes based on sulfonated copolymers had higher thermal stability and ion exchange capacity than the composites based on sulfonated homopolymers.
Article
Infectious Diseases
Eglal I. Amer, Sonia R. Allam, Aceel Y. Hassan, Esmail M. El-Fakharany, Mona M. Agwa, Sherine N. Khattab, Eman Sheta, Marwa H. El-Faham
Summary: This study proposes a novel antibody-targeted nano-sized conjugated linoleic acid (CLA) delivery system for the treatment of Schistosoma mansoni infection and control of its transmission. The antibody-conjugated CLA nanomicelles showed significant schistosomicidal and anti-pathology activities against early and late stages of infection in a mouse model. The study highlights the potential of nanotechnology-based immunotherapy for parasitic infections and suggests that the immunodominant reactivity of the anti-SmI serum merits attention as a therapeutic candidate.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Christine A. Morcos, Sherine N. Khattab, Nesreen S. Haiba, Rafik W. Bassily, Marwa M. Abu-Serie, Mohamed Teleb
Summary: This study reports new hybrid triazines capable of simultaneously inhibiting MMP-10/13 and inducing ferroptosis. Preliminary screening revealed outstanding anticancer activity for certain compounds, which depleted cellular GSH, induced lipid peroxidation, and triggered ferroptosis. These findings contribute to a better understanding of the role of MMPs in tumor development and provide new insights for the development of novel combination therapy strategies.
BIOORGANIC CHEMISTRY
(2023)