Signal Transducer and Activator of Transcription 3 - A Promising Target in Colitis-Associated Cancer

Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling

(2015) Manjinder Kaur et al.   NEOPLASIA

Autocrine Regulation of IL-21 Production in Human T Lymphocytes

(2014) F. Caprioli et al.   JOURNAL OF IMMUNOLOGY

Potential Targets for Prevention of Colorectal Cancer: a Focus on PI3K/Akt/mTOR and Wnt Pathways

(2013) Ashok Kumar Pandurangan   Asian Pacific Journal of Cancer Prevention

Pterostilbene Exerts Antitumor Activity via the Notch1 Signaling Pathway in Human Lung Adenocarcinoma Cells

(2013) Yang Yang et al.   PLoS One

Effect of Luteolin on the Levels of Glycoproteins During Azoxymethane-induced Colon Carcinogenesis in Mice

(2012) Ashok Kumar Pandurangan et al.   Asian Pacific Journal of Cancer Prevention

Prohibitin Attenuates Colitis-Associated Tumorigenesis in Mice by Modulating p53 and STAT3 Apoptotic Responses

(2012) A. S. Kathiria et al.   CANCER RESEARCH

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

Constitutive Notch2 signaling induces hepatic tumors in mice

(2012) Michael T. Dill et al.   HEPATOLOGY

O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms

(2012) Julia Kargl et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells

(2012) Hye-Sook Seo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

(2012) Qingyun Chen et al.   PLoS One

STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells

(2011) Li Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

(2011) Muthu K. Shanmugam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inflammation-mediated promotion of invasion and metastasis

(2010) Graziella Solinas et al.   CANCER AND METASTASIS REVIEWS

Matrix Metalloproteinase-9 Functions as a Tumor Suppressor in Colitis-Associated Cancer

(2010) P. Garg et al.   CANCER RESEARCH

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

(2010) Kiyoshi Hirahara et al.   CYTOKINE & GROWTH FACTOR REVIEWS

MicroRNA regulation of core apoptosis pathways in cancer

(2010) Raquel T. Lima et al.   EUROPEAN JOURNAL OF CANCER

Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6–STAT3 signaling pathway

(2010) Yun Tian et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

(2010) Li Lin et al.   Molecular Cancer

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

M-ORBIS: Mapping of mOleculaR Binding sItes and Surfaces

(2010) Laurent-Philippe Albou et al.   NUCLEIC ACIDS RESEARCH

Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer

(2010) S Danese et al.   ONCOGENE

Interleukin-21 triggers effector cell responses in the gut

(2010) Daniela De Nitto   WORLD JOURNAL OF GASTROENTEROLOGY

A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis

(2009) Lin Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

(2009) Aaron L Sarver et al.   BMC CANCER

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor- B and Signal Transducers and Activators of Transcription 3

(2009) A. Tyagi et al.   Cancer Prevention Research

Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth

(2009) K. Sakamoto et al.   CLINICAL CANCER RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease

(2009) Takanori Kanai et al.   CURRENT OPINION IN GASTROENTEROLOGY

Interleukin-6 Trans-Signaling and Colonic Cancer Associated with Inflammatory Bowel Disease

(2009) Stefan Rose-John et al.   CURRENT PHARMACEUTICAL DESIGN

Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

(2009) Zhipeng Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Intestinal Effector T Cells in Health and Disease

(2009) Craig L. Maynard et al.   IMMUNITY

Interleukin-23/Th17 pathways and inflammatory bowel disease

(2009) Clara Abraham et al.   INFLAMMATORY BOWEL DISEASES

Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ β-catenin pathway

(2009) Pandurangan Ashokkumar et al.   INVESTIGATIONAL NEW DRUGS

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival

(2008) Geoffrey E. Johnson et al.   APOPTOSIS

Chronic inflammation and pancreatic cancer

(2008) Colin J. McKay et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis

(2008) Pandurangan Ashokkumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

(2008) Sergei Grivennikov et al.   CANCER CELL

β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma

(2008) Shuang Yan et al.   CANCER LETTERS

Esophageal adenocarcinoma arising in Barrett esophagus

(2008) Hui Ying Zhang et al.   CANCER LETTERS

Signaling Molecules: The Pathogenic Role of the IL-6/STAT-3 Trans Signaling Pathway in Intestinal Inflammation and in Colonic Cancer

(2008) R. Atreya et al.   CURRENT DRUG TARGETS

Systematic review of the association between circulating interleukin-6 (IL-6) and cancer

(2008) Katriina Heikkilä et al.   EUROPEAN JOURNAL OF CANCER

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

Inflammation: Gearing the journey to cancer

(2008) J KUNDU et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

Nogo-66 Promotes the Differentiation of Neural Progenitors into Astroglial Lineage Cells through mTOR-STAT3 Pathway

(2008) Bin Wang et al.   PLoS One

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

(2008) Peter Laszlo Lakatos et al.   WORLD JOURNAL OF GASTROENTEROLOGY