Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

(2013) Daniel Zabala et al.   METABOLIC ENGINEERING

Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster

(2013) Adam C. Jones et al.   PLoS One

Elucidating the Biosynthetic Pathway for the Polyketide-Nonribosomal Peptide Collismycin A: Mechanism for Formation of the 2,2′-bipyridyl Ring

(2012) Ignacio Garcia et al.   CHEMISTRY & BIOLOGY

Amino Acid Precursor Supply in the Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin by Streptomyces lydicus

(2011) C. Gomez et al.   JOURNAL OF BACTERIOLOGY

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042

(2010) Kerstin Seeger et al.   Microbial Biotechnology

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain

(2009) Chaoxuan Li et al.   METABOLIC ENGINEERING

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

(2008) María Pérez et al.   CHEMBIOCHEM

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

(2008) A. Ramos et al.   MICROBIOLOGY-SGM